Anais da Academia Brasileira de Ciencias最新文献_第3页

Systematic investigation of phenolic compounds distribution in Libidibia ferrea (ironwood) seedling, using metabolomics and histochemical techniques.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240635

Seidel F Dos Santos, Ianara Tamyres F Borges, Ana Carla Feio, Alberdan S Santos

{"title":"Systematic investigation of phenolic compounds distribution in Libidibia ferrea (ironwood) seedling, using metabolomics and histochemical techniques.","authors":"Seidel F Dos Santos, Ianara Tamyres F Borges, Ana Carla Feio, Alberdan S Santos","doi":"10.1590/0001-3765202520240635","DOIUrl":"https://doi.org/10.1590/0001-3765202520240635","url":null,"abstract":"Ironwood (Libidibia ferrea) is cultivated and widely used due to its medicinal properties attributed especially to phenolic compounds. In the seedling stage, different environmental conditions influence the synthesis, composition, and accumulation of bioactive compounds in different ways, mainly under water stress. Thus, given the wide distribution, this study aimed to analyze the occurrence and distribution of phenolic compounds in L. ferrea seedling for three different states/climate typologies: Pará/Af, Amazonas/Am, and Maranhão/Aw. Gas chromatography-mass spectrometry (GC-MS) and plantlet histochemistry were applied to determine the phenolic compounds distribution present in the extracts of leaflets and roots, respectively. Three different metabolic profiles were described, of which Pará/Af and Maranhão/Aw were similar, while Amazonas/Am showed quantitative differences in the composition. Among the main phenolic compounds were found gallic acid, ferulic acid, and caffeic acid, and presented different concentrations according to origin. The only phenolic compound found for all origins was gallic acid. Therefore, it was demonstrated that the chemical profile of phenolic compounds is conserved in L. ferrea, and significant variations were not observed, which ensures the use of this species regardless of origin.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240635"},"PeriodicalIF":1.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 - an interesting year for the Annals of the Brazilian Academy of Sciences.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-24 DOI: 10.1590/0001-376520259701

Alexander W A Kellner

引用次数: 0

Extraction of phenolic compounds from Pfaffia glomerata leaves and evaluation of composition, antioxidant and antibacterial properties.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240317

Larissa Millena Girotto, Suelen P R Herrig, Maria Graciela I F Nunes, Otavio A Sakai, Beatriz C B Barros

{"title":"Extraction of phenolic compounds from Pfaffia glomerata leaves and evaluation of composition, antioxidant and antibacterial properties.","authors":"Larissa Millena Girotto, Suelen P R Herrig, Maria Graciela I F Nunes, Otavio A Sakai, Beatriz C B Barros","doi":"10.1590/0001-3765202520240317","DOIUrl":"https://doi.org/10.1590/0001-3765202520240317","url":null,"abstract":"This work aimed to evaluate the extraction conditions of total phenolic compounds (TPC) from Pfaffia glomerata leaves (PGLs) and characterize the extract obtained in the best conditions. Aqueous extraction was performed in a Shaker, varying the levels of rotation (100, 150, 200 rpm), temperature (30, 45, 60° C) and mass to volume (w v-1) ratio (1:10, 1:20, 1:30 g ml-1). The variables w v-1 ratio and temperature, and their combination, showed a positive effect (p<0.05) in TPC extraction. The time of extraction increased TPC extraction until 30 min, thereafter, the values decreased. The extraction performed at 60o C, 1:30 g ml-1, 125 rpm and 30 min allowed to reach the maximum TPC content (11.94 mg g-1). This extract contains β-ecdysone (4.64 g 100g-1), a chemical marker of P. glomerata, and, phenolic compounds, as gallic acid (28.51 mg 100g-1) and catechin (24.82 mg 100g-1). PGLs extract exhibits antioxidant activity by the in vitro methods evaluated (iron reduction powder and radical scavenging ability). Antibacterial activity was also detected, being found the minimum inhibitory concentration of 20 mg mL-1 for Escherichia coli and Pseudomonas aeruginosa. Therefore, PGL extract had a potential application as natural antioxidant and antimicrobial in food or pharmaceutical products.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 2","pages":"e20240317"},"PeriodicalIF":1.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the physicochemical, bioactive properties and antioxidant potential of seeds of native fruits from Brazil: a study on the tucumã (Astrocaryum vulgare), bacupari (Garcinia gardneriana) and pupunha (Bactris gasipaes).

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240862

Larissa S Gualberto, Andréia Ibiapina, Bianca B Dias, Bárbara C B DE Freitas, Antônio A DE Melo Filho, Rômulo A Morais, Glêndara A S Martins

{"title":"Investigation of the physicochemical, bioactive properties and antioxidant potential of seeds of native fruits from Brazil: a study on the tucumã (Astrocaryum vulgare), bacupari (Garcinia gardneriana) and pupunha (Bactris gasipaes).","authors":"Larissa S Gualberto, Andréia Ibiapina, Bianca B Dias, Bárbara C B DE Freitas, Antônio A DE Melo Filho, Rômulo A Morais, Glêndara A S Martins","doi":"10.1590/0001-3765202520240862","DOIUrl":"https://doi.org/10.1590/0001-3765202520240862","url":null,"abstract":"The seeds of bacupari, tucumã, and peach palm fruits have distinct characteristics that significantly influence their industrial applications and nutritional value. These seeds have slightly acidic pH levels (5.88 - 6.79), indicating the presence of organic acids. The tucumã seed, for instance, stands out with a high lipid content of 19.35 g 100 g-1, contributing to a high energy value, while the bacupari seed has low lipid levels (0.73 g 100 g-1). Bacupari seeds exhibit high antioxidant potential using the β-carotene/linoleic acid method (244% inhibition) and vitamin C (91.17 mg AA 100 g-1). There were significant variations in phenolic compounds and antioxidant capacity among the seeds analyzed. The fatty acid profile, with a predominance of saturated acids, 90.42 and 88.66%, for tucumã and peach palm oil, respectively. However, the high atherogenicity and thrombogenicity rates suggest caution in consumption. The analysis of triacylglycerol molecules in pupunha and tucumã seeds demonstrated the predominance of mono-, di- and triacylglycerols. When analyzing the acidity index throughout the storage period, a clear trend towards an increase in its results is observed. Therefore, proposing control measures is essential for its correct use.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240862"},"PeriodicalIF":1.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal diabetes on fetal endocrine pancreas development in rats.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240807

Isabela L Iessi, Bruna Dallaqua, Yuri K Sinzato, Franciane Q Gallego, Jens H Nielsen, Gustavo T Volpato, José E Corrente, Débora C Damasceno

{"title":"Maternal diabetes on fetal endocrine pancreas development in rats.","authors":"Isabela L Iessi, Bruna Dallaqua, Yuri K Sinzato, Franciane Q Gallego, Jens H Nielsen, Gustavo T Volpato, José E Corrente, Débora C Damasceno","doi":"10.1590/0001-3765202520240807","DOIUrl":"https://doi.org/10.1590/0001-3765202520240807","url":null,"abstract":"To evaluate if an unfavorable maternal environment induced by hyperglycemia, hypoxia, and oxidative stress status impairs the morphological development of pancreatic islets in the fetuses on days 18 and 21 of pregnancy. Wistar rats were injected with streptozotocin for diabetes induction. At adulthood (3 months), all animals underwent an oral glucose tolerance test (OGTT) for glucose assessment as an inclusion criterion. Following, the animals were mated. On day 18 and 21 of pregnancy, the mothers were killed for blood biochemical data and, fetal pancreas was collected for immunohistochemical analysis. On the GD18/21, the diabetic (D) dams showed higher glycemia, erythropoietin and TBARS levels, and a disorganized cell distribution in fetal pancreatic islets compared to control (C) rat mothers. The fetal endocrine pancreas of D dams presented a higher ratio of insulin-stained cells on GD18. No difference in the immunostaining for PDX-1 was observed. Fetuses of D dams showed a lower ratio of cells immunostained for Ki-67 in GD18 and greater cell proliferation in GD21. At the GD21, the D group showed a higher ratio of cells undergoing apoptosis. Maternal hyperglycemia impairs fetal pancreatic islet structure, which causes functional changes contributing to fetal hyperglycemia at birth.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240807"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory effect of trans-anethole in acute inflammation: involvement of macrophage-derived mediators.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520231288

Edson L Ponte, Alana F Pires, Diego F Araujo, Timna V Martins, Renata Gorjão, Gilson M Murata, Pedro Marcos G Soares, Rui Curi, Ana Maria S Assreuy

{"title":"Inhibitory effect of trans-anethole in acute inflammation: involvement of macrophage-derived mediators.","authors":"Edson L Ponte, Alana F Pires, Diego F Araujo, Timna V Martins, Renata Gorjão, Gilson M Murata, Pedro Marcos G Soares, Rui Curi, Ana Maria S Assreuy","doi":"10.1590/0001-3765202520231288","DOIUrl":"https://doi.org/10.1590/0001-3765202520231288","url":null,"abstract":"This study investigated in vivo and in vitro the trans-anethole anti-inflammatory activity on vascular and cell events and the involvement of inflammatory mediators. In vivo Wistar male rats (180 - 200 g; n=6/group) received trans-anethole per oral and the anti-inflammatory activity was assessed on the models of paw edema, peritonitis and air pouch. In vitro, peritoneal macrophages were incubated with trans-anethole to evaluate cytotoxicity, cytokines and reactive oxygen species (ROS) stimulated by phorbol myristate acetate (PMA). In vivo trans-anethole (1 mg/kg) inhibited: edema (42%), vascular permeability (58%), migration of total leukocytes (50%) and neutrophils (42%), IL-1β (75%), IL-6 (61%), macrophage inflammatory protein-MIP-3α (64%), NO2 -/NO3 - (35%), malondialdehyde (MDA) and histological alterations induced by carrageenan. Trans-anethole (25 μM) also inhibited polymorphonuclear migration (90%), MIP-3α (83%) and TNF-α (60%) challenged by LPS. In vitro trans-anethole (10 - 50 μM) increased IL-6 per se and reduced inflammatory mediators released by macrophages: TNF-α (up to 80%) and IL-1β (up to 81%) challenged by LPS, and ROS (up to 43%) by PMA, without causing cytotoxicity. In conclusion, trans-anethole has anti-inflammatory effects on vascular and cellular events of acute inflammation via inhibition of cytokines and free radicals produced by macrophages.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20231288"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An institutional COVID-19 initiative: creation of a biobank and serological data analysis in pre- and post-vaccination cohorts.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240819

Lorena O Fernandes-Siqueira, Raphael R A Melo, Luciana S Wermelinger, Fabio C L Almeida, Didier Salmon, Gustavo C Ferreira, Andrea T DA Poian

{"title":"An institutional COVID-19 initiative: creation of a biobank and serological data analysis in pre- and post-vaccination cohorts.","authors":"Lorena O Fernandes-Siqueira, Raphael R A Melo, Luciana S Wermelinger, Fabio C L Almeida, Didier Salmon, Gustavo C Ferreira, Andrea T DA Poian","doi":"10.1590/0001-3765202520240819","DOIUrl":"https://doi.org/10.1590/0001-3765202520240819","url":null,"abstract":"The COVID-19 pandemic has left a legacy in the management of health emergencies, but sentinel surveillance was relatively underused, despite its significant role in decision-making during epidemics. Here we describe a sentinel surveillance for anti-SARS-CoV-2 serology carried out on a cohort of 395 individuals at a Brazilian institution, from October 2020 to December 2022. A total of 1,507 serum samples were analyzed for IgG and IgA against SARS-CoV-2 Spike (S) or nucleocapsid (N) proteins, in the pre- and post-vaccination periods. The latter included two doses of CoronaVac (group 1, G1), or ChAdOx-1 or BNT162b2 (group 2, G2), followed by heterologous booster doses. In the pre-vaccination phase, 26.5% of the participants showed IgG reactivity for S and 13.7% for N. After the vaccines' first dose, S IgG response was positive in 66.6% or 98% of G1 or G2 participants, respectively, whereas 100% of the participants showed S IgG positivity after the second dose, and S IgG and IgA after the booster. This initiative enabled the examination of viral transmission beyond hospital environments, which has rarely been explored, and established protocols for managing future emergencies. In addition, a serum bank and a comprehensive database are now available to the scientific community.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240819"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of wireless web-based multiplatform system for thermal environmental control of broiler facilities using fuzzy set theory.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240032

Cosme Teixeira DA Silva, Tadayuki Yanagi Junior, Raphael Winckler DE Bettio, Marcelo Bahuti

{"title":"Design of wireless web-based multiplatform system for thermal environmental control of broiler facilities using fuzzy set theory.","authors":"Cosme Teixeira DA Silva, Tadayuki Yanagi Junior, Raphael Winckler DE Bettio, Marcelo Bahuti","doi":"10.1590/0001-3765202520240032","DOIUrl":"https://doi.org/10.1590/0001-3765202520240032","url":null,"abstract":"The control and monitoring process for broiler facilities needs to be improved to mitigate or eliminate birds' thermal stress. Thus, the objective was to develop of a fuzzy controller embedded in a microcontroller and a multiplatform web application that communicates with the fuzzy controller to control the aviary climate system. An architecture based on the Internet of Things (IoT) and agribusiness 4.0 was used to implement a fuzzy controller embedded in a microcontroller. Data were collected by temperature and humidity sensors. A multiplatform web application communicated the climate system to the fuzzy controller. This information was transmitted to the central web server via message queuing telemetry transport (MQTT). The system performed decision-making to control the aviary thermal environment of broilers ranging from one to 49 days old. The input variables of the system were the black globe-humidity index (BGHI) and the bird age. Defuzzification by the center of gravity method produced environmental ratings that were used to control the thermal environment automatically and smartly. Using the intelligent prototype produced a 98% accuracy in the validation process. This low-cost system can be used as an agribusiness 4.0 application to mitigate thermal stress conditions in aviaries and, consequently, reduce productivity losses.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240032"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, preparation, and characterization of bovine papillomavirus chitosan-based nanoparticles as a prototype for a bovine papillomatosis vaccine.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241155

Raquel Andressa Brito, Carla A Silva, Andre C Amaral

{"title":"Design, preparation, and characterization of bovine papillomavirus chitosan-based nanoparticles as a prototype for a bovine papillomatosis vaccine.","authors":"Raquel Andressa Brito, Carla A Silva, Andre C Amaral","doi":"10.1590/0001-3765202520241155","DOIUrl":"https://doi.org/10.1590/0001-3765202520241155","url":null,"abstract":"The bovine papillomavirus (BPV) is known to cause lesions in the epithelial tissue of cattle, which causes bovine papillomatoses. This disease is characterized by wart lesions in different body parts, causing losses in the animal value. Despite the economic impact, there are no effective vaccines available at this moment. The present study aims to develop a nanoformulated autogenous vaccine using the inactivated virus present in warts to control the diseases associated with BPV. To this end, papillomavirus was collected from infected bovines on a farm in Goiás, Brazil. The warts containing the viruses were macerated to obtain the inactivated viruses to be formulated within chitosan nanoparticles. The chitosan nanoparticles containing the inactivated viruses presented 330.7 nm in size, a polydispersity index of 0.41, and a positive Zeta potential of 38.2 mV. The association efficiency was 58.3%. The nanoparticles containing the inactivated virus were stable for up to 30 days and presented no hemolysis toxicity. This could be an interesting approach to develop a vaccine to protect bovines from BPV infection.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20241155"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental contamination and male reproductive health: (ir) reversible effects in child- and adulthood.

IF 1.1 4区综合性期刊

Anais da Academia Brasileira de Ciencias Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240717

Carine Dahl Corcini, Antonio Sergio Varela Junior, Marc Yeste

{"title":"Environmental contamination and male reproductive health: (ir) reversible effects in child- and adulthood.","authors":"Carine Dahl Corcini, Antonio Sergio Varela Junior, Marc Yeste","doi":"10.1590/0001-3765202520240717","DOIUrl":"https://doi.org/10.1590/0001-3765202520240717","url":null,"abstract":"Infertility affects 10-15% of reproductive-age couples, with causes ranging from genetic factors to unidentified reasons. Environmental conditions, particularly pollutants, play a significant role in male fertility. Yet, public health policies often overlook reproductive health, despite mounting evidence of pollutants' detrimental repercussion. Understanding this impact is crucial to prevent the effects of dangerous exposure, especially given the high levels of environmental pollutants in today's world. Most of the previous research about the adverse effects from contaminants has been conducted in rodents, with limited human epidemiological research. This article reviews the evidence about the impact of various contaminants (air pollutants, water contaminants, pesticides, herbicides, radiation, heavy metals, and plastics) on male reproductive health, particularly sperm quality and fertility. The literature suggests that exposure to contaminants during fetal development and childhood has irreversible effects, while those of adult exposure are often reversible. These findings highlight the need to alert society about reproductive health threats from certain contaminants. Public authorities should consider this situation when designing health plans, and individuals envisaging fatherhood should be aware of these risks.","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 1","pages":"e20240717"},"PeriodicalIF":1.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0