Diagnostic and clinical immunology最新文献_第4页

Localization of human colorectal carcinoma xenografts in mice using radiolabeled monoclonal antibody to carcinoembryonic antigen. 用放射性标记癌胚抗原单克隆抗体定位小鼠人结直肠癌异种移植物。

Diagnostic and clinical immunology Pub Date : 1988-01-01

L C Tsai, H M Chen, S H Yeh, C C Yuan, D Tsao, S H Han

引用次数: 0

Detection of circulating immune complexes by Raji cell assay: comparison of flow cytometric and radiometric methods. Raji细胞法检测循环免疫复合物:流式细胞术与放射法的比较。

Diagnostic and clinical immunology Pub Date : 1988-01-01

S F Kingsmore, A D Crockard, A C Fay, T A McNeill, S D Roberts, J M Thompson

引用次数: 0

Human IgG subclasses and their relation to carbohydrate antigen immunocompetence. 人IgG亚类及其与糖类抗原免疫能力的关系。

Diagnostic and clinical immunology Pub Date : 1988-01-01

M G Scott, P G Shackelford, D E Briles, M H Nahm

引用次数: 0

Age-associated changes of T lymphocyte subsets. T淋巴细胞亚群的年龄相关变化。

Diagnostic and clinical immunology Pub Date : 1987-01-01

R P Falcão, S J Ismael, E A Donadi

引用次数: 0

Humoral and cellular immune abnormalities in adult hemophiliacs followed over a 2-year period. 成人血友病患者体液和细胞免疫异常随访2年。

Diagnostic and clinical immunology Pub Date : 1987-01-01

J Freedman, R Mazaheri, S Read, M B Garvey, J Teitel

{"title":"Humoral and cellular immune abnormalities in adult hemophiliacs followed over a 2-year period.","authors":"J Freedman, R Mazaheri, S Read, M B Garvey, J Teitel","doi":"","DOIUrl":"","url":null,"abstract":"Immune function was assessed in 93 adult hemophiliacs in the 2 years prior to HTLV-III antibody testing of blood donors and routine heat treatment of coagulation factor concentrates. Parameters of humoral and cellular immunity studied included serum complements, immunoglobulins, immune complexes, blood cell counts, lymphocyte subsets, lymphocyte transformation, 2-5A synthetase, serology for HTLV-III and hepatitis B, skin tests, and clinical status. HTLV-III seropositivity was significantly more prevalent in patients treated with factor VIII concentrate; seropositive patients had a higher proportion of abnormal test results and were more symptomatic. Although many subjects had abnormal test results, specific test results generally did not correlate with type of blood component received or time of preceding treatment. The proportion of tests abnormal in individual patients was correlated with the intensity of factor replacement therapy when the time interval from the last treatment was a covariate. While T8+ lymphocytes were increased and T4/T8 ratios were decreased in many patients, significantly reduced T4+ lymphocytes were seen only in seropositive patients and in those treated with factor VIII concentrate. Neither seropositivity nor presence of symptoms correlated with abnormal lymphocyte mitogenic response or 2-5A synthetase levels, but synthetase levels were increased in 65% of patients tested. Over the 2-year study period, no significant deterioration of clinical or laboratory variables was observed in the patients. Abnormalities of immune function were found to be common in hemophiliacs regardless of type of treatment or of evidence of HTLV-III infection.","PeriodicalId":77705,"journal":{"name":"Diagnostic and clinical immunology","volume":"5 1","pages":"30-40"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13585387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the immune complex precipitation-inhibiting capacity of sera of patients with chronic lymphocytic leukaemia. 慢性淋巴细胞白血病患者血清免疫复合物沉淀抑制能力的研究。

Diagnostic and clinical immunology Pub Date : 1987-01-01

L Varga, Z Miszlay, E Czink, K Pálóczi, G Szegedi, G Füst, S R Hollán

{"title":"Study of the immune complex precipitation-inhibiting capacity of sera of patients with chronic lymphocytic leukaemia.","authors":"L Varga, Z Miszlay, E Czink, K Pálóczi, G Szegedi, G Füst, S R Hollán","doi":"","DOIUrl":"","url":null,"abstract":"Two procedures measuring the capacity of different sera to prevent the precipitation of nascent immune complexes were compared: a kinetic method with a constant immune complex/serum ratio and a new procedure--the increasing immune complex load method--using different immune complex/serum ratios. Immune complex precipitation inhibition is known to depend on complement. The sera of 25 patients with chronic lymphocytic leukaemia (CLL) and the sera of nine healthy blood donors were compared with the two procedures. The kinetic method discriminated poorly between the patients' sera and the control sera, whereas the increasing immune complex load method showed a highly significant difference between the two groups. Sera with low C4 level had the lowest immune complex precipitation-inhibiting activity. Interestingly, however, in the increasing immune complex load method not only hypocomplementaemic but also normocomplementaemic sera from CLL patients were found to be markedly defective. This finding suggests that the CLL patients' sera contain a factor which modulates complement-dependent inhibition of immune complexes.","PeriodicalId":77705,"journal":{"name":"Diagnostic and clinical immunology","volume":"5 3","pages":"129-34"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14447045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-cell morphology in nodular follicular center cell lymphomas. 结节性滤泡中心细胞淋巴瘤的t细胞形态。

Diagnostic and clinical immunology Pub Date : 1987-01-01

M J Bonar, P E Hurtubise, S H Swerdlow

{"title":"T-cell morphology in nodular follicular center cell lymphomas.","authors":"M J Bonar, P E Hurtubise, S H Swerdlow","doi":"","DOIUrl":"","url":null,"abstract":"T cells are known to be frequently numerous in follicular lymphomas but are generally considered to be a homogeneous population of small, round, \"resting\" lymphocytes. Although immunologic studies have suggested the presence of some \"activated\" T cells in these B-cell neoplasms, virtually no attention has been paid to the T-cell morphology. Wright-stained cytocentrifuged sheep erythrocyte (SRBC) rosette preparations from 20 cases of nodular follicular center cell lymphomas were therefore examined and the morphologic appearance of the SRBC rosetting cells was categorized. A mean of 19% (range 11-33%) of the SRBC-positive cells present were medium or large in size (diameter greater than two SRBCs, approximately 10 micron). A mean of 62% of SRBC-positive cells had round nuclei; 18% had indented nuclei and 20% had irregularly shaped nuclei. These data provide supportive morphologic evidence for some T-cell \"activation\" in certain follicular lymphomas. In addition to having possible functional and biologic implications, the previously undescribed presence of enlarged and sometimes \"atypical\" T cells in uncomplicated follicular lymphomas has implications for interpreting the histopathology of these B-cell neoplasms and the reported occurrence of composite T-cell/follicular center-cell lymphomas.","PeriodicalId":77705,"journal":{"name":"Diagnostic and clinical immunology","volume":"5 1","pages":"14-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14620017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-2 receptor levels are increased in blood of heart transplant patients during infections. 心脏移植患者感染期间血液中白细胞介素-2受体水平升高。

Diagnostic and clinical immunology Pub Date : 1987-01-01

V Stolc, J R Krause

引用次数: 0

CD4 and CD8 subsets defined by dual-color cytofluorometry which distinguish symptomatic from asymptomatic blood donors seropositive for human immunodeficiency virus. CD4和CD8亚群由双色细胞荧光测定法定义，区分有症状和无症状的献血者对人类免疫缺陷病毒血清阳性。

Diagnostic and clinical immunology Pub Date : 1987-01-01

H E Prince, L Arens, S H Kleinman

{"title":"CD4 and CD8 subsets defined by dual-color cytofluorometry which distinguish symptomatic from asymptomatic blood donors seropositive for human immunodeficiency virus.","authors":"H E Prince, L Arens, S H Kleinman","doi":"","DOIUrl":"","url":null,"abstract":"As part of a larger study to characterize immune alterations in blood donors seropositive for human immunodeficiency virus (HIV), we measured subsets of CD4 (T helper/inducer) and CD8 (T suppressor/cytotoxic) cells by 2-color cytofluorometry. Alterations observed in asymptomatic seropositive donors (ASP) included: 1) decreased mean levels of Leu 8+ CD4 cells, although the proportion of Leu 8+ cells within the CD4 population was unchanged; 2) a selective increase in Leu 8- CD8 and Leu 18- CD8 cell levels; and 3) increased levels of both CD8 subsets defined by Leu 7, Leu 17, or HLA-DR expression. Alterations observed in symptomatic seropositive donors (SSP) were: 1) a further decrease in Leu 8+ CD4 cell levels, with a decrease in the proportion of Leu 8+ CD4 cells; 2) decreased levels of both Leu 18- and Leu 18+ CD4 subsets; 3) selective increases in Leu 8- and Leu 18- CD8 cell levels; and 4) increases in Leu 7+ CD8, Leu 17+ CD8, and HLA-DR+ CD8 subsets but not the reciprocal negative CD8 subsets. Thus, changes merely reflective of HIV infection included decreased levels of Leu 8+ CD4 cells and increased levels of Leu 8- CD8, Leu 18- CD8, Leu 7+ CD8, Leu 17+ CD8, and HLA-DR+ CD8 cells. Development of symptoms were associated with a further, preferential loss of Leu 8+ CD4 cells, proportional losses of both CD4 subsets defined by Leu 18 expression, and a return to normal levels of Leu 7- CD8, Leu 17- CD8, and HLA-DR- CD8 cells.","PeriodicalId":77705,"journal":{"name":"Diagnostic and clinical immunology","volume":"5 4","pages":"188-93"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14097519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and characterization of circulating immune complexes in HIV-related diseases. hiv相关疾病中循环免疫复合物的检测和表征

Diagnostic and clinical immunology Pub Date : 1987-01-01

C Carini, R D'Amelio, I Mezzaroma, F Aiuti

引用次数: 0