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[Global prognosis and stage classification of colorectal carcinoma]. 【结直肠癌的总体预后及分期】。
Revista espanola de oncologia Pub Date : 1985-01-01
J M Terrazas Hontañón, J F Val Bernal, L Buelta Carrillo
{"title":"[Global prognosis and stage classification of colorectal carcinoma].","authors":"J M Terrazas Hontañón,&nbsp;J F Val Bernal,&nbsp;L Buelta Carrillo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study on the life prognosis of patients with carcinoma of the colon and rectum is made. 393 patients are studied, 90% of which were followed up during five years or until their death. The authors indicate the classification of stages they have followed with good correlation results, and without overlapping of the survival calculations for the different subgroups.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 2","pages":"323-41"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14960706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Residual tumor mass and other kinetic parameters of clinical relevance in cancer of the breast]. [乳腺癌残留肿瘤质量及其他动力学参数的临床相关性]。
Revista espanola de oncologia Pub Date : 1985-01-01
M Torres Avisbal, J M Ruíz de Almodovar Rivera, V Pedraza Muriel
{"title":"[Residual tumor mass and other kinetic parameters of clinical relevance in cancer of the breast].","authors":"M Torres Avisbal,&nbsp;J M Ruíz de Almodovar Rivera,&nbsp;V Pedraza Muriel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on data about illness-free survival obtained studying a group of 192 patients affected by breast cancer, we have made some calculations about tumoral growth kinetics, using the theoretical presumptions of the exponential model. Tumoral recurrence in the different stages (S-I = 35%, S-II = 38%, S-III = 53% y S-IV = 72%) were valued. Also the theoretical mean time of tumoral relapse was determined for each clinical stage of the illness (S-I = 4.6 years, S-II = 2.6 years, S-III = 1.9 years and S-IV = 1.2 years). Knowledge of these relapse time values makes it finally possible to value the residual tumoral mass after treating the primary in each clinical stage under study (S-I = 1.2 X 10(6) cells, S-II = 8.1 X 10(7) cells, S-III = 3.6 X 10(8) cells and E-IV = 1.6 X 10(9) cells). Comparison of the theoretical data obtained with the corresponding clinical data (real appearance time of relapses, percentage of patients of each Stage that have metastasis, etc.) shows that the formulations and theoretical concepts used, describe, with a certain degree of preciseness, the ordinary clinical observations phenomena that characterize the evolutive course of the breast carcinoma.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 2","pages":"237-53"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14962788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Investigation of cancer with unicellular algae]. [单细胞藻类对癌症的研究]。
Revista espanola de oncologia Pub Date : 1985-01-01
H Doetsch, B Benninghoff, M Möller
{"title":"[Investigation of cancer with unicellular algae].","authors":"H Doetsch,&nbsp;B Benninghoff,&nbsp;M Möller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Euglena alga culture modifications allow to distinguish between tumor serum and control serum. The modifications with ascites tumor AH 13R rat serum were also significatively different from healthy rat. These results suggest that this assay model could be applied for early cancer diagnostics. This communication is a summary of the 50 years work described on the bellow cited literature.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 4","pages":"613-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14995837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evolution of some epidemiologic factors in invasive carcinoma of the uterine cervix. The period from 1972-1985]. 宫颈浸润性癌流行病学因素的演变。[1972-1985年]。
Revista espanola de oncologia Pub Date : 1985-01-01
S Castán Mateo, P González Ramos, P A Clemente Pérez, A Martínez Tejero, J Suárez Trujillo, A Pérez Falo, M D de la Plaza
{"title":"[Evolution of some epidemiologic factors in invasive carcinoma of the uterine cervix. The period from 1972-1985].","authors":"S Castán Mateo,&nbsp;P González Ramos,&nbsp;P A Clemente Pérez,&nbsp;A Martínez Tejero,&nbsp;J Suárez Trujillo,&nbsp;A Pérez Falo,&nbsp;M D de la Plaza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>204 cases of invasive carcinoma of the uterine cervix seen in the period 1972-1985 are studied. The incidence was higher from 50 to 69 years of age and maximum during the last years of the decade of the fifties. It was verified that the early beginning of sexual intercourse increases the number of cases and the age of presentation, and also that invasive uterine cervix cancer is more common in women with 3 or more pregnancies, while the incidence decreases in women with 1 or 2 pregnancies and specially in nulliparous virgins.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 4","pages":"649-56"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14997154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contributions to the study of pulmonary carcinoma. Review of 138 cases]. 对肺癌研究的贡献。138例回顾]。
Revista espanola de oncologia Pub Date : 1985-01-01
S Bascuas Méliz, M T Gutiérrez Amares, F Cruz Fernández, A Bueno Becerra, J E Trigo Ferrer, M Gutierrez Espino, J L Bascuas Asta
{"title":"[Contributions to the study of pulmonary carcinoma. Review of 138 cases].","authors":"S Bascuas Méliz,&nbsp;M T Gutiérrez Amares,&nbsp;F Cruz Fernández,&nbsp;A Bueno Becerra,&nbsp;J E Trigo Ferrer,&nbsp;M Gutierrez Espino,&nbsp;J L Bascuas Asta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was carried out in 138 lung cancer patients from the Department of Radiology and Physiotherapy of the Faculty of Medicine of Cadiz between 1983 and 1986. The patients were classified according to the pathologic anatomy in order to analyze the statistical variations in relation to sex, localization, metastases, clinical stage and radiation therapy. The obtained results about the form of presentation and behavior of each one of the pathologic anatomy types of lung carcinoma agree in some aspects with other works that have been consulted, and may help the radiotherapists in their clinical and therapeutic approach.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 4","pages":"733-40"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14997162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of the levels of methionine enkephalin in the blood and CSF and of 5-hydroxyindoleacetic acid in the CSF, following intrathecal administration of morphine]. [鞘内注射吗啡后血液和脑脊液中蛋氨酸脑啡肽和脑脊液中5-羟基吲哚乙酸水平的测定]。
Revista espanola de oncologia Pub Date : 1985-01-01
F Seijo, L F Melcón, R M Simó
{"title":"[Determination of the levels of methionine enkephalin in the blood and CSF and of 5-hydroxyindoleacetic acid in the CSF, following intrathecal administration of morphine].","authors":"F Seijo,&nbsp;L F Melcón,&nbsp;R M Simó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors measured enkephalin and 5-HIAA levels in the CSF and enkephalin levels in plasma, after intrathecal morphine in 15 patients with terminal cancer.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 3","pages":"529-38"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13590854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Design of new antineoplastic drugs]. [新型抗肿瘤药物的设计]。
Revista espanola de oncologia Pub Date : 1985-01-01
Y G Smeyers
{"title":"[Design of new antineoplastic drugs].","authors":"Y G Smeyers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The theoretical design of new anticancerous drugs is considered into the general frame of the theoretical pharmacology. In this aim, two limit cases are taken into account: those of drugs with well known and unknown mechanism of action. The methods used presently in drug design are reviewed, emphasis is put on the molecular mechanics procedures. Two examples of calculations are given: the first deals with some alkylating agents the mechanism of action of which is well known. The second one deals with immunologic agents, such as human interleukin-2, the study of which is carried out by theoretical and experimental fragment analysis of the polypeptide. It is concluded that the theory may be an useful tool for solving the cancer problem.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 2","pages":"227-36"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14962787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cancer disease as a health care problem in internal medicine]. [作为内科保健问题的癌症]。
Revista espanola de oncologia Pub Date : 1985-01-01
R Palmeiro Troitiño, P García-Blanco Saceda
{"title":"[Cancer disease as a health care problem in internal medicine].","authors":"R Palmeiro Troitiño,&nbsp;P García-Blanco Saceda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 1","pages":"163-82"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14959482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epidemiology of colorectal carcinoma in Cantabria]. 坎塔布利亚大肠癌流行病学研究
Revista espanola de oncologia Pub Date : 1985-01-01
J M Terrazas Hontañón, J F Val Bernal, L Buelta Carrillo, J Ortega Gato, I Guerra Merino, E García Satue, O Acinas García
{"title":"[Epidemiology of colorectal carcinoma in Cantabria].","authors":"J M Terrazas Hontañón,&nbsp;J F Val Bernal,&nbsp;L Buelta Carrillo,&nbsp;J Ortega Gato,&nbsp;I Guerra Merino,&nbsp;E García Satue,&nbsp;O Acinas García","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Colorectal cancer is increasing due to both a real increase and a better diagnosis. More cases are seen in men than in women (ratio 1.45). The incidence increases with age, reaching the highest point at 75 years of age in men and at 84 years of age in women. Before 50 years of age, the risk of colorectal cancer is higher in women; the contrary happens after this age. Colorectal cancer is localized in the rectum (47.5%), sigmoid flexure (25.3%) and coecum (8.1%). Synchronous colorectal carcinomas are seen in 2.3% of the patients, frequently coexisting with multiple adenomas, and show a tendency to be localized out of the rectum. A higher proportion of carcinomas localized in the descending colon and a diminution of rectum carcinomas are observed in men with increasing age, while in women the number of carcinomas of the ascending colon increases and that of the descending colon decreases. For the considered period (1970-81), a diminution of the ascending colon carcinomas has been registered.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 1","pages":"23-53"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14959484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-lapse microcinematography of the effect of thiazolidine carboxylic acid (thioproline) upon tissue cultures. 噻唑烷羧酸(硫脯氨酸)对组织培养效果的延时微缩摄影。
Revista espanola de oncologia Pub Date : 1985-01-01
Y Alvarez-Rodríguez, A Ruano, J Alvarez-Noves, Y Valladares
{"title":"Time-lapse microcinematography of the effect of thiazolidine carboxylic acid (thioproline) upon tissue cultures.","authors":"Y Alvarez-Rodríguez,&nbsp;A Ruano,&nbsp;J Alvarez-Noves,&nbsp;Y Valladares","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This work deals with the effect of thiazolidine-4-carboxylic acid (thioproline) upon several in vitro established human cell lines. Times-lapse microcinematography is used to study the action of thioproline on HeLa cells, employing high doses during a short time, and continuous exposure to medium and small doses. The effect of thioproline in mixed cultures of HeLa cells and human lymphoblasts is described. Special attention is paid to the observed cell cycle phase specificity, and to the phenomenon described as reverse transformation that has been associated to the drug. Marked differences is the sensitivity to thioproline are observed for the different types of in vitro established cell lines. The effect is always produced during the G1 and S phases of the cell cycle. Cell changes are produced only after contacting with one another, and the biochemical reactions which are proper of cell contact inhibition of growth and/or genotypic reverse transformation were never observed, so that the mechanism of action of the drug has to be revised. From a morphodynamic point of view, thioproline is an interesting drug because it produces peculiar effects which differ markedly from those produced by the other cancer chemotherapy agents. Thioproline could prove to be useful for cancer chemotherapy if used in combination with other drugs, knowing that it is a low activity phase specific antineoplastic drug and not a drug producing reverse transformation.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 3","pages":"383-410"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14986363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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