{"title":"Receptor crosstalk: a surprising twist on an old concept","authors":"David Gurwitz PhD","doi":"10.1016/S1357-4310(00)01742-1","DOIUrl":"10.1016/S1357-4310(00)01742-1","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Page 261"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01742-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patent and be damned: the new slogan for human genetics?","authors":"Kathryn Senior (Freelance science writer)","doi":"10.1016/S1357-4310(00)01741-X","DOIUrl":"10.1016/S1357-4310(00)01741-X","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Pages 255-256"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01741-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21702219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gene therapy for peripheral arterial disease","authors":"Michael J Mann MD (Senior Surgical Resident)","doi":"10.1016/S1357-4310(00)01738-X","DOIUrl":"10.1016/S1357-4310(00)01738-X","url":null,"abstract":"<div><p>Our understanding of the molecular biology of vascular disease is rapidly expanding, and this scientific growth has brought with it new opportunities for therapeutic intervention at the molecular and genetic levels. Although our tools for genetic manipulation <em>in vivo</em> and our knowledge of potential molecular targets are still crude and incomplete, the early application of these concepts to clinical problems is already underway, both in the pre-clinical and clinical arenas. The treatment of peripheral vascular disease, although greatly improved over recent decades by surgical and minimally-invasive techniques, remains limited by vascular proliferative lesions and by our inability to modulate the progression of native disease. This review explores some of the evolving concepts of therapeutic gene manipulation and their initial application in the peripheral circulation.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Pages 285-291"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01738-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21702229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seizing the genes for inherited epilepsies","authors":"Robert A. Brooksbank PhD","doi":"10.1016/S1357-4310(00)01728-7","DOIUrl":"10.1016/S1357-4310(00)01728-7","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Page 262"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01728-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting human hair follicles","authors":"Siobhán A Jordan PhD","doi":"10.1016/S1357-4310(00)01745-7","DOIUrl":"10.1016/S1357-4310(00)01745-7","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Page 263"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01745-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guarding the fly genome","authors":"Jonathan B Weitzman PhD","doi":"10.1016/S1357-4310(00)01743-3","DOIUrl":"10.1016/S1357-4310(00)01743-3","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Page 263"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01743-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peta E. Jackson PhD (Research Associate) , Peter F. Scholl PhD (Senior Staff Research Scientist) , John D. Groopman PhD (Professor and Chair of Environmental Health Sciences)
{"title":"Mass spectrometry for genotyping: an emerging tool for molecular medicine","authors":"Peta E. Jackson PhD (Research Associate) , Peter F. Scholl PhD (Senior Staff Research Scientist) , John D. Groopman PhD (Professor and Chair of Environmental Health Sciences)","doi":"10.1016/S1357-4310(00)01698-1","DOIUrl":"10.1016/S1357-4310(00)01698-1","url":null,"abstract":"<div><p>Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 7","pages":"Pages 271-276"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01698-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21702227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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