Anais da Academia Brasileira de Ciencias最新文献

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Identification and antimicrobial resistance profile of Enterobacterales and Staphylococcus spp. isolated from subclinical mastitis milk. 亚临床乳腺炎乳分离肠杆菌和葡萄球菌的鉴定及耐药性分析。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241287
Juliana S Alves, Rossiane M Souza, Jeniffer F Miranda, Guilherme C L DA Silva, Jéssica P L Moreira, Alice G M Gonzalez
{"title":"Identification and antimicrobial resistance profile of Enterobacterales and Staphylococcus spp. isolated from subclinical mastitis milk.","authors":"Juliana S Alves, Rossiane M Souza, Jeniffer F Miranda, Guilherme C L DA Silva, Jéssica P L Moreira, Alice G M Gonzalez","doi":"10.1590/0001-3765202520241287","DOIUrl":"https://doi.org/10.1590/0001-3765202520241287","url":null,"abstract":"<p><p>This study aimed to identify and evaluate the antimicrobial resistance profile of Enterobacterales and <italic>Staphylococcus</italic> spp. isolated from raw milk samples from mammary quarters with subclinical mastitis (SCM), from three small dairy farms suppliers of raw milk for cheese production, in Rio de Janeiro state. Raw milk from each mammary quarter was investigated for signs of SCM using the California Mastitis Test (CMT). Raw milk with signs of SCM (SCMM) was seeded on Compact-Dry EC and Compact Dry X-SA. The strains were identified by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) and evaluated for antimicrobial resistance, by disk diffusion test. SCM was observed in 13 (8.02%) mammary quarters from farm A, 24 (25%) from farm B and 7 (7.95%) from farm C. <italic>Staphylococcus aureus</italic> was the most isolated on farms A (55.56%) and B (75.00%). <italic>Enterobacter roggenkampii</italic> was isolated for the first time from SCMM, being the most prevalent specie on farm C (50.00%). Methicillin-resistant <italic>Staphylococcus aureus</italic> (MRSA) and Methicillin-resistant <italic>Staphylococcus chromogenes</italic> (MRS)<italic> </italic>were isolated from SCMM from farms A and B. The health of the dairy herd requires great attention, mainly reflected in the control of MRSA/MRS.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20241287"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First report of pterosaur remains from the Lower Cretaceous Quiricó Formation, São Francisco Basin (Minas Gerais), Brazil. 巴西<s:1>奥弗朗西斯科盆地(米纳斯吉拉斯州)下白垩纪Quiricó组翼龙化石的首次报告。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241140
Flávia Sibele F Fialho, Rodrigo M Santucci, Mariana S Gomes, Dermeval A DO Carmo
{"title":"First report of pterosaur remains from the Lower Cretaceous Quiricó Formation, São Francisco Basin (Minas Gerais), Brazil.","authors":"Flávia Sibele F Fialho, Rodrigo M Santucci, Mariana S Gomes, Dermeval A DO Carmo","doi":"10.1590/0001-3765202520241140","DOIUrl":"https://doi.org/10.1590/0001-3765202520241140","url":null,"abstract":"<p><p>The record of pterosaur fossils in Brazil is significant, however, it remains limited to a few sedimentary basins from the Cretaceous period. This study describes an isolated pterosaur tooth assigned to Ornithocheiriformes, collected from the Quiricó Formation, São Francisco Basin, Early Cretaceous (Aptian), of Minas Gerais State. The tooth was found in association with fossil plants and articulate gonorynchiform fishes. The tooth has a narrow elliptical cross-section, with marked mesial and distal carinae bearing no denticles. In lateral view, the tooth is triangular, being slightly curved lingually. The enamel is thin with no striations. These features, coupled with the Lower Cretaceous age of the deposits it was found, suggest the tooth belongs to an ornithocheiriform pterosaur. This finding represents the first report of pterosaur material from the São Francisco Basin and fills a geographical gap when previous records of ornithocheiriforms in Brazil are considered (Araripe, Bauru, Grajaú, and Recôncavo basins), suggesting a broader distribution of these flying archosaurs in Brazil. Also, this new ornithocheiriform record in the São Francisco Basin strengthen the similarity of its vertebrate fauna to the vertebrates found in Kem Kem Beds in Morocco.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97Suppl. 1 Suppl. 1","pages":"e20241140"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testate amoebae (Arcellinida and Euglyphida) from the state of Bahia: a synthesis of 108 years of scientific discoveries and contributions. 巴伊亚州的遗属变形虫(阿塞利亚目和尤格菲亚目):108年科学发现和贡献的综合。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241421
Márcio B DA Silva, Barbara S Louzada, Simone S Silva, Milena S Cardoso, Valéria P Alves, Marianni N Simas, Ana Clara L R Ribeiro, Ricardo E Fraga, Sylvia Maria M S Ribeiro, Mariane A Rocha
{"title":"Testate amoebae (Arcellinida and Euglyphida) from the state of Bahia: a synthesis of 108 years of scientific discoveries and contributions.","authors":"Márcio B DA Silva, Barbara S Louzada, Simone S Silva, Milena S Cardoso, Valéria P Alves, Marianni N Simas, Ana Clara L R Ribeiro, Ricardo E Fraga, Sylvia Maria M S Ribeiro, Mariane A Rocha","doi":"10.1590/0001-3765202520241421","DOIUrl":"10.1590/0001-3765202520241421","url":null,"abstract":"<p><p>Testate amoebae are widely distributed organisms, playing essential roles in several aquatic and terrestrial ecosystems. This study presents an overview of the biodiversity of Testate amoebae (Arcellinida and Euglyphida) in the state of Bahia, Brazil, over the last 108 years, based on unpublished data and information from the literature. The records covered 19 municipalities and seven river basins. A total of 172 infrageneric <italic>taxa</italic> were identified, with Difflugiidae and Arcellidae standing out as the most representative and <italic>Centropyxis aculeata</italic> as the only constant species (FO = 100%). We observed a total of 25 occurrences that were new to the state. The study considered ecological and methodological aspects, including biomes, types of aquatic bodies, ecosystems, collection methods, mesh sizes, and compartments. Methods such as washing macrophyte rhizospheres and using 20 μm nets have demonstrated greater efficiency in estimating richness. The analysis of accumulation curves indicated that the sampling method recorded approximately 76.3% of the estimated biodiversity. Despite the advances, gaps remain, <italic>e.g.,</italic> in the Cerrado biome, in temporary lakes, and in sediments. This study reinforces the importance of methodological standardization and investment in studies in the Bahia state to improve knowledge about regional and global biodiversity.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20241421"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the initiation and duration of physical exercise on the deleterious effects induced by ionizing radiation on the brain. 体育锻炼的开始和持续时间对电离辐射引起的脑损伤的影响。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241165
Luciana P M Teixeira, Cláudio Sérgio C Lau, Eduardo M Nogueira, Giselle O G Cassimiro, André R C Barreto-Vianna, Roberto Salomão DE Souza, Andrea Mantuano, Bianca T Ciambarella, Maurício Moacir S Borges, Jhon Brandon Félix Ferreira, Jemima F R DA Silva, Luis Alexandre G Magalhães, Cláudio C Filgueiras, Samara Cristina Ferreira-Machado
{"title":"Effect of the initiation and duration of physical exercise on the deleterious effects induced by ionizing radiation on the brain.","authors":"Luciana P M Teixeira, Cláudio Sérgio C Lau, Eduardo M Nogueira, Giselle O G Cassimiro, André R C Barreto-Vianna, Roberto Salomão DE Souza, Andrea Mantuano, Bianca T Ciambarella, Maurício Moacir S Borges, Jhon Brandon Félix Ferreira, Jemima F R DA Silva, Luis Alexandre G Magalhães, Cláudio C Filgueiras, Samara Cristina Ferreira-Machado","doi":"10.1590/0001-3765202520241165","DOIUrl":"https://doi.org/10.1590/0001-3765202520241165","url":null,"abstract":"<p><p>Radiotherapy can damage healthy brain tissue, leading to cognitive deficits. Physical exercise enhances neurogenesis and synaptic plasticity, improving cognitive functions like memory and learning. This study evaluated aerobic exercise's effect on endothelial marker gene expression and memory in cranially irradiated mice. In total, 144 male Swiss mice were divided into sedentary control (SC), sedentary irradiated (SI), exercise control (EC), and irradiated exercise (EI) groups. The EI groups underwent treadmill training in three conditions: 3-months post-irradiation, 1-month pre-irradiation, and 1- month post-irradiation. Ninety days after irradiation, memory was tested using the open- field and object location memory tests. RT-qPCR analyzed hippocampal expression of VEGF-A, eNOS, and vWF. No differences were found in the open-field test, but sedentary irradiated mice showed impaired memory in the object location task. Treadmill training restored memory, especially in the 3-month post-irradiation group. Irradiation increased vWF expression, which physical exercise mitigated. Physical activity also increased VEGF-A and eNOS expression in irradiated mice. These findings suggest that post-irradiation exercise mitigates memory impairment and may influence vascular changes in the brain.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20241165"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of cage fish farming on diet composition of Sardela (Triportheus nematurus (Kner, 1858)) in a Neotropical reservoir. 网箱养鱼对新热带水库萨尔德拉(Triportheus nematurus (Kner, 1858))饲料组成的影响。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520230793
Vinicius Cesar DO Bonfim, Bruna Caroline K Kliemann, Natália Luiza DA Silva, Julia K K Ramos, José Daniel S Garves, Rosilene Luciana Delariva, Igor P Ramos
{"title":"Influence of cage fish farming on diet composition of Sardela (Triportheus nematurus (Kner, 1858)) in a Neotropical reservoir.","authors":"Vinicius Cesar DO Bonfim, Bruna Caroline K Kliemann, Natália Luiza DA Silva, Julia K K Ramos, José Daniel S Garves, Rosilene Luciana Delariva, Igor P Ramos","doi":"10.1590/0001-3765202520230793","DOIUrl":"10.1590/0001-3765202520230793","url":null,"abstract":"<p><p>Cage fish farming promotes the input of organic matter into the surrounding aquatic environment, which can alter the availability of food resources and consequently change the diet of wild fish. Thus, gathering information about cage fish farming influences on the aquatic environment is important. We aimed to evaluate the effects of cage fish farming on the trophic ecology of the omnivorous and non-native fish<italic> Triportheus nematurus</italic>. We collected individuals in areas with (CF) and without (CT) the influence of cage fish farms in April and July 2019, to analyze the stomach contents to determine the diet composition of the individuals. The diet composition and the trophic guild were different between the CT and CF groups. However, the average trophic niche breadth did not differ between groups. <italic>Triportheus nematurus</italic> did not directly consume the organic matter coming from the cages, such as feed. Still, we suggest that the differences occurred due to changes in the availability of food resources promoted by cage fish farms and the attractive potential of the cultivation cages. In short, these results can help understand the implications of this cultivation system in the aquatic environment, contributing with new information and expanding already described data.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20230793"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extending the Geographic Range of Pterosaurs in the Araripe Basin: First Record from the Romualdo Formation (Araripe Basin) in Piauí, Brazil. 扩展Araripe盆地翼龙的地理范围:来自巴西Piauí Araripe盆地Romualdo组的首次记录。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520250428
Renan A M Bantim, Esaú V DE Araújo, Artur F S Araújo, Flaviana J DE Lima, Juliana M Sayão, Paulo V DE Oliveira
{"title":"Extending the Geographic Range of Pterosaurs in the Araripe Basin: First Record from the Romualdo Formation (Araripe Basin) in Piauí, Brazil.","authors":"Renan A M Bantim, Esaú V DE Araújo, Artur F S Araújo, Flaviana J DE Lima, Juliana M Sayão, Paulo V DE Oliveira","doi":"10.1590/0001-3765202520250428","DOIUrl":"https://doi.org/10.1590/0001-3765202520250428","url":null,"abstract":"<p><p>The Araripe Basin in northeastern Brazil is a key site for Cretaceous pterosaur fossils from Gondwanan deposits. Most discoveries are concentrated in its northern portion, particularly in Ceará state, within the Crato and Romualdo formations. In contrast, records from the southern part of the basin, especially in Piauí and Pernambuco, remain scarce. This study reports the first pterosaur fossils from the Romualdo Formation in Piauí, represented by two three-dimensionally preserved, incomplete wing phalanges: LPP Pt-002 and LPP Pt-005. Osteohistological analysis of LPP Pt-002 reveals a cortex composed of parallel-fibered bone, with endosteal lamellae and an external fundamental system (EFS), indicating skeletal maturity. In contrast, LPP Pt-005 displays a cortex of woven bone and circumferential lamellae, with a highly vascularized matrix and no evidence of EFS or endosteal lamellae, suggesting a post-juvenile stage. These differences indicate that the specimens represent distinct individuals. Although the reasons for the lower abundance of pterosaur remains in the southern Araripe Basin are unclear, these findings expand the known geographic range of Pterosauria within the basin and underscore the importance of further paleontological exploration in underrepresented regions to better understand pterosaur diversity and distribution during the Cretaceous.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97Suppl. 1 Suppl. 1","pages":"e20250428"},"PeriodicalIF":1.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Amazon COP and the Need for Integration between the Environmental and Climate Agendas. 亚马逊缔约方会议和环境与气候议程整合的必要性。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520250533
Denilson S Bezerra, Flávia R Mochel, Sérgio S Costa, Fábio Augusto S Dos Santos, Deuzanir C A Lima, Edilane M Santos
{"title":"The Amazon COP and the Need for Integration between the Environmental and Climate Agendas.","authors":"Denilson S Bezerra, Flávia R Mochel, Sérgio S Costa, Fábio Augusto S Dos Santos, Deuzanir C A Lima, Edilane M Santos","doi":"10.1590/0001-3765202520250533","DOIUrl":"https://doi.org/10.1590/0001-3765202520250533","url":null,"abstract":"","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 4","pages":"e20250533"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Predicting Coronary Heart Disease Using Data Mining and Machine Learning Solutions. 勘误:使用数据挖掘和机器学习解决方案预测冠心病。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-15 DOI: 10.1590/0001-3765202520240811e
{"title":"Erratum: Predicting Coronary Heart Disease Using Data Mining and Machine Learning Solutions.","authors":"","doi":"10.1590/0001-3765202520240811e","DOIUrl":"https://doi.org/10.1590/0001-3765202520240811e","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0001-3765202520240811].</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20240811e"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is sweets consumption associated with depression? A cross-sectional study with 54,170 Brazilian adults and older adults. 吃甜食与抑郁有关吗?一项对54170名巴西成年人和老年人的横断面研究。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520240217
Yasmin M Castro, Ana Letícia S Rezende, Emanuela Conte, João Vitor C Santos, Natalia C Nunes, Samuel C Dumith
{"title":"Is sweets consumption associated with depression? A cross-sectional study with 54,170 Brazilian adults and older adults.","authors":"Yasmin M Castro, Ana Letícia S Rezende, Emanuela Conte, João Vitor C Santos, Natalia C Nunes, Samuel C Dumith","doi":"10.1590/0001-3765202520240217","DOIUrl":"https://doi.org/10.1590/0001-3765202520240217","url":null,"abstract":"<p><p>The objective is to analyze the association between depression and sweets consumption. Cross-sectional study carried out with data from VIGITEL (Brasil 2021). Surveillance of Risk Factors for Chronic Diseases by telephone survey, a system for monitoring the frequency and distribution of risk factors and protection against chronic non-communicable diseases (NCDs) in Brazilian adults ≥18 years. Crude Poisson regression, adjusted for sociodemographic and behavioral covariates, was used to verify the association between depression and sweets consumption. The total sample included 54.170 Brazilian adults. The consumption of sweets was reported by 25.6% and the diagnosis of depression by 11%. Consumption of sweets was associated with a statistically significant protection of 8% for the diagnosis of depression (95%CI 0.85-0.98). This finding can be seen as positive, as it encompasses a widely adopted, non-drug behavior. However, a warning should be raised about the harm caused by the exaggerated consumption of sweets.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 4","pages":"e20240217"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal exposure to BPA during the perinatal period leads to imbalances in the testicular antioxidant enzymatic system and apoptosis in adult rat offspring. 围产期母体暴露于BPA会导致成年大鼠后代睾丸抗氧化酶系统失衡和细胞凋亡。
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.1590/0001-3765202520241335
Daniele DE Paula, Luciana D Santos, Gabriel Ian DA Silva, Najeh Maissar Khalil, Marco Aurelio Romano, Renata Marino Romano
{"title":"Maternal exposure to BPA during the perinatal period leads to imbalances in the testicular antioxidant enzymatic system and apoptosis in adult rat offspring.","authors":"Daniele DE Paula, Luciana D Santos, Gabriel Ian DA Silva, Najeh Maissar Khalil, Marco Aurelio Romano, Renata Marino Romano","doi":"10.1590/0001-3765202520241335","DOIUrl":"https://doi.org/10.1590/0001-3765202520241335","url":null,"abstract":"<p><p>Bisphenol A (BPA) is a widely used plasticizer that can leach from packaging, leading to contamination of food and beverages. Exposure to endocrine-disrupting chemicals during critical windows of development may lead to functional abnormalities in adulthood. Disruption of redox homeostasis and impaired activity of key antioxidant enzymes contribute to testicular dysfunction and reduced sperm quality. We evaluated the effects of perinatal BPA exposure on the testicular enzymatic antioxidant system in the adult offspring of dams treated with BPA (0.5 or 5 mg BPA/kg BW/day) from gestational day 18 throughout postnatal day (PND) 5. The testes of offspring were collected at PND90, and the transcription levels of <italic>Sod1</italic> and <italic>Gsr</italic> were reduced, those of <italic>Nfe2l2</italic> and <italic>Blc2 </italic>were increased, and those of <italic>Casp3</italic> were not altered, whereas an increased ratio of <italic>Bcl2</italic>/<italic>Bax</italic> expression was observed in the BPA5 group. An increase in SOD activity was observed in the BPA0.5 group, and a decrease in GSR activity was observed in the BPA5 group. Functional enrichment analysis revealed interactions between antioxidant genes and those involved in the hypothalamic‒pituitary‒testicular axis and spermatogenesis. These findings suggest that BPA exposure can disrupt the antioxidant defense system in male reproductive tissues, potentially leading to adverse reproductive outcomes.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"97 3","pages":"e20241335"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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