Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae.

IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES
Anais da Academia Brasileira de Ciencias Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI:10.1590/0001-3765202520240842
Eduardo José DE Arruda, Cícera Maria DA Silva, Alessandra R Lima, Glenda B Porzani, Monize M DA Silva, Cláudio T DE Carvalho, Isaías Cabrini, Magda F Fernandes
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引用次数: 0

Abstract

The larval control of Aedes aegypti has been done mainly by insecticides, which cause resistance and environmental contamination and have a high-cost development and application. The need for alternative solutions to problems caused by synthetic insecticides has led to studies to find new, active, and less toxic compounds, such as metallo-insecticides. In the present study, the toxic activity of Cu(II) - complexes with the amino acids tryptophan, histidine, methionine, and taurine in Ae. aegypti larvae were evaluated. The Cu(II) - histidine complex showed no toxicity. For the Cu(II) - tryptophan and Cu(II) - methionine complexes, the mortality percentages ranged from 3.16% to 46.55% and 5.46% to 12.42%, respectively. Cu(II) - taurine presented 100% mortality in 24 h at the lowest concentration tested (50 mg L-1, ppm). Considering the concentration range of 50 to 1000 mg L-1 and 24 h of exposure of the larvae to the metal complexes, the series of decreasing toxicity is Cu(II) - taurine > Cu(II) - tryptophan > Cu(II) - methionine > Cu(II) - histidine. From these studies, the Cu (II) - taurine complex can be a candidate to be used as an alternative and less toxic insecticide, low-cost for control of Ae.aegypti larvae.

铜(II)金属配合物与氨基酸配体的毒性:对埃及伊蚊幼虫的活性研究。
埃及伊蚊的幼虫控制主要是通过杀虫剂进行的,但杀虫剂造成抗药性和环境污染,开发和应用成本高。对合成杀虫剂引起的问题的替代解决方案的需要导致了寻找新的、有效的、毒性较小的化合物的研究,例如金属杀虫剂。在本研究中,铜(II) -配合物与Ae中氨基酸色氨酸、组氨酸、蛋氨酸和牛磺酸的毒性活性。对埃及伊蚊幼虫进行评价。Cu(II) -组氨酸复合物无毒性。铜(II) -色氨酸复合物和铜(II) -蛋氨酸复合物的死亡率分别为3.16% ~ 46.55%和5.46% ~ 12.42%。Cu(II) -牛磺酸在最低浓度(50 mg L-1, ppm)下24 h死亡率为100%。在50 ~ 1000 mg L-1的浓度范围和24 h的金属配合物暴露条件下,其毒性递减序列为Cu(II) -牛磺酸> Cu(II) -色氨酸> Cu(II) -蛋氨酸> Cu(II) -组氨酸。从这些研究中,Cu (II) -牛磺酸络合物可以作为一种低毒性、低成本的替代杀虫剂用于控制伊蚊。蚊幼虫。
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来源期刊
Anais da Academia Brasileira de Ciencias
Anais da Academia Brasileira de Ciencias 综合性期刊-综合性期刊
CiteScore
2.20
自引率
0.00%
发文量
347
审稿时长
1 months
期刊介绍: The Brazilian Academy of Sciences (BAS) publishes its journal, Annals of the Brazilian Academy of Sciences (AABC, in its Brazilianportuguese acronym ), every 3 months, being the oldest journal in Brazil with conkinuous distribukion, daking back to 1929. This scienkihic journal aims to publish the advances in scienkihic research from both Brazilian and foreigner scienkists, who work in the main research centers in the whole world, always looking for excellence. Essenkially a mulkidisciplinary journal, the AABC cover, with both reviews and original researches, the diverse areas represented in the Academy, such as Biology, Physics, Biomedical Sciences, Chemistry, Agrarian Sciences, Engineering, Mathemakics, Social, Health and Earth Sciences.
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