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Atypical Kawasaki Disease in a 5-month-old Infant. 1例5月龄婴儿的不典型川崎病。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 DOI: 10.4103/aam.aam_27_25
Hiba Habeebu Rahiman, Subhranshu Sekhar Kar, Mariam Mehwish Mohsin, Rajani Dube, Naheel Mohammed Jumaa Alboot
{"title":"Atypical Kawasaki Disease in a 5-month-old Infant.","authors":"Hiba Habeebu Rahiman, Subhranshu Sekhar Kar, Mariam Mehwish Mohsin, Rajani Dube, Naheel Mohammed Jumaa Alboot","doi":"10.4103/aam.aam_27_25","DOIUrl":"https://doi.org/10.4103/aam.aam_27_25","url":null,"abstract":"<p><strong>Abstract: </strong>Kawasaki disease (KD) is an acute febrile vasculitis primarily affecting medium-sized arteries in children under 5 years. Infants under 6 months represent a diagnostic challenge due to atypical or incomplete presentations, increasing the risk of coronary artery lesions and complications such as aneurysms. Early diagnosis and treatment with intravenous immunoglobulin (IVIG) and aspirin are crucial to prevent long-term cardiac sequelae. We report a rare case of KD in a 5-month-old Bangladeshi girl presenting with prolonged fever, rash, and sterile pyuria. Initial evaluations pointed to partially treated meningitis, delaying KD diagnosis. Subsequent symptoms included edema, osteoarthritis, and persistent inflammation, leading to an echocardiographic detection of a small coronary aneurysm. Treatment with IVIG, aspirin, and corticosteroids resulted in the resolution of symptoms and normalization of cardiac findings. Infants below 6 months often present with incomplete KD, complicating diagnosis and delaying treatment. This case underscores the importance of considering KD in febrile infants with persistent inflammation, even in the absence of classic symptoms. Echocardiography and laboratory markers remain essential for early detection and management. Increased awareness and timely intervention in atypical and incomplete KD presentations are critical for reducing complications, particularly in high-risk groups like infants under 6 months.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Risk Factors of Restless Legs Syndrome among Medical Students in Saudi Arabia: An Observational Study. 不宁腿综合征在沙特阿拉伯医学生中的患病率和危险因素:一项观察性研究
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.4103/aam.aam_232_24
Razan Alabdulqader, Raghad Alqahtani, Khadija Alsunaikh, Sara Almousa, Ammar Alsalem, Alia Alokley
{"title":"Prevalence and Risk Factors of Restless Legs Syndrome among Medical Students in Saudi Arabia: An Observational Study.","authors":"Razan Alabdulqader, Raghad Alqahtani, Khadija Alsunaikh, Sara Almousa, Ammar Alsalem, Alia Alokley","doi":"10.4103/aam.aam_232_24","DOIUrl":"10.4103/aam.aam_232_24","url":null,"abstract":"<p><strong>Background: </strong>Restless legs syndrome (RLS) is a sensorimotor condition that affects the quality of sleep for those who have it. The diagnosis is made according to the consensus criteria by the National Institute of Health panel as follows: \"(i) a strong desire to move one's legs, usually in response to an unpleasant sensation; (ii) a stronger urge in the evening and at night; (iii) movement usually satisfies the urge; and (iv) rest increases the urge.\" This study aims to investigate the prevalence and associated risk factors of RLS among medical students in Saudi Arabia; furthermore, the severity and impact of RLS on sleep status.</p><p><strong>Methodology: </strong>A cross-sectional study conducted between 2022 and 2024 in medical students in Saudi Arabia. Three hundred and thirty-one students (233 female and 98 male) participated and completed an online consented questionnaire to detect the prevalence of RLS and associated risk factors including medical comorbidities, smoking, and caffeine intake based on criteria proposed by the International Restless Legs Syndrome Study Group. Furthermore, the severity and impact of RLS on sleep status were studied using the Epworth Sleepiness Scale and the RLS rating scale, respectively.</p><p><strong>Results: </strong>The frequency of RLS among medical students is 20.2%. The severity of RLS reported in 23.9% of the students with mild-to-severe rates. About 40.3% of students with RLS had daytime fatigue and 33.4% had sleep disturbances. About 64.1% of medical students who suffer from RLS have associated medical comorbidities including iron-deficiency anemia, diabetes mellitus, and peripheral neuropathy. Thirty-seven percent are smokers and 42.9% of students who had 3-4 cups of coffee daily had RLS compared to 18.6% of others who did not.</p><p><strong>Conclusion: </strong>RLS has a significant prevalence among medical students, in Saudi Arabia. RLS is highly associated with sleeping disturbance and daytime fatigue. Caffeine and smoking are considered risk factors for RLS.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"421-426"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Postoperative Analgesia in Modified Radical Mastectomy Following Instillation of Bupivacaine through Surgical Drains. 改良乳房根治术经引流管灌注布比卡因术后镇痛效果评价。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.4103/aam.aam_151_24
R Sneha, R K Ranjan, Mahesh Nayak, Shilpa A Naik, Ashna Shetty, B Prathvi
{"title":"Assessment of Postoperative Analgesia in Modified Radical Mastectomy Following Instillation of Bupivacaine through Surgical Drains.","authors":"R Sneha, R K Ranjan, Mahesh Nayak, Shilpa A Naik, Ashna Shetty, B Prathvi","doi":"10.4103/aam.aam_151_24","DOIUrl":"10.4103/aam.aam_151_24","url":null,"abstract":"<p><strong>Background: </strong>Globally, breast cancer is a significant public health concern in women. Modified radical mastectomy (MRM) is a commonly used surgical treatment. Postmastectomy pain is a serious concern because, if left untreated, can have psychological effects, resulting in postoperative complications. This observational study aimed to assess the effectiveness of bupivacaine for postoperative analgesia administered using surgical drains after MRM.</p><p><strong>Methods: </strong>Sixty female patients who underwent MRM were included in the study. Patients in Group A received 40 mL of 0.25% bupivacaine, 20 mL through each drain placed in the axilla and chest wall below flap. Patients in Group B received standard postoperative pain management. The postoperative visual analog scale (VAS) score was evaluated every 4 h for 24 h. When the patient's VAS score was higher than 3 at any point during the treatment, they received slow intravenous injections of 1 mg/kg tramadol. The period of analgesia was measured from the point when the analgesic was introduced until the onset of the first rescue analgesia. Both the total number of times the medication was administered, and the total number of analgesics needed were recorded.</p><p><strong>Results: </strong>The median total dose of rescue analgesia given to Group B (median = 113.0 mg tramadol) was higher compared to Group A (median = 47.5 mg tramadol) with P = 0.001.</p><p><strong>Conclusion: </strong>Patients who received bupivacaine through surgical drains experienced longer and more effective analgesia. It is an easy, economical way to get good analgesia following surgery with minimal adverse reactions.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"292-297"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Smokeless Tobacco Use on the Upper Gastrointestinal Tract Mucosa: Gross and Histopathological Changes. 无烟烟草使用对上消化道黏膜的影响:肉眼和组织病理学改变。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.4103/aam.aam_292_24
Bhumika Vaishnav, Anjitha S Valiyil, Shubhangi Anand, Anushka Ghosal, Ruchitha Pailla, Gayatri R Nair
{"title":"Effects of Smokeless Tobacco Use on the Upper Gastrointestinal Tract Mucosa: Gross and Histopathological Changes.","authors":"Bhumika Vaishnav, Anjitha S Valiyil, Shubhangi Anand, Anushka Ghosal, Ruchitha Pailla, Gayatri R Nair","doi":"10.4103/aam.aam_292_24","DOIUrl":"10.4103/aam.aam_292_24","url":null,"abstract":"<p><strong>Background/aim: </strong>Tobacco addiction is prevalent in South and Southeast Asia. This study aimed to assess upper gastrointestinal (GI) tract changes in smokeless tobacco (SLT) users through upper GI endoscopy (UGIE).</p><p><strong>Materials and methods: </strong>A cross-sectional observational study, including 108 SLT users and 90 controls who did not use tobacco, was conducted at an Indian tertiary care hospital from March 2022 to February 2023. Participants were categorized into three groups: Non-SLT users (Group A), SLT users for <10 years (Group B), and SLT users for >10 years (Group C). UGIE and biopsies from the lower esophagus, stomach, and duodenum were performed, noting gross and pathological findings.</p><p><strong>Results: </strong>There were 89 males and 19 females. More than 60% of patients used SLT for more than 10 years. Grossly, erosive and ulcerative lesions of the esophagus and stomach were the most common findings. Barrett's esophagus (14/108 patients) and esophageal neoplasms (5/108 patients) were found in 19/108 patients (17.59%). Common biopsy findings were chronic gastritis and duodenitis. Group C had a significantly high finding of gastric ulcers compared to other 2 groups. A total of 68/108 SLT users (62.96%) had Helicobacter pylori infection which was significantly higher compared to the controls ( P < 0.05).</p><p><strong>Conclusion: </strong>Chronic SLT use was found to be associated with gross and histological changes in the upper GI tract such as chronic erosions, peptic ulcers, and neoplastic growths. UGIE must be done routinely in all these patients whenever they develop chronic dyspepsia for early diagnosis and management.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"450-455"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Rapid Shallow Breathing Index and Ultrasonographic Diaphragmatic Parameters as Predictors of Weaning Outcome in Critically Ill Patients on Mechanical Ventilation. 快速浅呼吸指数和超声膈参数作为危重病人机械通气脱机结果的预测因子。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-04-10 DOI: 10.4103/aam.aam_10_25
{"title":"Erratum: Rapid Shallow Breathing Index and Ultrasonographic Diaphragmatic Parameters as Predictors of Weaning Outcome in Critically Ill Patients on Mechanical Ventilation.","authors":"","doi":"10.4103/aam.aam_10_25","DOIUrl":"10.4103/aam.aam_10_25","url":null,"abstract":"","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"513"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Malaria among Apparently Healthy Blood Donors at Tertiary Health-care Center in Northeastern Tribal Region of India. 印度东北部落地区三级保健中心貌似健康的献血者中疟疾流行情况
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.4103/aam.aam_127_24
Sushma Kumari, Divakar Kumar, Abhay Kumar, Usha Saroj, Priyanka Shrivastava, Saket Verma, Manisha Kujur, Upendra P Sahu, Anupa Prasad
{"title":"Prevalence of Malaria among Apparently Healthy Blood Donors at Tertiary Health-care Center in Northeastern Tribal Region of India.","authors":"Sushma Kumari, Divakar Kumar, Abhay Kumar, Usha Saroj, Priyanka Shrivastava, Saket Verma, Manisha Kujur, Upendra P Sahu, Anupa Prasad","doi":"10.4103/aam.aam_127_24","DOIUrl":"10.4103/aam.aam_127_24","url":null,"abstract":"<p><strong>Background: </strong>Transfusion Transmitted Malaria is a major concern among blood donors in endemic countries. The Drugs and Cosmetic Act 1940 in India mandated testing of all blood donations for Malaria. Regular screening of malaria prevents severe transfusion-transmitted malaria, and shows its prevalence and enables its control among the population.</p><p><strong>Material and methods: </strong>This is a 09-year retrospective observational study from 1 st August 2014 to 31 st July 2023 among apparently healthy blood donors in Blood Centre of Rajendra Institute of Medical Sciences, Jharkhand, a tertiary health care centre in tribal population-dominant region of India. Every donor's sample is subjected to a malaria antigen test both for Plasmodium falciparum and Plasmodium vivax by One step, rapid, immunochromatographic test. Positive result by rapid diagnostic Antigen card tests were also analysed by microscopy (peripheral blood smear).</p><p><strong>Results: </strong>In the present study, the total number of blood units collected was 246,147. On screening of the total blood donors, 62,225 (25.27%) were voluntary donors and 183,942 (74.72%) were replacement donors. There were 2,27,731 (92.51%) male donors and 18,416 (7.48%) female donors. Among all the donors, only 61 (0.024%) malaria-positive donors were seen, all male.</p><p><strong>Conclusion: </strong>Malaria transmission is strictly monitored and controlled by governments in endemic regions. In addition to the direct spread by mosquito bites, malaria can also be transmitted by transfusion as blood is transfused mainly as whole blood in developing countries. The transmission by transfusion of blood remains a challenge to blood centres because of carriers of malaria in the population in endemic regions like Jharkhand, India. This is first long retrospective observational study of prevalence of malaria among apparently healthy blood donors in a tertiary care centre in Northeastern tribal region of India. It gives a rough idea of the effectiveness of various malaria control programs in remote, malaria-endemic regions.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"231-236"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Incidence of Pregnancy-related Acute Kidney Injury and Its Associated Risk Factors and Outcomes: In Preponderant Tribal State of India. 妊娠相关急性肾损伤发生率及其相关危险因素和结局的研究:在印度优势部落邦。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.4103/aam.aam_200_24
Pooja Kumari, Kiran Trivedi, Sudipto Banerjee, Apoorwa Sharma, Tulika Sinha, Payal Boipai, Shiwani Kumari
{"title":"Study on Incidence of Pregnancy-related Acute Kidney Injury and Its Associated Risk Factors and Outcomes: In Preponderant Tribal State of India.","authors":"Pooja Kumari, Kiran Trivedi, Sudipto Banerjee, Apoorwa Sharma, Tulika Sinha, Payal Boipai, Shiwani Kumari","doi":"10.4103/aam.aam_200_24","DOIUrl":"10.4103/aam.aam_200_24","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy-related acute kidney injury (PRAKI) may occur due to various causes from conception to puerperium. This study was undertaken to determine the incidence and associated risk factors and evaluate fetomaternal outcomes in PRAKI at tertiary care institution.</p><p><strong>Materials and methods: </strong>A prospective longitudinal study was conducted with enrollment of pregnant females with PRAKI, ≥28 weeks, and up to 7 days of puerperium, diagnosed as per the Kidney Disease Improving Global Outcomes (KDIGO) criteria - serum creatinine >1.3 mg/dl at admission or increased by 0.3 mg/dL within 48 h or >1.5 times within 7 days or urine output <0.5 ml/kg/h. A detailed history including sociodemographic factors, obstetric history, and underlying medical disorders with primary cause and obstetric precipitating factors of PRAKI was noted. The sample size was 184 patients and followed up with serial renal function test, serum electrolytes, input/urine output monitoring, and dialysis, on nephrologist advice. Complete renal recovery was considered if serum creatinine <1.3 mg/dl at discharge.</p><p><strong>Results: </strong>In the present study, the incidence of PRAKI was 3.16%, the mean age was 25.36 ± 5.13 years, and 76.08% of patients were antenatal, mostly primigravida. Primary causes were hypertension (57.06%), hemorrhage (20.65%), multiorgan failure (MOF), sepsis, and other causes. Obstetric complications which precipitate PRAKI were eclampsia (antepartum [52.38%], severe preeclampsia [44.77%], and postpartum [2.86%]), hemorrhage (antepartum [28.59%] and postpartum [23.68%]), hemolysis, elevated liver enzymes, and low platelet count syndrome (3.8%), and acute fatty liver of pregnancy (2.71%). The mean serum creatinine (mg/dL) at admission, after 48 h, and at discharge were 1.92 ± 0.87, 2.69 ± 1.33, and 1.09 ± 0.32, respectively ( P = 0.0001). The mean blood urea (mg/dL) at admission and at discharge were 83.9 ± 30.42 and 37.2 ± 7.12, respectively ( P = 0.0001). Hemodialysis was performed in 42 (22.83%) patients; 142 patients (77.17%) were managed conservatively. Complete recovery in 137 (74.46%), 19 (10.33%) maternal mortality, 5 (11.9%) patients progressed to chronic kidney disease, median hospital stay 10 days, intensive care unit (ICU) stay 8 days ( P = 0.0001). Live birth, intrauterine death, and neonatal ICU admission were in 128 (69.57%), 56 (30.43%), and 42 (32.81%) patients, respectively.</p><p><strong>Conclusion: </strong>Proper antenatal care, timely referral, and early detection and management of PRAKI may minimize fetomaternal morbidity and mortality.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"304-309"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interstitial Capillary Congestion and Diffuse Alveolar Damage: Incidental or Factual Findings in the Lungs of Autopsy Cases Positive for Coronavirus Disease-19. 间质毛细血管充血和弥漫性肺泡损伤:冠状病毒阳性尸检病例的偶然或事实表现[19]
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.4103/aam.aam_263_24
Preeti Agarwal, Shiuli Rathore, Anurag Singh, Poorvi Mathur, Anuragani Verma, Ravindra Kumar Garg, Anoop Kumar Verma, Amita Jain
{"title":"Interstitial Capillary Congestion and Diffuse Alveolar Damage: Incidental or Factual Findings in the Lungs of Autopsy Cases Positive for Coronavirus Disease-19.","authors":"Preeti Agarwal, Shiuli Rathore, Anurag Singh, Poorvi Mathur, Anuragani Verma, Ravindra Kumar Garg, Anoop Kumar Verma, Amita Jain","doi":"10.4103/aam.aam_263_24","DOIUrl":"10.4103/aam.aam_263_24","url":null,"abstract":"<p><strong>Background: </strong>Interstitial capillary congestion and diffuse alveolar damage (DAD) were frequently observed in patients who died from Coronavirus disease-19 (COVID-19). The research question pertains to observing these findings in COVID-19-positive patients lacking pulmonary symptoms. The histological examination of lung samples from COVID-19-positive patients who do not succumb to COVID-19-related pulmonary complications can provide an answer. This study analyzed postmortem lung autopsy samples from individuals who did not succumb to COVID-19-related pulmonary complications. The research article aimed to examine the morphological variations in postmortem lung samples of COVID-19 patients who did not succumb to the disease, and to compare these changes with those observed in cases of COVID-19-related deaths, utilizing existing English literature.</p><p><strong>Methodology: </strong>This prospective study included subjects who died without complications from COVID-19-related injuries, had positive real-time polymerase chain reaction throat swabs, and exhibited no pulmonary manifestation of COVID-19 disease. A comprehensive histomorphological analysis of the lung samples was conducted.</p><p><strong>Results: </strong>A total of 20 subjects were enrolled in this study. Capillary congestion was the most prevalent histomorphological change observed in lung autopsies, seen in 90% (18/20) of cases, followed by emphysema in 75% (15/20) and the acute phase of DAD in 25% (5/20) of cases. Acute bronchopneumonia and fibrotic nodules were identified in 20% (4/20) and 10% (2/20) of the study population, respectively.</p><p><strong>Conclusion: </strong>In postmortem lung autopsy of COVID-19-positive patients lacking symptomatic pulmonary issues, capillary congestion, diffuse alveolar destruction, and emphysema were prevalent. The findings indicate that COVID-19 exhibits varied responses to damage and inflammation that do not correlate with mortality. This study enhances the understanding of pathophysiological lung tissue variations in COVID-19 patients who have non-COVID-19-related deaths, potentially educating forensic pathologists and supporting future research endeavors.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"391-397"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Serum Uric Acid Levels and Islet Beta-cell Function in Type 2 Diabetes Mellitus. 2型糖尿病患者血清尿酸水平与胰岛β细胞功能的关系
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.4103/aam.aam_190_24
Nitesh Shukla, Ashok Kumar, Lalit Kumar Tyagi, K P Sindhura
{"title":"Association between Serum Uric Acid Levels and Islet Beta-cell Function in Type 2 Diabetes Mellitus.","authors":"Nitesh Shukla, Ashok Kumar, Lalit Kumar Tyagi, K P Sindhura","doi":"10.4103/aam.aam_190_24","DOIUrl":"10.4103/aam.aam_190_24","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a disease characterized by insulin resistance (IR) and insufficiency. Serum uric acid (SUA) is a biomarker of diabetes risk, with Indian populations having varying levels due to diet, lifestyle, and genetic susceptibility. However, the relationship between UA and T2DM is contentious due to its association with obesity. The study explores the relationship between serum uric acid levels and islet beta-cell function in type 2 diabetes patients, estimating the correlation, examining factors such as age, gender, or body mass index (BMI), and estimating the correlation between uric acid levels and IR.</p><p><strong>Methods: </strong>A study at Santosh Medical College in Ghaziabad involved 167 patients over 18 years old with type 2 diabetes, diagnosed based on fasting plasma glucose levels, and glycated hemoglobin (HbA1c). The patients underwent detailed history and physical examination, including fasting blood glucose, lipid profile, serum urea, creatinine, uric acid, HbA1c, insulin sensitivity index, and islet beta-cell function indices.</p><p><strong>Results: </strong>The study involved 170 patients, with 84 (49.41%) being male and 86 (50.59%) being female. The mean lipid profile was similar across genders, with no significant differences in HbA1c, random blood sugar (RBS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), and homeostatic model assessment of IR (HOMA-IR). Smoking and alcohol consumption were significantly higher in males, while family history of T2DM was comparable between both genders. The relationship between SUA quartiles and other parameters and HOMA-IR in males was not significantly different, while in females, the mean age, BMI, waist circumference, waist-hip ratio, HbA1c, RBS, TC, TG, HDL-c, low-density lipoprotein-cholesterol, HOMA-IR, and creatinine were not significantly different. The correlation of HOMA-IR and uric acid was positive but not significantly associated.</p><p><strong>Conclusion: </strong>The study found a significant positive correlation between serum uric acid levels and IR in males and females and a positive but nonsignificant correlation with BMI, suggesting that SUA could predict islet β-cell activity.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"268-273"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lichen Planus Pemphigoides: From Lichenoid to Bullous Disease. 类天疱疮扁平苔藓:从类地衣到大疱性疾病。
IF 0.6
Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.4103/aam.aam_252_24
Avinash Jadhav, Kirti Deo, Anuja Masare, Shambhavi Singh
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