NF-κB as a therapeutic target in chronic inflammation: recent advances

Abstract

The family of nuclear factor κB (NF-κB) transcription factors is a topic of intense interest in the biomedical community stemming from the role NF-κB plays in almost every aspect of cell regulation: stress responses, immune cell activation, apoptosis, proliferation, differentiation and oncogenic transformation. The objective of this article is to provide an overview of recent developments in the field with an emphasis on the role of NF-κB in chronic inflammation, and to discuss the feasibility of therapeutic approaches based on the specific suppression of the NF-κB pathway.