Annals of African Medicine最新文献

{"title":"Prevalence, Clinical Correlation, and Antifungal Susceptibility of Candidemia Patients in Various Intensive Care Unit's of a Tertiary Care Hospital in Jharkhand.","authors":"Bhuvan Shome, Abhay Kumar, Ashok Kumar Sharma, Kumari Seema, Manju Boipai, Manoj Kumar","doi":"10.4103/aam.aam_917_26","DOIUrl":"https://doi.org/10.4103/aam.aam_917_26","url":null,"abstract":"<p><strong>Introduction: </strong>Candidemia represents grave healthcare-associated fungal infections. Being an opportunistic pathogen, Candida is becoming a cause of significant morbidity and mortality in patients at greater risk. The aim of the present study was to examine Candida isolates collected from blood cultures in intensive care unit patients at a tertiary care hospital in Jharkhand and to illustrate their various properties and its clinical correlations along with various antifungal susceptibility profiles.</p><p><strong>Materials and methods: </strong>In this prospective study of 12 months, Candida isolates from blood were differentiated by conventional methods and compared by matrix-assisted laser desorption/ionization time-of-flight and VITEK 2 compact automated system. Findings were clinically correlated with various parameters like death, patients requiring assisted ventilation, and number of hospital stay days.</p><p><strong>Results: </strong>Out of 985 positive blood cultures, 95 were Candida species (9.64%). Seventy-nine isolates were Non-Albicans Candida (83.15%) and 16 isolates were Candida albicans (16.8%). Candida tropicalis 30 isolates (31.5%) was isolated, followed by Candida glabrata, Candida parapsilosis, and others. Mean age of the patients was 18.67 years. With a mortality rate of 45.2%, children were mostly deceased, accounting for 58% of all the deaths. Male predominance is seen, constituting 72% of all the deaths. C. tropicalis and C. glabrata were the most common organisms leading to death, both contributing 31% each, while C. tropicalis is the most common organism due to which patients required assisted ventilation. These isolates were susceptible to common antifungals.</p><p><strong>Conclusion: </strong>Judicious start of antifungal drugs in patients of high risk is very important. This study will help clinicians to opt for best antifungal agents in the management of candidemia shortening hospital stay days.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Thyroid Disorder and Liver Function Tests in Pregnancy.","authors":"Aleena Haider, Shikhar Singh, Shahina Perween, Lily Singh","doi":"10.4103/aam.aam_907_26","DOIUrl":"https://doi.org/10.4103/aam.aam_907_26","url":null,"abstract":"<p><strong>Background: </strong>Thyroid disease is prevalent among women of reproductive age and has a complex interplay with liver function, affecting both healthy and diseased states, including during pregnancy. To determine the relationship between thyroid disorders and liver function abnormalities during pregnancy among pregnant women.</p><p><strong>Methods: </strong>This was an unmatched case-control study over a period of 2 years. A total of 90 pregnant women who were above 24 weeks of gestation were recruited in the study. They were divided into two groups of 45 antenatal women each; those with normal liver function tests (LFT) were taken as controls (Group A) and those with abnormal LFT were considered as cases (Group B). Women in both these groups were then subjected to thyroid function tests. The number of women with thyroid disorder in both these groups was compared, and data analysis was done.</p><p><strong>Results: </strong>Among 90 pregnant women (45 cases with deranged LFT and 45 controls with normal liver functions), baseline demographic characteristics were comparable between groups. Liver enzymes and bilirubin levels were significantly higher in cases (P < 0.05). Mean serum thyroid-stimulating hormone (TSH) was also significantly elevated in cases (3.3 ± 2.4 mIU/L) compared to controls (2.3 ± 1.1 mIU/L; P = 0.011). Women with elevated TSH (>3 mIU/L) had significantly higher odds of abnormal liver function (adjusted odds ratio = 3.6-3.8; P = 0.008).</p><p><strong>Conclusion: </strong>These findings demonstrate a significant association between thyroid dysfunction and liver function abnormalities in pregnancy. Early and combined screening of thyroid and liver function may facilitate timely diagnosis and management, thereby improving maternal and fetal outcomes.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Diabetic Ketoacidosis in Remote and Resource-constrained Settings in India.","authors":"Ubair Masood, Soumya Chandrasekhar, Radhika Wanjale, Priyanka Mahale, Sumati Dadkar, Shrikanth Muralidharan, Satyajit Singh Gill","doi":"10.4103/aam.aam_834_26","DOIUrl":"https://doi.org/10.4103/aam.aam_834_26","url":null,"abstract":"<p><strong>Abstract: </strong>Diabetic ketoacidosis (DKA) remains a major endocrine emergency in India, particularly in remote and resource-constrained settings where standard intensive care-based protocols are often difficult to implement. This narrative review examines the challenges of DKA management in rural Indian healthcare systems and evaluates the feasibility of pragmatic adaptations to existing treatment recommendations. Available evidence suggests that delayed presentation, infection, interrupted insulin access, limited laboratory support, inadequate monitoring facilities, and shortages of trained personnel significantly influence DKA outcomes in India. Selected patients with mild-to-moderate DKA may be managed safely using structured subcutaneous insulin protocols, although Indian prospective data remain limited. Future Indian DKA guidelines should incorporate resource-stratified recommendations that distinguish ideal care from minimum safe care. Context-sensitive management pathways, simplified monitoring protocols, improved diabetes education, and strengthened healthcare infrastructure are essential for improving DKA outcomes in underserved regions.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talquetamab and Its Effect on Relapsed and Refractory Multiple Myeloma.","authors":"Naga Alekhya Garikipati, Sri Vaishnavi Guntupalli, Rakesh Kumar Korrapati, Jahnavi Mikkilineni, Srinidhi Kondepudi, Bushra Shaik, Simhachalam Gurugubelli, Rithish Nimmagadda","doi":"10.4103/aam.aam_391_25","DOIUrl":"https://doi.org/10.4103/aam.aam_391_25","url":null,"abstract":"<p><strong>Abstract: </strong>Relapsed and refractory multiple myeloma (RRMM) remains a challenging condition despite many advances in immunotherapies. Outcomes are particularly dismal in patients who are refractory to these three major classes of proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies (mAbs), and chimeric antigen receptor (CAR) T-cell therapies. Novel bispecific antibodies (BsAbs) have shown some promising efficacy in heavily pretreated patients, even those with triple- and penta-refractory disease. Talquetamab is a BsAb recently approved for the treatment of relapsed and refractory multiple myeloma. Talquetamab demonstrated a high overall response rate of approximately 70%, including in patients that are previously treated with T-cell therapies. The safety profile of talquetamab is consistent with other BsAbs, with similar adverse events. The efficacy of talquetamab and other therapies, including CAR-T cell treatments, remains an area of active research, as resistance to anti-B-cell maturation antigen therapies poses a clinical challenge. Current trials are exploring the use of talquetamab in combination therapies. There is now adequate data to further support talquetamab's efficacy, making it a very important addition to the RRMM treatment domain.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Preemptive Oral Gabapentin versus Pregabalin for Postoperative Pain Management after Lower Limb Surgeries under Spinal Anesthesia: A Prospective Randomized Study.","authors":"P Divya, Shakti Singhal, Gunjan Agarwal, Ghanshyam D Singhal, Preeti Goyal","doi":"10.4103/aam.aam_619_26","DOIUrl":"https://doi.org/10.4103/aam.aam_619_26","url":null,"abstract":"<p><strong>Background and aim: </strong>This study aimed to compare oral Gabapentin and Pregabalin as preemptive analgesics in lower limb surgeries under spinal anesthesia, evaluating their effectiveness in postoperative pain relief and reduction of opioid consumption.</p><p><strong>Materials and methods: </strong>This prospective, randomized, double-blind study included 140 American Society of Anaesthesiologists physical status I-II patients aged 18-60 years scheduled for elective lower limb surgery under spinal anesthesia. Patients received either oral gabapentin 1200 mg or oral pregabalin 300 mg 1 h before surgery. Postoperative pain was assessed using the Visual Analogue Scale (VAS) for 24 h. Time to first rescue analgesia, total tramadol consumption, sedation score, postoperative nausea and vomiting, and adverse effects were recorded. A P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>No significant difference in VAS scores was observed between the groups during the first 2 postoperative h. However, from the 3rd postoperative h onward, VAS scores were significantly lower in the pregabalin group (P < 0.001). The mean time to first rescue analgesia was significantly longer in the pregabalin group compared to the gabapentin group (395.57 ± 91.17 min vs. 340.29 ± 57.58 min; P < 0.001). Total tramadol consumption during the first 24 h was significantly lower in the pregabalin group (121.71 ± 17.53 mg vs. 153.57 ± 34.47 mg; P < 0.001). The incidence of adverse effects was comparable between the groups.</p><p><strong>Conclusion: </strong>In lower limb surgeries under spinal anesthesia, oral Pregabalin provides better postoperative analgesia than oral Gabapentin, with longer pain relief, reduced opioid requirement, and similar side effects.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Duration of Yoga Practice on the Physiological and Cardiopulmonary Variables.","authors":"Anwesha Das, Sneha B Shetty, K Bhagyalakshmi, N Anupama","doi":"10.4103/aam.aam_749_26","DOIUrl":"https://doi.org/10.4103/aam.aam_749_26","url":null,"abstract":"<p><strong>Background: </strong>Yoga is a holistic practice linked with various physiological and cardiopulmonary benefits. However, the relationship between the duration of yoga practice and these parameters remains insufficiently explored.</p><p><strong>Objectives: </strong>To assess the association between the duration of yoga practice and selected anthropometric, cardiovascular, and respiratory parameters among healthy adults.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 100 healthy adults who practiced yoga for at least 30 min per day on a minimum of 4 days per week. Participants were classified into two groups according to the duration of yoga practice: <6 months (n = 50) and >6 months (n = 50). Anthropometric and cardiopulmonary parameters were assessed and compared between the groups.</p><p><strong>Results: </strong>Participants practicing yoga for >6 months had significantly lower body weight, body mass index, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, and heart rate compared with those practicing for <6 months (P < 0.05). Oxygen saturation and peak expiratory flow rate were significantly higher in the >6-month group (P < 0.001). Waist-hip ratio did not differ significantly between the groups.</p><p><strong>Conclusion: </strong>Longer duration of yoga practice was associated with more beneficial anthropometric, cardiovascular, and respiratory parameters among healthy adults. Future longitudinal studies using standardized yoga protocols are warranted to further clarify the relationship between yoga practice duration and physiological and cardiopulmonary outcomes.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related Upper Airway Changes and Their Significance in Orthodontic Treatment Planning: A Scoping Review.","authors":"Carol Winnie Lobo, Ratna Rachel Ponraj, Rajinderpal Singh, Sharol Annie Lobo","doi":"10.4103/aam.aam_911_26","DOIUrl":"https://doi.org/10.4103/aam.aam_911_26","url":null,"abstract":"<p><strong>Abstract: </strong>Orthodontic treatment outcomes and airway stability may be impacted by age-related changes in upper airway morphology and function, especially in adults. A thorough search was conducted in PubMed, Scopus, and Web of Science. PRISMA-ScR guidelines were used to analyze and select the studies that were associated with aging, craniofacial morphology, and orthodontic or orthognathic interventions. Aging is related to reduction in airway volume, decreased neuromuscular tone, soft-tissue laxity, and increased airway collapsibility are associated with aging. Vertical skeletal pattern variations and craniofacial aging may further compromise the airway dimensions. Airway dimensions are also affected by the orthodontic treatment modality. Minimal clinically significant airway compromise is seen in extraction therapy, whereas favorable airway outcomes are seen in mandibular advancement and orthognathic surgery. Age-related airway changes are important considerations in orthodontic treatment planning. Individualized airway assessment and interdisciplinary management are essential to optimize functional and respiratory outcomes.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Reticulocyte Hemoglobin Equivalent Cutoff to Diagnose Iron Deficiency: A Study from South Indian Population.","authors":"Narendhar Ayyappan, Muthu Sudalaimuthu, P Renuka","doi":"10.4103/aam.aam_726_26","DOIUrl":"https://doi.org/10.4103/aam.aam_726_26","url":null,"abstract":"<p><strong>Background: </strong>Anemia is the most common health problem affecting approximately one-third of the population worldwide, with 50% of patients suffering from iron-deficiency anemia (IDA). Hematological parameters along with peripheral smear finding may help in picking up patients with IDA but are insensitive to early stages of iron deficiency. Serum iron studies are required for confirmation but these are affected by inflammation, infection, and liver disease. Reticulocyte hemoglobin equivalent (Ret He) measures the hemoglobin (HGB) content in circulating reticulocytes, reflecting iron availability for erythropoiesis over the preceding 3-4 days and it is not influenced by inflammation or diurnal variation and provides a real-time assessment of iron deficiency. However, Ret He cutoff show variation across different population.</p><p><strong>Methods: </strong>This cross-sectional study done at a tertiary care health center in South India, for the period of 2 years (September 2024-February 2026). The study population includes individuals more than 18 years of age and is categorized into two categories. Category I composed of 100 normal individuals with HGB values and serum iron studies within normal limits. Category II comprising of 200 individuals having serum ferritin levels <30 ng/mL or transferrin saturation (T-SAT) of <20%.</p><p><strong>Results: </strong>Comparison of the mean values of parameters such as HGB, red blood cell (RBC) count, RBC indices, reticulocyte parameters, Ret He, serum iron, T-SAT, and serum ferritin levels were reduced below normal limits in cases with iron deficiency. A strong statistically significant positive correlation is observed with mean corpuscular hemoglobin (r = 0.823), mean corpuscular volume (r = 0.8186), and HGB (r = 0.8165). Moderate positive correlations are evident with key iron profile parameters, including T-SAT%, serum iron, and ferritin. Receiver operating characteristic analysis Ret He cutoff of 29.85 pg was obtained which showed 85% sensitivity and 88% specificity with excellent area under the curve of 0.941 and statistically significant P < 0.001 in predicting iron deficiency.</p><p><strong>Conclusion: </strong>Reticulocyte hemoglobin equivalent (Ret-He) is a reliable and effective marker for detecting iron deficiency, demonstrating excellent diagnostic accuracy, with a cutoff of 29.85 pg. Its incorporation into routine hematological evaluation may facilitate early identification of iron deficiency, although population-specific cutoffs should be considered.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of Orexin-A and Implications for Renal Function Assessment in Chronic Kidney Disease.","authors":"Haider Ridha Mohammed Saeed, Raghad H Al-Ani, Sura Ahmed Abdulsattar, Muntadher Hussein Challoob","doi":"10.4103/aam.aam_809_26","DOIUrl":"https://doi.org/10.4103/aam.aam_809_26","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a long-standing kidney condition in which the kidneys are gradually damaged. It usually has multiple symptoms and is often accompanied by complications, such as hormonal imbalances, high blood pressure, anemia, and sleep disorders. Orexin, occasionally mentioned as hypocretin, is a neuropeptide that is mostly generated by orexin-containing neurons in the hypothalamus. Their receptors are found in a variety of tissues, such as the brain and kidney. This study aims to evaluate the impact of renal function on orexin-A levels in CKD.</p><p><strong>Materials and methods: </strong>The study included 44 adult patients diagnosed with CKD, and their results were compared with 44 healthy participants of the same age and sex. An enzyme-linked immunosorbent assay kit was used to measure orexin-A, while urea, creatinine, and lipid profile were measured using spectrophotometric methods. Association with orexin-A was performed using Pearson's correlation analysis.</p><p><strong>Results: </strong>The results showed a significant decrease in serum orexin-A (P < 0.001) in patients with CKD. Correlation analysis showed that orexin-A in CKD patients was positively correlated with serum creatinine (r = 0.353, P = 0.018) and high-density lipoprotein (r = 0.354, P = 0.017), while negatively correlated with glomerular filtration rate (GFR) (r = -0.424, P = 0.004).</p><p><strong>Conclusions: </strong>Orexin-A levels decreased in patients with CKD, and this decrease reflects the disruption of the orexin system, which was inversely related to the GFR and directly related to creatinine and high-density lipoprotein levels.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing Endometrial and Procedural Predictors of Clinical Pregnancy in Ghanaian Assisted Reproductive Technology Cycles: A Null-finding Retrospective Cohort Study.","authors":"Rex Mawuli Kwadjo Djokoto, Edward Anabila Agana, Kingsley Afreh Nduroh, Johnny Arthur-Komeh, Opei Adarkwa, Andrew Panyin Vormawor, Amponsah Peprah, Anthony Amanfo Ofori, Wilfred Kwamina Junior Sam-Awortwi, Victor Boachie Owusu","doi":"10.4103/aam.aam_716_26","DOIUrl":"https://doi.org/10.4103/aam.aam_716_26","url":null,"abstract":"<p><strong>Background: </strong>Assisted reproductive technology (ART) has improved globally, yet pregnancy outcomes per cycle remain suboptimal, with limited evidence from Sub-Saharan Africa (SSA). Endometrial characteristics, embryo placement depth, and transfer timing are commonly used as predictors of success, but their combined value in African populations is unclear.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at Oak Specialist Hospital, Kumasi, Ghana. Women who underwent fresh or frozen-thawed embryo transfer between October 2024 and February 2025 were included. Data on sociodemographic factors, body mass index (BMI), surgical history, uterine myomata, endometrial thickness (EMT) and pattern, embryo placement depth, and transfer duration were extracted.</p><p><strong>Results: </strong>A total of 199 women were analyzed (mean age: 37.93 ± 7.15 years; 52.26% aged >38 years; 77.78% overweight or obese). Clinical pregnancy rates showed no significant differences across age groups, BMI categories, surgical history, EMT or pattern, embryo placement depth, or transfer duration (P > 0.05). A nonsignificant trend suggested higher pregnancy rates among obese women compared with those of normal weight (65.06% vs. 50.00%), likely reflecting selection bias and confounding.</p><p><strong>Conclusion: </strong>Common clinical and procedural parameters were not significantly associated with clinical pregnancy in this Ghanaian ART cohort. These findings provide context-specific evidence from SSA and suggest that, under standardized ultrasound-guided embryo transfer protocols, isolated endometrial and procedural measures have limited predictive value. The results discourage unnecessary cycle cancellation based on marginal findings and emphasize the need for larger multicenter studies and regional ART registries to improve predictive models and optimize outcomes in African ART practice.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}