Anais da Academia Brasileira de Ciencias最新文献_第4页

Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability. 聚乳酸-羟基乙酸纳米颗粒包封桉叶提取物：标准化、优化及细胞活力。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241069

Maria C Cely-Garcia, Diana Y Espinel-Pabón, Nancy Jaimes-Mendez, Norman Balcazar-Morales, Edwin A Murillo-Ruiz

{"title":"Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimization and cell viability.","authors":"Maria C Cely-Garcia, Diana Y Espinel-Pabón, Nancy Jaimes-Mendez, Norman Balcazar-Morales, Edwin A Murillo-Ruiz","doi":"10.1590/0001-3765202520241069","DOIUrl":"https://doi.org/10.1590/0001-3765202520241069","url":null,"abstract":"Eucalyptus tereticornis extract is a promising drug for the treatment of type 2 diabetes mellitus and obesity, showing in vitro effects, such as increased glucose uptake and reduced lipid storage. However, its in vivo efficacy has been demonstrated only when administered intraperitoneally. Thus, this study focused on standardisation and optimisation of the preparation of polylactic-co-glycolic acid 50:50 nanoparticles (NPs). The size distribution of the NPs, polydispersity index, and zeta potential were evaluated to identify the NPs with the best encapsulation efficiency and loading capacity based on a first-order design using the response surface methodology. To evaluate cell viability of the NPs, in vitro viability assessments were performed using C2C12, 3T3-L1, HepG2, and J774A.1 cell lines and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The highest encapsulation efficiency and load capacity were 81.569 ± 1.798% and 1.885 ± 0.042%, respectively. These results confirmed the effective encapsulation of Eucalyptus tereticornis extract and the interactions between the components of the system. Finally, none of the evaluated concentrations negatively affected the cell line viability, confirming the reproducibility of the method with great pharmacological potential. In addition, this model can be used to develop nanoformulations that efficiently improve response.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20241069"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in optimized biogas production: synthesis, characterization and use of magnetic iron nanoparticles to enhance the anaerobic digestion process. 优化沼气生产的趋势：磁性铁纳米颗粒的合成、表征和使用，以增强厌氧消化过程。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 DOI: 10.1590/0001-3765202520241057

Jhenifer S Lopes, Wyllerson Evaristo Gomes, Betânia Hoss Lunelli

{"title":"Trends in optimized biogas production: synthesis, characterization and use of magnetic iron nanoparticles to enhance the anaerobic digestion process.","authors":"Jhenifer S Lopes, Wyllerson Evaristo Gomes, Betânia Hoss Lunelli","doi":"10.1590/0001-3765202520241057","DOIUrl":"https://doi.org/10.1590/0001-3765202520241057","url":null,"abstract":"Magnetic iron oxide nanoparticles were investigated for their potential to enhance biogas production through the anaerobic digestion of fruit and vegetable waste. The nanoparticles were synthesized via co-precipitation and characterized using Atomic Force Microscopy (AFM), UV-visible spectroscopy, and Magnetic Force Microscopy (MFM). MFM analysis revealed a magnetic force of -20 nN at a distance of 42 nm from the nanoparticles, with a magnetic gradient extending up to 100 nm in nanoparticle clusters. Anaerobic digestion experiments, conducted in Erlenmeyer flasks, employed a factorial design to optimize conditions such as moisture content, temperature, and inoculum percentage. Results demonstrated that the addition of iron oxide nanoparticles, at 34°C with 7% inoculum and 42% moisture content, led to a 55.53% reduction in substrate residual compared to control tests without nanoparticles. The presence of lactic acid confirmed the occurrence of acidogenesis, while higher concentrations of acetic acid in nanoparticle-enhanced tests suggested an influence on the acetogenesis phase. Additionally, the nanoparticles showed potential as adsorbents. These findings highlight the potential of magnetic iron oxide nanoparticles as an effective and sustainable method for improving biogas production from organic waste, with implications for urban areas and fueling centers seeking alternative, renewable energy solutions.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20241057"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis-Bacteria Interaction: Trends in Secondary Metabolites, Biocontrol, and By-products. 大麻-细菌相互作用：次级代谢物、生物防治和副产物的趋势。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520231335

Paola Alzate, Mónica J Henao-López, Katherin Castro-Ríos, Claudia N Montoya-Estrada

{"title":"Cannabis-Bacteria Interaction: Trends in Secondary Metabolites, Biocontrol, and By-products.","authors":"Paola Alzate, Mónica J Henao-López, Katherin Castro-Ríos, Claudia N Montoya-Estrada","doi":"10.1590/0001-3765202520231335","DOIUrl":"https://doi.org/10.1590/0001-3765202520231335","url":null,"abstract":"In the last decade, the interest in cannabis cultivation has grown significantly, driven by its various applications and the presence of key cannabinoids such as cannabidiol (CBD) and cannabigerol (CBG). However, this increase in production has heightened susceptibility to contaminants, especially microorganisms, such as pathogenic bacteria, which pose risks to both human health and the plant itself. Nonetheless, a promising outlook emerges with the biological utilization of certain bacterial species. This study focused on a bibliometric evaluation of the interaction between Cannabis and bacteria, analyzing research trends related to metabolites, biocontrol, and by-products. To achieve this, scientific literature was reviewed in databases such as Scopus and Web of Science (WOS) from 2000 to 2023. The data was processed and analyzed using methodologies such as \"Tree of Science\" (ToS) and Prisma, using tools like R-Studio and Bibliometrix. The results highlight two predominant areas in this interaction: the application of biotechnology to enhance cultivation and utilize metabolites for medical purposes and the assessment of antibacterial properties in Cannabis extracts and essential oils, along with the use of beneficial bacteria for biocontrol in cannabis plants. Several avenues for future research are proposed, considering identified knowledge gaps.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20231335"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruitment of Polymorphonuclear Myeloid-Derived Suppressor Cells During Cryptococcus neoformans Infection. 新型隐球菌感染过程中多形核髓源性抑制细胞的募集。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240985

Joyce C Guimarães-DE-Oliveira, Israel Diniz-Lima, Idália M Ferreira-Dos-Santos, Elias B DA Silva-Junior, Luciana P Covre, Matheus Freire-DE-Lima, Leonardo M DA Fonseca, Alexandre Morrot, Leonardo Freire-DE-Lima, Lucia Mendonça-Previato, Jose O Previato, Herbert L DE Matos Guedes, Debora Decote-Ricardo, Celio Geraldo Freire-DE-Lima

{"title":"Recruitment of Polymorphonuclear Myeloid-Derived Suppressor Cells During Cryptococcus neoformans Infection.","authors":"Joyce C Guimarães-DE-Oliveira, Israel Diniz-Lima, Idália M Ferreira-Dos-Santos, Elias B DA Silva-Junior, Luciana P Covre, Matheus Freire-DE-Lima, Leonardo M DA Fonseca, Alexandre Morrot, Leonardo Freire-DE-Lima, Lucia Mendonça-Previato, Jose O Previato, Herbert L DE Matos Guedes, Debora Decote-Ricardo, Celio Geraldo Freire-DE-Lima","doi":"10.1590/0001-3765202520240985","DOIUrl":"https://doi.org/10.1590/0001-3765202520240985","url":null,"abstract":"Cryptococcosis is a disease originating in the lungs, often seen in immunosuppressed patients. In severe cases, it can lead to meningoencephalitis and can be fatal. Biochemical studies have shown that the capsule of Cryptococcus neoformans is predominantly composed of glucuronoxylomannan (GXM), with glucuronoxylomannogalactan (GXMGal) present in smaller amounts. These polysaccharides have different effects on the immune system, with GXM mainly having anti-inflammatory properties, while GXMGal is more pro-inflammatory. Myeloid-derived suppressor cells (MDSCs) are a diverse group of immature myeloid cells, including progenitor cells and precursors of macrophages, granulocytes, and dendritic cells at different stages of development. MDSCs are known to suppress immune responses in various diseases, including bacterial and fungal infections, through mechanisms such as the inhibition of T cell proliferation. In this study, we show that infection with either B3501 or CAP67 strains results in the accumulation of granulocytic MDSC precursors in bronchoalveolar cavities. The MDSCs recruited by the B3501 strain suppress T cell proliferation, while those recruited by the CAP67 strain do not. Furthermore, we observed the expression of PD-L1 on these MDSCs, suggesting a potential mechanism of immunosuppression during infection. These findings reveal how the polysaccharides of C. neoformans might weaken the host's immune defense.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240985"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of mechanical and thermal behaviors of dual fibre loaded reinforced vinylester composites. 双纤维负载增强乙烯基复合材料的力学和热性能研究。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 DOI: 10.1590/0001-3765202520240988

Vetrivel Appusamy, Chandrasekaran Sowmya Dhanalakshmi

{"title":"Investigation of mechanical and thermal behaviors of dual fibre loaded reinforced vinylester composites.","authors":"Vetrivel Appusamy, Chandrasekaran Sowmya Dhanalakshmi","doi":"10.1590/0001-3765202520240988","DOIUrl":"https://doi.org/10.1590/0001-3765202520240988","url":null,"abstract":"Due to ecological imbalances and global warming caused by synthetic fibres and petrochemical polymers, researchers are increasingly focusing on the study and fabrication of natural fibre-reinforced polymer composites. To date, no reports have been found on the synergistic effect of abaca and sisal fibre on vinylester (VE). In this research, a novel composite based on VE matrix containing sisal and abaca, ranging from 10 to 30 wt% loadings was developed. After fabrication of different composite samples, their physico-chemical properties were evaluated and examined. The results indicated that the dual fibre loaded vinyl ester composite with 30 wt% revealed maximum mechanical strength (29 MPa) compared to the pure VE (6 MPa). Similarly, the values of flexural (855 MPa), impact (10.77 kJ/mm2) and hardness strengths (86 HRB) of 30 wt% dual fibre loadings were increased compared to the neat VE (Flexural - 238 MPa, Impact - 6 kJ/mm2, Hardness - 9 HRB). The thermogravimetric analysis (TGA) depicted that the addition of sisal and abaca fibre decreases the initial onset degradation temperature of VE, respectively, but their weight residues were higher than those of pure VE indicating higher thermal stability. Further, the water absorption studies depicted decreased moisture absorption for the developed VE composites containing sisal and abaca fibre. Hence, the enhanced physico-chemical properties of newly developed composites were suitable for various applications ranging from aerospace to sports equipment.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240988"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coculturing Streptomyces sp. with Acanthamoeba polyphaga enhances the antimicrobial effectiveness of its crude extract against multidrug-resistant Pseudomonas aeruginosa and Escherichia coli. 链霉菌与多食棘阿米巴共培养可提高其粗提物对多重耐药铜绿假单胞菌和大肠杆菌的抑菌效果。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240655

Keli C C Barroso, Veridiana G Virginio, Beni J M Chaúque, Vinicius J Maschio, Sueli T VAN DER Sand, Marilise B Rott

{"title":"Coculturing Streptomyces sp. with Acanthamoeba polyphaga enhances the antimicrobial effectiveness of its crude extract against multidrug-resistant Pseudomonas aeruginosa and Escherichia coli.","authors":"Keli C C Barroso, Veridiana G Virginio, Beni J M Chaúque, Vinicius J Maschio, Sueli T VAN DER Sand, Marilise B Rott","doi":"10.1590/0001-3765202520240655","DOIUrl":"https://doi.org/10.1590/0001-3765202520240655","url":null,"abstract":"Bacterial infections stand as prominent contributors to global mortality and morbidity rates. Harnessing the potential antimicrobial activity of secondary metabolites derived from natural sources holds promise for developing novel therapeutic drugs. Streptomyces spp. represents pivotal microorganisms in the synthesis of these compounds. Acanthamoeba spp. serves as natural virulence amplifiers for a wide range of bacterial pathogens. This study evaluates the antimicrobial efficacy of crude extracts of Streptomyces sp. cocultured trials with Acanthamoeba polyphaga against multidrug-resistant Pseudomonas aeruginosa and Escherichia coli. The production of crude extracts from Streptomyces sp. was monitored over 28 days. The antimicrobial activity against P. aeruginosa and E. coli was evaluated by measuring the inhibitory halos. Viability amoebae and bacteria were assessed. A slight decrease in the viability of A. polyphaga was noted during the coculture. Conversely, coculture promoted bacterial growth and facilitated the synthesis of extracts that showed antimicrobial effects against P. aeruginosa and E. coli, while showing no impact on amoebae. The extracts were active mainly against P. aeruginosa. The findings show that the interaction between A. polyphaga and Streptomyces sp. modulates the production of antimicrobial secondary metabolites by bacteria. Further investigations are needed to characterize the nature of this modulation, and the bactericidal components.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240655"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titanite U-Pb dating by LA-Quadrupole-ICP-MS: analytical procedures and applications to Rhyacian metamorphic rocks of the Southeastern Guiana Shield. la -四极柱- icp - ms测定钛矿U-Pb年龄：分析方法及其在圭亚那东南部盾构纹变质岩中的应用

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 DOI: 10.1590/0001-3765202520240831

João Alberto E Pinto, Jean Michel Lafon, João M Milhomem Neto, Kei Sato

{"title":"Titanite U-Pb dating by LA-Quadrupole-ICP-MS: analytical procedures and applications to Rhyacian metamorphic rocks of the Southeastern Guiana Shield.","authors":"João Alberto E Pinto, Jean Michel Lafon, João M Milhomem Neto, Kei Sato","doi":"10.1590/0001-3765202520240831","DOIUrl":"https://doi.org/10.1590/0001-3765202520240831","url":null,"abstract":"We present a comprehensive set of LA-Q-ICP-MS U-Pb ages on titanite standards (Tory Hill, Khan, Mud Tank, and CKHB titanites) together with samples from the Southeastern Guiana Shield, as a geological application of the method implemented at the Pará-Iso Laboratory. The results showed good reproducibility, accuracy, and precision for Mesoproterozoic to Mesozoic titanite standards, with uncertainties below 2%. The analytical protocol was validated through interlaboratory calibration with SHRIMP IIe dating, yielding ages consistent with LA-Q-ICP-MS results. Khan titanite were the most suitable primary standard due to its low common Pb content, high analytical signal, and homogeneous U-Pb radiogenic ratios. Distinct ages were observed for Tory Hill titanite and for a selected sample based on different common Pb-correction approaches, with the 204Pb correction being less effective than the 207Pb method. New titanite U-Pb ages identified a late orogenic metamorphic event around 2.05 Ga recorded in an orthogneiss of the Neoarchean Guianense Complex and a collisional metamorphic event around 2.11-2.10 Ga in two samples located at the frontier between the French Guiana and Amapá state. Both linked to the Transamazonian geodynamic evolution of the Southeastern Guiana Shield during the late Rhyacian.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240831"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the past to protect the future: an analysis of conservation paleobiology in South America. 探索过去保护未来：对南美洲保护古生物学的分析。

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 DOI: 10.1590/0001-3765202520240641

Anna Clara A DE Assumpção, Matias N Ritter

{"title":"Exploring the past to protect the future: an analysis of conservation paleobiology in South America.","authors":"Anna Clara A DE Assumpção, Matias N Ritter","doi":"10.1590/0001-3765202520240641","DOIUrl":"https://doi.org/10.1590/0001-3765202520240641","url":null,"abstract":"Conservation paleobiology, an expanding field, employs taphonomy tools to investigate past environmental conditions and organisms before human impacts, thereby addressing key conservation issues. This review examines the concepts, approaches and events in conservation paleobiology, emphasizing aquatic and coastal organisms and the often-overlooked contributions from Brazil and South America. South America, with its vulnerable biodiversity, unique geology and rich fossil diversity, is a natural laboratory for understanding ecosystems-a considerable potential as a center for leading conservation paleobiology research. However, South America is underrepresented, contributing to only 5% of total publications (67% of it is from Brazil). Most South American authors are geoscientists publishing mainly on mollusks, also they produced fewer studies than those from more developed countries. Noteworthy, the Brazilian National Council for Scientific and Technological Development ranks third globally in funding for conservation paleobiology articles. Clearly, conservation paleobiology is still predominantly practiced in developed nations and geoscience fields. Other challenges include underutilization of geohistorical data and a gap between theory and practice. To address these issues, future studies should integrate conservationist perspectives and align them with societal and conservation needs. Hence, the anticipated growth in South American conservation paleobiology could bolster environmental conservation and promote sustainability for future generations.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240641"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer. 血清miR-21和miR-145在卵巢癌中的预后意义及治疗结果预测

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-14 DOI: 10.1590/0001-3765202520240565

Shulin Zhong, Weiquan Wu, Yuzhen Liang, Zhixi Wu

{"title":"Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer.","authors":"Shulin Zhong, Weiquan Wu, Yuzhen Liang, Zhixi Wu","doi":"10.1590/0001-3765202520240565","DOIUrl":"https://doi.org/10.1590/0001-3765202520240565","url":null,"abstract":"This study investigated the diagnostic value of serum microRNA-21 (miR-21) and miR-145 in assessing the treatment response and prognosis of ovarian cancer patients. A total of 139 patients enrolled in this study were categorized based on their chemotherapy outcomes into three groups: partial response, stable disease, and disease progression. Significant differences in serum levels of miR-21 and miR-145 among these groups were observed. Specifically, elevated miR-21 and reduced miR-145 levels were associated with worse treatment outcomes and poorer prognoses. Multivariate logistic regression analysis identified miR-21 and miR-145, along with age, tumor stage, and lymph node metastasis, as independent predictors of patient outcomes. The receiver operating curve (ROC) analysis indicated that the combination of miR-21 and miR-145 provided higher accuracy in predicting patient prognosis compared to each biomarker alone. The findings suggest that miR-21 and miR-145 can be effective supplementary tools for evaluating treatment effectiveness and prognostic assessments in ovarian cancer patients.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240565"},"PeriodicalIF":1.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency and method of seeking for information about COVID-19 and its relationship with psychological symptoms and stress levels. COVID-19信息查询频率和方法及其与心理症状和压力水平的关系

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520231050

Lucas C Pedro, Jessica L Fernandes, Camila O Arent, Joseane Nazário, Ritele H Silva, Graziela Amboni, Caion A Rodrigues, Daniela Pizoni, Marcela M F DE Leo, Zuleide Maria Ignácio, Taiane A Cardoso, Renan A Ceretta, Luciane B Ceretta, Gislaine Z Réus

{"title":"Frequency and method of seeking for information about COVID-19 and its relationship with psychological symptoms and stress levels.","authors":"Lucas C Pedro, Jessica L Fernandes, Camila O Arent, Joseane Nazário, Ritele H Silva, Graziela Amboni, Caion A Rodrigues, Daniela Pizoni, Marcela M F DE Leo, Zuleide Maria Ignácio, Taiane A Cardoso, Renan A Ceretta, Luciane B Ceretta, Gislaine Z Réus","doi":"10.1590/0001-3765202520231050","DOIUrl":"https://doi.org/10.1590/0001-3765202520231050","url":null,"abstract":"Elevated search for information could increase rumors and misinformation, which significantly impacted the daily lives and mental health of individuals. We tested the association between the frequency and methods of communication used and psychological symptoms. Cross-sectional study that included individuals with COVID-19 and individuals without the disease. Participants completed a questionnaire about the frequency with which were informed about COVID-19. The severity of depressive and anxious symptoms, and stress levels were assessed. The sample included 350 individuals (66% female, mean age 38.09 ± 14.18 years), and 32.6% had a confirmed COVID-19 diagnosis. Most of the sample was informed about COVID-19 almost always or always and the most common method used to search for information was the internet, followed by open TV, social media, WhatsApp, cable TV, radio, and newspaper. Individuals who sought information on social media had greater severity of depressive symptoms when compared to subjects who did not seek information on the media. Individuals who sought information via WhatsApp had lower anxiety symptoms and stress levels when compared to individuals who did not seek information via WhatsApp. The search for information had a negative impact on depressive symptoms and a decrease in anxiety symptoms.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20231050"},"PeriodicalIF":1.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0