实验性自身免疫性脑脊髓炎炎症的犁鼻器官化疗接受的潜在干扰

IF 1.2 Q3 ANATOMY & MORPHOLOGY
Kyungsook Jung, Deokho Ko, Sungmoo Hong, Irene Ortiz-Leal, Pablo Sanchez-Quinteiro, Meejung Ahn, Changjong Moon, Taeyoung Kang, Taekyun Shin, Jeongtae Kim
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引用次数: 0

摘要

在实验性自身免疫性脑脊髓炎(EAE)的背景下,评估了VNO的炎症。取髓鞘少突胶质细胞糖蛋白诱导EAE小鼠VNO标本,进行石蜡包埋处理。对这些切片进行免疫组织化学评估,以检测各种标志物,包括离子钙结合受体分子1 (Iba1)、髓过氧化物酶(MPO)和嗅觉标记蛋白(OMP)。结缔组织可见炎性细胞浸润。iba1阳性的巨噬细胞和mpo阳性的中性粒细胞浸润EAE的VNO,粘液分泌增加进入管腔。eae诱导小鼠犁鼻感觉上皮中omp阳性免疫反应强度降低。我们假设EAE中VNO的炎症反应与副嗅觉系统的功能障碍有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis.

Inflammation of the vomeronasal organ (VNO) was evaluated in the context of experimental autoimmune encephalomyelitis (EAE). The VNO was sampled in mice with myelin oligodendrocyte glycoprotein-induced EAE, and processed for paraffin embedding. The sections were immunohistochemically evaluated for various markers, including ionized calcium binding adaptor molecule 1 (Iba1), myeloperoxidase (MPO), and olfactory marker protein (OMP). Inflammatory cell infiltration was detected in the connective tissues. Both Iba1-positive macrophages and MPO-positive neutrophils infiltrated the VNO of EAE, with increased secretion of mucus into the lumen. The intensity of the OMP-positive immunoreaction was decreased in the vomeronasal sensory epithelium of EAE-induced mice. We postulate that the inflammatory response of the VNO in EAE is associated with dysfunction of the accessory olfactory system.

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来源期刊
Anatomy & Cell Biology
Anatomy & Cell Biology ANATOMY & MORPHOLOGY-
CiteScore
1.80
自引率
9.10%
发文量
75
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