Annales de biologie clinique最新文献_第10页

Lymphoma diagnosis: lessons learned from the comparison of histology and cytology associated with flow cytometry. 淋巴瘤诊断:与流式细胞术相关的组织学和细胞学比较的经验教训。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-03-01 DOI: 10.1684/abc.2022.1712

Guillaume Aussedat, Juliette Fontaine, Luc-Marie Gerland, Alexandra Traverse-Glehen, Lucille Baseggio

{"title":"Lymphoma diagnosis: lessons learned from the comparison of histology and cytology associated with flow cytometry.","authors":"Guillaume Aussedat, Juliette Fontaine, Luc-Marie Gerland, Alexandra Traverse-Glehen, Lucille Baseggio","doi":"10.1684/abc.2022.1712","DOIUrl":"https://doi.org/10.1684/abc.2022.1712","url":null,"abstract":"For lymphoma diagnosis, the flow cytometry (FCM) and cytology associated with FCM (C-FCM) performed on fine needle aspiration (FNA) or cell suspension/imprints from fresh tissue display a good concordance (from 85 to 90%) with the diagnosis made using histological data. Herein is reported a retrospective series of discordant cases, five of them are discussed in details, and some recommendations are proposed for the interpretation of C-FCM data. Firstly, this review highlights the importance of analyzing simultaneously the cytological and FCM data. In particular, the cytological data are crucial to interpret FCM data and/or to complete Ab panels when the strategy of the laboratory is to systematically perform a first screening, which don't always allow the detection of lymphoma cells. Secondly, this report underlines that cytology and FCM analysis should be followed by a confrontation/discussion with a pathologist. Finally, C-FCM appears to be a rapid and particularly important technic to guide the choice of the following diagnosis tools (IHC and genetic).","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 2","pages":"157-168"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neglected comorbidity of chronic heart failure: iron deficiency 慢性心力衰竭的一个被忽视的合并症:缺铁

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-03-01 DOI: 10.1684/abc.2022.1719

Katell Peoc'h, Jérôme Ausseil, Jean-Paul Feugeas, Régis Guieu, Damien Masson, Bernard Sablonniere, Hervé Puy

{"title":"A neglected comorbidity of chronic heart failure: iron deficiency","authors":"Katell Peoc'h, Jérôme Ausseil, Jean-Paul Feugeas, Régis Guieu, Damien Masson, Bernard Sablonniere, Hervé Puy","doi":"10.1684/abc.2022.1719","DOIUrl":"https://doi.org/10.1684/abc.2022.1719","url":null,"abstract":"The functioning of the heart muscle is particularly sensitive to iron deficiency, the easily curable comorbidity most frequently associated with heart failure. Iron-deficient heart failure patients are more often rehospitalized and have reduced survival. Heart muscle function is particularly susceptible to martial deficiency. Recent randomized studies have shown that exogenous iron intake is accompanied by improved functional capacity (walking test), quality of life, and re-hospitalization rate in these patients. The symptoms of iron deficiency are not very specific and often confused with those of heart failure or other comorbidities, which explains why management is often too late. Anemia is only a late consequence of this iron deficiency. Due to the inflammatory state associated with chronic heart failure, only the parenteral route can bypass the macrophage tissue sequestration of iron and inhibit its intestinal absorption. Recent European guidelines recommend screening for iron deficiency (serum ferritin and transferrin saturation coefficient) in all patients with suspected heart failure, routine iron parameters assessment in all patients with heart failure, and intravenous iron supplementation in case of deficiency in symptomatic patients. Given the pejorative nature of iron deficiency on disease progression, the frequency and financial impact of hospitalizations linked to episodes of decompensation, as well as the effectiveness of simple supplementation, screening for this comorbidity, screening for this frequent comorbidity should now be part of routine testing in all heart failure patients.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 2","pages":"109-118"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40405207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apport du dosage des monomères de fibrine en situations obstétricales aiguës. 撿你的dosage monomères de fibrine en situations水果étricales aiguës .

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-03-01 DOI: 10.1684/abc.2022.1724

Fanny Mingant, Hubert Galinat, Jacob Hannigsberg, Simon Jaouen

引用次数: 0

La warfarine est-elle plus stable que la fluindione ? Étude rétrospective en soins premiers (étude STAB-AVK). 华法林比氟地酮更稳定吗?急救回顾性研究(STAB-AVK研究)。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-03-01 DOI: 10.1684/abc.2022.1709

Thanh Tam Quach Hiep, Christian Creveuil, Sophie de Jaecher, Pierre Bustany, Noel Angoujard, Joachim Alexandre, Xavier Humbert

{"title":"La warfarine est-elle plus stable que la fluindione ? Étude rétrospective en soins premiers (étude STAB-AVK).","authors":"Thanh Tam Quach Hiep, Christian Creveuil, Sophie de Jaecher, Pierre Bustany, Noel Angoujard, Joachim Alexandre, Xavier Humbert","doi":"10.1684/abc.2022.1709","DOIUrl":"https://doi.org/10.1684/abc.2022.1709","url":null,"abstract":"Malgré leur prescription en seconde intention après les anticoagulants oraux directs, les antivitamines K (AVK) sont encore largement utilisés en soins premiers. En France, la fluindione représentait 82 % des AVK prescrits en 2016 contre 13 % pour la warfarine. Pourtant, la warfarine est l'AVK de référence ailleurs dans le monde et sa demi-vie plus longue devrait la rendre plus adaptée avec des International Normalized Ratio (INR) plus stables. Les objectifs de notre travail étaient de comparer ces deux molécules en termes de stabilité de leur effet anticoagulant au long cours et sur la fréquence des INR réalisés. Nous avons mené une étude rétrospective de type exposé/non-exposé sur données issues d'un laboratoire de biologie médicale ornais concernant des patients majeurs traités par fluindione ou warfarine du 1er janvier 2014 au 31 décembre 2016 inclus, quelle que soit l'indication. La stabilité du traitement était évaluée par le temps passé dans l'intervalle thérapeutique (TTR), calculé selon la méthode de Rosendaal, à partir des INR dosés en pratique courante. Les comparaisons entre les deux groupes ont été faites par régression linéaire multi-niveaux avec analyse univariée puis multivariée avec ajustement sur l'âge, le genre et la fonction rénale. Deux-cent-quatre patients ont été inclus (77,0 ± 10,0 ans, 49,5 % de femmes), 170 sous fluindione et 34 sous warfarine. Le TTR moyen sous fluindione était de 68,0 % contre 72,0 % sous warfarine (p = 0,085). Le délai moyen entre deux INR était de 22,8 jours sous fluindione contre 31,1 jours sous warfarine (p = 0,049). Par rapport à la fluindione, la warfarine semble présenter un bénéfice en termes de qualité de vie pour les patients. Malgré nos résultats, nous invitons à privilégier la warfarine à la fluindione en soins premiers.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 2","pages":"133-140"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Relapse of acquired von Willebrand syndrome in a patient non-compliant with Crohn's disease]. [克罗恩病患者的获得性血管性血友病复发]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2021.1692

Myriam Hormi, Melchior Le Méné, Céline Comparon, Imededdine El Kout, Fanny Baran-Marszak, Nathalie Itzhar-Baikian, Virginie Siguret, Robin Dhote

引用次数: 0

Undetectable triglycerides related to the combined intake of ascorbic acid and tacrolimus. 无法检测到的甘油三酯与抗坏血酸和他克莫司的联合摄入有关。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2022.1702

Corentine Klos, Guillaume Grzych, Emeline Gernez, Isabelle Kim, Jean-David Pékar, Julie Demaret, Marie Joncquel Chevalier Curt

{"title":"Undetectable triglycerides related to the combined intake of ascorbic acid and tacrolimus.","authors":"Corentine Klos, Guillaume Grzych, Emeline Gernez, Isabelle Kim, Jean-David Pékar, Julie Demaret, Marie Joncquel Chevalier Curt","doi":"10.1684/abc.2022.1702","DOIUrl":"https://doi.org/10.1684/abc.2022.1702","url":null,"abstract":"Management of triglyceride (TG) levels is essential in intensive care units (ICU), especially to manage the risk of pancreatitis induced by propofol. However, some therapeutics in ICU such as intravenous ascorbic acid protocol, especially used in the context of Covid-19 could lead to false decrease of triglycerides by analytical disruption of Trinder reaction. We report here the case of a sample with unmeasurable triglyceride levels partly due to high plasma ascorbic acid levels. However, repeated measure on the same sample four days later revealed that interference mechanism on TG was still present whereas the level of ascorbic acid was very reduced by oxidation degradation. Hence, additional interference mechanism was suspected. After clinical investigation, we found that the patient had also received high doses of tacrolimus due to a transplant. As previous studies reported that tacrolimus treatment lead to a decrease of the measured plasma activity of lipoprotein lipase (LPL), we hypothesized that tacrolimus or related metabolites could also interfere by direct inhibition of LPL involved in TG analytical method used.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 1","pages":"65-68"},"PeriodicalIF":0.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39758491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hyperhomocysteinemia and cardiovascular diseases. 高同型半胱氨酸血症和心血管疾病。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2021.1694

Régis Guieu, Jean Ruf, Giovanna Mottola

引用次数: 9

[The wishes of the SFBC President]. [SFBC主席的愿望]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2022.1703

Vincent Sapin

引用次数: 0

[Qualitative dysalbuminemia in capillary serum protein electrophoresis: a case series of 70 patients]. 【毛细管血清蛋白电泳定性白蛋白异常血症:70例病例分析】。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2021.1696

Hind Zrikem, Adil Jahdaoui, Siham Aboulmakarim

引用次数: 0

[Uncertainty of measurement and result from a complex calculation: about the risk of fetal Down's syndrome by maternal serum markers]. [测量的不确定性和复杂计算的结果:母体血清标记物对胎儿唐氏综合征风险的影响]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-02-01 DOI: 10.1684/abc.2021.1695

Estelle Roland, Etienne Voirin-Mathieu, Sophie Dreux, Gilles Renom

{"title":"[Uncertainty of measurement and result from a complex calculation: about the risk of fetal Down's syndrome by maternal serum markers].","authors":"Estelle Roland, Etienne Voirin-Mathieu, Sophie Dreux, Gilles Renom","doi":"10.1684/abc.2021.1695","DOIUrl":"https://doi.org/10.1684/abc.2021.1695","url":null,"abstract":"Screening for fetal Down's syndrome has the peculiarity of combining the biochemical assay of 2 or 3 serum markers with the risk associated with maternal age. If the accuracy of measurement of each parameter is known by the biologist, the uncertainty of the ultimate risk to the patient is not. Indeed, the means of risk calculation involve numerous multi-parameter equations which are not practical for daily use. Defining a re-test limit on thresholds of 1/50 and 1/1,000 is therefore impossible. Since the use of an arbitrarily defined threshold is not being satisfactory, we propose, by default, a methodology based on the exploitation of patient files in the laboratory with risks close to the two decision thresholds. Modulations of the concentrations of all the markers according to their uncertainty allow new risks to be obtained, which can be averaged and framed by an interval of several standard deviations. Choosing the level of uncertainty, the number of files to include, the number of standard deviations framing the average risk, as well as the calculation software, are all choices available to the biologist. The proposed methodology is therefore highly empirical but open, and adaptable, to the specific environment and performance capabilities of each and every laboratory involved.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 1","pages":"85-90"},"PeriodicalIF":0.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39758494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0