Annals of African Medicine最新文献

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Effect of Glycated Hemoglobin and Duration of Disease on 2-min Step Test in Type 2 Diabetes Mellitus Patients. 糖化血红蛋白与病程对2型糖尿病患者2分钟步进试验的影响
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_37_25
C A Jayashankar, Faria Abousher, Pooja Prasad, Sahil Srinivas, Ramya Raju, Melkunte Dhananjaya Shanthaiah, Mir Hussain
{"title":"Effect of Glycated Hemoglobin and Duration of Disease on 2-min Step Test in Type 2 Diabetes Mellitus Patients.","authors":"C A Jayashankar, Faria Abousher, Pooja Prasad, Sahil Srinivas, Ramya Raju, Melkunte Dhananjaya Shanthaiah, Mir Hussain","doi":"10.4103/aam.aam_37_25","DOIUrl":"https://doi.org/10.4103/aam.aam_37_25","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) impairs cardiorespiratory fitness and functional capacity. The 2-minute step test (2MST) is a simple, space-efficient method to assess aerobic capacity, especially in resource-limited settings.</p><p><strong>Aims and objectives: </strong>To assess the relationship between glycated hemoglobin (HbA1c), disease duration, and 2MST performance in T2DM patients.</p><p><strong>Materials and methods: </strong>A cross-sectional prospective study was conducted at Vydehi Institute of Medical Sciences with 150 T2DM patients (age 30-65 years, BMI <30 kg/m²). Participants performed the 2MST, and pre- and post-exercise vitals were recorded. HbA1c was measured using HPLC. Statistical analysis included Spearman correlation and regression analysis.</p><p><strong>Results: </strong>T2DM patients performed significantly fewer steps compared to nondiabetic controls (P = 0.001). Significant associations were found between post-test parameters (MBDS, SBP) and HbA1c. No strong correlations were observed between HbA1c and posttest oxygen saturation.</p><p><strong>Conclusion: </strong>The 2MST is a useful, practical tool to evaluate functional decline in T2DM patients. Its ease of use makes it suitable for diabetes screening and management in primary care and resource-limited environments.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis and HIV Coinfection Admissions and Outcome in Children at a Nigerian Tertiary Hospital. 尼日利亚一家三级医院儿童结核病和艾滋病毒合并感染的入院情况和结果。
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_89_25
Olusola Adetunji Oyedeji, Funso Abidemi Olagunju, Abimbola Ololade Odeyemi, Adebimpe Ajibola Afolabi, Efeturi Agelebe, Olamide Valentine Kayode, Samuel Olorunyomi Oninla
{"title":"Tuberculosis and HIV Coinfection Admissions and Outcome in Children at a Nigerian Tertiary Hospital.","authors":"Olusola Adetunji Oyedeji, Funso Abidemi Olagunju, Abimbola Ololade Odeyemi, Adebimpe Ajibola Afolabi, Efeturi Agelebe, Olamide Valentine Kayode, Samuel Olorunyomi Oninla","doi":"10.4103/aam.aam_89_25","DOIUrl":"https://doi.org/10.4103/aam.aam_89_25","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis and HIV are significant contributors to morbidity and mortality in children living in developing countries. Factors associated with morbidity in tuberculosis and HIV coinfections have not been sufficiently exhaustively studied.</p><p><strong>Aim: </strong>The aim of this study was to study the pattern of presentation and outcome of tuberculosis in HIV infected children and identify factors associated with outcome of management.</p><p><strong>Methodology: </strong>Consecutive children diagnosed with tuberculosis and HIV coinfections at the pediatric unit of UNIOSUN teaching hospitals were studied. Necessary data were obtained and analyzed.</p><p><strong>Results: </strong>A total of 36 children with HIV and tuberculosis coinfection were studied, with age ranging from 3 months to 17 years (mean 6.7 ± 4.3 years). The 36 children consisted of 21 boys (58.3%) boys and 15 (53.6%) girls. The forms of tuberculosis diagnosed were pulmonary 23 (63.9%). Disseminated and abdominal tuberculosis were diagnosed in 6 (16.7%) and 4 (11.1%) children, respectively. Miliary, meningeal forms of tuberculosis with tuberculoma were diagnosed in 1 (2.7%) child each. Twelve (33.3%) children exhibited treatment failure to Category I antituberculous (Anti-Tb) drugs. The majority 8 (66.7%) of the 12 with Category 1 treatment failure had underlying AIDS. Category I Anti-Tb therapy treatment failure was significantly associated with immunological suppression, (CD4 <200 cells/ml, poor viral load suppression (viral load >1000copies/mL, disseminated disease and AIDS (P < 0.01). Six deaths (16.7%) were recorded in the course of the study, whereas 30 (83.3%) survived.</p><p><strong>Conclusion: </strong>Pediatric tuberculosis HIV coinfection should not be managed with Category 1 (Short course) Anti-Tb therapy in HIV tuberculosis coinfected children with associated immunosuppression or unsuppressed viral loads or with disseminated tuberculosis or AIDS.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Observational Study on the Comparative Analysis of Trans Abdominal Preperitoneal and Totally Extraperitoneal: A Single-center Experience of 105 Patients. 105例经腹腹膜前和全腹膜外手术的观察性比较分析。
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_183_24
Manoj Kumar, Ashesh Kumar Jha, Deepak Kumar, Iqbal Hasan, Dhirendra Kumar
{"title":"An Observational Study on the Comparative Analysis of Trans Abdominal Preperitoneal and Totally Extraperitoneal: A Single-center Experience of 105 Patients.","authors":"Manoj Kumar, Ashesh Kumar Jha, Deepak Kumar, Iqbal Hasan, Dhirendra Kumar","doi":"10.4103/aam.aam_183_24","DOIUrl":"https://doi.org/10.4103/aam.aam_183_24","url":null,"abstract":"<p><strong>Background: </strong>Inguinal hernia repair remains one of the most common surgical procedures performed in the elective setting. trans abdominal preperitoneal (TAPP) and totally extraperitoneal (TEP) are the two well-established laparoscopic methods of inguinal hernia repair. However, doubts still exist about their relative merits and risks. In this study, we are sharing our observations on the comparative analysis of TAPP versus TEP.</p><p><strong>Materials and methods: </strong>This retrospective analysis was carried out on 105 cases of inguinal hernia, repaired laparoscopically over the last 2 years. Patients within the age group of 20-60 years, operated for primary unilateral inguinal hernia using either TAPP or TEP were included in this study. All the repairs were done by a single surgeon in the same unit, having more than 3 years of experience in laparoscopic hernia repair.</p><p><strong>Results: </strong>Among 105 patients, who underwent laparoscopic hernia repair, 53 were operated on by TAPP and 52 by TEP. There was no significant visceral or vascular injury in either group. The mean duration of surgery in the TAPP group was 103.43 ± 12.24, and in TEP group 89.83 ± 14.25 min (P < 0.0001) Mean hospital stay was 2.47 ± 0.79 and 2.0 ± 0.65 days in TAPP and TEP groups (P = 0.001). Patients in the TAPP group were able to return to their work after 14.30 ± 1.60 and in TEP after 13.73 ± 1.24 days (P = 0.04).</p><p><strong>Conclusion: </strong>Both TAPP and TEP are well-established methods for laparoscopic hernia repair. In terms of outcome, we observed that TEP requires less operative time and is associated with a relatively shorter hospital stay and earlier return to work.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Platinum-based versus Other Chemotherapies on Health-related Quality of Life and Hospital Anxiety and Depression Scale in Patients with Malignancies in a Tertiary Center in Western India. 在印度西部的一个三级中心,铂类化疗与其他化疗对恶性肿瘤患者健康相关生活质量和医院焦虑抑郁量表的影响
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_128_25
Bhumika Vaishnav, Saish Nitin Mondkar
{"title":"Impact of Platinum-based versus Other Chemotherapies on Health-related Quality of Life and Hospital Anxiety and Depression Scale in Patients with Malignancies in a Tertiary Center in Western India.","authors":"Bhumika Vaishnav, Saish Nitin Mondkar","doi":"10.4103/aam.aam_128_25","DOIUrl":"https://doi.org/10.4103/aam.aam_128_25","url":null,"abstract":"<p><strong>Background: </strong>Cancer remains a significant public health concern globally, with increasing incidence in developing countries like India. While chemotherapy has improved survival rates, the quality of life and psychological well-being of cancer patients frequently deteriorate due to treatment-related toxicities, including electrolyte disturbances and psychological effects. This study aimed to examine the differential impact of platinum-based chemotherapy versus other regimens on Health-related Quality of Life (HRQoL) and Hospital Anxiety and Depression Scale (HADS) scores in cancer patients.</p><p><strong>Methodology: </strong>This cross-sectional observational study enrolled 90 cancer patients from a tertiary care center in western India between October 2023 and February 2025. Patients were categorized into three groups based on treatment: platinum-based chemotherapy (n = 32), combination chemotherapy (n = 28), and other treatments including immunotherapy and hormonal therapy (n = 30). Serum electrolytes were analyzed, and patients completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 for HRQoL assessment and HADS questionnaire. Data were analyzed using SPSS version 21, with P < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Patients receiving platinum-based chemotherapy showed significantly worse HRQoL scores (mean: 55.4 ± 10.2) compared to combination therapy (62.8 ± 9.7) and other treatments (71.3 ± 8.5, P < 0.001). Similarly, HADS scores were highest in the platinum group (13.8 ± 3.4), indicating moderate anxiety and depression, compared to combination therapy (9.6 ± 2.7) and other treatments (6.2 ± 2.1, P < 0.001). Potassium and phosphate abnormalities were significantly more common in patients receiving platinum-based regimens (P < 0.05) and correlated with poorer HRQoL and higher HADS scores.</p><p><strong>Conclusion: </strong>Platinum-based chemotherapy is associated with significantly worse HRQoL, higher anxiety and depression scores, and more frequent electrolyte disturbances compared to other treatment modalities. Regular monitoring of psychological well-being and electrolyte levels, along with appropriate supportive care interventions, should be integrated into routine cancer management, particularly for patients receiving platinum-based regimens.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetomaternal Outcome in Obstetric Cholestasis in a Tertiary Care Hospital. 三级医院产科胆汁淤积症的胎母结局
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_100_25
Madhu, Rani Hansda, Atima Bharti, Priya Kumari
{"title":"Fetomaternal Outcome in Obstetric Cholestasis in a Tertiary Care Hospital.","authors":"Madhu, Rani Hansda, Atima Bharti, Priya Kumari","doi":"10.4103/aam.aam_100_25","DOIUrl":"https://doi.org/10.4103/aam.aam_100_25","url":null,"abstract":"<p><strong>Introduction: </strong>Intrahepatic cholestasis is a potentially serious condition that can develop during the late half of pregnancy. It can increase the risk of preterm birth and stillbirth in fetus and postpartum hemorrhage in mothers. The main symptoms are severe pruritus. Since this condition is hormone-induced, it is a reversible condition and likely to recur in subsequent pregnancy. Early diagnosis, adequate treatment, and well-timed delivery are imperative for better maternal and fetal outcomes.</p><p><strong>Materials and methods: </strong>This is a prospective observational study done in a tertiary care center, RIMS, Ranchi, Jharkhand. Data were collected from 203 affected pregnant females from July 2023 to June 2024. Proper history, examination, and investigations were done.</p><p><strong>Results: </strong>The incidence was found to be 2.62% in our hospital. Women of 26-30 years were affected mostly (33.99%). 53.69% were from rural areas and belonged to the lower middle socioeconomic class. Primigravidae were affected more (45.81%). Jaundice was the most common complication (8.87%). Postpartum hemorrhage was observed in 8.87% of cases. 28.5% had preterm delivery. Intrauterine fetal death was seen in 4.43% and 1.97% had stillbirth in women affected with the disorder. Liver enzymes were significantly raised.</p><p><strong>Conclusion: </strong>It affects the fetal outcome adversely, resulting in preterm birth, fetal distress, stillbirth, meconium aspiration, and respiratory distress syndrome. There is a high risk of postpartum hemorrhage in mothers. Proper counseling, investigations, and treatment with ursodeoxycholic acid will help in alleviating the symptoms and result in a better outcome for the mother and fetus. It is a self-limiting condition.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Adding a Millet Diet on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus. 添加小米饮食对2型糖尿病患者血糖控制和血脂的影响
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_69_25
Ritu Grover, Himanshu Khutan, Amit Jain, Hobinder Arora, Gaurav Kushwaha, Naman Goyal
{"title":"Impact of Adding a Millet Diet on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus.","authors":"Ritu Grover, Himanshu Khutan, Amit Jain, Hobinder Arora, Gaurav Kushwaha, Naman Goyal","doi":"10.4103/aam.aam_69_25","DOIUrl":"https://doi.org/10.4103/aam.aam_69_25","url":null,"abstract":"<p><strong>Context: </strong>Millets contain complex carbs, which are \"good\" kinds of carbs. These carbs do not propel blood sugar to rise to a dangerous extent. These findings should provide insight into the possibility of ameliorating type 2 diabetes through diet modulation.</p><p><strong>Aims: </strong>This study aims to study the effect of millet intake on glycemic control and lipid profile on patients of type 2 diabetes mellitus.</p><p><strong>Settings and design: </strong>This study was a cross-sectional study.</p><p><strong>Materials and methods: </strong>After following the inclusion and exclusion criteria, study participants were enrolled. Baseline glycated hemoglobin (HbA1c) and lipid profile were recorded at day zero. A booklet on millet uses and its benefits on glycemic control were provided to the patients in their vernacular language. A daily diary was provided to each patient to note down their daily intake of millets. At the end of 6 weeks, HbA1c and lipid profile of each patient was recorded.</p><p><strong>Statistical analysis used: </strong>The results of the study were analyzed by nonparametric Wilcoxon's test of significance and nonparametric Kruskal-Wallis test was used.</p><p><strong>Results: </strong>There was a significant change in both glycemic control and lipid profile of the study participants. The fasting blood sugar (FBS) for the study participants reduced by more than 20% from 237 ± 50 to 188 ± 33, which is statistically significant with a P < 0.05. Further, there was a 2.7% statistically significant reduction in the HbA1c levels of the study participants.</p><p><strong>Conclusions: </strong>The intake of millet even in a single meal per day significantly improved the glycemic control, especially the FBS and lipid profile.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Pyosalpinx Mimicking Acute Appendicitis: An Uncommon but Critical Diagnostic Challenge. 双侧脓输卵管炎模拟急性阑尾炎:罕见但关键的诊断挑战。
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_75_25
Rishika Mishra, Sarang Gotecha, Prabhat Bhaskarrao Nichkaode
{"title":"Bilateral Pyosalpinx Mimicking Acute Appendicitis: An Uncommon but Critical Diagnostic Challenge.","authors":"Rishika Mishra, Sarang Gotecha, Prabhat Bhaskarrao Nichkaode","doi":"10.4103/aam.aam_75_25","DOIUrl":"https://doi.org/10.4103/aam.aam_75_25","url":null,"abstract":"<p><strong>Abstract: </strong>A perforated appendix has been believed to be a potential risk for damage to adnexal structures that may escalate the chances of infertility in girls in future. Acute complications that are uncommomly described postperforation of appendix may be salpingitis, hydrosalpinx, and pyosalpinx. A pyosalpinx or tubal abscess is the acute inflammation of the fallopian tube that fills up and swells with pus, which commonly results from inadequate or delayed treatment of pelvic inflammatory disease (PID). Pyosalpinx may present with common symptoms such as lower abdominal pain, vomiting, nausea, per vaginal discharge, and lesser noted symptoms such as fever and chills or remain silent. Primay pyosalpinx might occur as a severe sequelae of PID that is characterized by the inflammation of upper genital tract incorporating endometritis, salpingitis, and pelvic peritonitis. Secondary pyosalpinx, on the other hand, arises from adjacent pelvic structures such as appendix, colon, urinary bladder or may be from a pelvic malignancy. Herein, we report the case of acute appendicitis with bilateral pyosalpinx.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinico-epidemiological Patterns, Risk Factors, and Seroprevalence of Hepatitis C in Patients Attending a Tertiary Care Center in North India. 印度北部三级医疗中心丙型肝炎患者的临床流行病学模式、危险因素和血清阳性率
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_216_24
Sana Islahi, Sweta Singh, Shefali Gupta, Altaf Ahmad Mir, Arti Dwiwedi, Akhalesh Kumar Shakya, Priyanka Dwiwedi, Somdatt Sen
{"title":"Clinico-epidemiological Patterns, Risk Factors, and Seroprevalence of Hepatitis C in Patients Attending a Tertiary Care Center in North India.","authors":"Sana Islahi, Sweta Singh, Shefali Gupta, Altaf Ahmad Mir, Arti Dwiwedi, Akhalesh Kumar Shakya, Priyanka Dwiwedi, Somdatt Sen","doi":"10.4103/aam.aam_216_24","DOIUrl":"https://doi.org/10.4103/aam.aam_216_24","url":null,"abstract":"<p><strong>Introduction: </strong>The hepatitis C virus is an important cause of chronic hepatitis and primary hepatocellular carcinomas. Early treatment of HCV infection, especially in the acute phase, can facilitate elimination of the virus and prevent chronic infection. This will limit HCV-related liver damage and mortality. This study provides the current clinical-epidemiologic pattern, risk factors and seroprevalence of hepatitis C in clinical suspected cases attending different departments of a tertiary care centre.</p><p><strong>Methods: </strong>The study was conducted for a period of 1 year (March 2023 to March 2024) in the Department of Microbiology, AIIMS, Raebareli. After obtaining ethical clearance, serum samples were collected from all patients referred to the Department of Microbiology to determine antibodies against HCV. An ELISA was performed for anti-HCV antibodies and HBsAg. The results and relevant clinical information were noted and analysed.</p><p><strong>Results: </strong>Of the 16911 samples, 127 (0.75%) were positive for anti-HCV antibodies. Of the 127 anti-HCV positive samples, 88 (69.3%) samples had an S/Co ratio >5.0, while 39 (30.7%) samples had an S/Co ratio <5.0. Majority of the cases were in the age group 46-60 years (31%), followed by the age group 31-45 years (26.%) and 61-75 years (26.%). The number of male cases (55.91%) was slightly higher than female cases (44.09%). In our study, serum bilirubin was elevated in 29.8% (29/127) of anti-HCV seropositive patients, alanine transaminase (ALT) was elevated in 56.7% (72/127) of seropositive patients and 49.6% (63/127) of seropositive patients had elevated aspartate transaminase (AST). A history of surgery (30.9%) was the most important risk factor in the seropositive patients.</p><p><strong>Conclusion: </strong>The study shows the seroprevalence of hepatitis C virus in patients with clinical suspicion, with 0.75% of samples testing positive for anti-HCV antibodies. Most positive cases were observed in adults aged 46-60 years, with elevated ALT and AST levels found in several seropositive patients. Surgical history has emerged as a notable risk factor.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of the Profile of Cognitive Impairment and Associated Factors among Subsets of Human Immunodeficiency Virus Patients in a Special Human Immunodeficiency Virus Clinic in South-East Nigeria. 尼日利亚东南部一家特殊人类免疫缺陷病毒诊所中人类免疫缺陷病毒亚群患者认知功能障碍及其相关因素的比较研究
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_36_25
Olisaeloka Ginikachi Ebeogu, Paul Osemeke Nwani, Harriet Chinwe Nwadimkpa, Obiora Daniel Anaje, Nnamdi Joseph Morah, Ifeoma Adaigwe Amaechi, Stephen Okorafor Kalu, Linda Ifunanya Eze, Azuoma Lasbrey Asomugha, Maduaburochukwu Cosmas Nwosu, Ogunniyi Adesola
{"title":"A Comparative Study of the Profile of Cognitive Impairment and Associated Factors among Subsets of Human Immunodeficiency Virus Patients in a Special Human Immunodeficiency Virus Clinic in South-East Nigeria.","authors":"Olisaeloka Ginikachi Ebeogu, Paul Osemeke Nwani, Harriet Chinwe Nwadimkpa, Obiora Daniel Anaje, Nnamdi Joseph Morah, Ifeoma Adaigwe Amaechi, Stephen Okorafor Kalu, Linda Ifunanya Eze, Azuoma Lasbrey Asomugha, Maduaburochukwu Cosmas Nwosu, Ogunniyi Adesola","doi":"10.4103/aam.aam_36_25","DOIUrl":"https://doi.org/10.4103/aam.aam_36_25","url":null,"abstract":"<p><strong>Context: </strong>The human immunodeficiency virus (HIV) is a neurotropic virus with several neurological manifestations including cognitive impairment.</p><p><strong>Aims: </strong>This study aimed to determine and compare the frequency of cognitive impairment and associated factors among subsets of HIV-positive patients and matched controls using neuropsychological test battery.</p><p><strong>Settings and design: </strong>This was a comparative cross-sectional descriptive study conducted in a Southeastern Nigerian Special HIV clinic.</p><p><strong>Subjects and methods: </strong>Two subsets of HIV patients; the combination antiretroviral therapy (CART) experienced patients and the CART naïve patients and matched HIV negative subjects were surveyed using the World Health Organization/University of California, Los Angeles neuropsychological test battery.</p><p><strong>Statistical analysis: </strong>Statistical Package for the Social Science version 20.0 was used.</p><p><strong>Results: </strong>The overall frequency of neurocognitive impairment was 76.1% (mild 44.6% and moderate-to-severe cognitive 31.5%). Although there was no statistically significant difference in the percentages of CART naïve patients (76.3%; n = 29/38) and CART-exposed (75.9%, n = 41/54) that had cognitive impairment, severe cognitive impairment was more among the CART naïve patients (44.4%; n = 24/54) and mild cognitive impairment more among CART-exposed (63.1%; n = 24/38). CART-exposed patients had better scores in most of the subtests of the battery compared to CART-naïve patients but the observed difference was not statistically significant. The observed relationship between cognitive impairment and age, sex, or level of education was also not statistically significant.</p><p><strong>Conclusion: </strong>HIV-associated neurocognitive impairment is still common in HIV patients and treatment with ART may reduce its severity.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Experiential Learning versus Traditional Instruction for Snakebite Treatment Protocols in Toxicology Training. 评估毒理学培训中蛇咬伤治疗方案的体验式学习与传统教学。
IF 0.6
Annals of African Medicine Pub Date : 2025-07-23 DOI: 10.4103/aam.aam_117_25
Harshal R Thube, Manish Shrigiriwar, Mandar Sane, Shailesh Raut, Devendra Jadav
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