Annals of African Medicine最新文献

{"title":"Validation of Peripheral Perfusion Index as a Noninvasive Screening Tool in Predicting Adverse Neonatal Outcome.","authors":"Rizwana Abdul Nasser, Shiji Joseph, Anila Arangassery Poulose, Ramaraj Subbiah","doi":"10.4103/aam.aam_101_24","DOIUrl":"https://doi.org/10.4103/aam.aam_101_24","url":null,"abstract":"<p><strong>Introduction: </strong>Timely identification of suboptimal organ perfusion is crucial to detect adverse outcomes early and to prevent its long-term motor and cognitive effects. Peripheral perfusion index (PI) is a noninvasive screening tool which can identify babies at risk for hemodynamic compromise.</p><p><strong>Aim: </strong>We aimed to study the validity of peripheral PI as an early predictor of adverse neonatal outcome in comparison with other commonly used noninvasive screening modalities such as heart rate (HR), respiratory rate, temperature, capillary refill time (CRT), and blood pressure.</p><p><strong>Materials and methods: </strong>This prospective observational study was carried out between January 2021 and May 2022. All infants born beyond 32 weeks of pregnancy who are admitted to the neonatal intensive care unit and needed hemodynamic were included in the study. Peripheral PI was monitored along with other noninvasive parameters at specific intervals and compared with those parameters for the degree of variation in each at specified time intervals and with the changing hemodynamic status of these babies including adverse outcomes.</p><p><strong>Results: </strong>A cohort of 93 neonates was enrolled in the study. Our study found lower PI values among newborns with adverse outcomes. This study also revealed negative correlations between HR and PI, suggesting that low PI could indicate early neonatal compromise and circulatory inadequacy. We also established positive correlations between PI and CRT, systolic blood pressure, mean arterial blood pressure, and pulse pressure.</p><p><strong>Conclusion: </strong>PI can serve as a noninvasive screening tool which can identify babies at risk for hemodynamic compromise, especially in resource-poor settings.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Teriflunomide and Dimethyl Fumarate on Quality of Life in Relapsing-remitting Multiple Sclerosis: Insights from Eastern Saudi Arabia.","authors":"Dhafer Alshayban, Foziah J Al-Shamrani, Khalid A Alamer, Mohammad Y Muazen, Khalid A Alqahtani, Layan Alsulaiman, Md Ashraful Islam, Bander Balkhi, Saad Alqahtani, Khalid S AlHarkan","doi":"10.4103/aam.aam_259_24","DOIUrl":"https://doi.org/10.4103/aam.aam_259_24","url":null,"abstract":"<p><strong>Introduction: </strong>Relapsing-remitting multiple sclerosis (RRMS) is a chronic neurological condition prevalent in Saudi Arabia. It causes a spectrum of neurological impairments that result in functional limitations and disability. The physical and psychological burdens of multiple sclerosis (MS) significantly impact patients' health-related quality of life (HRQoL). However, research evaluating its effects on HRQoL within the Saudi context remains scarce. This study aimed to compare HRQoL among RRMS patients undergoing treatment with teriflunomide or dimethyl fumarate and identify factors influencing treatment outcomes.</p><p><strong>Methodology: </strong>A cross-sectional study involving all MS patients was conducted at King Fahd Hospital of the University from November 2022 to April 2023. Participants were categorized into two groups based on their treatment: those receiving teriflunomide and those on dimethyl fumarate. Data were collected using the EQ-5D-5L questionnaire.</p><p><strong>Results: </strong>Of the 280 patients invited, 82 RRMS patients met the inclusion criteria, comprising 28 males and 54 females, with most participants over 40. Approximately 43.9% were treated with teriflunomide, whereas 56.1% received dimethyl fumarate. No statistically significant differences were found in the three health indicators assessed between the two treatment groups. Nonetheless, the descriptive analysis indicated that RRMS patients on dimethyl fumarate reported superior health outcomes to those on teriflunomide.</p><p><strong>Conclusion: </strong>The study revealed that patients with RRMS in the dimethyl fumarate and teriflunomide treatment groups reported low physical and mental HRQoL. While no statistically significant differences were observed between the two groups, those receiving dimethyl fumarate indicated a better QoL than their counterparts on teriflunomide. Future research is necessary to identify specific gaps that could facilitate improvements in HRQoL among RRMS patients. Furthermore, the findings from this study may inform the development and implementation of targeted intervention programs aimed at enhancing HRQoL for RRMS patients within the Saudi population.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Detection of Novel Thalassemia Variant hemoglobin J in Extensive Tharu Population.","authors":"Nitu Nigam, Ruchi Gupta, Madan Lal Brahma Bhatt, Swasti Sinha, Nishant Verma, Sanjay Kumar Nigam, Shailendra Prasad Verma, Kirti Upadhyay, Surbhi Gupta","doi":"10.4103/aam.aam_207_24","DOIUrl":"https://doi.org/10.4103/aam.aam_207_24","url":null,"abstract":"<p><strong>Background: </strong>Thalassemia is an autosomal recessive genetic disorder that disrupts hemoglobin production, resulting in varying degrees of anemia and associated health problems. In the Terai region of southern Nepal and northern India, the Tharu people has a high prevalence of hemoglobinopathies, including beta and alpha thalassemia.</p><p><strong>Aims and objectives: </strong>This study sought to ascertain the prevalence of hemoglobinopathies in Tharu school-age children in Lakhimpur Kheri, Uttar Pradesh, as well as the associated hematological and demographic traits.</p><p><strong>Materials and methods: </strong>In cooperation with the National Medical Organization (NMO) and Rashtriya Swayamsevak Sangh (RSS), the study was carried out between February 22-26, 2023. 369 blood samples were taken from youngsters enrolled in school. The BIORAD VARIANT algorithm was utilized to diagnose thalassemia characteristics and hemoglobinopathies using High Performance Liquid Chromatography (HPLC). The relationships between hematological markers, diagnostic results, and demographic factors were assessed by statistical analysis.</p><p><strong>Results: </strong>(1) Normal cases: 78.8% of participants were classified as normal. (2) Beta thalassemia heterozygous: 6.2%. (3) HbJ Meerut heterozygous: 4.0%. (4) HbS heterozygous: 9.8%. Statistical analysis revealed a significant association between sex and diagnosis (p=0.001), while no significant association was observed between age and diagnosis (P = 0.846). Hematological parameters, including Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin (MCH), differed significantly across diagnostic groups (P < 0.05). Variations in hemoglobin types Hb A, Hb F, and Hb A2 were statistically significant (P < 0.001).</p><p><strong>Conclusion: </strong>The study highlights a high prevalence of hemoglobinopathies within the Tharu community, emphasizing the need for accurate diagnosis and awareness campaigns to manage the disorder effectively. By reducing stigma and empowering the community with knowledge, these efforts can improve outcomes for individuals with thalassemia and related disorders.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes, Behaviors, and Stigmatization toward Women with Breast Cancer among Saudi Arabian Men.","authors":"Israa Aqeel Alghafli, Ghadeer Aqeel Alghafli, Latifah Khalid Alnami, Zahra Ali Alhajji, Reem Ali AlQarni, Ghadah Abdullah Albejais, Jumanah Jamal Alabbad, Loai S Albinsaad, Mohammed Yousef Alessa, Ali Saleh Albinsaad","doi":"10.4103/aam.aam_247_24","DOIUrl":"https://doi.org/10.4103/aam.aam_247_24","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, breast cancer is the most frequent cancer to affect women. The death rate from breast cancer has dramatically dropped as a result of recent advancements in screening and therapy. The negative attitude that society has toward cancer patients, known as the stigma, keeps them from developing effective coping strategies. This study aimed to examine the attitudes of Saudi Arabian men, their behaviors, and their stigma toward females with breast cancer.</p><p><strong>Materials and methods: </strong>This descriptive cross-sectional study was conducted in the Eastern Province of Saudi Arabia between February 4 and March 31, 2024. Following a comprehensive pilot study involving 50 participants, the researchers developed and validated a pre-structured online questionnaire.</p><p><strong>Results: </strong>In total, 796 (68.2%) met the inclusion criteria and completed the study questionnaire. Participants' ages ranged between 18 and 60 years with a mean age of 31.6 ± 11.8 years old. Regarding educational level, 129 (23.8%) had a secondary level of education or below, and 403 (74.2%) were university students/graduates. Regarding males' attitudes toward females with breast cancer, the lowest score, indicating the most positive attitude, was reported for a section on cancer-related myths and preconceptions (1.4/5), followed by women's working ability (1.6/5), disease severity (1.8/5), and nervousness (2.1/5). Attitudes toward marriage and concealing showed the highest scores, indicating the lowest attitude and perception levels (2.3/5 for each). Men's score for attitude and stigma was 1.9 ± 0.6 of 5 (38%).</p><p><strong>Conclusion: </strong>This study showed that educated men with sufficient knowledge about breast cancer showed positive attitudes and low stigma towards females with the disease.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Conventional Opioid-based Anesthesia and Opioid-sparing Anesthesia in Patients Undergoing Laparoscopic Surgeries.","authors":"Prajakta Vetal, Sumesh T Rao, Kavya Prabhu, Anusha Nayak","doi":"10.4103/aam.aam_214_24","DOIUrl":"https://doi.org/10.4103/aam.aam_214_24","url":null,"abstract":"<p><strong>Purpose: </strong>Opioid-sparing anesthesia (OSA) is an emerging concept in an attempt to overcome the potential side effects during postoperative recovery associated with opioid-based anesthesia. However, there is a need to assess the extent of pain control and side effects between the two. The objective of the study was to evaluate and compare intraoperative hemodynamic parameters, and postoperative pain control with a secondary objective to determine the postoperative nausea vomiting, and patient satisfaction levels postlaparoscopic surgery.</p><p><strong>Methodology: </strong>Eighty patients with ASA physical statuses 1 and 2 who were scheduled for laparoscopic procedures, ranging in age from 20 to 70, participated in the study. They were categorized into opioid group (n = 40) and opioid sparing group (n = 40). Participants in the opioid group provided general anesthesia with fentanyl and participants in the opioid-sparing group received general anesthesia without fentanyl but got an infusion after receiving a loading dose of dexmedetomidine. Assessing pain scores and hemodynamic parameters were the primary objective while postoperative nausea and vomiting (PONV) and patient satisfaction were the secondary objective.</p><p><strong>Results: </strong>The systolic blood pressure and diastolic blood pressure intraoperative hemodynamic parameters were comparable, with the exception of the heart rate, which was considerably greater in the opioid-sparing group at baseline, at 6 h, and 24 h (P = 0.001). Up to 2 h, the opioid-sparing group's visual analog scale scores were considerably lower (P = 0.001), and their patient satisfaction levels were higher (P = 0.01). In both groups, the incidence of PONV was similar.</p><p><strong>Conclusion: </strong>OSA can be used as an effective alternative to opioid anesthesia.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Surgical Outcomes and Complications in Children Undergoing Ventriculoperitoneal Shunt in a Tertiary Care Hospital of Eastern India.","authors":"Sanjiv Kumar, Gautam Dutta, Rajesh Kumar Singh, Anand Prakash, Ravi Bhushan Singh, Khushboo Saran, Jay Prakash","doi":"10.4103/aam.aam_283_24","DOIUrl":"https://doi.org/10.4103/aam.aam_283_24","url":null,"abstract":"<p><strong>Context: </strong>Hydrocephalus, which is characterized by an abnormal elevation of cerebrospinal fluid within the ventricles of the brain, is one of the more formidable neurosurgical challenges, particularly in pediatric patients. Ventriculoperitoneal (VP) shunt is the preferred procedure; however, it is often associated with high rates of complication, including obstruction, infection, and overdrainage. The present study evaluated the outcomes and complications from VP-shunting in a tertiary hospital in eastern India.</p><p><strong>Aim: </strong>This study aims to evaluate the surgical outcomes and complications of VP shunting in pediatric patients of hydrocephalus and to determine risk factors associated with complications.</p><p><strong>Settings and design: </strong>A prospective observational study carried out from October 2022 to June 2024 at a tertiary care center in eastern India.</p><p><strong>Materials and methods: </strong>All pediatric patients diagnosed with hydrocephalus aged below 20 years were enrolled. The data were collected with the standard pro forma. All the procedures were performed under globally accepted protocols. Postoperative monitoring included routine computed tomography scan and shunt functioning assessment. The patients were followed up 3 and 6 months after the surgery to assess outcomes and complications.</p><p><strong>Statistical analysis: </strong>The data were analyzed using SPSS version 22. Descriptive statistics summarized the demographic and clinical information. The Chi-square test, independent t-tests, and Kaplan-Meier survival analysis were performed to study associations of variables, comparison of variables, and analysis of the trend of shunt survival. Statistical significance was fixed at P < 0.05.</p><p><strong>Results: </strong>The majority of patients were infants aged below 1 year (43.3%), with a male-to-female ratio of 3:2. The most common presenting symptom was an increase in head circumference (68.3%). The most common complication was shunt obstruction (11.7%); all others tied for second place, with infection and overdrainage occurring at 5% each. Clinically, 60% of patients improved at 3 months; however, this figure dropped to 53.3% by 6 months. Follow-up problems arose with 28.3% of the patients lost to follow-up at 6 months.</p><p><strong>Conclusions: </strong>VP shunting is an effective intervention for pediatric hydrocephalus, with a high rate of early postoperative improvement. However, complications such as obstruction, infection, and overdrainage remain significant concerns. The findings highlight the need for improved surgical techniques, rigorous postoperative care, and strategies to enhance long-term follow-up in resource-limited settings.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Hypothyroidism, Withdrawal of Thyroxin Supplementation, and Heart Failure in Dilated Cardiomyopathy: Case Report and Review of Literature.","authors":"Paschal Okuchi Njoku, Tobechukwu Chigha Iyidobi, Obumneme Benneth Anyim, Peter Chinenye Mba","doi":"10.4103/aam.aam_274_24","DOIUrl":"https://doi.org/10.4103/aam.aam_274_24","url":null,"abstract":"<p><strong>Abstract: </strong>Heart failure (HF) is a major world health problem and has been described as a global scourge, with varied epidemiology, affecting about 64.3 million persons worldwide. In Africa, the impact of HF is huge and responsible for as much as 30%-50% of cardiovascular cases seen in hospitals. The report of HF in hypothyroidism is more in Western and Asian countries but rarely seen in Africa and other developing nations. This is a case report of HF in an adult with congenital hypothyroidism, precipitated by discontinuation of thyroxine supplementation.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excipient Lung Disease and Fatal Outcome Among Young Adults: A Case Series on the Hidden Dangers of Intravenous Drug Abuse in India.","authors":"Dhivya Prakash, R Vijay Balaji, R Raguram, S Narayanan, Venkatesh Janarthanan, Senthil Kumaran","doi":"10.4103/aam.aam_210_24","DOIUrl":"https://doi.org/10.4103/aam.aam_210_24","url":null,"abstract":"<p><strong>Background: </strong>Excipient lung disease (ELD) arises from the intravenous (IV) injection of crushed oral tablets, leading to acute or chronic pulmonary complications. Despite its significance, ELD is under-recognized, particularly in countries like India, where over-the-counter availability of pharmaceutical drugs contributes to rising abuse rates. This study investigates sudden deaths among young adults due to ELD, emphasizing the need for increased awareness and preventive measures.</p><p><strong>Materials and methods: </strong>This case series examined 10 cases of sudden death in individuals aged 18-25 with a history of IV drug abuse. Data were collected from postmortem examinations, death scene investigations, and toxicological and histopathological analyses. The aim was to confirm ELD as the cause of death and understand its presentation.</p><p><strong>Results: </strong>Deaths in these cases were strongly associated with drug overdoses. Death scene investigations revealed signs of IV drug use, such as track marks and drug paraphernalia. External and internal examinations showed consistent pathological findings, including edematous lungs with frothy secretions, granulomatous reactions in the pulmonary vasculature, and right ventricular hypertrophy. Toxicological analyses detected substances such as tapentadol and tetrahydrocannabinol, with excipients linked to ELD found in histopathological examinations.</p><p><strong>Conclusion: </strong>When injected, excipients such as talc and microcrystalline cellulose lead to granulomatous reactions and pulmonary complications. The study highlights the prevalence of ELD among young adults in India and the challenges in diagnosing this condition due to its nonspecific presentation and lack of disclosure of drug abuse history. Effective public health measures and stricter regulation of prescription drugs are crucial in preventing ELD-related deaths. This study underscores the severe health risks associated with IV drug abuse of oral tablets, leading to ELD. The findings emphasize the need for enhanced awareness, accurate documentation, and preventive strategies to address the rising substance abuse among youth in India.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis Presenting as Space Occupying Lesions in Liver.","authors":"Devansh Bajaj, Deepak Suvarna, H V Aradya, H P Nandeesh, Abhishek Kabra","doi":"10.4103/aam.aam_246_24","DOIUrl":"https://doi.org/10.4103/aam.aam_246_24","url":null,"abstract":"<p><strong>Abstract: </strong>This case report illustrates a typical presentation of hepatic sarcoidosis, a granulomatous liver disease that often manifests as an extrapulmonary feature of systemic sarcoidosis. The patient, a 60-year-old female, exhibited dyspeptic symptoms and anorexia. An abdominal ultrasound revealed space-occupying lesions in the liver, and elevated levels of alkaline phosphatase and gamma-glutamyl transferase were noted. Liver biopsy findings showed Grade 2 macrovesicular steatosis and noncaseating granulomatous inflammation. In addition, significantly elevated angiotensin-converting enzyme levels were observed, further supporting the diagnosis. This case underscores the importance of recognizing hepatic granulomatous foci, which can be crucial in determining the etiology and facilitating the diagnosis of sarcoidosis. The combination of clinical, biochemical, and histological findings played a pivotal role in diagnosing systemic sarcoidosis with hepatic involvement.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Acute Massive Pulmonary Embolism with Multiple Cardiac Arrests and Successful Systemic Thrombolysis.","authors":"S Mohammed Mahaboob Pasha, Bony Baiju, Boban Varghese, Ajin A Sunny","doi":"10.4103/aam.aam_273_24","DOIUrl":"https://doi.org/10.4103/aam.aam_273_24","url":null,"abstract":"<p><strong>Abstract: </strong>Massive pulmonary embolism (PE) is a potential noncardiac cause of cardiac arrest with unfavorable prognosis. Maintaining a high degree of clinical suspicion, use of bedside focused cardiac ultrasound and computed tomography pulmonary angiography (CTPA) aid in rapid management. Thrombolytic therapy with anticoagulation is indicated in treatment of massive PE provided that there are no contraindications and there is low risk of bleeding. We present a case of massive PE with multiple cardiac arrests who successfully responded to systemic thrombolysis along with anticoagulation, barring a moderate bleeding complication.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}