Anatomy & Cell Biology最新文献

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A juxta-ethmoidal course of the infraorbital canal in cases with large ethmomaxillary sinuses or giant Haller cells. 眶下管靠近筛窦的路线,适用于有大筛窦或巨大的哈勒细胞的病例。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-12-31 Epub Date: 2025-10-27 DOI: 10.5115/acb.25.144
Mugurel Constantin Rusu, Alexandra Diana Vrapciu, Răzvan Costin Tudose
{"title":"A juxta-ethmoidal course of the infraorbital canal in cases with large ethmomaxillary sinuses or giant Haller cells.","authors":"Mugurel Constantin Rusu, Alexandra Diana Vrapciu, Răzvan Costin Tudose","doi":"10.5115/acb.25.144","DOIUrl":"10.5115/acb.25.144","url":null,"abstract":"<p><p>Ethmomaxillary sinuses (EMSs) and infraorbital Haller's cells (HCs) are rare anatomical variations that can impact sinus surgery. Two such rare variants are presented here. Archived computed tomography angiography (CTA) scans were retrospectively analysed. Two cases with an ethmoidal origin of an intramaxillary additional pneumatisation above hypoplastic maxillary sinuses (MSs) were found and examined. In the first case, bilateral EMSs were anterior to the pterygopalatine fossa, transforming the inferior orbital fissure into an ethmomaxillary fissure. Each EMS drained into the superior nasal meatus, which is different from a middle meatal drainage of the MS. The infraorbital sulcus (IOS) was found on the roof of the right EMS but in the angle between the left EMS and MS. In the second case, a complicated air cell anatomy was found: a giant HC reached above the right MS and ethmoidal infundibulum and communicated internally through a narrow isthmus with a retrobullar air cell that, in turn, drained into the upper meatus via an orifice of the basal lamella of the middle turbinate. Posteriorly, the ipsilateral IOS was applied to the posterolateral dehiscent wall of the HC, and the infraorbital canal (IOC) was applied at the HC-MS angle. These cases highlight the anatomical variability of ethmoid air cells' migration within the maxilla and raise awareness of a supra- or juxta-ethmoidal course of the IOS and IOC. This underscores the importance of detailed imaging techniques like CTA for accurate diagnosis and surgical planning. Awareness of such variations is essential to prevent complications during endoscopic sinus surgery.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"647-651"},"PeriodicalIF":1.2,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral quadricipital biceps brachii: a rare anatomical variation with clinical implications. 双侧肱四头肌:一种罕见的解剖变异与临床意义。
IF 1.1
Anatomy & Cell Biology Pub Date : 2025-12-31 Epub Date: 2025-12-03 DOI: 10.5115/acb.25.137
Klea Ahmet, Daniel Otero-Pfaeffle, Olga Avilova, Mohammadali M Shoja
{"title":"Bilateral quadricipital biceps brachii: a rare anatomical variation with clinical implications.","authors":"Klea Ahmet, Daniel Otero-Pfaeffle, Olga Avilova, Mohammadali M Shoja","doi":"10.5115/acb.25.137","DOIUrl":"10.5115/acb.25.137","url":null,"abstract":"<p><p>We report our observation of bilateral quadricipital biceps brachii muscle with usual coracoid and glenoid heads and two supernumerary heads arising from the anterior surface of the humerus above the origin of the brachialis muscle. On each side, the lateral supernumerary head merged with the fleshy part of the long head, and the medial heads inserted into the biceps tendon and partially contributed to the bicipital aponeurosis. The median nerve and brachial artery coursed medial to these supernumerary heads, which posed no perceivable risk of neurovascular compression. This variation highlights the complexity and clinical relevance of upper limb muscular anatomy. The occurrence of a four- or five-headed biceps brachii remains exceedingly rare. This paper includes a review of similar cases previously reported in the literature.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"642-646"},"PeriodicalIF":1.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral presentation of a flexor digiti minimi longus: an aberrant fifth digit flexor. 双侧表现为手指小长屈肌:异常的第五指屈肌。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-12-31 Epub Date: 2025-07-29 DOI: 10.5115/acb.25.019
Dylan Loeffler, Justin Robert Siebert
{"title":"Bilateral presentation of a flexor digiti minimi longus: an aberrant fifth digit flexor.","authors":"Dylan Loeffler, Justin Robert Siebert","doi":"10.5115/acb.25.019","DOIUrl":"10.5115/acb.25.019","url":null,"abstract":"<p><p>Anatomical variations in upper extremity musculature can affect motor function, contribute to neuropathies, or enhance functionality. This clinical case report describes a bilateral anomalous muscle in the forearm, a \"flexor digiti minimi longus,\" originating in the anterior proximal forearm and extending via a distinct tendon to the distal phalanx of the fifth digit. Recognizing such variations is crucial for understanding digit function, guiding orthopedic surgery, and identifying potential neurovascular complications.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"633-637"},"PeriodicalIF":1.2,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of gibberellic acid toxicity on pre and postnatal ovarian development and potential protective effect of selenium in albino rats: histological, immunohistochemical, and biochemical study. 赤霉素酸对白化病大鼠出生前后卵巢发育的毒性及硒的潜在保护作用:组织学、免疫组织化学和生化研究。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-04-08 DOI: 10.5115/acb.24.305
Shimaa A Fareed, Amira El Sayed Farag, Eman M Kamel Elshireef
{"title":"Evaluation of gibberellic acid toxicity on pre and postnatal ovarian development and potential protective effect of selenium in albino rats: histological, immunohistochemical, and biochemical study.","authors":"Shimaa A Fareed, Amira El Sayed Farag, Eman M Kamel Elshireef","doi":"10.5115/acb.24.305","DOIUrl":"10.5115/acb.24.305","url":null,"abstract":"<p><p>Gibberellic acid (GA3) is a biocide with insecticidal properties. Selenium (Se) has an enzymatic structure that mediates its antioxidant activities. This study aimed to assess the GA3 toxicity on pre and postnatal ovarian development and to investigate the protective effect of Se against GA3 toxicity in albino rats. Two experiments were conducted in this study (n=24 rats for each): the first was performed on pregnant female rats and the second on prepubertal females (4 weeks old). Rats were divided into Group I (controls: Ia, negative and Ib, positive rats received sodium selenite 0.3 mg/kg/body weight); Group II (GA3-treated, the rats received 55 mg/kg, 1/100 of lethal dose 50); and Group III (the rats were cotreated with GA3 plus Se). Treatments in the first experiment began at gestational day 7 until postnatal day 4, while in the second experiment, treatments lasted two weeks. All hormonal levels were decreased in pre and postnatal GA3 rats' exposure. Histological examination of GA3-treated prenatal rats showed disturbance in ovarian development as shown by ovigerous cords with germ cell breakdown. Meanwhile, multiple histopathological and developmental changes occur in all stages of the ovarian follicles in postnatal rats. In both developmental ages, there was collagen deposition with decreased proliferative marker and androgen receptor expressions, which was confirmed by a decrease in the morphometric measures of the ovarian follicles. All biochemical, immunostaining, and histological results were improved after Se co-administration due to its antioxidant activity against GA3 toxicity.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"427-443"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histomorphogenesis of human pancreatic islets amidst maternal anaemia: a critical insight. 人胰岛在母体贫血中的组织形态发生:一个关键的见解。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-04-23 DOI: 10.5115/acb.24.274
Sruthy Babu, Pravash Ranjan Mishra, Praveen Kumar Ravi, Sashikanta Swain, Jasmina Begum, Madhumita Patnaik
{"title":"Histomorphogenesis of human pancreatic islets amidst maternal anaemia: a critical insight.","authors":"Sruthy Babu, Pravash Ranjan Mishra, Praveen Kumar Ravi, Sashikanta Swain, Jasmina Begum, Madhumita Patnaik","doi":"10.5115/acb.24.274","DOIUrl":"10.5115/acb.24.274","url":null,"abstract":"<p><p>Maternal anaemia, the most common nutritional deficiency, adversely affects the growth and development of the fetus as a whole and the fetal pancreas in particular. These changes lead to the young onset of diabetes in the near future. To understand the pathophysiology behind this, present study investigates the histomorphogenesis of human fetal pancreatic islets and the impact of maternal anaemia on islet dimension, area proportion, and cellular composition across various gestational weeks using immunohistochemistry. The research was conducted on 18 human fetal pancreases obtained from spontaneous abortions or stillbirths between 17 to 36 weeks of gestation, categorized into normal (n=10) and anaemic (n=8) maternal groups. Results revealed a larger islet diameter in fetuses from anaemic mothers compared to the non-anaemic group (<i>P</i>=0.039). The beta cell percentage was significantly lower in the anaemic group across all gestational ages (<i>P</i>=0.003), while the alpha cell proportion remained unchanged in the anaemic group but increased significantly in the non-anaemic group after 20 weeks (<i>P</i>=0.006). The non-alpha/beta cell proportion in anaemic group was consistently higher than in the non-anaemic group. In conclusion, maternal anaemia results in the reprogramming of fetal pancreatic islets, characterized by a reduction in beta cell proportion, an increase in non-alpha/beta cells, and a disruption in the alpha-to-beta cell ratio. These changes may impair fetal pancreatic function and predispose the offspring to glucose intolerance and diabetes in later life. Ensuring adequate maternal nutrition through iron and folic acid supplementation during pregnancy is essential to prevent these developmental disruptions.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"418-426"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The muscular branching characteristics of the deep peroneal nerve in adult human cadavers. 成人尸体腓深神经的肌肉分支特征。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-05-23 DOI: 10.5115/acb.25.017
Kıvanç Goral, Tania Marur
{"title":"The muscular branching characteristics of the deep peroneal nerve in adult human cadavers.","authors":"Kıvanç Goral, Tania Marur","doi":"10.5115/acb.25.017","DOIUrl":"10.5115/acb.25.017","url":null,"abstract":"<p><p>The aim of this study was to investigate the number of muscular branches and muscular branching characteristics of the deep peroneal nerve to the muscles. In this study, a total of 16 lower extremities from 8 male cadavers fixed with formalin, ethanol, and glycerol solution were dissected and the number of muscular branches of the deep peroneal nerve and muscular branching features were investigated. It was observed that 31.5% of the muscular branches given by the deep peroneal nerve came to the tibialis anterior muscle, 28.9% to the extensor digitorum longus muscle, 25.5% to the extensor hallucis longus muscle, 11.4% to the peroneus tertius muscle and 2.7% to the peroneus longus muscle. Muscular branches to the tibialis anterior muscle, extensor digitorum longus muscle, and peroneus tertius muscle were generally originated from the deep peroneal nerve in the proximal 1/3 of the leg. Muscular branches to the extensor hallucis longus muscle arose usually from the deep peroneal nerve in the middle 1/3 of the leg. We think that the data we obtained in our research will reduce the rate of important complications such as neurovascular injury in interventions planned for the deep peroneal nerve and the structures adjacent to the nerve.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"357-364"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The maxillary vein: an anatomical narrative review with clinical implications for oral and maxillofacial surgeons. 上颌静脉:口腔颌面外科的临床意义解剖叙述回顾。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-06-09 DOI: 10.5115/acb.25.024
Kazzara Raeburn, Yohei Takeshita, Hiroaki Takakura, Shogo Kikuta, Yuki Kunisada, Soichiro Ibaragi, Rarinthorn Samrid, Marios Loukas, R Shane Tubbs, Joe Iwanaga
{"title":"The maxillary vein: an anatomical narrative review with clinical implications for oral and maxillofacial surgeons.","authors":"Kazzara Raeburn, Yohei Takeshita, Hiroaki Takakura, Shogo Kikuta, Yuki Kunisada, Soichiro Ibaragi, Rarinthorn Samrid, Marios Loukas, R Shane Tubbs, Joe Iwanaga","doi":"10.5115/acb.25.024","DOIUrl":"10.5115/acb.25.024","url":null,"abstract":"<p><p>The maxillary vein, despite its clinical significance, remains underexplored in anatomical literature. It plays a crucial role in venous drainage of the maxillofacial region and is closely associated with surgical procedures such as sagittal split ramus osteotomy, mandibuloplasty, and condylar or parotid surgeries. Due to its variable anatomy and proximity to critical structures, the maxillary vein poses a risk of significant hemorrhage if injured. Its small size and deep location make preoperative identification challenging, especially without contrast-enhanced imaging. Embryologically, the maxillary vein originates from the primitive maxillary vein and develops through complex anastomoses with other craniofacial veins. Anatomical studies have revealed several variations, including the presence of accessory mandibular foramina and unusual venous connections, which may increase surgical risk. Understanding the detailed anatomy and potential variations of the maxillary vein is essential for minimizing complications and improving surgical outcomes. Despite its importance, more anatomical and clinical research is needed to better define its course, variations, and implications in oral and maxillofacial surgery.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"317-321"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orbital roof cartilage and bone in human fetuses with special reference to changing territories among the ala minor of the sphenoid, frontal bone, and ethmoid. 人类胎儿的眶顶软骨和骨,特别涉及在蝶翼、额骨和筛骨之间的区域变化。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-06-30 DOI: 10.5115/acb.25.100
Zimeng Li, Zhe-Wu Jin, Chun-Ai Li, Masahito Yamamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Shogo Hayashi
{"title":"Orbital roof cartilage and bone in human fetuses with special reference to changing territories among the ala minor of the sphenoid, frontal bone, and ethmoid.","authors":"Zimeng Li, Zhe-Wu Jin, Chun-Ai Li, Masahito Yamamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Shogo Hayashi","doi":"10.5115/acb.25.100","DOIUrl":"10.5115/acb.25.100","url":null,"abstract":"<p><p>The orbital roof in adults consists mainly of the frontal bone (FB), with the ala minor of the sphenoid at the posterior margin. In fetuses, these bones have been observed to overlap at the junction. The present study examined sagittal, frontal, and horizontal histological sections from 38 human fetuses at a gestational age (GA) of approximately 7-39 weeks. At GA 7-8 weeks, the ala minor extended anterolaterally from the orbitosphenoid, covering the posteromedial quadrant of the roof until GA 9 weeks and reaching to almost the center of the roof at late-term. Simultaneously, the FB appeared in front of the cerebral frontal lobe, reached the anterolateral corner of the roof, and at late-term, it extended posteromedially to cover at least the anterior half of the orbit. In addition, a superolateral plate of the ethmoid, originating from the future cribriform plate, covered the medial marginal part of the roof and had a maximum area at GA 11-16 weeks. At the junction, the FB overlapped and extended below the ala minor or ethmoid. Therefore, at birth, the FB and ala minor seemed to overlap widely at the central one-third of the orbital roof. Because the ala minor was ossified at late-term, postnatal degeneration and absorption were unlikely. The fetal anterior skull base was not flat because of the delayed elevation of the nose and the deeply caved cranial fossa. The overlapping bone and cartilage might slide and migrate, providing materials for reconstruction and later growth of the skull base.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"395-411"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating relation terms and comparison in Terminologia Anatomica: a study on supreme. 《解剖学术语》中关系术语的评价与比较——以supreme为例。
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-06-04 DOI: 10.5115/acb.25.056
Laura García-Orozco, Jhonatan Duque-Colorado, Mariano Del Sol
{"title":"Evaluating relation terms and comparison in <i>Terminologia Anatomica</i>: a study on supreme.","authors":"Laura García-Orozco, Jhonatan Duque-Colorado, Mariano Del Sol","doi":"10.5115/acb.25.056","DOIUrl":"10.5115/acb.25.056","url":null,"abstract":"<p><p>The terms of relationship and comparison, which consist of 44 elements grouped as general terms in <i>Terminologia Anatomica</i>, describe the location of anatomical structures and facilitate communication between health professionals and students. During a review in <i>Terminologia Anatomica</i>, the term 'supreme' was found in various structures. However, it is not part of the general terms, which could create confusion when describing and comparing anatomical structures. For this reason, this study aimed to analyze the relevance of supreme and its possible relationship with the superior term. A review of <i>Terminologia Anatomica</i> was conducted to identify structures designated by the adjective \"supreme\" or its Latin equivalent, suprema. The term was then categorized based on anatomical context. An etymological analysis of supreme and superior revealed that both terms stem from the Latin root super, meaning above or over. However, over time, each term evolved with distinct meanings. In <i>Terminologia Anatomica</i>, 'superior' is used as a comparative adjective for a higher position relative to another structure. 'Supreme' is a superlative adjective that indicates the highest level and the designation of structures in a principal position relative to others. Due to inconsistent usage, we suggest including 'supreme' in <i>Terminologia Anatomica</i> and unifying its application. Specifically, it should be limited to structures where terms such as superior, middle, and inferior are applied and when describing structures that occupy a principal position relative to others. In this sense, we suggest changing the supreme, superior and inferior nuchal lines to superior, middle and inferior nuchal lines, respectively.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"412-417"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effect of Chlorella vulgaris against experimental hepatic ischemia reperfusion injury downregulating oxidative stress, inflammation, and apoptosis. 下调氧化应激、炎症和细胞凋亡的小球藻对实验性肝缺血再灌注损伤的保护作用
IF 1.2
Anatomy & Cell Biology Pub Date : 2025-09-30 Epub Date: 2025-04-23 DOI: 10.5115/acb.24.318
Amira E Farage, Mona A Abdel-Kareem, Medhat Taha, Sara Abubakr, Nora Elshehawy Helal, Mahmoud Hendawy, Hanan A Elgendy, Ahmed Abdel-Monem Elmetwally, Hala Mahfouz, Tourki A S Baokbah, Mohammed R Rabei, Mohammad Akbar Hossain, Azza I Helal, Mohie Mahmoud Ibrahim
{"title":"Protective effect of <i>Chlorella vulgaris</i> against experimental hepatic ischemia reperfusion injury downregulating oxidative stress, inflammation, and apoptosis.","authors":"Amira E Farage, Mona A Abdel-Kareem, Medhat Taha, Sara Abubakr, Nora Elshehawy Helal, Mahmoud Hendawy, Hanan A Elgendy, Ahmed Abdel-Monem Elmetwally, Hala Mahfouz, Tourki A S Baokbah, Mohammed R Rabei, Mohammad Akbar Hossain, Azza I Helal, Mohie Mahmoud Ibrahim","doi":"10.5115/acb.24.318","DOIUrl":"10.5115/acb.24.318","url":null,"abstract":"<p><p>Hepatic ischemia/reperfusion (Hep I/R) is a great health burden during hepatic transplantation surgery. The present work aimed to examine the mitigative effect of <i>Chlorella vulgaris</i> against Hep I/R and its underlying protective mechanisms. The animals in the present research were classified into four equal experimental groups (n=6): the sham group, sham+<i>Chlorella vulgaris</i> group, Hep I/R group, and Hep I/R+<i>Chlorella vulgaris</i> group. Hepatic ischemia results in liver impairment, as evidenced by elevated liver enzyme levels and altered liver histology. It also reduced antioxidant enzyme levels and increased lipid peroxidation. Additionally, the Hep I/R group displayed significant suppression of the nuclear factor erythroid 2-related factor 2 (Nrf2)/haem oxygenase-1 pathway. There was a marked elevation in the expression of inflammatory markers, including nuclear factor kappa beta (NF-κB), tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and myloperoxidase, and NOD-like receptor protein 3 (NLRP3) and caspase-1. Furthermore, the levels of apoptotic markers such as caspase-3 and Bax were greater than those in the sham groups. Pretreatment with <i>Chlorella vulgaris</i> significantly protected against Hep I/R by reversing these effects. Rats pretreated with <i>Chlorella vulgaris</i> exhibited a hepatoprotective effect against Hep I/R through its inhibition of the NF-κB and NLRP3 cascades and Nrf2 stimulation.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"460-472"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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