Amino Acids最新文献

{"title":"Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens","authors":"Raja Aadil Hussain Bhat,&nbsp;Victoria C. Khangembam,&nbsp;Vinita Pant,&nbsp;Ritesh Shantilal Tandel,&nbsp;Pramod Kumar Pandey,&nbsp;Dimpal Thakuria","doi":"10.1007/s00726-024-03388-4","DOIUrl":"10.1007/s00726-024-03388-4","url":null,"abstract":"<div><p>In the face of increasing antimicrobial resistance in aquaculture, researchers are exploring novel substitutes to customary antibiotics. One potential solution is the use of antimicrobial peptides (AMPs). We aimed to design and evaluate a novel, short, and compositionally simple AMP with potent activity against various bacterial pathogens in aquaculture. The resulting peptide, KK12YW, has an amphipathic nature and net charge of + 7. Molecular docking experiments disclosed that KK12YW has a strong affinity for aerolysin, a virulence protein produced by the bacterial pathogen <i>Aeromonas sobria</i>. KK12YW was synthesized using Fmoc chemistry and tested against a range of bacterial pathogens, including <i>A. sobria, A. salmonicida, A. hydrophila</i><i>, </i><i>Edwardsiella tarda, Vibrio parahaemolyticus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis</i>, and methicillin-resistant <i>S. aureus</i>. The AMP showed promising antibacterial activity, with MIC and MBC values ranging from 0.89 to 917.1 µgmL⁻¹ and 3.67 to 1100.52 µgmL⁻¹, respectively. In addition, KK12YW exhibited resistance to high temperatures and remained effective even in the presence of serum and salt, indicating its stability. The peptide also demonstrated minimal hemolysis toward fish RBCs, even at higher concentrations. Taken together, these findings indicate that KK12YW could be a highly promising and viable substitute for conventional antibiotics to combat microbial infections in aquaculture.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00726-024-03388-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior bioavailability of the calcium salt form of β-hydroxy-β-methylbutyrate compared with the free acid form","authors":"Heitor Rodrigues Ribeiro,&nbsp;Felipe Gregório Jardim,&nbsp;Miriam Sanz Roldán,&nbsp;Vitor de Salles Painelli,&nbsp;Vinicius da Eira Silva,&nbsp;Aline Cristina Capparelli Tritto,&nbsp;Andressa Formalioni,&nbsp;Giovani Boldrini Custoias,&nbsp;Wagner Ribeiro Pereira,&nbsp;Marina Yazigi Solis,&nbsp;Felipe Carvalho,&nbsp;Ernani Pinto Junior,&nbsp;Guilherme Giannini Artioli","doi":"10.1007/s00726-023-03369-z","DOIUrl":"10.1007/s00726-023-03369-z","url":null,"abstract":"<div><p>We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of β-hydroxy-β-methylbutyrate (HMB). Sixteen young individuals received the following treatments on three different occasions in a counterbalanced crossover fashion: (1) HMB-FA in clear capsules; (2) HMB-Ca in gelatine capsules; (3) HMB-Ca dissolved in water. All treatments provided 1 g of HMB. Blood samples were taken before and on multiple time points following ingestion. The following parameters were calculated: peak plasma (Cmax), time to peak (Tmax), slope of HMB appearance in blood, area under the curve (AUC), half-life time (<i>t</i>_<i>1/2</i>) and relative bioavailability (HMB-Ca in water set as reference). All treatments led to rapid and large increases in plasma HMB. HMB-Ca in capsules and in water showed similar plasma HMB values across time (<i>p</i> = 0.438). HMB-FA resulted in lower concentrations vs<i>.</i> the other treatments (both <i>p</i> &lt; 0.001). AUC (HMB-Ca in capsules: 50,078 ± 10,507; HMB-Ca in water: 47,871 ± 10,783; HMB-FA: 29,130 ± 12,946 µmol L⁻¹ × 720 min), Cmax (HMB-Ca in capsules: 229.2 ± 65.9; HMB-Ca in water: 249.7 ± 49.7; HMB-FA: 139.1 ± 67.2 µmol L⁻¹) and relative bioavailability (HMB-Ca in capsules: 104.8 ± 14.9%; HMB-FA: 61.5 ± 17.0%) were lower in HMB-FA vs. HMB-Ca (all <i>p</i> &lt; 0.001). HMB-Ca in water resulted in the fastest Tmax (43 ± 22 min) compared to HMB-Ca in capsules (79 ± 40 min) and HMB-FA (78 ± 21 min) (all <i>p</i> &lt; 0.05), while <i>t</i>_<i>1/2</i> was similar between treatments. To conclude, HMB-Ca exhibited superior bioavailability compared to HMB-FA, with HMB-Ca in water showing faster absorption. Elimination kinetics were similar across all forms, suggesting that the pharmaceutical form of HMB affects the absorption rates, but not its distribution or elimination.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reductive amination of ω-conotoxin MVIIA: synthesis, determination of modification sites, and self-assembly","authors":"Xiufang Ding,&nbsp;Yue Wang,&nbsp;Sida Zhang,&nbsp;Ruihua Zhang,&nbsp;Dong Chen,&nbsp;Changcai Liu,&nbsp;Jianfu Xu,&nbsp;Long Chen","doi":"10.1007/s00726-023-03366-2","DOIUrl":"10.1007/s00726-023-03366-2","url":null,"abstract":"<div><p>Peptide drugs have disadvantages such as low stability, short half-life and side effects, which limit their widespread use in clinical practice. Therefore, peptide drugs can be modified to improve these disadvantages. Numerous studies have shown that alkyl-modified peptide drugs can self-assemble to prolong the duration of efficacy and/or reduce side effects. However, the commonly used solid-phase synthesis method for alkyl-modified peptides is time-consuming. To overcome this, a simple reductive amination reaction was employed, which can directly graft the alkyl chain to the peptide sequence and effectively avoid stepwise synthesis from C- to N-terminal with amino acids. In this study, ω-conotoxin MVIIA was used as the peptide drug, while myristic aldehyde was used as the alkylating agent. To obtain the maximum productivity of modified peptides, the molar ratio of peptide MVIIA to myristic aldehyde in the reductive amination reaction was optimized. Furthermore, the peptide modification sites in this reaction were confirmed by secondary mass spectrometry analysis. Besides, alkyl-modified peptide MVIIA was able to form micelles by self-assembly and improved stability in serum, which was related to our previous work where myristoylated peptide MVIIA micelles can improve the drug stability. Finally, this study was intended to provide a methodological basis for modifying the alkyl chain of peptide drugs.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R","authors":"Ron Wehrens,&nbsp;Jasper Engel,&nbsp;Jurriaan Mes,&nbsp;Aard de Jong,&nbsp;Diederik Esser","doi":"10.1007/s00726-024-03386-6","DOIUrl":"10.1007/s00726-024-03386-6","url":null,"abstract":"<div><p>Nowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, <span>(textbf{aaresponse})</span>, for the <span>(textsf{R})</span> environment, available as open source. It features ample visualization functions, supports consistent curation strategies, and compares amino acid uptake of different protein meals (interventions) through the use of mixed models analysing parameters of interest like the area under the curve (AUC). The defining feature is the use of parametric curves to fit the amino acid levels over time, increasing the robustness of the approach and allowing for more strict quality control strategies.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into role of amino acids as antioxidants via NRF2 activation","authors":"Melford C. Egbujor,&nbsp;Olugbemi T. Olaniyan,&nbsp;Chigbundu N. Emeruwa,&nbsp;Sarmistha Saha,&nbsp;Luciano Saso,&nbsp;Paolo Tucci","doi":"10.1007/s00726-024-03384-8","DOIUrl":"10.1007/s00726-024-03384-8","url":null,"abstract":"<div><p>Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids are notably the building block of proteins and constitute the major class of nitrogen-containing natural products of medicinal importance. They exhibit a broad spectrum of biological activities, including the ability to activate NRF2, a transcription factor that regulates endogenous antioxidant responses. Moreover, amino acids may act as synergistic antioxidants as part of our dietary supplementations. This has aroused research interest in the NRF2-inducing activity of amino acids. Interestingly, amino acids' activation of NRF2-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway exerts therapeutic effects in several diseases. Therefore, the present review will discuss the relationship between different amino acids and activation of NRF2–KEAP1 signaling pathway pinning their anti-inflammatory and antioxidant properties. We also discussed amino acids formulations and their applications as therapeutics. This will broaden the prospect of the therapeutic applications of amino acids in a myriad of inflammation and oxidative stress-related diseases. This will provide an insight for designing and developing new chemical entities as NRF2 activators.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00726-024-03384-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction","authors":"Prasenjit Manna,&nbsp;Mahua Sinha,&nbsp;Parames C. Sil","doi":"10.1007/s00726-024-03390-w","DOIUrl":"10.1007/s00726-024-03390-w","url":null,"abstract":"","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted metabolomic analysis of serum amino acids in heart failure patients","authors":"Chunjing Yang,&nbsp;Zhengyuan Shi,&nbsp;Li Bao,&nbsp;Xiqiao Xv,&nbsp;Dechun Jiang,&nbsp;Longtai You","doi":"10.1007/s00726-024-03385-7","DOIUrl":"10.1007/s00726-024-03385-7","url":null,"abstract":"<div><p>Heart failure (HF) has been recognized as a global epidemic with high rates of morbidity, hospitalization, and mortality. The role of amino acids, which provide the body with energy, in the development of HF is still unclear. The aim of this study was to explore changes in serum amino acids in patients with HF and identify potential biomarkers. First, the serum amino acid metabolism profiles of 44 patients with HF and 30 healthy controls (Con) were quantitatively measured. Then, candidate markers were identified through the utilization of <i>T</i> test, multivariate statistical analysis, and receiver operating characteristic (ROC) curve analysis. The results found that there were 11 amino acid levels that were significantly different between patients with HF and Con. Based on ROC curve analysis, the biomarkers of eight amino acids (Glutamic acid, Taurine, <span>l</span>-aspartic acid, <span>l</span>-ornithine, Ethanolamine, <span>l</span>-Serine, <span>l</span>-Sarcosine, and Cysteine) showed high sensitivity and specificity (AUC &gt; 0.90), and binary logistic regression analysis was used in MetaboAnalyst 5.0. Among the amino acids examined, six exhibited notable alterations in accordance with the severity of HF. In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00726-024-03385-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients","authors":"Svetlana Baskal,&nbsp;Rene A. Posma,&nbsp;Alexander Bollenbach,&nbsp;Willem Dieperink,&nbsp;Stephan J. L. Bakker,&nbsp;Maarten W. Nijsten,&nbsp;Daan J. Touw,&nbsp;Dimitrios Tsikas","doi":"10.1007/s00726-024-03383-9","DOIUrl":"10.1007/s00726-024-03383-9","url":null,"abstract":"<div><p>Metformin (<i>N</i>,<i>N</i>-dimethylbiguanide), an inhibitor of gluconeogenesis and insulin sensitizer, is widely used for the treatment of type 2 diabetes. In some patients with renal insufficiency, metformin can accumulate and cause lactic acidosis, known as metformin-associated lactic acidosis (MALA, defined as lactate ≥ 5 mM, pH &lt; 7.35, and metformin concentration &gt; 38.7 µM). Here, we report on the post-translational modification (PTM) of proline (Pro) to 4-hydroxyproline (OH-Pro) in metformin-associated lactic acidosis and in metformin-treated patients with Becker muscular dystrophy (BMD). Pro and OH-Pro were measured simultaneously by gas chromatography–mass spectrometry before, during, and after renal replacement therapy in a patient admitted to the intensive care unit (ICU) because of MALA. At admission to the ICU, plasma metformin concentration was 175 µM, with a corresponding lactate concentration of 20 mM and a blood pH of 7.1. Throughout ICU admission, the Pro concentration was lower compared to healthy controls. Renal excretion of OH-Pro was initially high and decreased over time. Moreover, during the first 12 h of ICU admission, OH-Pro seems to be renally secreted while thereafter, it was reabsorbed. Our results suggest that MALA is associated with hyper-hydroxyprolinuria due to elevated PTM of Pro to OH-Pro by prolyl-hydroxylase and/or inhibition of OH-Pro metabolism in the kidneys. In BMD patients, metformin, at the therapeutic dose of 3 × 500 mg per day for 6 weeks, increased the urinary excretion of OH-Pro suggesting elevation of Pro hydroxylation to OH-Pro. Our study suggests that metformin induces specifically the expression/activity of prolyl-hydroxylase in metformin intoxication and BMD.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of matrilineal specific patatin-like protein governing in-vivo maternal haploid induction in maize using support vector machine and di-peptide composition","authors":"Suman Dutta,&nbsp;Rajkumar U. Zunjare,&nbsp;Anirban Sil,&nbsp;Dwijesh Chandra Mishra,&nbsp;Alka Arora,&nbsp;Nisrita Gain,&nbsp;Gulab Chand,&nbsp;Rashmi Chhabra,&nbsp;Vignesh Muthusamy,&nbsp;Firoz Hossain","doi":"10.1007/s00726-023-03368-0","DOIUrl":"10.1007/s00726-023-03368-0","url":null,"abstract":"<div><p>The mutant <i>matrilineal</i> (<i>mtl</i>) gene encoding patatin-like phospholipase activity is involved in <i>in-vivo</i> maternal haploid induction in maize. Doubling of chromosomes in haploids by colchicine treatment leads to complete fixation of inbreds in just one generation compared to 6–7 generations of selfing. Thus, knowledge of patatin-like proteins in other crops assumes great significance for <i>in-vivo</i> haploid induction. So far, no online tool is available that can classify unknown proteins into patatin-like proteins. Here, we aimed to optimize a machine learning-based algorithm to predict the patatin-like phospholipase activity of unknown proteins. Four different kernels [radial basis function (RBF), sigmoid, polynomial, and linear] were used for building support vector machine (SVM) classifiers using six different sequence-based compositional features (AAC, DPC, GDPC, CTDC, CTDT, and GAAC). A total of 1170 protein sequences including both patatin-like (585 sequences) from various monocots, dicots, and microbes; and non-patatin-like proteins (585 sequences) from different subspecies of <i>Zea mays</i> were analyzed. RBF and polynomial kernels were quite promising in the prediction of patatin-like proteins. Among six sequence-based compositional features, di-peptide composition attained &gt; 90% prediction accuracies using RBF and polynomial kernels. Using mutual information, most explaining dipeptides that contributed the highest to the prediction process were identified. The knowledge generated in this study can be utilized in other crops prior to the initiation of any experiment. The developed SVM model opened a new paradigm for scientists working in <i>in-vivo</i> haploid induction in commercial crops. This is the first report of machine learning of the identification of proteins with patatin-like activity.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00726-023-03368-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary branched-chain amino acids intake and new-onset hypertension: a nationwide prospective cohort study in China","authors":"Lianlong Yu,&nbsp;Qianrang Zhu,&nbsp;Pengkun Song,&nbsp;Yuqian Li,&nbsp;Qingqing Man,&nbsp;Beibei Liu,&nbsp;Shanshan Jia,&nbsp;Jian Zhang","doi":"10.1007/s00726-023-03376-0","DOIUrl":"10.1007/s00726-023-03376-0","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the relationship between dietary branched-chain amino acids (BCAAs) and the risk of developing hypertension.</p><h3>Methods</h3><p>A cohort study of 14,883 Chinese adults without hypertension at baseline with were followed for an average of 8.9 years. Dietary intakes of BCAAs, including Ile, Leu, and Val, were collected using 3-day 24-h meal recall and household condiment weighing. Cox proportional hazards regression, restricted cubic splines, interaction analysis, and sensitivity analysis were used to assess the relationship between dietary BCAAs and risk of developing self-reported hypertension, adjusting for age, gender, region, body mass index (BMI), smoking and drinking status, physical activity, energy intake, salt intake.</p><h3>Results</h3><p>Among 14,883 study subjects, 6386(42.9%) subjects aged ≥ 45 years at baseline, 2692 (18.1%) had new-onset hypertension during the study period, with a median age of 56 years. High levels of dietary BCAAs were associated with an increased risk of new-onset hypertension. Compared with the 41st–60th percentile, multivariable adjusted hazard ratio (HR) for new-onset hypertension was 1.16 (95% CI 1.01–1.32) for dietary BCAAs 61st–80th percentiles, 1.30 (1.13–1.50) for 81st–95th, 1.60 (1.32–1.95) for 96th–100th. The cut-off value of new-onset hypertension risk, total BCAAs, Ile, Leu, and Val were 15.7 g/day, 4.1 g/day, 6.9 g/day, 4.6 g/day, respectively, and the proportion of the population above these intake values were 13.9%, 13.1%, 15.4%, and 14.4%, respectively. Age, BMI, and salt intake had an interactive effect on this relationship (<i>P</i> &lt; 0.001).</p><h3>Conclusion</h3><p>There was a significant positive association between total dietary BCAAs, Ile, Leu, Val intake and the risk of developing hypertension, after adjustment for confounders. This relationship was influenced by age, BMI, and salt intake. Further research is needed to clarify the mechanism and potential role of BCAAs in the pathogenesis of hypertension.</p></div>","PeriodicalId":7810,"journal":{"name":"Amino Acids","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}