American Journal of Tropical Medicine and Hygiene最新文献_第10页

Water Treatment Practices and Misperceived Social Norms among Women Living with Young Children in Rural Uganda. 乌干达农村地区有年幼子女的妇女的水处理方法和误解的社会规范。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0723

Jessica M Perkins, Bernard Kakuhikire, Charles Baguma, Meredith Meadows, Raphael Abayateye, Justin D Rasmussen, Emily N Satinsky, Patrick Gumisiriza, Justus Kananura, Elizabeth B Namara, David R Bangsberg, Alexander C Tsai

{"title":"Water Treatment Practices and Misperceived Social Norms among Women Living with Young Children in Rural Uganda.","authors":"Jessica M Perkins, Bernard Kakuhikire, Charles Baguma, Meredith Meadows, Raphael Abayateye, Justin D Rasmussen, Emily N Satinsky, Patrick Gumisiriza, Justus Kananura, Elizabeth B Namara, David R Bangsberg, Alexander C Tsai","doi":"10.4269/ajtmh.23-0723","DOIUrl":"10.4269/ajtmh.23-0723","url":null,"abstract":"Access to water safe for consumption is critical for health and well-being, yet substantial structural barriers often necessitate household action to make water safer. Social norms about water treatment practices are understudied as a driver of personal water treatment practice. This study assesses reported and perceived water treatment practices among women in a rural, water insecure setting. We used cross-sectional data from a population-based study of women living with children under 5 years old across eight villages in southwest Uganda. Participants reported their typical household water treatment practices and what they perceived to be the common practices among most other women with young children in their own village. Modified multivariable Poisson regression models estimated the association between individual behavior and perceptions. Of 274 participants (78% response rate), 221 (81%) reported boiling water and 228 (83%) reported taking at least one action to make water safer. However, 135 (49%) misperceived most women with young children in their village not to boil their water, and 119 (43%) misperceived most to take no action. Participants who misperceived these norms were less likely to practice safe water treatment (e.g., for boiling water, adjusted relative risk = 0.80; 95% CI 0.69-0.92, P = 0.002), adjusting for other factors. Future research should assess whether making actual descriptive norms about local water treatment practices visible and salient (e.g., with messages such as \"most women in this village boil their drinking water\") corrects misperceived norms and increases safe water treatment practices by some and supports consistent safe practices by others.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women's Perceived HIV Stigma and Testing in Stann Creek District, Belize: A Population-Representing, Mixed-Methods Study. 伯利兹 Stann Creek 区妇女感知到的 HIV 耻辱和检测：人口代表性混合方法研究》。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0059

Sarah L Rossi, Kalee Young, Paulette Wade, Shane M Khan, Karsten Lunze

{"title":"Women's Perceived HIV Stigma and Testing in Stann Creek District, Belize: A Population-Representing, Mixed-Methods Study.","authors":"Sarah L Rossi, Kalee Young, Paulette Wade, Shane M Khan, Karsten Lunze","doi":"10.4269/ajtmh.23-0059","DOIUrl":"10.4269/ajtmh.23-0059","url":null,"abstract":"Stigma affects adversely the HIV prevention continuum and care cascade. Our population-based, mixed-methods study aimed to assess women's perceived HIV stigma and discriminatory attitudes, and their relation with HIV testing in a high-prevalence area in Belize. This population-representing household survey in the mixed urban-rural setting of Stann Creek District, Belize, collected data from 236 women age 15 to 49 years. We analyzed HIV testing rates, HIV prevention and transmission knowledge, perceived stigma manifestations, and participant attitudes. Concurrently, a nested qualitative component of study cognitive interviews with a purposive sample of 23 women explored HIV stigma in their community. A vast majority of women (96%) perceived HIV stigma manifestations in their communities as pervasive and a deterrent to people from testing. Discriminatory attitudes (16% believe children with HIV should not attend school) and HIV misconceptions (53% fear acquiring HIV through saliva) tended to be more common in nonurban areas and among women with less formal education. Stigma persisted even with high HIV testing rates among women. Qualitative findings triangulated survey results and, taken together, suggest that prejudices held against people with HIV led to avoidance of HIV preventive measures such as testing and status disclosure, fueled by a strong distrust of the medical care system regarding confidentiality of HIV test results. Misconceptions about HIV and stigmatizing attitudes remain pervasive among women in Stann Creek, Belize. Health literacy, stigma interventions, and expansion of routine confidential testing to include men are needed to address the HIV and stigma syndemic in Belize.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the Impact of Proactive Community Case Management on Reducing Confirmed Malaria Cases in Sub-Saharan African Countries. 模拟积极主动的社区病例管理对减少撒哈拉以南非洲国家确诊疟疾病例的影响。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0844

Yifan Wang, Xingjian Wang, Brian Gurbaxani, Julie R Gutman, Pinar Keskinocak, Hannah K Smalley, Julie Thwing

{"title":"Modeling the Impact of Proactive Community Case Management on Reducing Confirmed Malaria Cases in Sub-Saharan African Countries.","authors":"Yifan Wang, Xingjian Wang, Brian Gurbaxani, Julie R Gutman, Pinar Keskinocak, Hannah K Smalley, Julie Thwing","doi":"10.4269/ajtmh.23-0844","DOIUrl":"10.4269/ajtmh.23-0844","url":null,"abstract":"Malaria continues to be a major source of morbidity and mortality in sub-Saharan Africa. Timely, accurate, and effective case management is critical to malaria control. Proactive community case management (ProCCM) is a new strategy in which a community health worker \"sweeps\" a village, visiting households at defined intervals to proactively provide diagnostic testing and treatment if indicated. Pilot experiments have shown the potential of ProCCM for controlling malaria transmission; identifying the best strategy for administering ProCCM in terms of interval timings and number of sweeps could lead to further reductions in malaria infections. We developed an agent-based simulation to model malaria transmission and the impact of various ProCCM strategies. The model was validated using symptomatic prevalence data from a ProCCM pilot study in Senegal. Various ProCCM strategies were tested to evaluate the potential for reducing parasitologically confirmed symptomatic malaria cases in the Senegal setting. We found that weekly ProCCM sweeps during a 21-week transmission season could reduce cases by 36.3% per year compared with no sweeps. Alternatively, two initial fortnightly sweeps, seven weekly sweeps, and finally four fortnightly sweeps (13 sweeps total) could reduce confirmed malaria cases by 30.5% per year while reducing the number of diagnostic tests and corresponding costs by about 33%. Under a highly seasonal transmission setting, starting the sweeps early with longer duration and higher frequency would increase the impact of ProCCM, though with diminishing returns. The model is flexible and allows decision-makers to evaluate implementation strategies incorporating sweep frequency, time of year, and available budget.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Psychosocial Factors and Mental Well-Being for Baby WASH- and Nutrition-Related Behaviors in Lao PDR. 社会心理因素和心理健康对老挝人民民主共和国婴儿讲卫生和营养相关行为的作用。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.22-0418

Jurgita Slekiene, Claire Chase, Simi Mishra, Hans-Joachim Mosler

{"title":"Role of Psychosocial Factors and Mental Well-Being for Baby WASH- and Nutrition-Related Behaviors in Lao PDR.","authors":"Jurgita Slekiene, Claire Chase, Simi Mishra, Hans-Joachim Mosler","doi":"10.4269/ajtmh.22-0418","DOIUrl":"10.4269/ajtmh.22-0418","url":null,"abstract":"In Lao PDR, 30% of children under age 5 years are affected by stunting. Stunting in childhood is associated with poorer outcomes for both physical and cognitive development. Baby WASH is a focused approach to water supply, sanitation, and hygiene for infants and children that targets numerous contextual and psychosocial factors including child handwashing, food hygiene, clean play spaces, and management of animal feces in the household environment. Using the risks, attitudes, norms, abilities, and self-regulation approach to behavior change (BC), the objective of this study was to investigate psychosocial factors of Baby WASH and nutrition related-behaviors, considering caregivers mental well-being, to design evidence-based BC interventions. A cross-sectional survey of 616 caregivers of a child under 2 years was conducted in Lao PDR. Caregivers well-being was significantly associated with handwashing before feeding a baby, controlling \"mouthing,\" and the intention to exclusively breastfeed for the first 6 months. All psychosocial factors of the three behaviors were correlated with mental well-being. Results suggest that attitudinal and ability factors underlying handwashing with soap before feeding a child should be the primary focus of BC interventions. For controlling mouthing factors, interventions should target attitude and norm factors. To increase the intention of exclusive breastfeeding for the first 6 months attitude, ability, and self-regulation factors should be targeted through BC interventions. The findings of this study can be used to support the inclusion of vulnerable caregivers with poor mental well-being with BC interventions designed to improve child health and prevent stunting.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Multiple Metastatic Primary Multidrug-Resistant Tubercular Abscesses. 病例报告：多个转移性原发性耐多药结核脓肿

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0514

Megha Priyadarshi, Harish Pant, Sunit Sikdar, Sanjeev Sinha, Surabhi Vyas, Piyush Ranjan

{"title":"Case Report: Multiple Metastatic Primary Multidrug-Resistant Tubercular Abscesses.","authors":"Megha Priyadarshi, Harish Pant, Sunit Sikdar, Sanjeev Sinha, Surabhi Vyas, Piyush Ranjan","doi":"10.4269/ajtmh.23-0514","DOIUrl":"10.4269/ajtmh.23-0514","url":null,"abstract":"This case report presents an atypical manifestation of tuberculosis in a 21-year-old male who presented with multiple subcutaneous swellings in the bilateral heel, left elbow, and base of the left third finger for the previous 6 months. The patient also experienced loss of appetite and unintentional weight loss. Despite initial suspicion of bacterial abscesses, antibiotics did not lead to significant improvement. Further investigations revealed an elevated erythrocyte sedimentation rate and findings suggestive of osteomyelitis on imaging. Gene Xpert testing confirmed multidrug-resistant Mycobacterium tuberculosis as the causative agent. The patient was prescribed a bedaquiline-based multidrug-resistant tuberculosis regimen, which resulted in reduction in swelling size. This report highlights the challenges in diagnosing and managing complex cases of primary multiple tubercular abscesses, especially with drug-resistant strains, emphasizing the importance of timely diagnosis and multidisciplinary management for successful outcomes.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicoepidemiological Profile of Ciguatera Cardiotoxicity: A Systematic Review. 雪卡毒素心脏毒性的临床流行病学概况：系统回顾。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.24-0207

Clarke Morihara, Thanaboon Yinadsawaphan, Christian John Capirig, Bradley Fujiuchi, Yusuke Hirao, Joshua Hu, Reed McCardell Malone, Jadon Neuendorf, Sable Neuendorf, Sorawit Ongsupankul, Kazushige Shiraishi, Kevin Benavente, Yoshito Nishimura

{"title":"Clinicoepidemiological Profile of Ciguatera Cardiotoxicity: A Systematic Review.","authors":"Clarke Morihara, Thanaboon Yinadsawaphan, Christian John Capirig, Bradley Fujiuchi, Yusuke Hirao, Joshua Hu, Reed McCardell Malone, Jadon Neuendorf, Sable Neuendorf, Sorawit Ongsupankul, Kazushige Shiraishi, Kevin Benavente, Yoshito Nishimura","doi":"10.4269/ajtmh.24-0207","DOIUrl":"10.4269/ajtmh.24-0207","url":null,"abstract":"Patients with ciguatera poisoning commonly present with gastrointestinal and neurologic symptoms, but its cardiotoxicity has been largely unrecognized. This systematic review is the first to summarize the evidence regarding clinical characteristics of cardiotoxicity from ciguatera poisoning to provide the illness script and pertinent knowledge for clinicians. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement, we searched MEDLINE and EMBASE for all peer-reviewed articles using keywords including \"ciguatera\" and \"cardiotoxicity\" from their inception to January 2024. We included 20 articles, including 148 cases, in this systematic review. Among the included cases, the median age was 54 years with male predominance (62.2%). Based on the WHO designation, 68.5% were reported from the Western Pacific Region. Common symptoms included hypotension (75.0%) and bradycardia (67.6%), and chest pain or syncope were less commonly reported (2.7% and 1.4%, respectively). Sinus bradycardia was the most common electrocardiogram abnormality (35.9%), followed by atrioventricular blocks (15.4%). Symptomatic treatments such as atropine, dopamine, and epinephrine were commonly used, and only 4.1% required intensive care unit admission. None expired due to cardiotoxicity from ciguatera. This review summarizes the current evidence and the characteristics of cardiotoxicity from ciguatera. Although ciguatera cardiotoxicity is currently underrecognized, increased awareness of the condition in clinicians is crucial because the clinical outcomes of the patients could be benign as long as it is identified and intervened early.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the Environmental Suitability and Identifying Climate and Sociodemographic Correlates of Guinea Worm (Dracunculus medinensis) in Chad. 预测乍得几内亚蠕虫（Dracunculus Medinensis）的环境适应性并确定气候和社会人口相关因素。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-03 DOI: 10.4269/ajtmh.23-0681

Obiora A Eneanya, Maryann G Delea, Jorge Cano, Philip Ouakou Tchindebet, Robert L Richards, Yujing Zhao, Abdalla Meftuh, Karmen Unterwegner, Sarah Anne J Guagliardo, Donald R Hopkins, Adam Weiss

{"title":"Predicting the Environmental Suitability and Identifying Climate and Sociodemographic Correlates of Guinea Worm (Dracunculus medinensis) in Chad.","authors":"Obiora A Eneanya, Maryann G Delea, Jorge Cano, Philip Ouakou Tchindebet, Robert L Richards, Yujing Zhao, Abdalla Meftuh, Karmen Unterwegner, Sarah Anne J Guagliardo, Donald R Hopkins, Adam Weiss","doi":"10.4269/ajtmh.23-0681","DOIUrl":"10.4269/ajtmh.23-0681","url":null,"abstract":"A comprehensive understanding of the spatial distribution and correlates of infection are key for the planning of disease control programs and assessing the feasibility of elimination and/or eradication. In this work, we used species distribution modeling to predict the environmental suitability of the Guinea worm (Dracunculus medinensis) and identify important climatic and sociodemographic risk factors. Using Guinea worm surveillance data collected by the Chad Guinea Worm Eradication Program (CGWEP) from 2010 to 2022 in combination with remotely sensed climate and sociodemographic correlates of infection within an ensemble machine learning framework, we mapped the environmental suitability of Guinea worm infection in Chad. The same analytical framework was also used to ascertain the contribution and influence of the identified climatic risk factors. Spatial distribution maps showed predominant clustering around the southern regions and along the Chari River. We also identified areas predicted to be environmentally suitable for infection. Of note are districts near the western border with Cameroon and southeastern border with Central African Republic. Key environmental correlates of infection as identified by the model were proximity to permanent rivers and inland lakes, farmlands, land surface temperature, and precipitation. This work provides a comprehensive model of the spatial distribution of Guinea worm infections in Chad 2010-2022 and sheds light on potential environmental correlates of infection. As the CGWEP moves toward elimination, the methods and results in this study will inform surveillance activities and help optimize the allocation of intervention resources.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series: Microbacterium aurum Bacteremia in Immunosuppressed Patients-An Emerging Threat. 病例系列：免疫抑制患者的金黄色葡萄球菌菌血症--一种新出现的威胁。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-03 DOI: 10.4269/ajtmh.23-0701

Gerlin Varghese, Deepika Sarawat, Ashima Jamwal, Sangram Singh Patel, Nidhi Tejan, Chinmoy Sahu

{"title":"Case Series: Microbacterium aurum Bacteremia in Immunosuppressed Patients-An Emerging Threat.","authors":"Gerlin Varghese, Deepika Sarawat, Ashima Jamwal, Sangram Singh Patel, Nidhi Tejan, Chinmoy Sahu","doi":"10.4269/ajtmh.23-0701","DOIUrl":"10.4269/ajtmh.23-0701","url":null,"abstract":"Blood stream infection with Microbacterium species in humans is rare and frequently linked to the presence of immunosuppressed conditions such as patients on chemotherapy or corticosteroids. Presence of indwelling catheters is also a potential risk factor for M. aurum infection. No case report has been documented in the literature regarding the pathogenic potential of M. aurum in causing bacteremia. This is the first case series reporting bacteremia by M. aurum describing the risk factors and sensitivity pattern of this pathogen. In this case series, we have described bacteremia caused by M. aurum. The risk factors and sensitivity pattern of this pathogen have also been evaluated. Here, we describe the clinical course and presentation of three patients whose blood culture showed growth of M. aurum. Indwelling venous catheter for hemodialysis or for chemotherapy for the treatment of acute lymphoblastic leukemia was found to be a risk factor in two patients. Rheumatoid arthritis was the underlying condition in the second patient and was started on immunosuppressants. Blood samples were collected during the febrile period. The blood culture samples of all these patients had pure isolates of M. aurum, identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. All three patients were managed according to the sensitivity reports and were discharged in stable condition.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare Providers' and Frontline Workers' Experiences of an Ebola Vaccine Trial in the Boende Health District of the Democratic Republic of the Congo. 在刚果民主共和国博恩代卫生区开展的埃博拉疫苗试验中医疗服务提供者和一线工作者的经历。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-02 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0581

Trésor Zola Matuvanga, Freddy Bikioli Bolombo, Antea Paviotti, Ynke Larivière, Gwen Lemey, Maha Salloum, Bernard Isekah Osang'ir, Junior Matangila, Vivi Maketa, Emmanuel Esanga, Solange Milolo, Patrick Mitashi, Pierre Van Damme, Hypolite Muhindo-Mavoko, Jean-Pierre Van Geertruyden

{"title":"Healthcare Providers' and Frontline Workers' Experiences of an Ebola Vaccine Trial in the Boende Health District of the Democratic Republic of the Congo.","authors":"Trésor Zola Matuvanga, Freddy Bikioli Bolombo, Antea Paviotti, Ynke Larivière, Gwen Lemey, Maha Salloum, Bernard Isekah Osang'ir, Junior Matangila, Vivi Maketa, Emmanuel Esanga, Solange Milolo, Patrick Mitashi, Pierre Van Damme, Hypolite Muhindo-Mavoko, Jean-Pierre Van Geertruyden","doi":"10.4269/ajtmh.23-0581","DOIUrl":"10.4269/ajtmh.23-0581","url":null,"abstract":"This study explored the experiences of healthcare providers (HCPs) and frontline workers who were involved in an Ebola vaccine trial in the Democratic Republic of the Congo. The researchers interviewed a total of 99 participants (HCPs and frontline workers) living and working in the Boende health district during the period of the study, from February to March 2022. These individuals included a mix of trial participants and non-trial participants (staff of the trial, local health authorities, and head nurses of health centers). In-depth individual interviews, as well as focus group discussions (FGDs), were used to understand interviewees' experiences and perceptions. The data were analyzed to identify the main themes. The findings unveiled a multitude of positive experiences among interviewees/FGD participants. The commitment of the trial investigators to improve the study site and to equip the volunteers with necessary skills and knowledge greatly contributed to a positive trial experience. However, some interviewees felt that the reimbursement for time and travel expenses during their trial visits was insufficient in comparison with their expectations. Additionally, there were expressions of worry about the frequency of blood draws during scheduled trial visits. Our findings emphasize the critical importance of addressing and continuously considering the perspectives and concerns of trial participants before designing and implementing vaccine trials. By actively incorporating their inputs, researchers can mitigate concerns and tailor communication strategies, potentially enhancing the overall success and impact of the vaccine trial.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Epidemiology and Clinical Features of Deinagkistrodon acutus Envenomation: A Retrospective Study from a Medical Center in Hangzhou, Southeast China. 尖吻蝮的流行病学和临床特征：中国东南部杭州一家医疗中心的回顾性研究。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-02 Print Date: 2024-09-04 DOI: 10.4269/ajtmh.23-0680

Sipin Hu, Shuhua Bao, Yuchen Shen, Mengyun Tu

{"title":"The Epidemiology and Clinical Features of Deinagkistrodon acutus Envenomation: A Retrospective Study from a Medical Center in Hangzhou, Southeast China.","authors":"Sipin Hu, Shuhua Bao, Yuchen Shen, Mengyun Tu","doi":"10.4269/ajtmh.23-0680","DOIUrl":"10.4269/ajtmh.23-0680","url":null,"abstract":"Deinagkistrodon acutus envenomation is one of the most common types of venomous snakebite in China and causes a series of envenomating effects on its victims. However, more specific information on the characteristics of D. acutus envenomation is rare in the English literature. Therefore, we aimed to give a detailed description of the epidemiological and clinical features of patients with D. acutus envenomation. Patients who were admitted with D. acutus envenomation between January 2018 and December 2021 were enrolled in this retrospective study. The data on demographics, clinical manifestations, laboratory features, management, and outcomes were collected. A total of 158 cases of D. acutus envenomation were enrolled. Men (n = 121; 76.6%) and rural populations (n = 133; 84.2%) were the high-risk groups, and most incidents (n = 141; 89.2%) happened between May and September. The specific effect was tissue necrosis at bite site, which occurred in 72 patients (45.6%). Other envenomation effects include extensive limb swelling, blistering, wound bleeding, and coagulopathy. In the envenomed patients, 155 (98.1%) received antivenom, 47 (29.7%) needed operations, 20 (12.7%) required intensive care, and one died. Deinagkistrodon acutus envenomation is a common snakebites emergency in Hangzhou area. A high rate of tissue necrosis at bite site and venom-induced consumption coagulopathy are the characteristics of D. acutus envenomation. Although the mortality rate is low, some patients still require intensive care.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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