Anatomy & Cell Biology最新文献

Venous sinus of Kelch: a cadaveric study with embryological insights and clinical implications. Kelch静脉窦：具有胚胎学见解和临床意义的尸体研究。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-10-20 DOI: 10.5115/acb.26.177

Mary Hydrina D'Silva, Rijied Thompson Swer, Shanmugam Shanthini, Lalhmunzauvi Hnamte

{"title":"Venous sinus of Kelch: a cadaveric study with embryological insights and clinical implications.","authors":"Mary Hydrina D'Silva, Rijied Thompson Swer, Shanmugam Shanthini, Lalhmunzauvi Hnamte","doi":"10.5115/acb.26.177","DOIUrl":"https://doi.org/10.5115/acb.26.177","url":null,"abstract":"The venous sinus of Kelch (VSK) represents a rare but clinically significant venous variant of the middle cranial fossa, with very limited documentation in the existing literature. This study aimed to understand the morphology, course, and morphometry of VSK along with associated variations in the drainage pattern of the superficial middle cerebral vein (SMCV) and middle meningeal sinus (MMS). This study was conducted over the period from 2022 to 2025 at Zoram Medical College and Hospital, Aizawl, Mizoram. In the present study, VSK was observed in 9.26% of the 54 middle cranial fossae examined from 27 cadavers. Moreover, SMCV and MMS, which normally drain into either the spheno-parietal sinus or cavernous sinus, drained into VSK. From an embryological perspective, VSK can be understood as a persistent primitive tentorial sinus (PTS). The variable course and termination of PTS may also result in other reported venous variants like Spheno-basal sinus, Spheno-petrosal sinus and Petro-basal sinus, which underscore the complexity of venous adaptations influenced by hemodynamic factors. Clinically, awareness of such variants is crucial for accurate radiological interpretation and for minimising the risk of iatrogenic injury during surgical and endovascular procedures involving the middle cranial fossa. Importantly, recognition of these alternative venous pathways may have future implications in facilitating novel endovascular approaches for neuromodulation, targeted therapy, and minimally invasive access to the temporal lobe and trigeminal nerve.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an infographic design framework for public communication of personalized cancer therapy. 为个体化癌症治疗的公众交流开发一个信息图表设计框架。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-10-16 DOI: 10.5115/acb.26.108

Nari Kim, Hye Jin Kim, Mi-Sun Hur, Kwan Hyun Youn

{"title":"Development of an infographic design framework for public communication of personalized cancer therapy.","authors":"Nari Kim, Hye Jin Kim, Mi-Sun Hur, Kwan Hyun Youn","doi":"10.5115/acb.26.108","DOIUrl":"https://doi.org/10.5115/acb.26.108","url":null,"abstract":"Personalized cancer therapy (PCT) has become a central paradigm in modern oncology, yet its core concepts-genomic variability, biomarker analysis, and next-generation sequencing (NGS)-based decision-making-remain difficult for the general public to understand. Improving visual communication is essential for enhancing health literacy and supporting patient-centered care. This study employed a design-based research framework integrating literature review, concept modeling, visual metaphor development, and iterative prototype refinement. Core elements of PCT were analyzed and translated into a structured infographic system consisting of four narrative modules: (1) cancer formation, (2) principles of personalized therapy, (3) NGS and genetic profiling, and (4) patient-centered care workflow. The final outputs included an animated educational video, an infographic poster, and a public-facing booklet. The proposed infographic framework effectively visualized the sequential processes of PCT through color-coded pathways, simplified anatomical schematics, and personified cellular characters. Storyboard-based modules depicted cancer development, genetic variability among patients, differences between conventional and personalized therapies, and integrated clinical workflows. This study presents a systematic and replicable design methodology for visualizing PCT. By translating complex oncologic concepts into intuitive visual narratives, the infographic system enhances public comprehension and supports patient-centered communication in precision oncology. These findings highlight the utility of information design as an effective medium for bridging the gap between clinical expertise and public understanding.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of morphogenesis of the tibia and the regenerate formed within it following prolonged exposure to the azo dye tartrazine and correction with sodium selenite. 长期暴露于偶氮染料酒石黄和亚硒酸钠校正后，胫骨及其再生组织形成的形态发生特征。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-10-13 DOI: 10.5115/acb.26.251

Vitaliy Nikolaevich Morozov, Ekaterina Sergeevna Novik, Elena Nikolaevna Morozova

{"title":"Features of morphogenesis of the tibia and the regenerate formed within it following prolonged exposure to the azo dye tartrazine and correction with sodium selenite.","authors":"Vitaliy Nikolaevich Morozov, Ekaterina Sergeevna Novik, Elena Nikolaevna Morozova","doi":"10.5115/acb.26.251","DOIUrl":"https://doi.org/10.5115/acb.26.251","url":null,"abstract":"Tartrazine is a synthetic dye widely used in the food industry; however, it is capable of causing DNA damage, inducing oxidative stress in cells, triggering their apoptosis. The effect of tartrazine on the bone regenerate formation remains insufficiently studied. Selenium shows promise as an antioxidant agent and has the potential to reduce tartrazine-induced oxidative stress. Thirty-six white rats divided into a control group, a group exposed to tartrazine for 60 days at a dose of 750 mg/kg, a group additionally administered sodium selenite at a dose of 40 μg/kg. On day 61, tibial perforation were induced in rats. On days 10, 24 after surgery, changes in the organometric parameters of the bone, its strength, as well as the histological structure, chemical composition of its regenerate were studied. Exposure to tartrazine was accompanied by a lag, compared with the control, in tibial mass gain, parameters of its longitudinal and appositional growth, delayed remodeling of regenerate tissues, disruption of the balance of its chemical composition, and reduced strength of the organ. The parameter values were statistically significant according to the Kruskal-Wallis test, Dunn's test showed a significant difference between the control group and group receiving tartrazine (P<0.05). The use of sodium selenite reduced the magnitude of the tartrazine exposure effect and more rapidly restored the parameter values to control levels. Prolonged administration of tartrazine leads to impaired morphogenesis of the tibia and its regenerate; however, these changes are reversible with the use of selenium-containing preparations.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex determination through metric analysis of teeth crown. 通过牙冠计量分析确定性别。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-10-13 DOI: 10.5115/acb.26.180

Hyo-Sang Ahn, Eun Jin Woo, Joong Yeon Lim, Hee-Jin Kim, Kyung-Seok Hu

{"title":"Sex determination through metric analysis of teeth crown.","authors":"Hyo-Sang Ahn, Eun Jin Woo, Joong Yeon Lim, Hee-Jin Kim, Kyung-Seok Hu","doi":"10.5115/acb.26.180","DOIUrl":"https://doi.org/10.5115/acb.26.180","url":null,"abstract":"Teeth that are resistant to external stimuli and have little diversity for individuals can be an important identification factor. This study aimed to present a method that can be used easily and accurately to identify individuals using their teeth, specifically to determine their sex. In this study, all teeth were extracted from 166 cadavers and, from these teeth, the crown length, mesiodistal width, and buccolingual width were measured using a digital caliper. The measurements were then analyzed using SPSS and MATLAB software. First, tooth crown morphology was compared between males and females. Regression analysis was performed for each measurement separately for both males and females. Finally, each linear discriminant was calculated from the measurements of all tooth crowns to confirm accuracy. Since teeth began to be used for individual identification, most methods required various types of teeth and measurements for sex determination, even if high accuracy was presented. Considering these limitations, sex determinants were derived from all teeth, suggesting that an easy and objective way could be derived to determine sex, even in a limited situation where all teeth could not be used.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of machine learning for sex estimation using the first and second ribs in the Northern Thai population. 机器学习在泰国北部人口中使用第一和第二肋骨进行性别估计的应用。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 Epub Date: 2026-06-10 DOI: 10.5115/acb.26.085

Napadol Poomkert, Tawachai Monum, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh

{"title":"Application of machine learning for sex estimation using the first and second ribs in the Northern Thai population.","authors":"Napadol Poomkert, Tawachai Monum, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh","doi":"10.5115/acb.26.085","DOIUrl":"10.5115/acb.26.085","url":null,"abstract":"Sex estimation is a fundamental component of forensic biological profiling, yet primary markers such as the pelvis and skull are frequently fragmented or absent due to taphonomic factors. This study investigates the diagnostic efficacy of the first and second atypical ribs for sex estimation within a Northern Thai population using advanced machine learning (ML). Osteometric variables, 15 for the first rib and 14 for the second were recorded from 200 right side ribs (100 males, 100 females) and 177 left side ribs (100 males, 77 females) at Chiang Mai University. Twelve ML algorithms, including ensemble stacking and voting classifiers, were refined via recursive feature elimination with cross-validation (RFECV) and hyperparameter optimization through the Optuna framework. Results demonstrated pronounced sexual dimorphism, with male dimensions consistently exceeding those of females across nearly all variables (P<0.05). Optimized models exhibited superior predictive performance; specifically, quadratic discriminant analysis for the right first rib yielded a hold-out accuracy of 85%. Notably, the stacking model applied to the right second rib achieved an accuracy of 90%, equivalent to the performance of models utilizing both ribs combined. In conclusion, ML integrated rib morphometry provides a highly accurate and robust alternative for sex estimation in the Northern Thai population, particularly in cases where standard skeletal markers are compromised.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"414-428"},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-plane paradoxical masseteric bulging after dual-plane botulinum neurotoxin injection: a case report. 双平面肉毒杆菌神经毒素注射后深平面悖论性咬肌膨出1例。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 DOI: 10.5115/acb.26.041

Wu-Chul Song

引用次数: 0

Fetal development of external nose cartilages. 鼻外软骨的胎儿发育。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 Epub Date: 2026-06-10 DOI: 10.5115/acb.26.057

Wei Wang, Zhe-Wu Jin, Dan Guo, Yiping Zhang, Gen Murakami, Masahito Yamamoto, José Francisco Rodríguez-Vázquez

{"title":"Fetal development of external nose cartilages.","authors":"Wei Wang, Zhe-Wu Jin, Dan Guo, Yiping Zhang, Gen Murakami, Masahito Yamamoto, José Francisco Rodríguez-Vázquez","doi":"10.5115/acb.26.057","DOIUrl":"10.5115/acb.26.057","url":null,"abstract":"There seems to be no information on when and how the nasal capsule cartilage is divided into the lateral nasal cartilage (LNC) and greater alar cartilage (GAC). Likewise, there is no information of timing and sequence of development of the medial crus of GAC. We examined histological sections from 22 human fetuses with 45-350 mm of crown-rump length (approximately 9-40 weeks of gestational age). The LNC and GAC were separated from the antero-inferior marginal part of the nasal capsule cartilage at 10-12 weeks. The initial sesamoid was a wavy bar and it did not accompany a joint cavity. The LNC did not make an end-to-end attachment to the septal cartilage and these cartilages were separated by sesamoid cartilages in levels below the nasal bone. However, we did not find a sesamoid between the LNC and GAC. After 27 weeks, the medial crus of the GAC was seen in the antero-inferior side of the septal cartilage. Thus, independently from the septal cartilage, it seemed to develop secondarily from the GAC main part. Relative to the nasal bone, the LNC at late-term was small in the supero-inferior axis. The vomeronasal cartilage was distant from and located in the posterior side of the external nasal cartilages and vestibulum. At birth, the LNC as well as the GAC including its medial crus seemed to be still separated from the septal cartilage. Their connections most likely establish postnatally with tight interdigitation of highly flexed cartilage ends. No lesser alar cartilage appeared at late-term.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"483-492"},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of calcium and phosphorus elements in the developing human fetal long bone at different trimesters of pregnancy. 不同妊娠期人胎儿长骨钙、磷元素的测定。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 Epub Date: 2026-07-08 DOI: 10.5115/acb.26.024

Kumar Megur Ramakrishna Bhat, Vishwanath Managuli, Lokadolalu Chandrachar Prasanna

{"title":"Evaluation of calcium and phosphorus elements in the developing human fetal long bone at different trimesters of pregnancy.","authors":"Kumar Megur Ramakrishna Bhat, Vishwanath Managuli, Lokadolalu Chandrachar Prasanna","doi":"10.5115/acb.26.024","DOIUrl":"10.5115/acb.26.024","url":null,"abstract":"Recent bone research has emphasized the importance of mineral composition and peak bone mass during the fetal and postnatal periods, impairment in which are related to subsequent bone diseases in later life. However, there is no quantitative data on the variations in the composition across the growth period of fetal bone to gain better insight into the fetal origin of adult bone disorders and old-age bone diseases. This study analyzed the mineral composition of the developing humerus bone in different trimesters of pregnancy. Stillbirth or medically terminated human fetal specimens ranging from approximately 10-36 weeks were obtained after institutional ethical committee clearance. The transverse section of each humerus close to mid-diaphysis was subjected for mineral analysis by scanning electron microscopy and energy dispersive spectroscopy techniques. The results indicated that the calcium (Ca) noticeably varies between 10 and 20 weeks and 24 and 36 weeks. It is also noted that the mean phosphorus level remained constant from 12 to 36 weeks. Further, significant differences were observed in Ca to phosphate ratio at different gestational weeks. The study provides preliminary quantitative insight into fetal cortical bone mineral composition and may serve as a foundation for future investigations examining broader anatomical regions, significance of mineral constituents, and functional correlations.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"449-456"},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing and sequence between a thick fascia covering muscles and a cutaneous nerve perforating it: a study using histological sections of human fetuses. 覆盖肌肉的厚筋膜和穿过它的皮神经之间的时间和顺序：一项使用人类胎儿组织学切片的研究。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 Epub Date: 2026-06-08 DOI: 10.5115/acb.26.102

Dan Guo, Dongming Xu, Zhe-Wu Jin, Feng Han, Gen Murakami, Masahito Yamamoto

{"title":"Timing and sequence between a thick fascia covering muscles and a cutaneous nerve perforating it: a study using histological sections of human fetuses.","authors":"Dan Guo, Dongming Xu, Zhe-Wu Jin, Feng Han, Gen Murakami, Masahito Yamamoto","doi":"10.5115/acb.26.102","DOIUrl":"10.5115/acb.26.102","url":null,"abstract":"A deep fascia is believed to develop after a cutaneous nerve (CN) reaches the subcutaneous tissue. The present study aimed to examine a developmental sequence of the CN perforation of the deep fascia. We examined the occipital and posterior neck region as well as the anterior abdominal wall using histological sections from 12 human early fetuses at approximately 7-9 weeks of gestation age (GA) and 10 midterm fetuses at approximately 12-18 weeks GA. When the anterior abdominal CN reached the anterior aspect of the rectus abdominis muscle at 7 weeks, the rectus sheath was still loose. However, the aponeurosis of the obliquus externus abdominis was relatively tight. Later, depending on the rectus sheath became evident, a \"window\" for the CN also became clear. After the anterior CN took a wavy course along the aponeurosis, it grew to the skin by 12 weeks. The occipital CNs reached the superficial surface of the semispinalis and ran superiorly along the fascia by 8 weeks. Later, depending on the superior extension of the splenius and trapezius muscles, the occipital CNs issued multiple twigs to perforate the superior margin of the upward extending fascia or muscle. Both a deep fascia and the window for CNs develop simultaneously. However, during several weeks, the CN likely stopped its further growth to the skin and remained on and along the fascia. Likewise, after perforation of the deep fascia, another fascia or muscle likely interferes with the straight course of CNs to the skin.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"393-401"},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accommodating color vision deficiencies in biomedical publications. 适应生物医学出版物的色觉缺陷。

IF 1.1

Anatomy & Cell Biology Pub Date : 2026-09-30 Epub Date: 2026-05-15 DOI: 10.5115/acb.26.011

Nark-Kyoung Rho

引用次数: 0