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[Visualization of specific leukocyte granules using morin and other fluorochromes]. [使用桑皮素和其他荧光染料显示特定的白细胞颗粒]。
Revista espanola de oncologia Pub Date : 1984-01-01
O D Colman, M L Molero, L Sen, M E Estévez, J C Stockert
{"title":"[Visualization of specific leukocyte granules using morin and other fluorochromes].","authors":"O D Colman,&nbsp;M L Molero,&nbsp;L Sen,&nbsp;M E Estévez,&nbsp;J C Stockert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The visualization of the specific granulation of leukocytes is useful in hematology to identify de cell type in leukemic diseases. The authors employed the acidic fluorochrome morin after testing its high affinity for the fluorescent reaction with morin in human and chicken peripheral blood smears, and in streak smears from rabbit spleen. The best results were obtained with a solution prepared either with 0.10 mg morin per ml of 50 per 100 ethanol, or with a saturated solution of morin in distilled water diluted to one fourth in 25 per 100 ethanol. When observed under blue-violet excited light (436 nm) the acidophilic granules of leukocytes produce a bright yellow fluorescence, while the cell nuclei show a faint greenish fluorescence. As for the mechanism of the reaction, it consists possibly in an interaction between morin and the basic components of the granules. Other acidic fluorochromes, as primulin and hematoxylin, produce similar fluorescent reactions with the acidophilic granules.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"393-9"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours]. n -亚硝基somethylurea诱导大鼠乳腺癌的时间治疗。1 . 8:00和14:00给药高剂量环磷酰胺的效果。
Revista espanola de oncologia Pub Date : 1984-01-01
F R Pérez-López, M Urcia, R Torralba, L Lafarga, M C Leal, V Guillén, J Hergueta
{"title":"[Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours].","authors":"F R Pérez-López,&nbsp;M Urcia,&nbsp;R Torralba,&nbsp;L Lafarga,&nbsp;M C Leal,&nbsp;V Guillén,&nbsp;J Hergueta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"401-7"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Programs for the detection of gynecologic cancer]. 【妇科癌症检测方案】。
Revista espanola de oncologia Pub Date : 1984-01-01
M Alonso de Miguel
{"title":"[Programs for the detection of gynecologic cancer].","authors":"M Alonso de Miguel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author reviews the problem of the early detection of breast cancer in women. He tells about the etiopathogenic complex, and the risk factors in relation to breast cancer, and indicates the protocol followed for breast cancer early detection. The usefulness of the employed method is supported by the obtained results after studying 69,635 women, and makes an economical evaluation of the cancer detection campaigns.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"465-76"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Specific receptors for sex hormones in tumors of the central nervous system]. [中枢神经系统肿瘤中性激素的特殊受体]。
Revista espanola de oncologia Pub Date : 1984-01-01
J M de Campos Gutiérrez, F Ramos Duce, P A Gómez Lopez, M E Kusak Lambea, J R Boixadós Servat
{"title":"[Specific receptors for sex hormones in tumors of the central nervous system].","authors":"J M de Campos Gutiérrez,&nbsp;F Ramos Duce,&nbsp;P A Gómez Lopez,&nbsp;M E Kusak Lambea,&nbsp;J R Boixadós Servat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hormone sensitivity of some tumors seems to be mediated by the presence of specific receptor proteins, and a correlation seems to exist between the amount of receptor molecules and the behavior of the tumor evolution. Epidemiological data suggest a relation between the steroid sexual hormones and the development of some tumors of the central nervous system (CNS). The authors determine the amount of receptors specific to 17-beta-estradiol and progesterone in several cases of meningioma, glioma, neurinoma and intracerebral metastases. 17-beta-estradiol receptors were always detected, although in very variable amount (3 to 74 fm/mg protein). Progesterone receptors were found in all the studied CNS in women, and only in a few male gliomas, in amounts varying between 3 and 17 fm/mg protein. The significance of hormone receptors in the CNS tumors need further studies to know if they can be applied to prognosis and suggest the assay of a complementary endocrine therapy of CNS tumors.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"289-97"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17603291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gradually diminishing tumor protection caused by reimplants]. [再植引起的肿瘤保护逐渐减弱]。
Revista espanola de oncologia Pub Date : 1984-01-01
L Manuel Piniés, B de las Heras, F M Keenoy, B Esparza, P García
{"title":"[Gradually diminishing tumor protection caused by reimplants].","authors":"L Manuel Piniés,&nbsp;B de las Heras,&nbsp;F M Keenoy,&nbsp;B Esparza,&nbsp;P García","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mice from which a MCA-induced sarcoma has been removed and which are exposed to repeated (every three months) tumoral cell transplants, gradually lose their protection against a certain threshold number of cells. Although the survival period after each transplant is longer than in non-protected animals (those that never received a primary tumor) it is seen that while some of them survive for three months (these are the ones to be re-inoculated with tumoral cells) others die. The proportion of mice which die rises with the number of inoculations received; and among those which die, the proportion of mice without localized tumor or neoplastic dissemination is also progressively higher. We do not know why these mice die at a later and cachectic stage without tumor but in a situation resembling a GVH (graft versus host) reaction. Repeated challenge through re-inoculation induces \"bradyphylaxis\" (progressively diminishing protection). On histopathological examination intense congestion is found, with haemorrhages in the lungs, liver, spleen and kidneys.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"331-7"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17603292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Correlations between PRL and 17-beta-E in human breast cancer]. [PRL与17- β - e在人乳腺癌中的相关性]。
Revista espanola de oncologia Pub Date : 1984-01-01
A Larrad Jiménez, A Ruiz-Tartas, J Zapatero Gaviria, N López Lazareno
{"title":"[Correlations between PRL and 17-beta-E in human breast cancer].","authors":"A Larrad Jiménez,&nbsp;A Ruiz-Tartas,&nbsp;J Zapatero Gaviria,&nbsp;N López Lazareno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors study the correlation existing between prolactin and E-17-beta in breast cancer. In both premenopausal and post-menopausal patients prolactin may be useful as an evolutive marker. Prolactin increases particularly as a consequence of the metastatic growth. E-17-beta shows no variation when studied during the luteal phase, diminishes after the extirpation of the primitive tumor, and augments again with metastases development. After chemotherapy the amount of E-17-beta becomes almost undetectable. No correlation was found between prolactin and E-17-beta; apparently, the prolactin increase does not depend directly from the amount of circulating estradiol, but relies on the activity of the hypothalamic-hypophyseal system. With regard to E-17-beta, this product also augments after ovariectomy, suggesting an ectopic production starting on adrenal gland precursors, perhaps modulated by prolactin.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"279-87"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17606080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cancer immunotherapy]. (癌症免疫疗法)。
Revista espanola de oncologia Pub Date : 1984-01-01
T Hurtado Ruano
{"title":"[Cancer immunotherapy].","authors":"T Hurtado Ruano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A revision of the most promising clinical assays suggest that immunotherapy is useful for a certain number of selected patients. Immunotherapy cannot be used alone for primary treatment of cancer, excepting perhaps as local immunotherapy for readily accessible tumors. The most important role of immunotherapy is to be found in combination with other kinds of therapy, considering that it may restrain effectively hidden micrometastases that are the cause of relapse and fatal outcome. However, it is necessary to recognize that immunotherapy has shown until now a limited therapeutic efficacy.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"359-69"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17603294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New surgical technic for the reconstruction of partial lip defects following tumor resection: the lip hatch flap]. 唇部肿瘤切除后部分缺损重建的新手术技术:唇口瓣。
Revista espanola de oncologia Pub Date : 1984-01-01
A M Gálvez García
{"title":"[New surgical technic for the reconstruction of partial lip defects following tumor resection: the lip hatch flap].","authors":"A M Gálvez García","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This work describes a new surgical procedure to repair the lip defects produced after malignant tumors ablation, consisting in the orbicularis oris muscle flap and its use for a VY plastic.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"503-9"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17603351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronochemotherapy of N-nitrosomethylurea-induced mammary tumors in rats. II. Circadian treatment with cyclophosphamide. n -亚硝基甲基脲诱导大鼠乳腺肿瘤的慢性化疗。2环磷酰胺昼夜治疗。
Revista espanola de oncologia Pub Date : 1984-01-01
F R Pérez-López, V Guillén, J Hergueta, L Lafarga, M Uurcia
{"title":"Chronochemotherapy of N-nitrosomethylurea-induced mammary tumors in rats. II. Circadian treatment with cyclophosphamide.","authors":"F R Pérez-López,&nbsp;V Guillén,&nbsp;J Hergueta,&nbsp;L Lafarga,&nbsp;M Uurcia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chemotherapeutic effectiveness of intraperitoneal administration of cyclophosphamide (CY) (100 mg/kg) was evaluated, on a circadian basis, on the N-nitrosomethylurea (NMU)-induced mammary tumors in female Wistar rats. Untreated rats showed a progressive increase in the mean tumor number/rat, tumor area and total tumor area/rat. The average number of tumors/rat was significantly lower in the rats treated with CY at 02:00 h than the values obtained in the control group days 21 and 28, and than that observed at the end of the 4-week period of study in the rats treated with CY at 20:00 h. Average tumor area and total tumor area/rat in all groups of treated rats were lower than those in the untreated animals, though without significant differences amongst those treated with CY. The body weight remained constant throughout the 4-week period of study in the control group, while a transient reduction was registered after CY administration.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 4","pages":"583-9"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17627993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neuropsychological effects of various cerebral tumors]. [各种脑肿瘤的神经心理学影响]。
Revista espanola de oncologia Pub Date : 1984-01-01
J A Flórez Lozano, F Seijo Fernández, M L Fernández Melcón, B Marín
{"title":"[Neuropsychological effects of various cerebral tumors].","authors":"J A Flórez Lozano,&nbsp;F Seijo Fernández,&nbsp;M L Fernández Melcón,&nbsp;B Marín","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have studied in this work, from the neuropsychological point of view, sixteen patients (9 with tumor in the frontal lobe, 3 with temporal and temporo-parietal tumor and 4 with parietal, occipital and parieto-occipital tumor). The results show an intellectual damage when the work to carry out involves time, visualmotricity and perceptive-visual integration. We have likewise observed the appearance of many disorders of the spatial orientation, the perceptive visual integration, the graphomotricity and the reading process.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 4","pages":"623-30"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17628936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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