Anatomy & Cell Biology最新文献_第10页

Effect of Sofosbuvir on rats' ovaries and the possible protective role of vitamin E: biochemical and immunohistochemical study. 索非布韦对大鼠卵巢的影响以及维生素 E 可能起到的保护作用：生化和免疫组化研究。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-01 DOI: 10.5115/acb.23.079

Neven A Ebrahim, Hussein Abdelaziz Abdalla, Neimat Abd Elhakam Yassin, Aya Elsayed Maghrabia, Amira Ibrahim Morsy

{"title":"Effect of Sofosbuvir on rats' ovaries and the possible protective role of vitamin E: biochemical and immunohistochemical study.","authors":"Neven A Ebrahim, Hussein Abdelaziz Abdalla, Neimat Abd Elhakam Yassin, Aya Elsayed Maghrabia, Amira Ibrahim Morsy","doi":"10.5115/acb.23.079","DOIUrl":"10.5115/acb.23.079","url":null,"abstract":"Hepatitis C virus (HCV) infection is a major health problem worldwide and its eradication is mandatory. Direct acting HCV polymerase inhibitors, such as Sofosbuvir (SOF), is an effective regimen. However, it has some side effects like mutagenesis, carcinogenesis, and the impairment of testicular function. It is important to evaluate the safety of SOF on the ovary, as there are no studies yet. Increasing the production of Reactive Oxygen Species (ROS), causes oxidative stress, which affects ovulation process, female reproduction, and fertility. Accumulation of SOF in the cells was demonstrated to promote ROS generation. Vitamin E (Vit E) is an antioxidant agent that has an essential role in the female reproductive system, its deficiency can cause infertility. We explored the effect of SOF treatment alone and co-treated with Vit E on ovarian ROS level and ovarian morphology experimentally using biochemical and immunohistochemical studies. Significant changes in oxidative stress markers; nitric oxide and malondialdehyde lipid peroxidation, antioxidant enzymes; catalase, super oxide dismutase, and reduced glutathione, proliferating markers; proliferation cell nuclear antigen and Ki-67 antigen and caspase 3 apoptotic marker were demonstrated. It was shown that where SOF induced oxidative stress, it also aggravated ovarian dysfunction. The essential role of Vit E as an antioxidant agent in protecting the ovarian tissue from the effect of oxidative stress markers and preserving its function was also displayed. This could be guidance to add Vit E supplements to SOF regimens to limit its injurious effect on ovarian function.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical variations of the tibial nerve and their clinical correlation. 胫神经的解剖变异及其临床相关性。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-11 DOI: 10.5115/acb.23.065

Anita Soraya Soetoko, Dina Fatmawati

引用次数: 0

Morphological and morphometric study of pulmonary vein anatomy in relation to cardiac invasive and electrophysiological procedures. 肺静脉解剖的形态学和形态计量学研究与心脏侵入性和电生理程序的关系。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-11-10 DOI: 10.5115/acb.23.141

Harshal Oza, Bhavik Doshi

{"title":"Morphological and morphometric study of pulmonary vein anatomy in relation to cardiac invasive and electrophysiological procedures.","authors":"Harshal Oza, Bhavik Doshi","doi":"10.5115/acb.23.141","DOIUrl":"10.5115/acb.23.141","url":null,"abstract":"Pulmonary veins (PVs) and their myocardial sleeves play an important role in the development of atrial fibrillation. Hence, detailed knowledge of PV anatomy is required to improve the procedural success rate and prevent complications during cardiac procedures. The aim of this study was to evaluate the PV anatomy along with anatomical variations in the Indian population. Total 100 formalin fixed cadaveric hearts were examined. The number and pattern of the PVs were observed along with the measurement of their horizontal and vertical diameters. The ovality index for each PV was calculated. Classical PV pattern was observed in 62% cases. Variant pattern like additional right middle PV pattern and left common PV pattern were found in 20% and 10% cases respectively. A separate pattern with presence of both right middle PV and left common PV was observed in 6% cases. In the classical pattern right superior PV was the largest followed by right inferior, left superior and left inferior PV. The additional right middle PV had the smallest diameter whereas the left common PV had the largest diameter. Almost all the veins had greater vertical diameters in comparison to horizontal diameters. The variant PVs were oval and had greater ovality index compared to the normal PVs. In classical pattern 54.8% hearts whereas in variant pattern 79% hearts had one or more oval PV. The given data can help clinicians for planning and execution of various interventional and electrophysiological procedures involving PVs.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats. 硒纳米粒子和枣肉提取物对四氯化碳诱导的白化大鼠肝损伤的保肝作用比较研究。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-12 DOI: 10.5115/acb.23.101

Ghada Nady Ouais, Doaa Mohamad Hassan

{"title":"A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats.","authors":"Ghada Nady Ouais, Doaa Mohamad Hassan","doi":"10.5115/acb.23.101","DOIUrl":"10.5115/acb.23.101","url":null,"abstract":"Exposure to environmental pollutants such as carbon tetrachloride (CCL4) causes liver damage. This study aimed to compare the ameliorative activity of the dates flesh extract (DFE) and selenium-nanoparticles (SeNPs) on CCL4-induced hepatotoxicity and if DFE could be a useful alternative supplement. Twenty-four male albino rats were enrolled and randomly divided into four equal groups (6 rats in each group): control group received only basal diet with no medications. Group II received CCL4 in a dose of 0.5 mg/kg intraperitoneal injection twice weekly for four weeks. Group III rats were pretreated with SeNPs in a dose of 2.5 mg/kg once a day orally three times/wk for four weeks alone then combined with the previously described dose of CCL4 for another four weeks. Group IV rats were pretreated with DFE in a dose of 8 ml of the aqueous extract/kg/d orally for four weeks alone then combined with the previously described dose of CCL4 for another four weeks. The liver damage was assessed by estimation of plasma concentration of albumin and enzymes activities of alanine aminotransferase and tissue genes expression. Liver oxidation levels were assessed by measuring the tissue concentration of the malondialdehyde, superoxide dismutase, and the total glutathione. Additionally, inflammatory mediators tumour necrosis factor--α and interleukin-6 were estimated. Detecting the liver's cellular structural damage was done by histopathological and immunohistochemical examination. This study suggests that CCL4-induced liver damage in rats can be protected by administration whether the costly SeNPs or the economical DFE.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum neurotoxin injection for treating plunged nose and post-rhinoplasty: anatomical perspectives of depressor septi nasi, nasalis, leveator labii superioris alaeque nasi muscle. 注射肉毒杆菌神经毒素治疗鼻下垂和鼻整形术后：从解剖学角度看鼻中隔下压肌、鼻侧肌、唇上提肌和鼻翼肌。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-07-27 DOI: 10.5115/acb.23.054

Kyu-Ho Yi, Ji-Hyun Lee, Seon-Oh Kim, Hyewon Hu, Hyung-Jin Lee, You-Jin Choi, Tae-Hwan Ahn, Hee-Jin Kim

引用次数: 0

A marginal branch of the left hepatic artery running along the umbilical vein and supplying the anterior surface of the liver left lobe: a report of 5 cases in 12 Japanese human fetuses. 肝左动脉沿脐静脉的边缘分支供应肝左叶的前表面：12 个日本胎儿中 5 个病例的报告。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-15 DOI: 10.5115/acb.23.091

Ji Hyun Kim, Shogo Hayashi, Gen Murakami, José Francisco Rodríguez-Vázquez, Hiroshi Abe

引用次数: 0

Osteoblastogenesis and osteolysis in the Zucker Diabetic Sprague Dawley rat humerus head. Zucker糖尿病Sprague-Dawley大鼠肱骨头的成骨细胞生成和骨溶解。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-10-04 DOI: 10.5115/acb.23.166

Gcwalisile Frances Dlamini, Robert Ndou

{"title":"Osteoblastogenesis and osteolysis in the Zucker Diabetic Sprague Dawley rat humerus head.","authors":"Gcwalisile Frances Dlamini, Robert Ndou","doi":"10.5115/acb.23.166","DOIUrl":"10.5115/acb.23.166","url":null,"abstract":"The endocrinology of type 2 diabetes (T2D) and its predisposing factors have been studied extensively while its skeletal effects have received negligible research despite this being a global disease. The cellular and molecular association between proximal humeral fractures and T2D has not been fully elucidated. We aimed to study bone cell quantities and immunolabel osteogenic and antiosteogenic cytokines. The study used 12-week-old rats (23 males) consisting of 8 Sprague Dawley (SD) and 15 Zucker Diabetic Sprague Dawley (ZDSD). Weekly mass measurements were taken while fasting blood glucose levels were recorded every 2 weeks with oral glucose tolerance tests conducted once every 4 weeks. Upon termination at the age of 28 weeks, humeri were fixed in 10% buffered formalin, prior to decalcification in ethylenediaminetetraacetic acid. The bone samples were then processed in ascending grades of alcohol using an automatic processor before embedding in paraffin wax. Sections were cut at 5 μm thickness in a series for Haematoxylin and Eosin stain, and immunohistochemistry was performed with the anti-tartrate-resistant acid phosphatase (TRAP), anti-alkaline phosphatase (ALP), anti-bone morphogenetic protein 3 (BMP3), anti-transforming growth factor beta 1 (TGFβ1), anti-aged glycation end product (AGE) antibodies in the sequence. ZDSD rats had more adipocytes, BMP3 and AGEs expression with higher numbers of TRAP positive osteocytes and fewer ALP cells although no differences were found in TGFβ1 immunopositivity. We also found that T2D increases the number of AGEs immuno-positive cells, as well as its extracellular expression, thus providing a conducive environment for the interaction of the osteogenic cytokine and its antagonist to suppress osteoblastogenesis. ZDSD groups had higher adipocyte numbers therefore increased marrow adiposity in T2D.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41098185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymelia (thoracomelia), an extremely rare appearance of congenital anomalic limb in a Nepalese child and its embryological basis. 多聚体细胞增多症，尼泊尔儿童先天性畸形肢体的一种极为罕见的表现及其胚胎学基础。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-27 DOI: 10.5115/acb.23.179

Ameet Kumar Jha, Samal Nauhria, Sabyasachi Maity

引用次数: 0

The use of precontoured plates for midshaft clavicle fractures is not always the best course of treatment. 使用预旋钢板治疗锁骨中段骨折并不总是最佳的治疗方案。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-09-25 DOI: 10.5115/acb.23.109

Manmohan Patel, Mohtashim Ahmad, Natwar Agrawal, Sumit Tulshidas Patil, John Ashutosh Santoshi, Bertha Rathinam, Kusum Rajendra Gandhi

{"title":"The use of precontoured plates for midshaft clavicle fractures is not always the best course of treatment.","authors":"Manmohan Patel, Mohtashim Ahmad, Natwar Agrawal, Sumit Tulshidas Patil, John Ashutosh Santoshi, Bertha Rathinam, Kusum Rajendra Gandhi","doi":"10.5115/acb.23.109","DOIUrl":"10.5115/acb.23.109","url":null,"abstract":"Plate fixation has become the preferred approach for treating displaced midshaft clavicle fractures. However, plate fixation of the clavicle presents several unique challenges, including its complex bony architecture and its immediate subcutaneous location. In many cases, we have observed that precontoured implants do not conform to the clavicular anatomy, and many patients complain of postoperative implant-related discomfort. A total of 111 clavicles, both left and right sides, were examined to match two commonly used designs of anatomical pre-contoured superior anterior clavicle plates, with and without lateral extension. The anteroposterior (AP) plane congruence of the plate to the underlying bone, the vertical gap between the bone and plate, and the length of the plate that was off the bone either anteriorly and/or posteriorly at both ends of the clavicle were measured. The scoring system was used to determine the fit of the implant on the clavicle as anatomic, good, or poor. We found that the maximum superior bow of the clavicle was lateral to the midline by 30.75 mm and 30.5 mm on the right and left sides, respectively. The magnitude of the bow was 4.28 mm and 4.46 mm on the right and left sides, respectively. We also found that the plate was a poor fit in 75.86% of cases on the left side and 73.5% of cases on the right side. Manipulating the plates during surgery was very difficult in the AP plane.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinical perspective on the anatomical study of digastric muscle. 二腹肌解剖学研究的临床展望。

IF 1.1

Anatomy & Cell Biology Pub Date : 2023-12-31 Epub Date: 2023-10-06 DOI: 10.5115/acb.23.043

Nandini Prashanth Bhat, Suhani Sumalatha, Ashwija Shetty, Sushma Prabhath

{"title":"A clinical perspective on the anatomical study of digastric muscle.","authors":"Nandini Prashanth Bhat, Suhani Sumalatha, Ashwija Shetty, Sushma Prabhath","doi":"10.5115/acb.23.043","DOIUrl":"10.5115/acb.23.043","url":null,"abstract":"One of the suprahyoid muscles is the digastric muscle which comprises anterior and posterior bellies joined by an intermediate tendon. Because of its close relationship with the submandibular gland, lymph nodes, and chief vessels of the neck, detailed knowledge about the morphometry of the digastric muscle is essential. The objective of the current cross-sectional evaluative study is to record morphometry along with the digastric muscle's origin, insertion, and variability. Forty human cadavers (25 males and 15 females) were dissected, and the head and neck regions were studied in detail. The attachment of the digastric muscle anterior belly to the digastric fossa of the mandible was noted, and the distal attachment of the posterior belly to the mastoid notch was traced. The length of the anterior belly from the digastric fossa to its intermediate tendon and the length of the posterior belly from the intermediate tendon to its mastoid attachment were measured. There is a fair correlation between the length of the neck and the length of the anterior and posterior belly. The study also identified two cases of bilateral accessory bellies of the anterior belly of the digastric. Normal morphometric data is provided by this study on details of the digastric muscle. It is significant from a clinical and surgical point of view as the muscle lies in proximity to the important structures of the neck.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41109024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0