American Journal of Tropical Medicine and Hygiene最新文献_第7页

Micro- and Macroenvironment and Habitat Influences on Tick Abundance in Oklahoma City Urban Parks. 俄克拉荷马城市公园微、宏观环境及生境对蜱虫丰度的影响

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0418

Melissa R Marquez, Himel Talukder, Wenwen Cheng, Daniel J Becker, Michael C Wimberly, Anni Yang

{"title":"Micro- and Macroenvironment and Habitat Influences on Tick Abundance in Oklahoma City Urban Parks.","authors":"Melissa R Marquez, Himel Talukder, Wenwen Cheng, Daniel J Becker, Michael C Wimberly, Anni Yang","doi":"10.4269/ajtmh.24-0418","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0418","url":null,"abstract":"Most studies on tick-borne diseases in the United States have focused on suburban and rural areas, leaving a gap in understanding risks in cities, where environmental conditions and human-tick interactions differ. Recent research has examined microhabitat effects on tick abundance but are limited in spatial and temporal scope. Tick behavior, such as host seeking, is shaped by local environmental factors and remains underexplored in urban landscapes. Integrating Earth observations of macroenvironmental and habitat conditions may improve our understanding of urban tick ecology. We hypothesize that a combination of micro- and macroenvironmental and habitat conditions predicts tick abundance in urban parks. Specifically, we expect microclimate factors (humidity and leaf litter depth) and macroconditions (habitat type and spatial arrangement) to influence questing tick abundance. In summer 2023, we collected ticks from 13 parks in the Oklahoma City metropolitan area using carbon dioxide traps and flagging techniques. Over 97% of ticks were Amblyomma americanum, a species known for aggressive host-seeking behavior. Our analysis of tick abundance in relation to microenvironmental (temperature, humidity, wind, and vegetation) and macroenvironmental (land-cover and landscape metrics) factors showed that solar radiation negatively affected tick abundance, whereas soil pH, woody vegetation, and forest cover were positive predictors. For adults, leaf litter depth and solar radiation were negative predictors, whereas woody vegetation and forest cover had positive impacts. Amblyomma americanum nymph abundance increased with humidity and soil pH. These findings underscore the complex interactions between environmental factors and tick distributions, with implications for urban health and park management.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological Analysis Indicating the Exposure of Two Volunteers to Relapsing Fever Borrelia sp. in Nayarit, Mexico. 血清学分析表明墨西哥纳亚里特两名志愿者暴露于疏螺旋体回归热。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0636

Sofía L Luna-Rojas, Edwin Vázquez-Guerrero, Jose A Hernández-Martínez, Jeanet Serafín-López, Fernando Martínez-Hernández, José Alejandro Martinez-Ibarra, Rigoberto Hernández-Castro, Job E López, J Antonio Ibarra

引用次数: 0

Omics Tools Applied to the Study of Chagas Disease Vectors: Proteomics and Metabolomics. 应用于恰加斯病媒介研究的组学工具：蛋白质组学和代谢组学。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.23-0395

Kelly Cristine Borsatto, Monika Aparecida Coronado, Cleber Galvão, Raghuvir Krishnaswamy Arni, Kaio Cesar Chaboli Alevi

{"title":"Omics Tools Applied to the Study of Chagas Disease Vectors: Proteomics and Metabolomics.","authors":"Kelly Cristine Borsatto, Monika Aparecida Coronado, Cleber Galvão, Raghuvir Krishnaswamy Arni, Kaio Cesar Chaboli Alevi","doi":"10.4269/ajtmh.23-0395","DOIUrl":"https://doi.org/10.4269/ajtmh.23-0395","url":null,"abstract":"Recent omics studies (cytogenomics, genomics, and transcriptomics) have provided extensive information on Chagas disease (CD) vectors. Here, we conduct a review of proteomic and metabolomic studies on these insect vectors. We address proteomic studies in triatomines, focusing on the identification and characterization of proteins in their saliva, midgut, and salivary glands, emphasizing their role in blood feeding by providing vasodilatory and anticoagulant substances, along with anti-inflammatory and antiplatelet activities. In addition, the review investigates protein diversity in different triatomine species, highlighting the importance of proteomic analysis in understanding adaptation to hematophagy, genetic evolution, and vector defense mechanisms. Metabolomic studies on CD vectors have revealed crucial information about their biology because metabolites correlate with the presence of Trypanosoma cruzi (T. cruzi), suggesting roles in the parasite-vector interaction. Additionally, some studies have predicted T. cruzi infection and observed altered metabolomes after feeding on infected blood, providing information about vector exposure to the parasite.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study. 与自然妊娠相比，体外受精-胚胎移植后肺结核的临床特征和结局：一项回顾性研究。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0644

Jiayu Wen, Jian-Qing He

{"title":"Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study.","authors":"Jiayu Wen, Jian-Qing He","doi":"10.4269/ajtmh.24-0644","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0644","url":null,"abstract":"We compared the clinical characteristics and outcomes of active tuberculosis (TB) during pregnancy after in vitro fertilization-embryo transfer (IVF-ET) with those in natural pregnancies. The aim was to assess the impact of the mode of pregnancy on TB and to gain a deeper understanding of the clinical characteristics of TB during pregnancy in women who conceived through IVF-ET. This study retrospectively reviewed medical records to analyze maternal and perinatal outcomes in women with active TB during pregnancy, comparing those who conceived through IVF-ET with those who conceived naturally. Using a 1:2 propensity score matching method, this study included 37 pregnant women with active TB who conceived through IVF-ET and 74 matched pregnant women with active TB who conceived naturally. In the IVF-ET group, all patients developed TB during early to mid-pregnancy, with an average onset at 11 weeks. In contrast, the natural pregnancy group had a later onset, averaging 17 weeks (P = 0.002). The IVF-ET group had higher fever and miliary TB frequency than the natural pregnancy group (94.6% versus 62.2% and 74.3% versus 27.4%, respectively, P <0.05). Although there were no significant differences in maternal intensive care unit admission rates or TB-related mortality between the two groups (24.3% versus 18.9% and 2.7% versus 6.8%, respectively, P >0.05), the IVF-ET group showed higher fetal mortality (94.6% versus 56.8%, respectively, P <0.001). IVF-ET was found to contribute to the exacerbation and spread of TB, underscoring the need for enhanced screening in the future.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumococcal Carriage in the Sahel Region of Burkina Faso before a 13-Valent Pneumococcal Conjugate Vaccination Campaign. 在开展13价肺炎球菌结合疫苗接种运动之前，布基纳法索萨赫勒地区的肺炎球菌携带情况。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0746

Robert Lamoussa Zoma, Lana Childs, Issa Ouedraogo, Guetwendé Sawadogo, T Félix Tarbangdo, Aristide Zoma, Soufiane Sanou, Brice Bicaba, Simon Sanou, Fahmina Akhter, Mahamoudou Ouattara, Jennifer R Verani, Lesley McGee, Miwako Kobayashi, H Flavien Aké

{"title":"Pneumococcal Carriage in the Sahel Region of Burkina Faso before a 13-Valent Pneumococcal Conjugate Vaccination Campaign.","authors":"Robert Lamoussa Zoma, Lana Childs, Issa Ouedraogo, Guetwendé Sawadogo, T Félix Tarbangdo, Aristide Zoma, Soufiane Sanou, Brice Bicaba, Simon Sanou, Fahmina Akhter, Mahamoudou Ouattara, Jennifer R Verani, Lesley McGee, Miwako Kobayashi, H Flavien Aké","doi":"10.4269/ajtmh.24-0746","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0746","url":null,"abstract":"Burkina Faso introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2013 and achieved >90% three-dose coverage. Recently, the Sahel Region has experienced a security crisis, resulting in decreasing PCV13 coverage. We examined pneumococcal carriage before a mass PCV13 campaign in the Sahel Region in 2022. In January and February 2022, we conducted a cross-sectional, age-stratified pneumococcal carriage study among healthy individuals in Dori, the capital of the Sahel Region. We collected nasopharyngeal (all participants) and oropharyngeal swabs (participants 5 years old and older). Pneumococci isolated by culture were serotyped by polymerase chain reaction and/or Quellung. We evaluated overall and vaccine serotype pneumococcal carriage prevalence by age group. Among 1,079 participants, overall pneumococcal carriage prevalence was 57.2%; carriage was highest in children 1 year old (71.8%) and 1-11 months old (69.7%) and lowest in participants 15 years old or older (30.0%). Vaccine serotype carriage prevalence was 12.8%, ranging from 5.6% in participants 15 years old or older to 17.8% in children 5-14 years old. PCV13 vaccination history was unknown for 59.6% of age-eligible children. Among children with card-confirmed or verbally reported PCV13 history, most (99.0%) had no history of PCV13 receipt. Eight years after PCV13 introduction and in a conflict-affected area with declining PCV13 coverage, more than 1 in 10 children and 1 in 20 participants 15 years old or older are colonized with a vaccine serotype. These results will be used to evaluate the mass PCV13 campaign impact and help inform policy surrounding pneumococcal conjugate vaccine use during humanitarian crises.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a Weighted Absolute Percentage Error-Based Method for Calculating the Aggregate Accuracy of Reported Malaria Surveillance Data. 基于加权绝对百分比误差的方法在计算疟疾监测报告数据总精度中的应用。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0804

Smita Das, Arantxa Roca-Feltrer, Michael Hainsworth

引用次数: 0

Investigating Oropouche as a Possible Etiology for Febrile Illness in a Clinical Cohort from Colombia, 2014-2015. 调查2014-2015年哥伦比亚临床队列中Oropouche作为发热性疾病的可能病因

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0758

Christine S Walsh, Jenny C Cardenas, Lady Y Gutierréz-Silva, Maria U González, Christopher N Mores, Berlin Londono-Renteria, Rebecca C Christofferson

引用次数: 0

Poached Egg Lesions in the Colon Because of Amebiasis. 阿米巴病引起的结肠病变。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0852

Lalit Chandra Kummetha, Venkatesh Vaithiyam, Surbhi Goyal

引用次数: 0

Transcriptomic Analysis of Mayaro Virus-Infected Human Macrophages: Effects on Inflammatory and Antiviral Response. Mayaro病毒感染的人巨噬细胞转录组学分析：对炎症和抗病毒反应的影响。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0682

Lady Johana Hernández-Sarmiento, Y S Tamayo-Molina, Silvio Urcuqui-Inchima

{"title":"Transcriptomic Analysis of Mayaro Virus-Infected Human Macrophages: Effects on Inflammatory and Antiviral Response.","authors":"Lady Johana Hernández-Sarmiento, Y S Tamayo-Molina, Silvio Urcuqui-Inchima","doi":"10.4269/ajtmh.24-0682","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0682","url":null,"abstract":"Mayaro virus (MAYV) belongs to the Togaviridae family and is the etiologic agent of Mayaro fever, a disease in which inflammatory responses play a critical role in viral pathogenesis. Macrophages are targets of viral infection and key components of innate immunity and antiviral response. This study analyzed an RNA-sequencing (RNA-seq) dataset to gain insights into inflammatory and antiviral responses in monocyte-derived macrophages (MDMs) infected with the MAYV strain (Venezuelan 2010) at a multiplicity of infection (MOI) of 10. The RNA-seq results were validated by real-time quantitative polymerase chain reaction in MDMs infected with the MAYV strain from Brazil (MOI of 2). In addition, the replication capacity of MAYV and the resulting cell death in infected MDMs were assessed using plaque assays and flow cytometry. At 72 hours post-infection, transcriptomic analysis revealed that MAYV promotes a robust proinflammatory response by upregulating the expression of Toll-like receptors, RIG-I-like receptors, and the nuclear factor-κB complex. This strong inflammatory response was accompanied by a robust antiviral response dependent on type I/III interferon and interleukin-27. Both antiviral responses are mediated through the Janus kinase/signal transducer and activator of transcription signaling pathway, leading to the expression of interferon-stimulated genes. Moreover, MAYV-infected MDMs expressed markers of programmed cell death. These findings highlight the inflammatory response and antiviral activity of MDMs at a late stage in MAYV infection, suggesting a critical role of macrophages in MAYV pathogenesis.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CCM and RTAT Malaria Interventions. CCM和RTAT疟疾干预措施。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 Print Date: 2025-06-04 DOI: 10.4269/ajtmh.25-0056

Richard W Steketee

引用次数: 0