胃腺癌DNA错配修复蛋白表达的临床病理及预后意义

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Nabiha Missaoui, Nozha Mhamdi, Hanene Saad, Ahlem Bdioui, Nihed Abdessayed, Atef Ben Abdelkader, Thouraya Zahmoul, Hajer Hamchi, Sihem Hmissa, Moncef Mokni
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引用次数: 0

摘要

尽管DNA错配修复(DNA mismatch repair, MMR)蛋白表达在结直肠癌中的意义已得到证实,但在结直肠癌外,主要是胃腺癌中,其表达仍存在争议。来自非洲和阿拉伯世界的数据仍然有限。本研究探讨MMR在胃腺癌中的表达,并评估其在突尼斯患者中的临床病理和预后意义。对72例胃腺癌进行回顾性研究。记录临床病理特点和患者预后。通过免疫组织化学对存档材料的整个切片进行MMR表达测定。生存分析采用Kaplan-Meier估计和Log-Rank检验。MMR蛋白在84.7%的胃腺癌标本中表达。其余11份样本(15.3%)显示MMR蛋白模式改变。MMR表达缺陷与高龄(p = 0.03)、肠道类型(p = 0.04)和淋巴结转移(p = 0.04)之间存在显著相关性。未观察到与其余选定肿瘤特征的其他显著关系。患者生存与淋巴结侵袭(p = 0.002)、远处转移(p = 0.02)和肿瘤分化(p = 0.03)显著相关,但与MMR状态无关(p = 0.83)。MMR缺乏与突尼斯胃腺癌患者的高龄、肠道类型和淋巴结转移有关,但与生存无关。需要更大的多中心研究和额外的分子研究来更多地探索这些肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinicopathological and prognostic significance of DNA mismatch-repair protein expression in gastric adenocarcinoma

Although the significance of DNA mismatch repair (MMR) protein expression in colorectal cancer is well-established, it remains contentious in extra-colorectal cancers and mainly in gastric adenocarcinoma. Data from Africa and Arab world remain limited. This study explored the MMR expression in gastric adenocarcinoma and evaluated its clinicopathological and prognostic signification among Tunisian patients. A retrospective study of 72 gastric adenocarcinomas was carried out. Clinicopathological particularities and patient outcomes were recorded. MMR expression was determined by immunohistochemistry on whole sections of archived material. Survival analysis was realized utilizing the Kaplan-Meier estimates and Log-Rank test. Expression of MMR proteins was observed in 84.7% of gastric adenocarcinoma samples. The 11 remaining samples (15.3%) exhibited an altered pattern of MMR protein. A significant association was identified between deficient MMR expression and advanced age (p = 0.03), intestinal type (p = 0.04) and lymph node metastases (p = 0.04). No other significant relationship was observed with the remaining selected tumor features. Patient survival was significantly associated with lymph node invasion (p = 0.002), distant metastases (p = 0.02) and tumor differentiation (p = 0.03), but not with MMR status (p = 0.83). MMR deficiency was related to advanced-age, intestinal type and nodal metastasis, but not to survival of Tunisian patients with gastric adenocarcinoma. Larger multicenter studies with additional molecular investigation are required to more explore these tumors.

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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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