F R Pérez-López, M Urcia, R Torralba, L Lafarga, M C Leal, V Guillén, J Hergueta
{"title":"n -亚硝基somethylurea诱导大鼠乳腺癌的时间治疗。1 . 8:00和14:00给药高剂量环磷酰胺的效果。","authors":"F R Pérez-López, M Urcia, R Torralba, L Lafarga, M C Leal, V Guillén, J Hergueta","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"401-7"},"PeriodicalIF":0.0000,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours].\",\"authors\":\"F R Pérez-López, M Urcia, R Torralba, L Lafarga, M C Leal, V Guillén, J Hergueta\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.</p>\",\"PeriodicalId\":77791,\"journal\":{\"name\":\"Revista espanola de oncologia\",\"volume\":\"31 3\",\"pages\":\"401-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista espanola de oncologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de oncologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
n -甲基亚硝基脲致乳腺肿瘤Wistar大鼠腹腔注射环磷酰胺(200mg /kg)死亡率高。上午8点给药比下午2点给药效果更明显下午2点注射环磷酰胺可减缓肿瘤生长，两周后与对照动物相比效果显著，四周后与上午8点注射环磷酰胺的动物相比效果显著
[Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours].
The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.
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