Anais da Academia Brasileira de Ciencias最新文献

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A third volume commemorating forty years of the Brazilian Antarctic Program.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420241261
Jefferson C Simões, Juliana M Sayão, Viviana Alder
{"title":"A third volume commemorating forty years of the Brazilian Antarctic Program.","authors":"Jefferson C Simões, Juliana M Sayão, Viviana Alder","doi":"10.1590/0001-3765202420241261","DOIUrl":"https://doi.org/10.1590/0001-3765202420241261","url":null,"abstract":"","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 2","pages":"e20241261"},"PeriodicalIF":1.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cretaceous spreite-dominated ichnoassemblages in Antarctica.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240627
Daniel Sedorko, Carolina Gutiérrez, Pablo J Pazos, James H Nebelsick, Luiz Carlos Weinschütz, Mariana Almeida Gomes Garcia, Rodrigo Cardoso, Juliana Manso Sayão, Alexander W A Kellner
{"title":"Cretaceous spreite-dominated ichnoassemblages in Antarctica.","authors":"Daniel Sedorko, Carolina Gutiérrez, Pablo J Pazos, James H Nebelsick, Luiz Carlos Weinschütz, Mariana Almeida Gomes Garcia, Rodrigo Cardoso, Juliana Manso Sayão, Alexander W A Kellner","doi":"10.1590/0001-3765202420240627","DOIUrl":"https://doi.org/10.1590/0001-3765202420240627","url":null,"abstract":"<p><p>This study investigates ichnoassemblages characterized by spreite trace fossils from the Upper Cretaceous Snow Hill Island Formation on Vega Island, Antarctica. The succession reveals alternating heterolithic beds of sandy siltstones to very fine- to fine-grained sandstones, suggestive of a deltaic depositional setting influenced by fluctuating energy conditions. The dominance of spreite structures, such as Paradictyodora antarctica and Euflabella, suggests the prevalence of a colonization window for deposit- or detritus-feeding activity. Notably, the prevalence of Euflabella towards the upper levels of the succession, in more proximal and impacted depositional setting, suggests an adaptive strategy for coping with varying food resources, corroborating its role as a trophic generalist. Additionally, the absence of distinct shifts between fully marine and stressed ichnofauna challenges a clear assignation to the Phycosiphon or Rosselia ichnofacies, although in vertical succession the Euflabella dominance in upper levels is related to a lower diverse ichnoassemblage than Paradictyodora in lower levels, suggesting some freshwater impact in the top. The occurrence of horizontal and vertical sessile deposit feeding structures would align with the Rosselia ichnofacies definition, but the presence of spreite burrows and high ichnodisparity better fits into the Cruziana ichnofacies. These spreite-dominated ichonoassemblages are here attributed to Cruziana ichnofacies.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 2","pages":"e20240627"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valorization of piassava fiber by its incorporation in adobe bricks.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240210
Cristian DA Conceição Gomes, Rafael DE Avila Delucis, Klaus Machado Theisen
{"title":"Valorization of piassava fiber by its incorporation in adobe bricks.","authors":"Cristian DA Conceição Gomes, Rafael DE Avila Delucis, Klaus Machado Theisen","doi":"10.1590/0001-3765202420240210","DOIUrl":"https://doi.org/10.1590/0001-3765202420240210","url":null,"abstract":"<p><p>This study investigates valorization of piassava fiber through its incorporation in adobe bricks. The objective was to analyze the properties of adobe bricks reinforced with varying weight fractions of piassava fiber. The fibers were characterized for their chemical and physical characteristics, while the sand and clay were characterized for granulometry, XRD patterns, and EDX. Initial bricks were prepared with a constant piassava fiber weight fraction of 3% and varying sand:clay weight ratios. The mechanical properties of the adobe bricks were evaluated, and subsequent investigations involved variable fiber weight fractions of 0.5%, 1%, and 3%. Characterization included compressive characterization, apparent density, three-point bending, resistance to water erosion, and cracking behavior. The results showed that the physical and chemical characteristics of the fibers were consistent with the existing literature. The adobe bricks exhibited a range of apparent density values and compressive strength, with the S40C60P3 brick demonstrating higher strength and reduced crack visibility. The bricks with 3% fiber content outperformed others in terms of bending strength and displacement before fracture. Erosion tests revealed that higher fiber contents resulted in lower levels of mass loss and erosion depth. These findings highlight the potential of piassava fiber incorporation in adobe bricks for enhancing their properties.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 3","pages":"e20240210"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of human tumor cell migration by a rice-derived chimeric cysteine protease inhibitor.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240778
Mateus Dias-Oliveira, Natalia Balbinott, Jéssica M O Ramos, João G Vasconcellos, Fátima Theresinha C R Guma, Geancarlo Zanatta, Rogerio Margis
{"title":"Inhibition of human tumor cell migration by a rice-derived chimeric cysteine protease inhibitor.","authors":"Mateus Dias-Oliveira, Natalia Balbinott, Jéssica M O Ramos, João G Vasconcellos, Fátima Theresinha C R Guma, Geancarlo Zanatta, Rogerio Margis","doi":"10.1590/0001-3765202420240778","DOIUrl":"https://doi.org/10.1590/0001-3765202420240778","url":null,"abstract":"<p><p>The cystatin superfamily includes proteins crucial for inhibiting cysteine proteases, enzymes involved in many biological processes. In plants, cystatins regulate seed germination, development, and pathogen defense. In humans, inhibiting legumain-type cysteine proteases offers a promising cancer treatment strategy, as this enzyme's expression often rises during tumor progression. We evaluated a novel rice-derived chimeric legumain inhibitor using in silico and in vitro methods. Computational simulations confirmed the inhibitor's stability and nanomolar affinity for legumain's active site. Post-expression and purification assays determined its kinetics and demonstrated its efficacy in reducing HT29 tumor cell migration and viability. Our findings suggest the chimeric Oryzacystatin I mutant with SNSL motifs is a promising candidate for cancer drug development.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 3","pages":"e20240778"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
May Antarctic plants grow on Martian and Lunar soil simulants under terrestrial conditions?
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240571
Cesar R L Amaral, Dafne Anjos, Fábio L V Bones, Antonio Carlos DE Freitas, Maithê G P Magalhães, Lucas M Moreira, Rodrigo Goldenberg-Barbosa, Anna Donato
{"title":"May Antarctic plants grow on Martian and Lunar soil simulants under terrestrial conditions?","authors":"Cesar R L Amaral, Dafne Anjos, Fábio L V Bones, Antonio Carlos DE Freitas, Maithê G P Magalhães, Lucas M Moreira, Rodrigo Goldenberg-Barbosa, Anna Donato","doi":"10.1590/0001-3765202420240571","DOIUrl":"https://doi.org/10.1590/0001-3765202420240571","url":null,"abstract":"<p><p>Extremophile organisms have been largely studied in Astrobiology. Among them, two antarctic plants emerge as good candidates to become colonizers of other celestial bodies, such as Mars and the Moon. The present research aimed to evaluate survival and growing capacity of Sanionia uncinata and Colobanthus quitensis on Martian (MGS-1) and Lunar (LMS-1) regolith simulants, under terrestrial conditions. The survival responses of both species on the simulators and the original sampling site of Antarctic soil were observed during 15 days, in laboratory conditions at 'Comandante Ferraz' Station. Based on physiological parameters changes under the three soil conditions tested, our results suggest that Martian soil can be too harsh for plant growth, showing expressive decay, especially for C. quitensis. While lunar soil might provide more favorable conditions, with less observed changes, similarly to how they would in Antarctic soil from their natural habitat. This preliminary study provides resources and fosters knowledge about the possibility of these Antarctic species to survive in extraterrestrial environments, starting with soil parameters; and discusses the importance and use of Antarctic plants in astrobiology.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 2","pages":"e20240571"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salt-affected soils in the Lopez de Bertodano Formation, polar semi-desert of Seymour Island, Antarctica: topographic or lithological controls?
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240584
Daniel N Krum, Carlos Ernesto G R Schaefer, Fábio S Oliveira, Roberto F M Michel, Heitor P Palma, Marcos Paulo E Tomaz, Ana Carolina P Amaral, Márcio R Francelino, Gustavo V Veloso
{"title":"Salt-affected soils in the Lopez de Bertodano Formation, polar semi-desert of Seymour Island, Antarctica: topographic or lithological controls?","authors":"Daniel N Krum, Carlos Ernesto G R Schaefer, Fábio S Oliveira, Roberto F M Michel, Heitor P Palma, Marcos Paulo E Tomaz, Ana Carolina P Amaral, Márcio R Francelino, Gustavo V Veloso","doi":"10.1590/0001-3765202420240584","DOIUrl":"https://doi.org/10.1590/0001-3765202420240584","url":null,"abstract":"<p><p>Salinization is one of the main pedogenetic processes occurring on the semiarid zone of the Weddel sea, like in Seymour Island, where salt-affected soils are widespread. This study aimed to investigate whether topography controls the distribution of salt-affected soils on Seymour Island, particularly with reference to the Lopez de Bertodano Formation. Chemical and physical results from 45 soil profiles were used, where morphometric variables were extracted. Descriptive statistical analysis, extraction of morphometric variables, cluster analysis and principal component analysis were carried out in this database. The separation of soils associated with the López de Bertodano Formation into two groups is explained by topographic atributes, and not by soil properties. Hence, the salts in soils have a geogenic origin, and despite differences in geological units, the uniform mineralogical composition of all Lopez de Bertodano Formation results in the widespread accumulation of salts in soils, influenced by the saline parent material and the semi-desert climate. Despite the lack of topographic control in the distribution of saline soils as a whole, geomorphology play a distinct role in the formation of secondary saline features, such as crusts, efflorescences, and columnar structures, or in salt composition of salts present in the soils.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 2","pages":"e20240584"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical distribution of the zooplankton in the Antarctic Peninsula during the austral summer of 2017.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420240144
Camila M Leonor, Erik Muxagata
{"title":"Vertical distribution of the zooplankton in the Antarctic Peninsula during the austral summer of 2017.","authors":"Camila M Leonor, Erik Muxagata","doi":"10.1590/0001-3765202420240144","DOIUrl":"https://doi.org/10.1590/0001-3765202420240144","url":null,"abstract":"<p><p>Zooplankton plays a crucial role as the primary consumers in the Southern Ocean and its ecological processes, particularly in the Antarctic Peninsula, influenced by regional glaciological and oceanographic changes. To assess the overall composition of these communities, vertical samples were collected at various depths using a Multinet at oceanographic stations in the Antarctic Peninsula during the XXXV OPERANTAR expedition in summer 2017. Abiotic data (temperature, salinity and chlorophyll-a) were collected using a CTD and a fluoremeter. Organisms were identified to a higher level, with Chaetognatha and Euphausiacea identified to species whenever possible. Copepoda were the most abundant (73.4%), with Calanoida present in all samples and more abundant at 300m. Salpidae ranked as the second most abundant taxon (16.6%) up to 100m. Three species of Chaetognatha were identified, with Eukrohnia hamata being the most abundant, particularly at 300m. Two species of Euphausiacea were found, Euphausia superba and Thysanoesa macrura, with low abundances. Abiotic parameters showed significant relationships with the taxa. The region exhibits complex oceanography associated with zooplankton communities. The recorded data align with the zooplankton characterization of this region, uncovering a prevalence of Copepoda and surface abundant Salpidae, along with Chaetognatha (particulary E. hamata) and Euphausiacea.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 2","pages":"e20240144"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First report of Penicillium brevicompactum causing disease in Pleurotus ostreatus.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420210103
Ricardo Scheffer DE Andrade Silva, Tiago Miguel Jarek, Gabriel Lucas DE Jesus, Gabriel Dias DE Oliveira, Francine Lorena Cuquel
{"title":"First report of Penicillium brevicompactum causing disease in Pleurotus ostreatus.","authors":"Ricardo Scheffer DE Andrade Silva, Tiago Miguel Jarek, Gabriel Lucas DE Jesus, Gabriel Dias DE Oliveira, Francine Lorena Cuquel","doi":"10.1590/0001-3765202420210103","DOIUrl":"https://doi.org/10.1590/0001-3765202420210103","url":null,"abstract":"<p><p>Oyster mushroom (Pleurotus ostreatus) is the second most produced mushroom globally, but increased production is linked to new diseases. This study reports the first occurrence of Penicillium brevicompactum on P. ostreatus mushrooms. Symptoms, identified in the primordia, include atrophy, malformation, drying, and sporulation, causing up to 100% losses. The pathogen was confirmed with 99% identity via ITS region analysis and phylogenetic comparison. The research highlights P. brevicompactum's infection of mushroom primordia, emphasizing the need for pathogen identification and preventive measures to mitigate production losses.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 3","pages":"e20210103"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gas Chromatography-mass Spectrometry analysis, Biotoxicity and Antibiofilm Activities of Syzygium aromaticum against Corynebacterium diphtheriae.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420230368
Marcia B Alves, Katyane S Nascimento, Jéssica Mayara M Araújo, Wellyson C A Firmo, Victor Elias Mouchrek Filho, Dionney A DE Sousa, Ana Luíza M Guaraldi, Lídio G Lima Neto, Priscila S Sabbadini
{"title":"Gas Chromatography-mass Spectrometry analysis, Biotoxicity and Antibiofilm Activities of Syzygium aromaticum against Corynebacterium diphtheriae.","authors":"Marcia B Alves, Katyane S Nascimento, Jéssica Mayara M Araújo, Wellyson C A Firmo, Victor Elias Mouchrek Filho, Dionney A DE Sousa, Ana Luíza M Guaraldi, Lídio G Lima Neto, Priscila S Sabbadini","doi":"10.1590/0001-3765202420230368","DOIUrl":"https://doi.org/10.1590/0001-3765202420230368","url":null,"abstract":"<p><p>The objective of this study was to investigate the chemical composition of Syzygium aromaticum essential oil (SAEO), both as its toxicity and biological activities on Corynebacterium diphtheriae. The essential oil (EO) was obtained by hydrodistillation and verified by GC-MS. The main chemical components were eugenol (48.79%), caryophyllene (44.29%) and α-humulene (4.87%). In vitro tests with human red blood cells, blood compatibility. SAEO showed high toxicity for Artemia salina and the bioassay on Tenebrio molitor larvae revealed an average survival rate of 80.00%. The antioxidant activity of SAEO was moderate (40.60%) using the phosphomolybdenum method. SAEO inhibited the growth of all C. diphtheriae strains tested at minimum inhibitory concentrations of 62.5-1000 µg mL-1 (strong to moderate). The minimum bactericidal concentration of SAEO was observed in two strains. Microorganisms cultivated in the presence of subinhibitory concentrations (subMIC) do not show morphological changes. The subMIC of SAEO inhibited in some strains, but in most cases, increased biofilm formation. In conclusion, the results of this study found that SAEO has an inhibitory effect against C. diphtheriae, representing an alternative antimicrobial therapy, although more in vivo biological studies, alone or in combination with occasional antimicrobials, should be carried out to better evaluate its effects.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 3","pages":"e20230368"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical and histological effects of the subchronic treatment with a beer containing Baccharis dracunculifolia in an experimental model of diabetes.
IF 1.1 4区 综合性期刊
Anais da Academia Brasileira de Ciencias Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/0001-3765202420231369
Ricardo A Pereira, Albimara Hey, Aline B DE Jesus, Aline T Marin, Fernanda Fiorini, Renata Corassa, Ana Karolina S Goes, Mayara Grolli, Anayana Z Dangui, Jéssica Wouk, Anaclara Prasniewski, Tatiane Luiza C Oldoni, Giuseppina Paola Parpinello, Urszula Tylewicz, Emerson Carraro, Carlos Ricardo M Malfatti
{"title":"Biochemical and histological effects of the subchronic treatment with a beer containing Baccharis dracunculifolia in an experimental model of diabetes.","authors":"Ricardo A Pereira, Albimara Hey, Aline B DE Jesus, Aline T Marin, Fernanda Fiorini, Renata Corassa, Ana Karolina S Goes, Mayara Grolli, Anayana Z Dangui, Jéssica Wouk, Anaclara Prasniewski, Tatiane Luiza C Oldoni, Giuseppina Paola Parpinello, Urszula Tylewicz, Emerson Carraro, Carlos Ricardo M Malfatti","doi":"10.1590/0001-3765202420231369","DOIUrl":"https://doi.org/10.1590/0001-3765202420231369","url":null,"abstract":"<p><p>This article reports the development of a beer made with Baccharis dracunculifolia and its application in an experimental model of diabetes. Initially, the production of the beverage was standardized in order to incorporate the plant extract properly. Next, the beer was analyzed by the UHPLC-MS to identify the substances present. Among others, caffeic acid (5.85 mg / L), m-coumaric acid (5.16 mg / L), pinocembrin (2.99 mg / L), chrysin (10.86 mg / L), myricetin (1.73 mg / L) and spathulenol (9.30 mg / L) were found. Animal tests indicate improvement in biochemical and histological parameters of STZ-induced Wistar rats that ingested the beer made with the plant. The antidiabetic potential of this beverage was observed in the different tests that evaluated insulin resistance and the decrease of the clinical manifestations of diabetes in animals. The use of the drink as an adjunct in clinical treatments for DM2 may be useful, especially in suppressing the oxidative damage caused by the disease.</p>","PeriodicalId":7776,"journal":{"name":"Anais da Academia Brasileira de Ciencias","volume":"96 suppl 3","pages":"e20231369"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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