{"title":"New hope for spinal-cord repair from immune activation","authors":"David Gurwitz","doi":"10.1016/S1357-4310(00)01799-8","DOIUrl":"10.1016/S1357-4310(00)01799-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Page 415"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01799-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SLAM the door on measles","authors":"Robert Brooksbank PhD","doi":"10.1016/S1357-4310(00)01802-5","DOIUrl":"10.1016/S1357-4310(00)01802-5","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Page 414"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01802-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George C. Tsokos MD (Professor Chief) , Gary M. Kammer MD (Professor)
{"title":"Molecular aberrations in human systemic lupus erythematosus","authors":"George C. Tsokos MD (Professor Chief) , Gary M. Kammer MD (Professor)","doi":"10.1016/S1357-4310(00)01798-6","DOIUrl":"10.1016/S1357-4310(00)01798-6","url":null,"abstract":"<div><p>Systemic lupus erythematosus is an autoimmune disorder that predominantly affects women during the childbearing years. Clinically, major organ systems are affected, including the skin, kidneys and nervous system. Genetic, hormonal, environmental and immunoregulatory factors contribute to the highly variable expression of the disease. Impaired cellular and humoral immune responses reflect disordered biochemical and molecular functions that might be determined genetically. Enhanced understanding of these molecular abnormalities should enable development of new, effective therapeutic agents in the near future.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 418-424"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01798-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NF-κB as a therapeutic target in chronic inflammation: recent advances","authors":"Sergei S Makarov","doi":"10.1016/S1357-4310(00)01814-1","DOIUrl":"https://doi.org/10.1016/S1357-4310(00)01814-1","url":null,"abstract":"<div><p>The family of nuclear factor κB (NF-κB) transcription factors is a topic of intense interest in the biomedical community stemming from the role NF-κB plays in almost every aspect of cell regulation: stress responses, immune cell activation, apoptosis, proliferation, differentiation and oncogenic transformation. The objective of this article is to provide an overview of recent developments in the field with an emphasis on the role of NF-κB in chronic inflammation, and to discuss the feasibility of therapeutic approaches based on the specific suppression of the NF-κB pathway.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 441-448"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01814-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71868868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The ABCR of visual impairment","authors":"Micheala A Aldred","doi":"10.1016/S1357-4310(00)01801-3","DOIUrl":"10.1016/S1357-4310(00)01801-3","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Page 417"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01801-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adeno-associated virus vectors for gene therapy: more pros than cons?","authors":"Paul E. Monahan , R.Jude Samulski","doi":"10.1016/S1357-4310(00)01810-4","DOIUrl":"10.1016/S1357-4310(00)01810-4","url":null,"abstract":"<div><p>Gene therapy vectors based on the adeno-associated virus (AAV) are being developed for a widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the relative safety of these vectors, but also to advances in understanding of the unique biology of this virus. This review examines a number of long-standing concerns regarding the utility of AAV for gene transfer in light of many new insights into the biology, immunology and production of AAV.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 433-440"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01810-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Murine, canine and non-human primate models of Krabbe disease","authors":"David A Wenger","doi":"10.1016/S1357-4310(00)01800-1","DOIUrl":"10.1016/S1357-4310(00)01800-1","url":null,"abstract":"<div><p>Globoid cell leukodystrophy (GLD) or Krabbe disease is an autosomal recessively inherited neurological disease caused by mutations in the gene coding for the lysosomal enzyme galacto-cerebrosidase (GALC). GALC is responsible for the degradation of specific galactolipids, including several that are important in the production of compact, stable myelin. A failure to adequately degrade galactosylceramide and psychosine (galactosylsphingosine) results in the characteristic pathological findings observed in tissue from humans and animals affected with GLD. These galactosphingolipids are normally synthesized during active myelination, and psychosine accumulates in individuals with very low GALC activity. Psychosine is highly toxic to the myelin-forming oligodendrocytes, causing their death and the paucity of myelin found on autopsy. While most human patients present with symptoms before six months of age and die before 18 months of age, older children and adults can also be diagnosed with GLD<span>[1]</span>, <span>[2]</span>. The cloning of both the human GALC cDNA and the <em>GALC</em> gene opened the way for the identification of mutations causing GLD in humans and animals and the development of novel strategies to treat this severe and fatal disease<span>[3]</span>. The pheno-typic differences between human patients result from the wide range of mutations identified, as well as additional unknown factors. Treatment of late-onset patients and pre-symptomatic individuals (identified either because prenatal testing was not requested or a fetus predicted to be affected was not aborted) by hemato-poietic stem cell transplantation (HSCT) resulted in a less severe phenotype than was predicted and, in some cases, a significant delay in the onset of symptoms<span>[4]</span>. Attempts to treat this disorder by <em>in utero</em> HSCT have not been successful<span>[5]</span>.GLD in dogs</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 449-451"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01800-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunomodulation in DNA damage and repair","authors":"Clare Sansom","doi":"10.1016/S1357-4310(00)01807-4","DOIUrl":"10.1016/S1357-4310(00)01807-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 411-412"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01807-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21901200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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