Molecular strategies for overcoming antibiotic resistance in bacteria

Yu-Ting Tan (Medical student), Darren J. Tillett PhD (Post-Doctoral Research Fellow), Ian A. McKay PhD (Senior Lecturer)
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引用次数: 94

Abstract

Overuse of antibiotics in humans and livestock has led to the rapid evolution of bacteria that are resistant to multiple drugs such that even vancomycin, the drug of last resort, is no longer effective against some strains. Apart from the discovery and exploitation of the natural peptide antimicrobial agents that form part of the innate immune systems of plants and animals, there have been few new antibiotics developed in recent years. Here we review strategies designed to exploit recent advances in molecular biology, including recombinant DNA technology, molecular modelling and genomics to develop new antibacterial agents that overcome antibiotic resistance.

克服细菌抗生素耐药性的分子策略
在人类和牲畜中过度使用抗生素,导致对多种药物具有耐药性的细菌迅速进化,甚至万古霉素这种最后的药物对某些菌株也不再有效。近年来,除了天然多肽抗菌药物的发现和开发,构成了动植物先天免疫系统的一部分,很少有新的抗生素开发。在这里,我们回顾了旨在利用分子生物学的最新进展,包括重组DNA技术,分子建模和基因组学来开发克服抗生素耐药性的新型抗菌剂的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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