Anatomy & Cell Biology最新文献

Peripheral neuroprotective potential and toxicological profile of fascaplysin in zebrafish models.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-21 DOI: 10.5115/acb.24.290

Ki-Hoon Park, Youngbuhm Huh, Hyung-Joo Chung, Hiroyuki Konishi, Junyang Jung, Na Young Jeong

{"title":"Peripheral neuroprotective potential and toxicological profile of fascaplysin in zebrafish models.","authors":"Ki-Hoon Park, Youngbuhm Huh, Hyung-Joo Chung, Hiroyuki Konishi, Junyang Jung, Na Young Jeong","doi":"10.5115/acb.24.290","DOIUrl":"https://doi.org/10.5115/acb.24.290","url":null,"abstract":"Fascaplysin is a bioactive compound derived from marine sponges, which have anticancer properties and potential neuroprotective effects mediated by mitigation of oxidative stress-induced neurotoxicity. This study investigated the concentration-dependent effects of fascaplysin in zebrafish models, focusing on embryonic survival, cardiac function, melanocyte formation, and peripheral nerve health. Zebrafish embryos were exposed to fascaplysin at concentrations ranging from 10 nM to 100 μM, and developmental parameters were assessed. At higher concentrations (≥1 μM), fascaplysin significantly decreased embryo survival rates, delayed hatching, impaired cardiac function, and caused morphological abnormalities, including disruption of melanocyte formation and structural deformities. By contrast, lower concentrations (10 nM and 100 nM) did not exhibit significant toxicity. In adult zebrafish, fascaplysin at 100 nM reduced the expression of superoxide-producing enzymes and preserved peripheral nerve integrity following injury, as demonstrated by maintenance of fluorescence in transgenic zebrafish with expression of green fluorescent protein in Schwann cells. These findings suggest that fascaplysin exhibits peripheral neuroprotective effects at low concentrations, potentially through the reduction of oxidative stress and preservation of Schwann cell function. However, the toxicity observed at higher concentrations highlights the importance of dose optimization. Fascaplysin is a promising candidate for the development of new therapeutic strategies for peripheral neuropathies, and further studies are required to elucidate the underlying mechanisms and validate its efficacy in mammalian models.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological analysis of occipital condyle and superior articular facet of first cervical vertebra and its congruence in a Thai population.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-18 DOI: 10.5115/acb.24.269

Suchada Treranan, Tawachai Monum, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh

{"title":"Morphological analysis of occipital condyle and superior articular facet of first cervical vertebra and its congruence in a Thai population.","authors":"Suchada Treranan, Tawachai Monum, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh","doi":"10.5115/acb.24.269","DOIUrl":"https://doi.org/10.5115/acb.24.269","url":null,"abstract":"The atlantooccipital joint, which involves the articulation between the occipital condyles (OC) at the base of the skull and the superior articular facet of the first cervical vertebra (C1), is considered a moderately reliable joint for congruence analysis. Evaluating the congruence of OC and C1 in terms of shape and measurement is critical for re-associating disarticulated cranial and postcranial elements in cases of commingled human remains. This study examined the morphological characteristics and congruence between OC and C1 in a Thai population. A total of 201 OC and C1 samples, including male and female specimens, were analyzed to classify their shapes and measurements. The most common OC shape was oval, while the C1 superior articular facet was predominantly eight-shaped. Males exhibited significantly larger OC and C1 measurements across all variables compared to females. Discriminant analysis showed an accuracy rate of 58.2%-70.1% for sex classification. Pearson's correlation coefficients for OC and C1 measurements ranged from 0.490 to 0.818, with the highest correlation observed for the maximum breadth of OC and C1. Sex-specific analysis revealed that males had the highest correlation for maximum breadth, while females showed the highest correlation for minimum breadth. The regression equation for predicting the paired size of OC and C1 had an accuracy rate of 39%-54.46%. These findings contribute to understanding craniovertebral morphology and have implications for forensic identification and surgical planning at the craniovertebral junction.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azygos lobe: exploring the bronchial supply and clinical implications.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-12 DOI: 10.5115/acb.24.240

Awal M Jimah, Ashley Taylor Goldstein, Melissa McCann, Claire Stoudemire

引用次数: 0

Variant of the coracohumeralis muscle.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-12 DOI: 10.5115/acb.24.184

Celia V Mayne, Rarinthorn Samrid, Yoko Tabira, Kazzara Raeburn, Kathleen Bubb, Joe Iwanaga, Samir Anadkat, R Shane Tubbs

引用次数: 0

The effect of rosuvastatin coated by nano-chitosan on developing hippocampus: association with hippocampal neurogenesis and memory in an Alzheimer's induced model of rats.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-07 DOI: 10.5115/acb.24.250

Armita Modiri, Zohreh Abdolmaleki, Mohammad Reza Paryani

{"title":"The effect of rosuvastatin coated by nano-chitosan on developing hippocampus: association with hippocampal neurogenesis and memory in an Alzheimer's induced model of rats.","authors":"Armita Modiri, Zohreh Abdolmaleki, Mohammad Reza Paryani","doi":"10.5115/acb.24.250","DOIUrl":"https://doi.org/10.5115/acb.24.250","url":null,"abstract":"Statins are long known to be beneficial for neurodegenerative conditions, including Alzheimer's disease (AD). Also, nanoparticle (NP) drugs can better affect the target tissue in various diseases. Therefore, the aim of this study was surveying the effect of rosuvastatin (RZV) coated by nano-chitosan in an Alzheimer's (Alz) induced model of rats. We examined learning, memory, and hippocampal amyloid plaques and evaluate expression levels of calbindin, doublecortin (DCX), NeuroD1, neuronal nuclei (NeuN), and neurofilament. Forty rats were randomly divided into five various groups. AD was induced by injecting bilaterally with 1 μl of amyloid beta (Aβ) into the hippocampus. After confirmation of AD, RZV, or NP, or RZV+NP were administered gavage orally daily in rats for 30 days. Induction of AD significantly raised Aβ plaques and dead cells compared to the control group. Results of Morris water maze in the test day indicated that Alz+NP+RZV group significantly reduced escape latency and travelled distance, also significantly increased spending time compared to the Alz group (P<0.05). RZV significantly decreased Aβ plaque percentage and the number of apoptotic cells compared to the Alz group (P<0.05). In addition, NeuN and neurofilament protein expression and calbindin, DCX, and NeuroD1 genes expression increased in Alz+RZV and Alz+RZV+NP compared to the Alz group. RZV coated by nano-chitosan has good potential for reducing Aβ plaques and dead cells, increasing brain NeuN and neurofilament proteins and calbindin, DCX, and NeuroD1 genes, and improving learning and memory in Alz rats.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hip joint and age relationship in Thai population by image processing technique.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-07 DOI: 10.5115/acb.24.235

Supachard Krudtong, Nipon Theera-Umpon, Parkpoom Jarupoom, Sukon Prasitwattanaseree, Apichat Sinthubua, Pasuk Mahakkanukrauh

{"title":"Hip joint and age relationship in Thai population by image processing technique.","authors":"Supachard Krudtong, Nipon Theera-Umpon, Parkpoom Jarupoom, Sukon Prasitwattanaseree, Apichat Sinthubua, Pasuk Mahakkanukrauh","doi":"10.5115/acb.24.235","DOIUrl":"https://doi.org/10.5115/acb.24.235","url":null,"abstract":"Bone age is a critical factor in personal identification, with the hip joint-encompassing the acetabulum and femoral head-commonly used in age estimation. Age assessments rely on factors such as bone porosity and morphological characteristics. These are currently conducted by experts and their conclusions can vary. The logistical challenge of transporting physical bones complicates the process. The increasing use of image processing techniques in the medical field provides a more efficient and convenient alternative. This study used image processing methods to analyze area ratios and percent porosity of the acetabulum and femoral head, with a statistical evaluation of the relationship between these parameters and age at a 90% confidence level (α=0.10). The dataset comprised images from 167 skeletons including 59 females aged 30 to 88 and 108 males aged 28 to 97. The analysis revealed a significant relationship between percent porosity and age in males, both in the acetabulum and femoral head, with P-values below 0.10 but this relationship was not observed in females. A significant relationship between area ratio and age was found in the femoral head region for both genders but not in the acetabulum. The accuracy and comparability of the results were enhanced by applying a standardized image processing protocol.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing anatomy education using anatomical sign language: expanding its expressive capabilities to the upper and lower extremities, face, and brain structures. 利用解剖学手语加强解剖学教育：将其表达能力扩展到上下肢、面部和大脑结构。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-05 DOI: 10.5115/acb.24.275

Mi-Sun Hur, Dong-Su Jang, Chang-Seok Oh

引用次数: 0

Effect of gestational diabetes mellitus and its management on the histological and histomorphometric structure of umbilical cord: a comparative study.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-02-05 DOI: 10.5115/acb.24.179

Seema Valsalan Ennazhiyil, Akshara Venmalassery Rajeev, Mahesh Kumar Damodaran, Tintu Thottiyil Sukumaran, Chitra Srinivasan, Ramakrishnan Panicker Kunnathu

{"title":"Effect of gestational diabetes mellitus and its management on the histological and histomorphometric structure of umbilical cord: a comparative study.","authors":"Seema Valsalan Ennazhiyil, Akshara Venmalassery Rajeev, Mahesh Kumar Damodaran, Tintu Thottiyil Sukumaran, Chitra Srinivasan, Ramakrishnan Panicker Kunnathu","doi":"10.5115/acb.24.179","DOIUrl":"https://doi.org/10.5115/acb.24.179","url":null,"abstract":"The umbilical cord lacks vasavasorum and is prone for hypoxic injuries. Gestational diabetes mellitus (GDM) causes structural changes with in umbilical cord blood vessels. Knowledge of which would be helpful for the gynecologist and obstetricians to assess the prognosis and prevent the complications. The present study was concentrated from December 2016 to December 2019 on 50 normal and 56 GDM umbilical cords. GDM group included 23 GDM mothers managed by diet (GDM-Diet) and 33 GDM mothers managed by drugs (GDM-Drug). Placentas along with the attached umbilical cords were collected and stored in 10% formaline. Tissue processing, slide preparation and stainings were done using standard protocols. A significant reduction was observed in the number of Hoboken nodules of umbilical arteries of GDM-Diet. Reduction of myofibroblasts with an increase in the empty spaces was observed in the Wharton's jelly of both GDM cases. Similarly, smooth muscle disintegration and migration of smooth muscles to intima was significantly higher in GDM umbilical arteries and veins than normal umbilical vessels. The total wall thickness and tunica media was significantly thicker in the umbilical arteries of GDM-Drug group only. The umbilical venous lumen was found significantly wider in GDM groups compared to normal. The elastin fibers were significantly found reduced in the tunics of umbilical arteries and veins in GDM. However, a significant difference in these parameters was not observed between the GDM-Diet and GDM-Drug groups except for total wall and tunica media thickness of umbilical arteries.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Y-shaped sphenoidal sinus septum: a case report.

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-01-23 DOI: 10.5115/acb.24.284

Rarinthorn Samrid, Joanna Jaworek-Troć, Tomasz Gładysz, Jerzy A Walocha, Joe Iwanaga, R Shane Tubbs

引用次数: 0

A constellation of anatomical variation: middle scalene, wrist extensor, and aortic arch variants share embryological origins in cervical somites. 一组解剖学变异：中斜角肌、腕伸肌和主动脉弓变异在颈小体中有共同的胚胎起源。

IF 1.4

Anatomy & Cell Biology Pub Date : 2025-01-22 DOI: 10.5115/acb.23.239

David V Rasicci, William C Weirich, Natalie K Yoshioka, Obadah Tolaymat, Najam Siddiqi

{"title":"A constellation of anatomical variation: middle scalene, wrist extensor, and aortic arch variants share embryological origins in cervical somites.","authors":"David V Rasicci, William C Weirich, Natalie K Yoshioka, Obadah Tolaymat, Najam Siddiqi","doi":"10.5115/acb.23.239","DOIUrl":"https://doi.org/10.5115/acb.23.239","url":null,"abstract":"During dissection of a 70-year-old male donor, several anatomical variations were observed, highlighted by a bilateral variant middle scalene muscle in the superolateral thoracic wall. The variant scalene muscle was traced from the transverse processes of cervical vertebrae to the fourth rib with a pronounced fascial slip. The elongated middle scalene muscle was thick in girth and abnormally wide at its insertion (56.0 mm), which is hypothesized to reflect compensatory hypertrophy secondary to lung carcinoma. A bilateral wrist extensor variant also was observed as well as an anomalous left vertebral artery from the aortic arch with an abnormal entrance into the vertebral canal. Collectively, these findings represent a constellation of anatomical variations that may be interrelated through altered cervical somite development, providing a fascinating example of how anatomical variations may cluster based on common embryological origin. Clinically, these observations have implications in thoracic outlet syndrome, tendon transfer, and vascular surgery.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0