Type 2 Diabetes in Morocco: Toward a Precision Diabetology, from Pathogenesis to Treatment.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-07-23 DOI:10.4103/aam.aam_87_25

Ahmed Anas Guerboub, Jade Issouani, Ikhlass Lakssir, Hajar Srifi, Malak Riznat, Mohamed Malad, Mustapha Asfour, Abderrahaman Tadlaoui, Yassine Errahali

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Abstract

Background: The traditional classification of diabetes into types 1 and 2 does not reflect its heterogeneity in presentation, progression, treatment response, and complications.

Methods: This study explores a new classification based on five distinct subgroups to enhance understanding and management. Its applicability was tested in 1002 newly diagnosed Moroccan type 2 diabetes patients and compared with the Indian "WellGen" and Swedish "ANDIS" cohorts.

Results: Newly diagnosed Moroccan type 2 diabetics were mainly classified into four subgroups designated as: severe insulin deficiency diabetes (SIDD), severe insulin resistance diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD). One thousand and two patients were included in our study with a sex ratio of 1. Patients were classified into the subgroups of MARD (42%), MOD (21%), and SIDD (19%), while SIRD was 14%. In our study, retinopathy and neuropathy were more prevalent in the SIDD subgroup, while nephropathy in the SIRD, while patients in the MARD group had a higher prevalence of cardiovascular complications.

Conclusions: Our results provide useful clues as to the pathophysiological mechanisms and susceptibility to complications of type 2 diabetes in the Moroccan population, and suggest a need to review management strategies. Our results confirm the new diabetic subgroups proposed by similar studies, suggesting a possible generalization of this diabetes classification to Africa and the MENA region.

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摩洛哥2型糖尿病：从发病机制到治疗的精准糖尿病学

背景：传统上将糖尿病分为1型和2型并不能反映其在表现、进展、治疗反应和并发症方面的异质性。方法：本研究以五个不同的亚群为基础，探索一种新的分类方法，以加强对疾病的认识和管理。在1002名新诊断的摩洛哥2型糖尿病患者中测试了其适用性，并与印度“WellGen”和瑞典“ANDIS”队列进行了比较。结果：新诊断的摩洛哥2型糖尿病患者主要分为4个亚组：重度胰岛素缺乏症（SIDD）、重度胰岛素抵抗（SIRD）、轻度肥胖相关糖尿病（MOD）和轻度年龄相关糖尿病（MARD）。我们的研究纳入了一千零二例患者，性别比例为1。患者分为MARD（42%）、MOD（21%）和SIDD（19%）亚组，而SIRD为14%。在我们的研究中，视网膜病变和神经病变在SIDD亚组中更为普遍，而肾病在SIRD中更为普遍，而MARD组患者心血管并发症的患病率更高。结论：我们的结果为摩洛哥人群中2型糖尿病的病理生理机制和并发症易感性提供了有用的线索，并建议需要审查管理策略。我们的研究结果证实了类似研究提出的新的糖尿病亚群，表明这种糖尿病分类可能推广到非洲和中东和北非地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.