Anatomy & Cell Biology最新文献

Three-headed duplicated omohyoid muscle in a human cadaver. 人类尸体上的三头复制肩胛舌骨肌。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-07-03 DOI: 10.5115/acb.25.118

Judney Cley Cavalcante, Bento João da Graça Azevedo Abreu, Wigínio Gabriel de Lira-Bandeira, Mauro Bezerra Montello, Nicol Zielinska, Łukasz Olewnik

引用次数: 0

Anatomical study of fascial and aponeurotic bands in the anterolateral leg. 腿前外侧筋膜和腱膜带的解剖学研究。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-07-03 DOI: 10.5115/acb.24.273

Devendra Shekhawat, Kristen Rizzuto, Rarinthorn Samrid, Chung Yoh Kim, Yoko Tabira, Kazzara Raeburn, Kathleen Bubb, Aaron S Dumont, Joe Iwanaga, Marios Loukas, Mahindra Kumar Anand, R Shane Tubbs

{"title":"Anatomical study of fascial and aponeurotic bands in the anterolateral leg.","authors":"Devendra Shekhawat, Kristen Rizzuto, Rarinthorn Samrid, Chung Yoh Kim, Yoko Tabira, Kazzara Raeburn, Kathleen Bubb, Aaron S Dumont, Joe Iwanaga, Marios Loukas, Mahindra Kumar Anand, R Shane Tubbs","doi":"10.5115/acb.24.273","DOIUrl":"https://doi.org/10.5115/acb.24.273","url":null,"abstract":"Foot drop can have debilitating effects on quality of life and is usually idiopathic. A better understanding of the nerve relationships of the anterior compartment of the leg could be important in treating some patients. Therefore, this study aimed to elucidate the deep fibular nerve and its relationship to various connective tissue bands along its course. Fifty-two cadaveric legs were dissected to reveal and identify the branching patterns of the common, superficial, and deep fibular nerves and their passage through the leg's posterior intermuscular septum (PIMS) and anterior intermuscular septum (AIMS). The oval passageway of the common fibular nerve was classified as the superior fibular band, and the crescentic passageways of the deep and superficial fibular nerves were classified as the middle and inferior fibular bands. The inferior boundary of the oval-shaped superior fibular band of the PIMS was positioned at the lateral aspect of the superior most region of the fibular neck. The crescentic middle fibular band of the AIMS was present in 96.15% of legs, its inferior boundary being consistently positioned in 98% of them. The other 2% presented with a thin band of connective tissue in the absence of a distinguishable AIMS. The crescentic inferior fibular band of the AIMS was present in 17.31% of legs. There were no significant differences between right and left sides in the presence or classifications of the fibular bands. Connective tissue bands along the course of the fibular nerves are common and should be considered in idiopathic palsies of these nerves.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology and morphometry of the vertebrobasilar system intracranial segment: a computed tomography angiography study. 椎基底动脉系统颅内段的形态学和形态计量学：计算机断层血管造影研究。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-07-03 DOI: 10.5115/acb.24.249

Savvas Melissanidis, George Triantafyllou, George Botis, Konstantinos Natsis, Katerina Vassiou, Marianna Vlychou, George Tsakotos, Theodosis Kalamatianos, Nikolaos Lazaridis, George Matsopoulos, Maria Piagkou

{"title":"Morphology and morphometry of the vertebrobasilar system intracranial segment: a computed tomography angiography study.","authors":"Savvas Melissanidis, George Triantafyllou, George Botis, Konstantinos Natsis, Katerina Vassiou, Marianna Vlychou, George Tsakotos, Theodosis Kalamatianos, Nikolaos Lazaridis, George Matsopoulos, Maria Piagkou","doi":"10.5115/acb.24.249","DOIUrl":"https://doi.org/10.5115/acb.24.249","url":null,"abstract":"The current computed tomography angiography (CTA) study aimed to investigate the vertebrobasilar system (VBS) intracranial segment variant morphological anatomy and morphometry. Two hundred CTAs of 142 male and 58 female patients (with a mean age of 62.85±14.08) were retrospectively evaluated. Four hundred vertebral arteries (VAs) and 200 basilar arteries (BAs) were studied. In the V3 segment, the vessel's high riding course was identified in 10.8%. An arcuate foramen (AF) was identified surrounding the V3 segment in 12.0%. When AF was present, the V3 diameter was statistically significantly narrower (P<0.001). The V4 segment was hypoplastic in 11.0% and fenestrated in one case (0.3%). The posterior inferior cerebellar artery typically originated from the V4 segment in 76.5%. On the BA morphology, we classified the vessel according to its inclination. The most common type was the J-shaped (55.5% of cases). The BA inclination was positively correlated with the vessel's length (P=0.002). The VBS intracranial segment was systematically investigated. Knowledge of the VBS typical and variant anatomy is essential for anatomists, radiologists, and clinicians. The most important findings was the following: (1) the AF presence significantly narrowed the VA diameter, which could lead to the vessel's compression, (2) the BA linear length (bending or inclination) positively correlated with the BA length, and (3) the V4 length was positively correlated with its diameter.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing anatomy education using anatomical sign language: expanding its expressive capabilities to the upper and lower extremities, face, and brain structures. 利用解剖学手语加强解剖学教育：将其表达能力扩展到上下肢、面部和大脑结构。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-02-05 DOI: 10.5115/acb.24.275

Mi-Sun Hur, Dong-Su Jang, Chang-Seok Oh

引用次数: 0

Concurrent variations of left testicular vessels. 左睾丸血管并发变异。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-01-10 DOI: 10.5115/acb.24.198

Satheesha Badagabettu Nayak

引用次数: 0

Peripheral neuroprotective potential and toxicological profile of fascaplysin in zebrafish models. fascaplysin在斑马鱼模型中的周围神经保护潜力和毒理学分析。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-02-21 DOI: 10.5115/acb.24.290

Ki-Hoon Park, Youngbuhm Huh, Hyung-Joo Chung, Hiroyuki Konishi, Junyang Jung, Na Young Jeong

{"title":"Peripheral neuroprotective potential and toxicological profile of fascaplysin in zebrafish models.","authors":"Ki-Hoon Park, Youngbuhm Huh, Hyung-Joo Chung, Hiroyuki Konishi, Junyang Jung, Na Young Jeong","doi":"10.5115/acb.24.290","DOIUrl":"10.5115/acb.24.290","url":null,"abstract":"Fascaplysin is a bioactive compound derived from marine sponges, which have anticancer properties and potential neuroprotective effects mediated by mitigation of oxidative stress-induced neurotoxicity. This study investigated the concentration-dependent effects of fascaplysin in zebrafish models, focusing on embryonic survival, cardiac function, melanocyte formation, and peripheral nerve health. Zebrafish embryos were exposed to fascaplysin at concentrations ranging from 10 nM to 100 μM, and developmental parameters were assessed. At higher concentrations (≥1 μM), fascaplysin significantly decreased embryo survival rates, delayed hatching, impaired cardiac function, and caused morphological abnormalities, including disruption of melanocyte formation and structural deformities. By contrast, lower concentrations (10 nM and 100 nM) did not exhibit significant toxicity. In adult zebrafish, fascaplysin at 100 nM reduced the expression of superoxide-producing enzymes and preserved peripheral nerve integrity following injury, as demonstrated by maintenance of fluorescence in transgenic zebrafish with expression of green fluorescent protein in Schwann cells. These findings suggest that fascaplysin exhibits peripheral neuroprotective effects at low concentrations, potentially through the reduction of oxidative stress and preservation of Schwann cell function. However, the toxicity observed at higher concentrations highlights the importance of dose optimization. Fascaplysin is a promising candidate for the development of new therapeutic strategies for peripheral neuropathies, and further studies are required to elucidate the underlying mechanisms and validate its efficacy in mammalian models.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"274-283"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Branched ends of Reichert's cartilage in the ear: a histological study using human near-term fetuses. 耳中Reichert软骨的分支末端：一项使用人类近期胎儿的组织学研究。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-02-26 DOI: 10.5115/acb.24.220

Chun-Ai Li, Zhe-Wu Jin, Yohei Honkura, Ai Hirano-Kawamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori

{"title":"Branched ends of Reichert's cartilage in the ear: a histological study using human near-term fetuses.","authors":"Chun-Ai Li, Zhe-Wu Jin, Yohei Honkura, Ai Hirano-Kawamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori","doi":"10.5115/acb.24.220","DOIUrl":"10.5115/acb.24.220","url":null,"abstract":"There is little information regarding whether the styloid process \"inserts\" deeply into the temporal bone petrosa. We examined the involvement of Reichert's cartilage (RC) in the petrosa using sagittal or horizontal histological sections of the heads from 17 near-term fetuses (25-40 weeks). The cranial part of RC usually carried two short branches or protrusions (T-shaped appearance). One of the branches ended in or adjacent to the future tympanic cavity, while another branch ended near the facial nerve canal. Near the latter end, a part of the RC was usually fused with the petrosa, but it was rarely separated from the latter. When a bar toward the tympanic cavity was short or absent, RC displayed a reversed J-shaped course near the facial nerve canal and ended at the attachment to the petrosa (3 of 17 specimens). Overall, considerable variations were evident in the shape, length and topographical relation of RC in the ear. Therefore, an intra-otic root of the styloid process, if identified in adults, seemed not to be a simple bar inserting between the tympanic cavity and the vertical portion of the facial nerve canal. Considerable variations in the RC head suggested that the shape was likely to be determined by mechanical loads from the developing petrosa and/or tympanic bone. Those observations were clearly contrast to the degenerating Meckel's cartilage that induces protrusions of the petrosa ant tympanic bone. After birth, endochondral ossification of the petrosa appeared to expand antero-inferiorly to involve all branches of RC.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"200-209"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver oval cells in response to HDAC1 inhibitor trichostatin A: immunohistochemical characterization using OV-6 hepatic expression. 肝卵圆细胞对HDAC1抑制剂曲古抑素A的反应：利用OV-6肝脏表达的免疫组织化学表征

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-01-15 DOI: 10.5115/acb.24.231

Hussein Abdellatif, Ruqaiya Al Jabri, Halima Albalushi, Mohamed Al Mushaiqri

{"title":"Liver oval cells in response to HDAC1 inhibitor trichostatin A: immunohistochemical characterization using OV-6 hepatic expression.","authors":"Hussein Abdellatif, Ruqaiya Al Jabri, Halima Albalushi, Mohamed Al Mushaiqri","doi":"10.5115/acb.24.231","DOIUrl":"10.5115/acb.24.231","url":null,"abstract":"Liver regeneration is intricate, involves many cells, and necessitates extended research. This study aimed to investigate the response of liver oval cells (bipotent liver progenitors) to the epigenetic modifier trichostatin A (TSA), an HDAC1 inhibitor, and to develop a scoring system for assessing the response of these cells. Three groups of equally divided rats (n=24) were selected: control (A, dimethyl sulfoxide treated); oval cell induction (B, acetylaminofluorene [2-AAF] to block hepatocyes/carbon tetrachloride [CCL4] to induce oval cell response); and epigenetic modulation (C, TSA post 2-AAF/CCL4 injury). The oval cell response was quantified using immunoreactivity to the OV-6 antibody, and the ductular response was measured by calculating the bile duct (BD) to portal vein (PV) ratio and the percentage of individual oval cells in liver sections. The expression level of HDAC1 was also analyzed. The administration of TSA significantly enhanced oval cell proliferation and the ductular response (6.13±0.28). The control group exhibited limited immunoreactivity to OV-6, while group B showed significant induction of ductular response with distinct morphology (4.13±0.28). The expression levels of HDAC1 were elevated in both the oval cell induction group and the epigenetic modulation group compared to the control group. This study developed a precise method for quantifying liver oval cells and analyzing their response to TSA. TSA administration enhanced oval cell proliferation, suggesting its significance in regulating hepatic progenitor cell dynamics. The findings support the use of epigenetic modifiers in liver regeneration and propose a scoring system for assessing the response of liver oval cells.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"247-263"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orbital roof cartilage and bone in human fetuses with special reference to changing territories among the ala minor of the sphenoid, frontal bone, and ethmoid. 人类胎儿的眶顶软骨和骨，特别涉及在蝶翼、额骨和筛骨之间的区域变化。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 DOI: 10.5115/acb.25.100

Zimeng Li, Zhe-Wu Jin, Chun-Ai Li, Masahito Yamamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Shogo Hayashi

{"title":"Orbital roof cartilage and bone in human fetuses with special reference to changing territories among the ala minor of the sphenoid, frontal bone, and ethmoid.","authors":"Zimeng Li, Zhe-Wu Jin, Chun-Ai Li, Masahito Yamamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Shogo Hayashi","doi":"10.5115/acb.25.100","DOIUrl":"https://doi.org/10.5115/acb.25.100","url":null,"abstract":"The orbital roof in adults consists mainly of the frontal bone (FB), with the ala minor of the sphenoid at the posterior margin. In fetuses, these bones have been observed to overlap at the junction. The present study examined sagittal, frontal, and horizontal histological sections from 38 human fetuses at a gestational age (GA) of approximately 7-39 weeks. At GA 7-8 weeks, the ala minor extended anterolaterally from the orbitosphenoid, covering the posteromedial quadrant of the roof until GA 9 weeks and reaching to almost the center of the roof at late-term. Simultaneously, the FB appeared in front of the cerebral frontal lobe, reached the anterolateral corner of the roof, and at late-term, it extended posteromedially to cover at least the anterior half of the orbit. In addition, a superolateral plate of the ethmoid, originating from the future cribriform plate, covered the medial marginal part of the roof and had a maximum area at GA 11-16 weeks. At the junction, the FB overlapped and extended below the ala minor or ethmoid. Therefore, at birth, the FB and ala minor seemed to overlap widely at the central one-third of the orbital roof. Because the ala minor was ossified at late-term, postnatal degeneration and absorption were unlikely. The fetal anterior skull base was not flat because of the delayed elevation of the nose and the deeply caved cranial fossa. The overlapping bone and cartilage might slide and migrate, providing materials for reconstruction and later growth of the skull base.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A constellation of anatomical variation: middle scalene, wrist extensor, and aortic arch variants share embryological origins in cervical somites. 一组解剖学变异：中斜角肌、腕伸肌和主动脉弓变异在颈小体中有共同的胚胎起源。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-06-30 Epub Date: 2025-01-22 DOI: 10.5115/acb.23.239

David V Rasicci, William C Weirich, Natalie K Yoshioka, Obadah Tolaymat, Najam Siddiqi

{"title":"A constellation of anatomical variation: middle scalene, wrist extensor, and aortic arch variants share embryological origins in cervical somites.","authors":"David V Rasicci, William C Weirich, Natalie K Yoshioka, Obadah Tolaymat, Najam Siddiqi","doi":"10.5115/acb.23.239","DOIUrl":"10.5115/acb.23.239","url":null,"abstract":"During dissection of a 70-year-old male donor, several anatomical variations were observed, highlighted by a bilateral variant middle scalene muscle in the superolateral thoracic wall. The variant scalene muscle was traced from the transverse processes of cervical vertebrae to the fourth rib with a pronounced fascial slip. The elongated middle scalene muscle was thick in girth and abnormally wide at its insertion (56.0 mm), which is hypothesized to reflect compensatory hypertrophy secondary to lung carcinoma. A bilateral wrist extensor variant also was observed as well as an anomalous left vertebral artery from the aortic arch with an abnormal entrance into the vertebral canal. Collectively, these findings represent a constellation of anatomical variations that may be interrelated through altered cervical somite development, providing a fascinating example of how anatomical variations may cluster based on common embryological origin. Clinically, these observations have implications in thoracic outlet syndrome, tendon transfer, and vascular surgery.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"306-310"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0