{"title":"Anatomical variations of the infrahyoid muscles and ansa cervicalis: a systematic review and an updated classification system for the omohyoid muscle.","authors":"Nymfodora Malkidou, Vasileios Papadopoulos, Aliki Fiska","doi":"10.5115/acb.24.307","DOIUrl":"https://doi.org/10.5115/acb.24.307","url":null,"abstract":"<p><p>The four infrahyoid muscles of the anterior neck are primarily innervated by the ansa cervicalis. This systematic review aims to evaluate the range of the anatomical variations in these muscles and their relationship to innervation patterns. A systematic search was conducted using PubMed and Google Scholar databases. Articles reporting variations in infrahyoid muscles and/or ansa cervicalis were independently evaluated following the PICOTS framework. The anatomical quality assessment tool was used to assess the quality of publications reporting anatomical variants. Seventy-seven studies, encompassing eighty-four cases, were included in the analysis. Of the 56-publication reporting infrahyoid muscle variations, 44 pertained to the omohyoid muscle (main or accessory), 3 to the sternohyoid, 4 to the sternothyroid, and 1 to the thyrohyoid, with no accessory variation observed in the latter. Atypical infrahyoid muscles were identified in 11 cases, 9 of which presented as levator glandulae thyroideae, and 2 as single cases. Variations in the ansa cervicalis were documented in 29 cases, only 1 case involved both ansa cervicalis and infrahyoid muscle variations. The extensive variability of the omohyoid muscle led to the development of a new classification system that integrates 4 types of consistency and 4 types of morphometric variations, providing valuable insights for clinical practice. The specialized use of the infrahyoid muscles in cancer staging, reconstruction after neck cancer surgery, and thyroid surgery underscores the need for a new framework to document their variations, particularly in the omohyoid muscle.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aberrant rib cage anatomy with false ribs attachment to the sternum: review of the literature focused on slipping ribs syndrome case reports.","authors":"Sayed Mehrdad Azimi, Fateme Keshtparvar, Zahra Sadeghi, Hamid Bahramian","doi":"10.5115/acb.24.227","DOIUrl":"https://doi.org/10.5115/acb.24.227","url":null,"abstract":"<p><p>The thoracic cage, formed by ribs and sternum, protects vital organs while enabling respiration. This review examines anatomical variations in rib-sternum attachments and their clinical significance through analysis of literature from 1993-2023. Variations, including bifid ribs (0.15%-3.4% prevalence) and cervical ribs (0.05%-3.0%), can lead to conditions like slipping rib syndrome (SRS). An extensive search of PubMed, Embase, Google Scholar, Web of Science, and specialized collections identified 17 comprehensive SRS case reports. Two independent reviewers evaluated these cases, revealing that rib-sternum morphological variations significantly impact respiratory biomechanics, with unstable costal cartilage identified as a primary cause of pain syndromes. These findings highlight the critical importance of recognizing aberrant rib-sternum anatomy for patient safety, particularly in thoracic procedures. Advanced imaging technologies have enhanced detection capabilities, allowing for improved surgical planning and patient management. This review underscores the value of both cadaveric and radiological examination in identifying these variations, and recommends further research to clarify their prevalence, functional implications, and clinical correlations to optimize treatment approaches and outcomes.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenshao Cai, Minyan Shi, David W Chan, Baohua Luo, Abudureyimujiang Ruze
{"title":"Challenging arterial patterns of renal and testicular arteries in a human cadaver: clinical significance and embryological bases revisited.","authors":"Wenshao Cai, Minyan Shi, David W Chan, Baohua Luo, Abudureyimujiang Ruze","doi":"10.5115/acb.24.336","DOIUrl":"https://doi.org/10.5115/acb.24.336","url":null,"abstract":"<p><p>Typically, a kidney gets its arterial supply from a single renal artery, and the testicular arteries originate from the anterolateral surface of the abdominal aorta. The present case describes a variation in the origin of the testicular artery, which originates from a right accessory renal artery. We observed two renal arteries with the inferior vena cava sandwiched in between. The testicular artery originates from the inferior margin of the accessory renal artery, coursing down alongside the testicular vein into the right testis. During cephalic migration in embryogenesis, the conjunction of the ascending kidney and the descending testis is considered an important factor contributing to variations in the number and location of the vasculature in the kidneys or the gonads. An elaborate description of these variations is clinically significant for surgical interventions, renal transplants, renal and testicular imaging, and pathology.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histomorphogenesis of human pancreatic islets amidst maternal anaemia: a critical insight.","authors":"Sruthy Babu, Pravash Ranjan Mishra, Praveen Kumar Ravi, Sashikanta Swain, Jasmina Begum, Madhumita Patnaik","doi":"10.5115/acb.24.274","DOIUrl":"https://doi.org/10.5115/acb.24.274","url":null,"abstract":"<p><p>Maternal anaemia, the most common nutritional deficiency, adversely affects the growth and development of the fetus as a whole and the fetal pancreas in particular. These changes lead to the young onset of diabetes in the near future. To understand the pathophysiology behind this, present study investigates the histomorphogenesis of human fetal pancreatic islets and the impact of maternal anaemia on islet dimension, area proportion, and cellular composition across various gestational weeks using immunohistochemistry. The research was conducted on 18 human fetal pancreases obtained from spontaneous abortions or stillbirths between 17 to 36 weeks of gestation, categorized into normal (n=10) and anaemic (n=8) maternal groups. Results revealed a larger islet diameter in fetuses from anaemic mothers compared to the non-anaemic group (<i>P</i>=0.039). The beta cell percentage was significantly lower in the anaemic group across all gestational ages (<i>P</i>=0.003), while the alpha cell proportion remained unchanged in the anaemic group but increased significantly in the non-anaemic group after 20 weeks (<i>P</i>=0.006). The non-alpha/beta cell proportion in anaemic group was consistently higher than in the non-anaemic group. In conclusion, maternal anaemia results in the reprogramming of fetal pancreatic islets, characterized by a reduction in beta cell proportion, an increase in non-alpha/beta cells, and a disruption in the alpha-to-beta cell ratio. These changes may impair fetal pancreatic function and predispose the offspring to glucose intolerance and diabetes in later life. Ensuring adequate maternal nutrition through iron and folic acid supplementation during pregnancy is essential to prevent these developmental disruptions.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amira E Farage, Mona A Abdel-Kareem, Medhat Taha, Sara Abubakr, Nora Elshehawy Helal, Mahmoud Hendawy, Hanan A Elgendy, Ahmed Abdel-Monem Elmetwally, Hala Mahfouz, Tourki A S Baokbah, Mohammed R Rabei, Mohammad Akbar Hossain, Azza I Helal, Mohie Mahmoud Ibrahim
{"title":"Protective effect of <i>Chlorella vulgaris</i> against experimental hepatic ischemia reperfusion injury downregulating oxidative stress, inflammation, and apoptosis.","authors":"Amira E Farage, Mona A Abdel-Kareem, Medhat Taha, Sara Abubakr, Nora Elshehawy Helal, Mahmoud Hendawy, Hanan A Elgendy, Ahmed Abdel-Monem Elmetwally, Hala Mahfouz, Tourki A S Baokbah, Mohammed R Rabei, Mohammad Akbar Hossain, Azza I Helal, Mohie Mahmoud Ibrahim","doi":"10.5115/acb.24.318","DOIUrl":"https://doi.org/10.5115/acb.24.318","url":null,"abstract":"<p><p>Hepatic ischemia/reperfusion (Hep I/R) is a great health burden during hepatic transplantation surgery. The present work aimed to examine the mitigative effect of <i>Chlorella vulgaris</i> against Hep I/R and its underlying protective mechanisms. The animals in the present research were classified into four equal experimental groups (n=6): the sham group, sham+<i>Chlorella vulgaris</i> group, Hep I/R group, and Hep I/R+<i>Chlorella vulgaris</i> group. Hepatic ischemia results in liver impairment, as evidenced by elevated liver enzyme levels and altered liver histology. It also reduced antioxidant enzyme levels and increased lipid peroxidation. Additionally, the Hep I/R group displayed significant suppression of the nuclear factor erythroid 2-related factor 2 (Nrf2)/haem oxygenase-1 pathway. There was a marked elevation in the expression of inflammatory markers, including nuclear factor kappa beta (NF-κB), tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and myloperoxidase, and NOD-like receptor protein 3 (NLRP3) and caspase-1. Furthermore, the levels of apoptotic markers such as caspase-3 and Bax were greater than those in the sham groups. Pretreatment with <i>Chlorella vulgaris</i> significantly protected against Hep I/R by reversing these effects. Rats pretreated with <i>Chlorella vulgaris</i> exhibited a hepatoprotective effect against Hep I/R through its inhibition of the NF-κB and NLRP3 cascades and Nrf2 stimulation.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Absent right superior vena cava and persistent left superior vena cava opening into the left auricle with transposition of the azygos system of veins.","authors":"Nanditha Pavikuttan, Kshema Jose, Minnie Pillay","doi":"10.5115/acb.24.255","DOIUrl":"https://doi.org/10.5115/acb.24.255","url":null,"abstract":"<p><p>Left superior vena cava (LSVC) opening into the left atrium without an atrial septal defect or right superior vena cava is extremely rare. During routine dissection for undergraduate medical teaching we came across a similar variation coexisting with variation of the azygos system of veins. Azygos vein (AV) was noted on the left and drained into LSVC before the latter opened into the left auricle. Accessory and hemiazygos veins were present on the right, but crossed over to the left across the vertebral column to drain into AV at the level of T5 and T8, respectively. LSVC may remain silent clinically and usually discovered incidentally. Its presence may complicate central venous access, implantation of pacemaker etc. Variation in azygos system of veins can become problematic during surgical procedures by causing unexpected haemorrhage. The present case highlights the importance of recognising this infrequent systemic venous anomaly by clinicians.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Age-dependent brain subcortical white and gray matter disruptions in patients with posttraumatic stress disorder.","authors":"Kambiz Kangarlou, Samira Raminfard, Jayran Zebardast, Elham Faghihzadeh, Bahman Jalali Kondori","doi":"10.5115/acb.24.200","DOIUrl":"https://doi.org/10.5115/acb.24.200","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) is a psychiatric condition that can develop after experiencing a traumatic event, and it is associated with a range of functional and structural brain abnormalities. This study aimed to investigate agerelated differences in subcortical gray and white matter in veterans with PTSD. This study recruited 44 patients with PTSD and 48 healthy controls. Participants were divided into two age groups to evaluate structural magnetic resonance imaging analysis. The results showed that individuals with PTSD had significantly smaller subcortical gray matter volumes, including the bilateral thalamus, hippocampus, amygdala, left pallidum, and right accumbens-area (<i>P</i><0.05). Diffusion tensor imaging (DTI) analyses revealed lower fractional anisotropy in several white matter structures, including the anterior limb of the internal capsule, anterior corona radiata, and cingulum in both hemispheres (<i>P</i><0.05). Additionally, the mean diffusivity was higher in the anterior limb of the internal capsule, anterior corona radiata and the right external capsule (<i>P</i><0.05). A comparative analysis between two age groups, over 50 and under 50 years old, showed that younger PTSD patients had a reduction in volume and abnormality in the corresponding white matter in more regions compared to the control group. These findings suggest that PTSD is associated with significant structural alterations in the brain, which may contribute to the pathophysiology of the disorder. So, patient age is an effective factor in exposure to traumatic events and an older age is continuously associated with a worsening traumatic brain injury outcome.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shimaa A Fareed, Amira El Sayed Farag, Eman M Kamel Elshireef
{"title":"Evaluation of gibberellic acid toxicity on pre and postnatal ovarian development and potential protective effect of selenium in albino rats: histological, immunohistochemical, and biochemical study.","authors":"Shimaa A Fareed, Amira El Sayed Farag, Eman M Kamel Elshireef","doi":"10.5115/acb.24.305","DOIUrl":"https://doi.org/10.5115/acb.24.305","url":null,"abstract":"<p><p>Gibberellic acid (GA3) is a biocide with insecticidal properties. Selenium (Se) has an enzymatic structure that mediates its antioxidant activities. This study aimed to assess the GA3 toxicity on pre and postnatal ovarian development and to investigate the protective effect of Se against GA3 toxicity in albino rats. Two experiments were conducted in this study (n=24 rats for each): the first was performed on pregnant female rats and the second on prepubertal females (4 weeks old). Rats were divided into Group I (controls: Ia, negative and Ib, positive rats received sodium selenite 0.3 mg/kg/body weight); Group II (GA3-treated, the rats received 55 mg/kg, 1/100 of lethal dose 50); and Group III (the rats were cotreated with GA3 plus Se). Treatments in the first experiment began at gestational day 7 until postnatal day 4, while in the second experiment, treatments lasted two weeks. All hormonal levels were decreased in pre and postnatal GA3 rats' exposure. Histological examination of GA3-treated prenatal rats showed disturbance in ovarian development as shown by ovigerous cords with germ cell breakdown. Meanwhile, multiple histopathological and developmental changes occur in all stages of the ovarian follicles in postnatal rats. In both developmental ages, there was collagen deposition with decreased proliferative marker and androgen receptor expressions, which was confirmed by a decrease in the morphometric measures of the ovarian follicles. All biochemical, immunostaining, and histological results were improved after Se co-administration due to its antioxidant activity against GA3 toxicity.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sareh Pandamooz, Mohammad Ghasemian, Zahra Jamali, Maryam Hassanpour, Mohammad Javad Mokhtari, Shahrokh Zare, Mehdi Dianatpour, Mohammad Reza Jafarzadeh Shirazi, Mohammad Saied Salehi
{"title":"Preconditioning enhances neurotrophic factor expression in rat bone marrow mesenchymal stem cells for neuroregenerative applications.","authors":"Sareh Pandamooz, Mohammad Ghasemian, Zahra Jamali, Maryam Hassanpour, Mohammad Javad Mokhtari, Shahrokh Zare, Mehdi Dianatpour, Mohammad Reza Jafarzadeh Shirazi, Mohammad Saied Salehi","doi":"10.5115/acb.24.289","DOIUrl":"https://doi.org/10.5115/acb.24.289","url":null,"abstract":"<p><p>Stroke is a leading cause of mortality and disability in adults worldwide. Among the various treatment strategies, cell-based therapies have gained considerable attention due to their regenerative potential. Enhancing the efficacy of stem cells is critical to improve therapeutic outcomes. Dimethyl fumarate (DMF) is one of the drugs that has been recognized for its ability to modulate the paracrine effects of stem cells. This study aimed to investigate the effect of different concentrations of DMF on rat bone marrow mesenchymal stem cells (BM-MSCs). The BM-MSCs viability following treatment with various doses of DMF was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and fluorescein diacetate staining at 24 and 72 hours. After identifying the optimal DMF concentration, BM-MSCs were cultured with selected DMF concentration for 72 hours, and their gene expression profiles of key neurotrophic factors were analyzed using quantitative real-time polymerase chain reaction. Our findings revealed that 1 µM DMF was the optimal concentration for enhancing BM-MSC viability. Treatment with this dose significantly upregulated the expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3, highlighting their potential in promoting neuronal support and regeneration. In contrast, the transcript level of glial-derived neurotrophic factor was significantly reduced, suggesting a selective regulatory effect of DMF on neurotrophic pathways. These findings shed light on the therapeutic promise of DMF in modulating neurotrophic factor expression in BM-MSCs, offering novel insights into its application in regenerative medicine for neurodegenerative conditions.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michal Benes, Vladislav Bartak, Jiri Uhlik, Tomas Novotny, Aneta Rybakova, David Kachlik, Vojtech Kunc
{"title":"Surgical anatomy of the anterior musculocapsular complex of the hip: a macroscopic and microscopic anatomical reappraisal.","authors":"Michal Benes, Vladislav Bartak, Jiri Uhlik, Tomas Novotny, Aneta Rybakova, David Kachlik, Vojtech Kunc","doi":"10.5115/acb.24.329","DOIUrl":"https://doi.org/10.5115/acb.24.329","url":null,"abstract":"<p><p>This study aimed to delineate the macroscopic and microscopic topography of muscles surrounding the anterior aspect of the hip joint and the underlaying joint capsule. Seven fresh-frozen cadavers were bilaterally dissected as per study protocol. Eleven hip joints were evaluated macroscopically, while three hip joints underwent histological analysis. Additionally, twenty hip bones and femurs were examined for the osseous morphology near the anterior portion of the articulating surfaces. Macroscopically, the rectus femoris muscle contributed to the articular capsule exclusively through its reflected head. The iliocapsularis and iliopsoas muscles were in direct contact with the articular capsule. Although the iliocapsularis muscle was adherent to the capsule throughout its whole course, the iliopsoas muscle was connected to the capsule through the iliopectineal bursa. Microscopically, different spatial thickness of the capsule was observed, with the thicker regions corresponding to the capsular ligaments. Osseous landmarks, relevant to the course of the iliopsoas muscle, included the iliopsoas notch and a groove for the psoas major muscle. Furthermore, split of the anterior inferior iliac spine and the \"subspine\" were constant findings corresponding to the origin of the direct head of the rectus femoris and the iliocapsularis muscles, and attachment of the medial band of the iliofemoral ligament, respectively. On the head of the femur, the Poirier's facet (35.0%), the Allen's fossa (60.0%), and the so-called plaque (50.0%) were observed. Conclusively, we introduce the concept of a four-layered anterior musculocapsular complex of the hip, aiming to aid the orthopaedic surgeon in both hip replacement and preservation procedures.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}