微环境对恶性表型的影响

Catherine C Park PhD (Research Resident) , Mina J Bissell PhD (Division Director) , Mary Helen Barcellos-Hoff PhD (Group Leader)
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引用次数: 431

摘要

正常的组织稳态是由上皮细胞与其微环境之间的动态相互作用维持的。当组织癌变时,肿瘤细胞与相邻的正常细胞(如基质和内皮细胞)及其微环境之间存在相互作用。目前占主导地位的范式认为,多种遗传病变既是癌症的动力,也是癌症的致命弱点,这可能不足以将癌症理解为一个疾病过程。在下面的简短回顾中,我们将使用选定的例子来说明微环境在恶性表型进化中的影响。我们还将讨论最近的研究表明,新的治疗干预可能源于关注微环境和肿瘤细胞的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The influence of the microenvironment on the malignant phenotype

Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions between neoplastic cells, adjacent normal cells such as stroma and endothelium, and their microenvironments. The current dominant paradigm wherein multiple genetic lesions provide both the impetus for, and the Achilles heel of, cancer might be inadequate to understand cancer as a disease process. In the following brief review, we will use selected examples to illustrate the influence of the microenvironment in the evolution of the malignant phenotype. We will also discuss recent studies that suggest novel therapeutic interventions might be derived from focusing on microenvironment and tumor cells interactions.

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