口服美司那对全氨基酸谱和 3-甲基组氨酸的急性影响：CYLOB 剂量测定研究的次要结果。

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amino Acids Pub Date : 2024-06-06 DOI:10.1007/s00726-024-03398-2

Thomas Olsen, Amany Elshorbagy, Emma Stolt, Anders Åsberg, Hasse K. Zaré, Nasser E. Bastani, Helga Refsum, Kjetil Retterstøl, Kathrine J. Vinknes

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引用次数: 0

摘要

血浆总半胱氨酸（tCys）与人体脂肪量密切相关。美斯那能以剂量依赖的方式降低血浆总半胱氨酸（tCys），但它是否会干扰其他氨基酸或蛋白质的代谢尚不清楚。在这项 1 期研究中，我们发现，6-7 人每次服用 400、800、1200 或 1600 毫克的单剂量美司那只会对氨基酸谱产生轻微影响，不同剂量水平的血浆缬氨酸均会增加。美司那对蛋白质分解的标志物--3-甲基组氨酸没有影响。

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Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6–7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.

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来源期刊

Amino Acids 生物-生化与分子生物学

CiteScore

6.40

自引率

5.70%

发文量

审稿时长

2.2 months

期刊介绍： Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology