[Design of new antineoplastic drugs].

Revista espanola de oncologia Pub Date : 1985-01-01
Y G Smeyers
{"title":"[Design of new antineoplastic drugs].","authors":"Y G Smeyers","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The theoretical design of new anticancerous drugs is considered into the general frame of the theoretical pharmacology. In this aim, two limit cases are taken into account: those of drugs with well known and unknown mechanism of action. The methods used presently in drug design are reviewed, emphasis is put on the molecular mechanics procedures. Two examples of calculations are given: the first deals with some alkylating agents the mechanism of action of which is well known. The second one deals with immunologic agents, such as human interleukin-2, the study of which is carried out by theoretical and experimental fragment analysis of the polypeptide. It is concluded that the theory may be an useful tool for solving the cancer problem.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"32 2","pages":"227-36"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de oncologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The theoretical design of new anticancerous drugs is considered into the general frame of the theoretical pharmacology. In this aim, two limit cases are taken into account: those of drugs with well known and unknown mechanism of action. The methods used presently in drug design are reviewed, emphasis is put on the molecular mechanics procedures. Two examples of calculations are given: the first deals with some alkylating agents the mechanism of action of which is well known. The second one deals with immunologic agents, such as human interleukin-2, the study of which is carried out by theoretical and experimental fragment analysis of the polypeptide. It is concluded that the theory may be an useful tool for solving the cancer problem.

[新型抗肿瘤药物的设计]。
抗癌新药的理论设计被纳入理论药理学的总体框架。在此目的中,考虑了两种极限情况:具有已知作用机制和未知作用机制的药物。综述了目前用于药物设计的方法,重点介绍了分子力学方法。给出了两个计算实例:第一个计算是对一些作用机理已知的烷基化剂的计算。第二部分涉及免疫因子,如人类白细胞介素-2,其研究是通过多肽的理论和实验片段分析进行的。结论是,这一理论可能是解决癌症问题的一个有用工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信