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Anatomical assessment of the Kambin's triangle for percutaneous posterolateral transforaminal endoscopic surgery of lumbar intervertebral discs: a magnetic resonance imaging based study. 腰椎间盘经皮后外侧经椎间孔内窥镜手术的 Kambin 三角区解剖学评估:一项基于磁共振成像的研究。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-12-31 Epub Date: 2024-11-08 DOI: 10.5115/acb.24.112
Naeeme Nikpour, Zahra Fazelinejad, Mozhgan Sametzadeh, Mohammad Ardeshiri Lordjani, Ali Reza Eftekhari Moghadam
{"title":"Anatomical assessment of the Kambin's triangle for percutaneous posterolateral transforaminal endoscopic surgery of lumbar intervertebral discs: a magnetic resonance imaging based study.","authors":"Naeeme Nikpour, Zahra Fazelinejad, Mozhgan Sametzadeh, Mohammad Ardeshiri Lordjani, Ali Reza Eftekhari Moghadam","doi":"10.5115/acb.24.112","DOIUrl":"10.5115/acb.24.112","url":null,"abstract":"<p><p>The aim of the present study was to utilize magnetic resonance imaging (MRI) as a noninvasive tool for evaluation of the Kambin's triangle safe zone. Lumbar MRIs of 67 healthy subjects were analyzed. On the coronal plane, the distance from the superior endplate to the nerve root exiting from the dura (distance a), the distance from the lateral aspect of the dura to the medial aspect of the nerve root (distance b), and the angle between the nerve root and plane of the corresponding disc (angle α) was measured. On the axial plane, the vertical distance from the upper facet surface to the exiting nerve root and root-disc distance was also measured. On the sagittal plane, foraminal height, diameter, nerve root-disc distance, and nerve root-pedicle distance were measured. On the coronal plane, right and left α angle was 50.78±4.43 (range, 48.52-51.84 degrees) and 51.07±4.08 (range, 49.25-51.91) degrees, respectively. Distance of right 'a' was 17.86±3.86 mm (range, 10.56-24.84 mm) and left 'a' was 18.03±3.73 mm (range, 10.98-24.82 mm), distance of right 'b' was 15.57±2.61 mm (range, 10.54-20.70 mm) and left 'b' was 15.46±2.68 mm (range, 10.93-19.23 mm). All these measurements increased as the spine level went down. Foraminal height and diameter decreased caudally. Nerve root-facet distance did not show change as the level went down. The study indicated that radiologic measurement is feasible to evaluate the anatomy of the Kambin's triangle. At lower lumbar levels, the exiting nerve root is at risk of injury.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"523-534"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Localizing motor entry points of adductor muscles of thigh for motor point procedures in the treatment of adductor spasticity. 定位大腿内收肌的运动入口点,用于治疗内收肌痉挛的运动点手术。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-12-31 Epub Date: 2024-08-28 DOI: 10.5115/acb.24.065
Anju Mary Albert, Henry Prakash Magimairaj, Jeyaseelan Lakshmanan, Sunil Jonathan Holla, Ivan James Prithishkumar
{"title":"Localizing motor entry points of adductor muscles of thigh for motor point procedures in the treatment of adductor spasticity.","authors":"Anju Mary Albert, Henry Prakash Magimairaj, Jeyaseelan Lakshmanan, Sunil Jonathan Holla, Ivan James Prithishkumar","doi":"10.5115/acb.24.065","DOIUrl":"10.5115/acb.24.065","url":null,"abstract":"<p><p>Spasticity which is focal or segmental such as affecting a single muscle group or limb can be treated by chemical neurolysis or surgical denervation at the neurovascular hilus. This study determines the motor entry points (MEPs) of adductor muscles of the thigh in the adult Indian population and identifies precise anatomical landmarks for the successful performance motor point procedures for the relief of muscle spasticity. A total of 10 adult lower limbs were dissected, and nerve branches to adductor muscles were carefully exposed up to their MEP. The morphometry of adductor muscles, precise locations of proximal and distal MEPs, and ideal sites for motor point procedures were identified. The median number of MEPs in adductor longus was two. Most of them were located between 40% and 50% of the muscle length <i>i.e.</i>, in the third-fifth of the total muscle length. Adductor magnus and gracilis had a median number of one and six MEPs respectively. The ideal site of motor point procedures is in the second-fifth of the muscle length for both. This preliminary study describes the location of MEPs and ideal sites of motor point procedures in the adductor muscle of the thigh. However, further cadaveric and electromyographic studies with larger samples are necessary to investigate precise locations of MEPs aiding in the treatment of spasticity.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"503-510"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A variant deep femoral artery passing anterior to femoral vein: an anatomical observation with implication in femoral vein cannulation. 股深动脉在股静脉前方穿过的变异股深动脉:对股静脉插管的解剖学观察。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-12-31 Epub Date: 2024-10-02 DOI: 10.5115/acb.24.083
Mohammadali M Shoja, Maria-Teresa De Leon, Jay Sheth, Sana Padival, Tara Tritsch, Gary B Schwartz
{"title":"A variant deep femoral artery passing anterior to femoral vein: an anatomical observation with implication in femoral vein cannulation.","authors":"Mohammadali M Shoja, Maria-Teresa De Leon, Jay Sheth, Sana Padival, Tara Tritsch, Gary B Schwartz","doi":"10.5115/acb.24.083","DOIUrl":"10.5115/acb.24.083","url":null,"abstract":"<p><p>The common femoral artery (CFA) typically gives rise to its superficial and deep branches, with the deep femoral artery (DFA) being the largest and most substantial of these branches. This case study presents a rare variation of the DFA characterized by an unusual branching pattern and its specific relationship with the femoral vein within the subinguinal region. In nutshell, the DFA and the medial femoral circumflex artery shared a common origin from the medial aspect of the CFA. The DFA assumed an unusual course, initially passing anterior to the femoral vein above the saphenofemoral junction, followed by a spiraling trajectory around the medial aspect of the femoral vein before running posteriorly. The embryological origins and clinical implications of this anatomical variation are thoroughly examined. This unusual vascular relationship in the subinguinal region may potentially result in arterial injury during femoral vein cannulation or formation of arteriovenous fistula after the procedure.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"616-620"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual nerve communication in gluteal region: embryological basis and clinical perspective. 臀部异常的神经沟通:胚胎学基础和临床视角。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-12-31 Epub Date: 2024-10-04 DOI: 10.5115/acb.24.076
Vidhu Dhawan, Sarah Sko Sangma, Suryakanta Seth, Vishwajit Deshmukh, Monica Baxla, Seema Singh
{"title":"Unusual nerve communication in gluteal region: embryological basis and clinical perspective.","authors":"Vidhu Dhawan, Sarah Sko Sangma, Suryakanta Seth, Vishwajit Deshmukh, Monica Baxla, Seema Singh","doi":"10.5115/acb.24.076","DOIUrl":"10.5115/acb.24.076","url":null,"abstract":"<p><p>The posterior femoral cutaneous nerve (PFCN) has been widely studied with context to its origin, distribution and mononeuropathies. Due to the vulnerability of the gluteal region to iatrogenic injuries and pressure ulcers etc., an understanding of the cutaneous innervation of the gluteal region holds immense relevance. The communication between the PFCN and the inferior gluteal nerve (IGN) was observed at the back of thigh of a 56-year-old male cadaver while exploring distribution of nerves in gluteal region during routine anatomical dissection. The above communication holds importance in numerous diagnostic and reconstructive procedures. It assumes relevance where nerve blocks in PFCN are needed for surgical procedures in the vicinity of the thigh, knee, and the postero-superior part of the leg. The grade of motor response elicited in IGN on attempted PFCN stimulation could be a reliable determinant of adequate PFCN block.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"621-624"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Striated muscle fiber crossings of the head and neck: a histological study using near-term human fetuses and elderly cadavers. 头颈部横纹肌纤维交叉:利用近月胎儿和老年尸体进行的组织学研究。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-12-31 Epub Date: 2024-07-19 DOI: 10.5115/acb.24.094
Ji Hyun Kim, Kei Kitamura, Yohei Honkura, Gen Murakami, Shin-Ichi Abe
{"title":"Striated muscle fiber crossings of the head and neck: a histological study using near-term human fetuses and elderly cadavers.","authors":"Ji Hyun Kim, Kei Kitamura, Yohei Honkura, Gen Murakami, Shin-Ichi Abe","doi":"10.5115/acb.24.094","DOIUrl":"10.5115/acb.24.094","url":null,"abstract":"<p><p>Striated muscle fiber crossings at almost right angle are known to exist in the face, soft palate, pharyngeal wall and tongue. We aimed to identify a specific interface tissue at the crossing. We observed histological sections from 22 half-heads of 12 near-term fetuses at 26-40 weeks (crown-rump length, 215-334 mm). For comparison, we also observed tongue frontal sections from 5 elderly cadavers (75-85 years old). At the angle of mouth as well as in the soft palate and pharyngeal wall, a solitary striated muscle fiber (<i>e.g.</i>, levator) consistently crossed a fiber bundle of the antagonist muscle (<i>e.g.</i>, depressor), but a solitary-to-solitary fiber interdigitation was unlikely with the antagonist muscle. Near the external nasal orifice as well as in the tongue intrinsic muscle layer, at every section, there was a crossing with an endomysium-to-endomysium contact: the nasalis and platysma muscles and; the vertical and transverse (or inferior longitudinal) tongue muscles. Therein, the functional vectors crossed at almost right angle. Also in adult tongue, the vertical and transverse muscle fibers sometimes (0-2 sites per section) crossed with an endomysium-to-endomysium contact. At the muscle crossing with an endomysium contact, the endomysium and basement membrane seemed to receive a friction stress between two muscles. Although some crossings might disappear due to high muscle activity after birth, not a few of them were likely to maintain. To minimize the mechanical stress, a minute nervous control of the timing, duration and strength of muscle contraction seemed to be necessary.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"570-578"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity. 食用菌提取物与格列本脲对阿脲诱导糖尿病的影响:Nrf2表达和肾毒性的亚急性体内研究。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-07-05 DOI: 10.5115/acb.24.054
Chinedu Godwin Uzomba, Uchenna Kenneth Ezemagu, Mary-Sonia Ofoegbu, Njoku Lydia, Essien Goodness, Chinedum Emelike, Uchewa Obinna, Alo Joseph Nwafor, Ejikeme Felix Mbajiorgu
{"title":"Edible mushroom (<i>Pleurotus cornucopiae</i>) extract vs. glibenclamide on alloxan induced diabetes: sub-acute <i>in vivo</i> study of Nrf2 expression and renal toxicity.","authors":"Chinedu Godwin Uzomba, Uchenna Kenneth Ezemagu, Mary-Sonia Ofoegbu, Njoku Lydia, Essien Goodness, Chinedum Emelike, Uchewa Obinna, Alo Joseph Nwafor, Ejikeme Felix Mbajiorgu","doi":"10.5115/acb.24.054","DOIUrl":"10.5115/acb.24.054","url":null,"abstract":"<p><p>The study aims to compare the action of <i>Pleurotus cornucopiae</i> and glibenclamide on alloxan-induced diabetes and ascertain how an aqueous extract of the edible mushroom regulates the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), oxidative stress biomarkers and renal toxicity in a diabetic male Wistar rat model. Twenty-five adult male Wistar rats were randomly grouped into five groups with five rats per. Group 1 and those in the treatment groups received normal feed and water <i>ad libitum</i>. Group 2 received intraperitoneal administration of alloxan monohydrate (150 mg/kg body weight). Group 3 received alloxan monohydrate and glibenclamide (5 mg/kg body weight bwt), group 4 received alloxan monohydrate plus the extract (250 mg/kg bwt) and group 5 received alloxan monohydrate plus the extract (500 mg/kg bwt). The administration of glibenclamide plus the extract was oral for 14 days. Glibenclamide and the extract lowered blood glucose level, catalase, and glutathione peroxidase activities, increased the superoxide dismutase (SOD) activity in rats with alloxan induced diabetes. The extract at 500 mg/kg bwt reduced the plasma urea and sodium concentration in the treated rats. The extract and glibenclamide could detoxify alloxan and restore its induced renal degeneration and glomeruli atrophy, intra renal hemorrhage and inflammation and oxidative biomarkers through activation of Nrf2 expression. The drug glibenclamide and <i>P. cornucopiae</i> have appreciable hypoglycemic activity and potential to restore the normal renal architecture in the rats, hence they offer similar curative effects. Additionally, the extract at 500 mg/kg bwt activated SOD and Nrf2 expression more than glibenclamide in rats with alloxan-induced diabetes.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"446-458"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atlantooccipital assimilation associated with combined atlas arch defect: a radiological case report. 伴有合并寰椎弓缺损的寰枕同位:一例放射学病例报告。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-05-13 DOI: 10.5115/acb.23.281
Athikhun Suwannakhan, Pannawat Trerattanavong, Laphatrada Yurasakpong, Woranan Kirisattayakul, Nutmethee Kruepunga, Kiarttiyot Tuntiseranee, Kanitin Rumpansuwon, Thanyaporn Senarai
{"title":"Atlantooccipital assimilation associated with combined atlas arch defect: a radiological case report.","authors":"Athikhun Suwannakhan, Pannawat Trerattanavong, Laphatrada Yurasakpong, Woranan Kirisattayakul, Nutmethee Kruepunga, Kiarttiyot Tuntiseranee, Kanitin Rumpansuwon, Thanyaporn Senarai","doi":"10.5115/acb.23.281","DOIUrl":"10.5115/acb.23.281","url":null,"abstract":"<p><p>In this report, atlantooccipital assimilation (AS), anterior arch defect (AAD), and posterior arch defect (PAD) of the atlas, and several variations around the craniocervical junction were identified on computed tomography (CT) of a patient of unknown sex and age. Coronal and sagittal CT scans showed AS and bilateral fusion of the atlas and the base of occipital bone. Axial CT scan at the atlas revealed PAD type B on the left side and midline AAD. Morphometric measurements indicated a potential ventral spinal cord compression. In addition, mid-sagittal CT revealed the presence of fossa navicularis magna and incomplete formation of the transverse foramen on the right side. This study reports an extremely rare AS associated with AAD, PAD, and other variations of the clivus and the atlas. To our knowledge, no similar case has been reported in the literature.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"468-472"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variability in the projection level of the vertebra prominens: a cadaveric study. 椎体突出水平的变化:尸体研究。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-06-25 DOI: 10.5115/acb.24.061
Trifon Totlis, Andreas Sammer, Maria Piagkou, Konstantinos Natsis, Panagiotis-Konstantinos Emfietzis, Filippos Karageorgos, George Tsakotos, George Triantafyllou, Georg Feigl
{"title":"Variability in the projection level of the vertebra prominens: a cadaveric study.","authors":"Trifon Totlis, Andreas Sammer, Maria Piagkou, Konstantinos Natsis, Panagiotis-Konstantinos Emfietzis, Filippos Karageorgos, George Tsakotos, George Triantafyllou, Georg Feigl","doi":"10.5115/acb.24.061","DOIUrl":"10.5115/acb.24.061","url":null,"abstract":"<p><p>The 7th cervical vertebra (C7) is described as having the most prominent spinous process (SP) and is characterized as the \"vertebra prominens\" (VP) of the cervical spine in anatomy textbooks. The VP is an important anatomical landmark of the neck for clinical examination and therapeutic intervention. The present study identifies the level of the most prominent SP of the cervical and uppermost thoracic vertebrae in a cadaveric cohort. Thirty-nine (23 female and 16 male) cadavers of a mean age of 77.5 years were investigated in a prone position and a certain cervical kyphotic bending. The most prominent SP, at the base of the neck, was palpated and marked with a wedging nail into the SP of the vertebra. The cervical region was dissected, and a blind investigator examined whether the nail was placed into the SP of C7 or the SP of another upper or lower vertebra. In 19 out of 39 cadavers (48.7%), the C7 was identified as the VP (typical anatomy), followed by the C6 (in 14 cadavers, 35.9%), C5 (in 4 cadavers, 10.3%). In 2 cadavers (5.1%) the first thoracic vertebra was identified as having the most prominent SP. Although C7 is described as the VP, in the present study the SP of C7 was the most prominent in less than 50%. The high variable projection level of the most prominent SP of the cervical vertebra holds great clinical significance for spine examination, neck surgery, and spinal anesthesia.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"378-383"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete transverse basilar cleft associated with hemifacial microsomia. 伴有半面小畸形的完全横向基底裂。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-03-07 DOI: 10.5115/acb.23.289
Laphatrada Yurasakpong, Athikhun Suwannakhan, Joe Iwanaga, R Shane Tubbs, Arada Chaiyamoon, Nutmethee Kruepunga, Somluk Asuvapongpatana, Thanwa Sudsang
{"title":"Complete transverse basilar cleft associated with hemifacial microsomia.","authors":"Laphatrada Yurasakpong, Athikhun Suwannakhan, Joe Iwanaga, R Shane Tubbs, Arada Chaiyamoon, Nutmethee Kruepunga, Somluk Asuvapongpatana, Thanwa Sudsang","doi":"10.5115/acb.23.289","DOIUrl":"10.5115/acb.23.289","url":null,"abstract":"<p><p>Transverse basilar cleft (TBC) is an extremely rare variation of the clivus or the basilar part of the occipital bone. In this report, a unilateral transverse basilar fissure was found at the clivus in a head computed tomography of an 18-year-old female patient diagnosed with hemifacial microsomia (HFM). Image analysis of this patient showed shortening of the ramus of the right mandible along with medial displacement of the right temporomandibular joint and hypoplastic right maxilla. In addition, observation of the clivus showed a cleft between the basioticum and basioccipital bones at the level of the pharyngeal tubercle on the right side. This cleft was identified as TBC. Clival variations, TBC included, attributed to HFM have never been reported. This report draws attention to the complex relationship between abnormal development of clivus and HFM syndrome, and sheds light on a possible genetic and molecular association between these two conditions.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"473-475"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model. 在 1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森病模型中,蜂蜜和左旋多巴通过调节核因子红细胞生成素 2 相关因子 2 信号通路,对黑质紧实旁神经元的保护效果相当。
IF 1.4
Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-07-12 DOI: 10.5115/acb.24.034
Fatimo Ajoke Sulaimon, Ruqayyah Yetunde Ibiyeye, Aminu Imam, Aboyeji Lukuman Oyewole, Abubakar Lekan Imam, Monsur Shehu, Sikiru Abayomi Biliaminu, Risikat Eniola Kadir, Gabriel Olaiya Omotoso, Moyosore Salihu Ajao
{"title":"Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model.","authors":"Fatimo Ajoke Sulaimon, Ruqayyah Yetunde Ibiyeye, Aminu Imam, Aboyeji Lukuman Oyewole, Abubakar Lekan Imam, Monsur Shehu, Sikiru Abayomi Biliaminu, Risikat Eniola Kadir, Gabriel Olaiya Omotoso, Moyosore Salihu Ajao","doi":"10.5115/acb.24.034","DOIUrl":"10.5115/acb.24.034","url":null,"abstract":"<p><p>Parkinson's disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and 8 days after MPTP administration respectively. The result showed that there were significantly (<i>P</i><0.05) higher motor activities in the PD models pretreated with the honey as well as levodopa. furthermore, the pretreatments protected the midbrain against the chromatolysis and astrogliosis induced by MPTP. The expression of antioxidant markers (glutathione [GSH] and nuclear factor erythroid 2-related factor 2 [Nrf2]) was also significantly upregulated in the pretreated PD models. It is thus concluded that honey and levodopa comparably protected the substantia nigra pars compacta neurons against oxidative stress by modulating the Nrf2 signaling molecule thereby increasing GSH level to prevent MPTP-induced oxidative stress.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"431-445"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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