The molecular role of mast cells in atherosclerotic cardiovascular disease

Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)
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引用次数: 97

Abstract

Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways.

肥大细胞在动脉粥样硬化性心血管疾病中的分子作用
人类动脉粥样硬化具有炎症性疾病的许多特征。最近的数据表明肥大细胞可能在动脉粥样硬化疾病的发病机制中起重要作用。肥大细胞通过分泌促炎细胞因子,协助单核细胞和淋巴细胞募集到血管组织,从而传播炎症反应。肥大细胞酶可能激活前金属蛋白酶,从而破坏动脉粥样硬化斑块的稳定。肥大细胞可以通过促进胆固醇的积累来促进泡沫细胞的形成。然而,肥大细胞胰蛋白酶可以通过干扰凝血来减缓斑块破裂部位的血栓形成。因此,肥大细胞可以通过促进和抑制两种途径调节冠状动脉疾病。
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