Anatomy & Cell Biology最新文献

Cost-effectiveness and other considerations for different research techniques applied in ancient DNA analysis. 古 DNA 分析中应用的不同研究技术的成本效益及其他考虑因素。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-11-06 DOI: 10.5115/acb.24.125

Jong Ha Hong, Hisashi Fujita, Jaehyup Kim, Dong Hoon Shin

引用次数: 0

Histological features of the Purkinje neurons of the Albino rat (Rattus norvegicus) following letrozole administration. 来曲唑给药后白化大鼠（Rattus norvegicus）浦肯野神经元的组织学特征。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-31 DOI: 10.5115/acb.24.088

Chaudhry Talha Hannan, Munguti Kilonzo Jeremiah, Pamela Mandela Idenya

{"title":"Histological features of the Purkinje neurons of the Albino rat (Rattus norvegicus) following letrozole administration.","authors":"Chaudhry Talha Hannan, Munguti Kilonzo Jeremiah, Pamela Mandela Idenya","doi":"10.5115/acb.24.088","DOIUrl":"https://doi.org/10.5115/acb.24.088","url":null,"abstract":"Aromatase inhibitors are increasingly being used as adjuvant therapy for hormone-responsive cancers. These drugs may reduce the endogenous estrogen production in the cerebellum. Prolonged use has been associated with symptoms such as ataxia, poorer balance performance and diminished verbal memory, suggesting impaired cerebellar function. Thus, this study sought to outline the structural basis for the cerebellar deficits observed. Twenty-seven male rats (3 baseline, 15 experimental, 9 control) aged three months were recruited with the intervention group receiving 0.5 mg/kg of letrozole daily for 50 days by oral gavage while the control group received normal saline. Their cerebella were harvested for histological processing on days 20, 35, and 50. Photomicrographs were taken and analysed using Fiji ImageJ software. The dendritic spine densities and Purkinje linear densities were coded and analyzed using IBM SPSS Statistics version 25.0. A P-value of ≤0.05 was considered significant. A temporal decline in the Purkinje linear density as well as pyknosis and cytoplasmic eosinophilia was noted in the intervention group (P=0.1). Further, the dendritic spine density of the Purkinje neurons in the intervention group was markedly reduced (P=0.01). The reduction in the linear cell density and the dendritic spine density of the Purkinje cells following letrozole administration may provide an anatomical basis for the functional cerebellar deficits seen in chronic aromatase inhibitor use.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical and morphometric features of the profunda brachii artery. 肱深动脉的解剖和形态特征。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-24 DOI: 10.5115/acb.23.243

Yüsra Nur Şanlıtürk, Nurşen Zeybek, Özcan Gayretli, Adnan Öztürk

引用次数: 0

A new metric method for sex estimation using three-dimensional imaging of the nuchal crest. 利用颈嵴三维成像进行性别估计的新度量方法。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-17 DOI: 10.5115/acb.24.114

Yun Taek Shim, Ye Hwon Jeong, Nahyun Aum, Hong-Il Ha, Minsung Choi, Jin Young Hyun, Ho-Seung Lee, Yi-Suk Kim

{"title":"A new metric method for sex estimation using three-dimensional imaging of the nuchal crest.","authors":"Yun Taek Shim, Ye Hwon Jeong, Nahyun Aum, Hong-Il Ha, Minsung Choi, Jin Young Hyun, Ho-Seung Lee, Yi-Suk Kim","doi":"10.5115/acb.24.114","DOIUrl":"https://doi.org/10.5115/acb.24.114","url":null,"abstract":"In Walker's nonmetric method, the nuchal crest serves as the representative region for indicating sexual dimorphism in cranial bones. However, the accuracy of sex estimation using the nuchal crest is lower than that using other anatomical regions. Furthermore, because of the protruding processes and structurally challenging features characterized by uneven and rough surfaces, there is a lack of metric methods for sex estimation, making quantification challenging. In this study, we aimed to validate a derived metric method for sex estimation by reconstructing the nuchal crest region in three-dimensional (3D) images obtained from computed tomography scans of cranial bones and compare its accuracy with that of the nonmetric method. A total of 648 images were collected, with 100 randomly selected for use in the nonmetric method. We applied our metric method to the remaining 548 images. Our findings showed that the surface area of the nuchal crests was greater in male individuals than in female individuals. The nuchal crest surface area quantified by the metric method increased the accuracy of sex estimation by 48% compared with that by the nonmetric method. Our metric method for sex estimation, which quantifies the nuchal crest surface area using 3D images of the skull, led to a high sex estimation accuracy of 93%. Future studies should focus on proposing and quantifying new measurement methods for areas showing sexual characteristics in the skull that are difficult to measure, thereby enhancing the accuracy and reliability of sex estimation in human skeletal identification across various fields.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiles, tissue and microbial integrity of cadavers used in medical faculties in South-western Uganda: implication in anatomical education. 乌干达西南部医学院使用的尸体的外形、组织和微生物完整性：对解剖学教育的影响。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-11 DOI: 10.5115/acb.24.159

Elisa Ndyamuhakyi, Ibe Michael Usman, Jackim Nabona, Victor Adolf Fischer, Emeka Anyanwu, Elna Owembabazi, Wusa Makena, Ekom Monday Etukudo

{"title":"Profiles, tissue and microbial integrity of cadavers used in medical faculties in South-western Uganda: implication in anatomical education.","authors":"Elisa Ndyamuhakyi, Ibe Michael Usman, Jackim Nabona, Victor Adolf Fischer, Emeka Anyanwu, Elna Owembabazi, Wusa Makena, Ekom Monday Etukudo","doi":"10.5115/acb.24.159","DOIUrl":"https://doi.org/10.5115/acb.24.159","url":null,"abstract":"Cadaveric dissection has remained an integral part of anatomical education globally; hence, the profiles of cadavers, their gross tissue and microbial integrity has great implication in anatomical education. This study determined the profiles, gross tissue and microbial integrity of cadavers used in South-western Uganda (SWU) medical schools. A cross-sectional study was carried out for three months in anatomy and microbiology laboratories of SWU medical teaching institutions. Ethical approval was obtained, cadavers were proportionately selected and examined grossly, and surface swabs taken for microbial analysis. Data collected was entered into Microsoft Excel, cleaned, and exported to Stata version 17 for analysis. Majority of cadavers were male (68%), adult (96%), blacks (100%), unknown cause of death (96%), obtained as unclaimed bodies (100%) and with no cadaver record tag (96%). Nearly a half (48%) cadavers had disrupted dentition, 68% had poor muscle integrity and 80% with abnormal fat. About 27% cadavers had poor surface microbial integrity among which 62.5% had a mixture of both bacteria and fungi, 25.0% had only fungi while 12.5% had only bacteria. A high number of cadavers had micro-organisms on their surfaces with majority having a mixture of bacteria and fungi. Majority of cadavers had poor gross tissue integrity. Better cadaver preservation methods should be adopted. To advocate for the establishment of cadaver donation policy and programs through which good quality cadavers can be obtained.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonographic study and anatomical guidelines for botulinum neurotoxin injection into the parotid gland. 腮腺注射肉毒杆菌神经毒素的超声研究和解剖学指南。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-10 DOI: 10.5115/acb.23.255

Kyu-Ho Yi, Soo-Bin Kim, Hyewon Hu, Hee-Jin Kim

{"title":"Ultrasonographic study and anatomical guidelines for botulinum neurotoxin injection into the parotid gland.","authors":"Kyu-Ho Yi, Soo-Bin Kim, Hyewon Hu, Hee-Jin Kim","doi":"10.5115/acb.23.255","DOIUrl":"https://doi.org/10.5115/acb.23.255","url":null,"abstract":"Benign enlargement of the parotid gland hypertrophy results in a bulky lateral facial contour and esthetic appearance. This study aimed to determine the depth from the skin surface to the parotid fascia, which encompasses the parotid gland. The anatomical properties of the parotid glands were evaluated in 40 patients using ultrasonography. An up-to-date understanding of the localization of botulinum neurotoxin (BoNT) injection based on anatomy could lead to better localization of the injection into the parotid gland through morphological measurements using data previously published from cadaveric studies. Measurement using the otobasion inferius as a landmark revealed parotideomasseteric fascia thickness averaging 4-6 mm from the skin surface, with the parotid gland extending approximately 15 mm anteriorly. Analysis showed a 3-7 mm thickness range, indicating an optimal injection depth for safety and efficacy in BoNT procedures. Utilizing the otobasion inferius as an anatomical landmark offers a practical approach for measuring parotideomasseteric fascia thickness, addressing cadaveric study limitations. These guidelines aim to maximize the effects of BoNT therapy, which can be useful in clinical settings, by minimizing its deleterious effects.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetrapleura tetraptera fruit phenolics fraction protects against the impact of ischemic stroke-induced hippocampal distortions and memory deficits in Wistar rats. 四叶草果实酚类成分可防止缺血性中风引起的 Wistar 大鼠海马变形和记忆缺陷。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-04 DOI: 10.5115/acb.24.013

Onyinoyi Bethel Onimisi, Sunday Abraham Musa, Uduak Emmanuel Umana, Sonhap James Sambo, Wusa Makena

{"title":"Tetrapleura tetraptera fruit phenolics fraction protects against the impact of ischemic stroke-induced hippocampal distortions and memory deficits in Wistar rats.","authors":"Onyinoyi Bethel Onimisi, Sunday Abraham Musa, Uduak Emmanuel Umana, Sonhap James Sambo, Wusa Makena","doi":"10.5115/acb.24.013","DOIUrl":"https://doi.org/10.5115/acb.24.013","url":null,"abstract":"Stroke is the most significant cause of disability worldwide. Despite mounting data supporting memory deficit after stroke, dysfunction and treatment effect mechanisms remain unknown. Phenolics can be found in a variety of fruits and vegetables. There is, however, a scarcity of research on the therapeutic potential of the phenolics fraction of Tetrapleura tetraptera (PTT) fruit against ischemic stroke-induced abnormalities in hippocampal tissue. The rats were divided into five groups: Group I, vehicle; group II, ischemia/reperfusion (I/R)+vehicle; group III, I/R+50 mg/kg minocycline (MNC); group IV, I/R+100 mg/kg PTT; and group V, I/R+200 mg/kg PTT. Ischemia was induced via bilateral common carotid artery occlusion for 30 minutes followed by reperfusion. PTT and MNC were intraorally administered daily for 7 days. Neurodegenerative changes, cornu ammonis 1 (CA1) and cornu ammonis 3 (CA3) pyramidal cell count, levels of oxidative stress indicators, and memory functions were assessed. Rats treated with PTT, as well as MNC compared to untreated I/R rats, showed a substantial (P<0.05) rise in catalase, superoxide dismutase, glutathione levels, as well as decreased lipid peroxidation and improved memory. I/R resulted in histoarchitectural distortions, a marked decrease (P<0.05) in the intensity of the Nissl substance, and a striking decrease (P<0.05) in the number of pyramidal cells in the CA1 and CA3. PTT and MNC-treated groups showed significant attenuation in all the above parameters. Taking together, these findings revealed that PTT attenuated oxidative stress, histologic alterations and substantially restored memory impairment in the I/R rat model.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual nerve communication in gluteal region: embryological basis and clinical perspective. 臀部异常的神经沟通：胚胎学基础和临床视角。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-04 DOI: 10.5115/acb.24.076

Vidhu Dhawan, Sarah Sko Sangma, Suryakanta Seth, Vishwajit Deshmukh, Monica Baxla, Seema Singh

引用次数: 0

A variant deep femoral artery passing anterior to femoral vein: an anatomical observation with implication in femoral vein cannulation. 股深动脉在股静脉前方穿过的变异股深动脉：对股静脉插管的解剖学观察。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-10-02 DOI: 10.5115/acb.24.083

Mohammadali M Shoja, Maria-Teresa De Leon, Jay Sheth, Sana Padival, Tara Tritsch, Gary B Schwartz

引用次数: 0

Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity. 食用菌提取物与格列本脲对阿脲诱导糖尿病的影响：Nrf2表达和肾毒性的亚急性体内研究。

IF 1.4

Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-07-05 DOI: 10.5115/acb.24.054

Chinedu Godwin Uzomba, Uchenna Kenneth Ezemagu, Mary-Sonia Ofoegbu, Njoku Lydia, Essien Goodness, Chinedum Emelike, Uchewa Obinna, Alo Joseph Nwafor, Ejikeme Felix Mbajiorgu

{"title":"Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity.","authors":"Chinedu Godwin Uzomba, Uchenna Kenneth Ezemagu, Mary-Sonia Ofoegbu, Njoku Lydia, Essien Goodness, Chinedum Emelike, Uchewa Obinna, Alo Joseph Nwafor, Ejikeme Felix Mbajiorgu","doi":"10.5115/acb.24.054","DOIUrl":"10.5115/acb.24.054","url":null,"abstract":"The study aims to compare the action of Pleurotus cornucopiae and glibenclamide on alloxan-induced diabetes and ascertain how an aqueous extract of the edible mushroom regulates the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), oxidative stress biomarkers and renal toxicity in a diabetic male Wistar rat model. Twenty-five adult male Wistar rats were randomly grouped into five groups with five rats per. Group 1 and those in the treatment groups received normal feed and water ad libitum. Group 2 received intraperitoneal administration of alloxan monohydrate (150 mg/kg body weight). Group 3 received alloxan monohydrate and glibenclamide (5 mg/kg body weight bwt), group 4 received alloxan monohydrate plus the extract (250 mg/kg bwt) and group 5 received alloxan monohydrate plus the extract (500 mg/kg bwt). The administration of glibenclamide plus the extract was oral for 14 days. Glibenclamide and the extract lowered blood glucose level, catalase, and glutathione peroxidase activities, increased the superoxide dismutase (SOD) activity in rats with alloxan induced diabetes. The extract at 500 mg/kg bwt reduced the plasma urea and sodium concentration in the treated rats. The extract and glibenclamide could detoxify alloxan and restore its induced renal degeneration and glomeruli atrophy, intra renal hemorrhage and inflammation and oxidative biomarkers through activation of Nrf2 expression. The drug glibenclamide and P. cornucopiae have appreciable hypoglycemic activity and potential to restore the normal renal architecture in the rats, hence they offer similar curative effects. Additionally, the extract at 500 mg/kg bwt activated SOD and Nrf2 expression more than glibenclamide in rats with alloxan-induced diabetes.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0