American Journal of Tropical Medicine and Hygiene最新文献_第10页

Intralesional Treatment of Non-American Cutaneous Leishmaniasis with Multiple Lesions.

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-28 DOI: 10.4269/ajtmh.24-0667

Clarissa Pieri, Stephen L Walker

引用次数: 0

Epidemiologic Investigation of Protozoa and Soil-Transmitted Helminths in Starr County, Texas.

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-28 DOI: 10.4269/ajtmh.24-0364

Lauren M Leining, Timothy A Erickson, Craig L Hanis, Cici Bauer, Maya D Murry, Eric L Brown, Rojelio Mejia, Sarah M Gunter

引用次数: 0

Web Visualization for Spatiotemporal Genomic Epidemiology, Annotation, and Mutation Dynamics of Orthohantavirus hantanense Using Nextstrain.

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-28 DOI: 10.4269/ajtmh.24-0432

Kyungmin Park, Kijin Kim, Jongwoo Kim, Juyoung Noh, Seong-Gyu Kim, Hee-Kyung Cho, Ye-Rin Seo, Jin Il Kim, Man-Seong Park, Won-Keun Kim, Jin-Won Song

{"title":"Web Visualization for Spatiotemporal Genomic Epidemiology, Annotation, and Mutation Dynamics of Orthohantavirus hantanense Using Nextstrain.","authors":"Kyungmin Park, Kijin Kim, Jongwoo Kim, Juyoung Noh, Seong-Gyu Kim, Hee-Kyung Cho, Ye-Rin Seo, Jin Il Kim, Man-Seong Park, Won-Keun Kim, Jin-Won Song","doi":"10.4269/ajtmh.24-0432","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0432","url":null,"abstract":"The phylogeographic inference approach aims to connect genomic data with epidemiology to understand the spread and evolution of pathogens using visualization of spatiotemporal reconstructions. Orthohantavirus hantanense (HTNV), the causative agent of hemorrhagic fever with renal syndrome (HFRS), represents a significant global public health concern. Here, we introduce a localized Nextstrain platform for HTNV, offering a comprehensive resource for facilitating spatiotemporal genomic surveillance and the study of evolutionary dynamics of viral genomes. Nextstrain enables web-based visualization and simple sharing of graphic and numeric data through unique web addresses. The Nextstrain build for HTNV stands out for its user-friendly interface and is readily accessible online at https://nextstrain.org/community/KU-MV/Hantavirus. This study provides valuable insights into genomic surveillance, viral phylodynamics, and the evolutionary history of orthohantaviruses for the development of public health policies against endemic HFRS outbreaks.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Enterocytozoon bieneusi Infection on Child Growth: A Secondary Analysis of the MAL-ED Birth Cohort Study.

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-28 DOI: 10.4269/ajtmh.23-0895

Md Ahshanul Haque, Shaumik Islam, Syed Jayedul Bashar, Abu Sayem Mirza Md Hasibur Rahman, A S G Faruque, Tahmeed Ahmed, Mustafa Mahfuz

{"title":"Influence of Enterocytozoon bieneusi Infection on Child Growth: A Secondary Analysis of the MAL-ED Birth Cohort Study.","authors":"Md Ahshanul Haque, Shaumik Islam, Syed Jayedul Bashar, Abu Sayem Mirza Md Hasibur Rahman, A S G Faruque, Tahmeed Ahmed, Mustafa Mahfuz","doi":"10.4269/ajtmh.23-0895","DOIUrl":"https://doi.org/10.4269/ajtmh.23-0895","url":null,"abstract":"Malnutrition in the early days of life is a global public health concern that affects children's growth. It results from a variety of factors, including pathogenic infections. Enterocytozoon bieneusi is a microsporidian parasite that can cause diarrhea and malnutrition in children. The study aimed to assess the impact of E. bieneusi on child growth. The MAL-ED study, a multicountry birth cohort research project, investigated the relationship between enteric infections and malnutrition in participating children from eight countries. A customized real-time polymerase chain reaction-based TaqMan array card was used in this study to identify enteropathogens from stool samples, where E. bieneusi was one of the target pathogens. The impacts of E. bieneusi infection on growth measures were assessed. Mixed-effect linear models were used to investigate the relationship between E. bieneusi and growth outcomes, including length-for-age (LAZ), weight-for-age (WAZ), and weight-for-length (WLZ) Z scores. At the endpoint (last month of measurement), the infected group had significantly lower scores than the noninfected group for all outcomes. The adjusted difference-in-difference (D-in-D) values were -0.53 (95% CI: -0.67 to -0.38) for LAZ, -0.38 (95% CI: -0.52 to -0.23) for WAZ, and -0.22 (95% CI: -0.38 to -0.06) for WLZ. Enterocytozoon bieneusi infection has been identified as a factor associated with reduced linear growth, weight gain, and weight gain relative to linear growth in children, underscoring the importance of treating this infection.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporating Community Case Management in Risk-Based Surveillance for Malaria Elimination in the Dominican Republic. 将社区病例管理纳入基于风险的监测以消除多米尼加共和国的疟疾。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0404

Isabel Byrne, Luca Nelli, Keyla Ureña, Luccène Désir, Claudia Hilario Rodriguez, Nicole Michelén Ströfer, Justin T Lana, Gregory S Noland, Manuel de Jesús Tejada Beato, Jose Luis Cruz Raposo, Chris Drakeley, Karen E S Hamre, Gillian Stresman

{"title":"Incorporating Community Case Management in Risk-Based Surveillance for Malaria Elimination in the Dominican Republic.","authors":"Isabel Byrne, Luca Nelli, Keyla Ureña, Luccène Désir, Claudia Hilario Rodriguez, Nicole Michelén Ströfer, Justin T Lana, Gregory S Noland, Manuel de Jesús Tejada Beato, Jose Luis Cruz Raposo, Chris Drakeley, Karen E S Hamre, Gillian Stresman","doi":"10.4269/ajtmh.24-0404","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0404","url":null,"abstract":"As countries strive for malaria elimination, it is crucial to gather sufficient evidence to confirm the absence of transmission. Routine surveillance data often lack the sensitivity to detect community transmission at low levels. In the Dominican Republic, community health workers (CHWs) have been deployed in malaria foci to perform active case detection. This study aimed to assess the added value of CHWs in enhancing the health system's malaria detection capabilities. Freedom from infection (FFI) is a statistical framework designed to demonstrate the absence of malaria by using routinely collected health data. We adapted this framework to include CHW data, estimating their contribution to the health system's malaria detection ability. The model was applied to facility and CHW data from 33 facilities across nine provinces in the Dominican Republic, covering the period from January 2018 to April 2022. The likelihood that a facility's catchment population is free from malaria infection (Pfree) was achieved in 52% of facilities by using only routine data, sustained for an average of 13 months. With the addition of CHW data, 88% of facilities reached Pfree, sustained for an average of 37 months. Incorporating CHW data enhanced the precision of model estimates by over 500-fold. The study demonstrated the near absence of malaria in several facility catchment populations. It highlighted the importance of community case management in supplementing routine surveillance, thereby improving the precision of malaria transmission estimates. These findings support the further application of the FFI framework to accelerate progress toward malaria elimination in the Dominican Republic.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Prevalence of Antimicrobial Resistance in Vibrio cholerae in the Capital and Provincial Areas of Zambia, January 2023-February 2024. 2023年1月至2024年2月，赞比亚首都和省级地区霍乱弧菌抗菌素耐药性流行率上升。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0558

Thandiwe Msipu Phiri, Tadatsugu Imamura, Peter Chibale Mwansa, Ilunga Mathews, Frazer Mtine, Jedidiah Chanda, Mulenga Salasini, Takanori Funaki, Kapona Otridah, Kunda Musonda, Roma Chilengi

{"title":"Increased Prevalence of Antimicrobial Resistance in Vibrio cholerae in the Capital and Provincial Areas of Zambia, January 2023-February 2024.","authors":"Thandiwe Msipu Phiri, Tadatsugu Imamura, Peter Chibale Mwansa, Ilunga Mathews, Frazer Mtine, Jedidiah Chanda, Mulenga Salasini, Takanori Funaki, Kapona Otridah, Kunda Musonda, Roma Chilengi","doi":"10.4269/ajtmh.24-0558","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0558","url":null,"abstract":"Zambia experienced the largest cholera epidemic in the country's history in 2023-2024; however, the antimicrobial susceptibility profile of Vibrio cholerae during the epidemic is unknown. A total of 2,384 stool samples were collected from suspected cholera cases in Eastern, Lusaka, and Luapula provinces in Zambia from January 2023 to March 2024. Among them, 549 (23.5%, n = 549 of 2,341) were culture positive for V. cholerae O1, and antimicrobial susceptibility results were available for 431 (78.5%, n = 431 of 549). Sensitivity for tetracycline was 84.5% (n = 316 of 374) in Lusaka, whereas it was 100% in Eastern and Luapula provinces. Isolates resistant to azithromycin were found only in Lusaka (1.6%, n = 1 of 61). Sensitivity for ciprofloxacin was 81.8% (n = 260 of 318) in Lusaka province, whereas it was 100% in other provinces. Our results suggested an increased prevalence of antimicrobial resistance in V. cholerae against the first- and second-line antibiotic treatments, particularly in the capital. Careful monitoring of the regional antibiogram is warranted.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Day with Gold Miners in the Amazon Fighting against Malaria. 与亚马逊淘金者对抗疟疾的一天。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0687

Maylis Douine

引用次数: 0

The First Autochthonous Case of Actinomycetoma in a Bedouin Patient in the Israeli Negev Region. 以色列内盖夫地区贝都因患者的首例本土放线菌瘤病例。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0532

Meital Haber, Tali Shafat, Benzion Samueli, Daniel Grupel

引用次数: 0

Assessment of Malaria Rapid Diagnostic Tests and Histidine-Rich Protein 2 Deletions among Asymptomatic Children and Adults in Bagamoyo, Tanzania. 坦桑尼亚巴加莫约地区无症状儿童和成人疟疾快速诊断试验和富组氨酸蛋白2缺失的评估

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0209

Billy Ngasala, Kofi B Opoku, Kano Amagai, Ashenafi Assefa, Mwajabu Loya, Mwanaidi Nyange, Meredith Muller, Hamza Said, Christopher Basham, Eric Rogier, Jonathan J Juliano, Jonathan B Parr, Jessica T Lin

{"title":"Assessment of Malaria Rapid Diagnostic Tests and Histidine-Rich Protein 2 Deletions among Asymptomatic Children and Adults in Bagamoyo, Tanzania.","authors":"Billy Ngasala, Kofi B Opoku, Kano Amagai, Ashenafi Assefa, Mwajabu Loya, Mwanaidi Nyange, Meredith Muller, Hamza Said, Christopher Basham, Eric Rogier, Jonathan J Juliano, Jonathan B Parr, Jessica T Lin","doi":"10.4269/ajtmh.24-0209","DOIUrl":"10.4269/ajtmh.24-0209","url":null,"abstract":"Malaria rapid diagnostic tests (mRDTs) that detect histidine-rich protein 2 (HRP2) remain the mainstay of falciparum malaria diagnosis in Sub-Saharan Africa. Understanding their test characteristics when used for surveillance in asymptomatic populations is important. We explored the rate of false-positive and false-negative mRDT results among asymptomatic persons >5 years old screened for malaria at schools and clinics in the rural Bagamoyo District using 18S ribosomal RNA real-time polymerase chain reaction (qPCR) as the reference test. Among 5,966 persons screened using mRDTs, microscopy, and qPCR tests from 2018 to 2021, 14% (832) were mRDT-positive. Twelve percent of these (98/832) were negative by both microscopy and qPCR, with children overrepresented among those with false-positive mRDTs. Among those who were mRDT-negative, 22% (1,136/5,134) tested qPCR-positive, predominantly because of low-density parasitemia (92% had <100 p/µL by qPCR). Among mRDT-negative samples with >100 p/µL, we looked for evidence of hrp2 or histidine-rich protein 3 (hrp3) deletion using two methods, multiplexed qPCR and multiplex bead-based immunoassay. When sufficient parasite material existed for a reliable deletion assessment, 12/34 (35%) had evidence of hrp2/3 deletion by qPCR (nine hrp2-/3+ and three hrp2-/3-), and 20/52 (38%) had evidence of deletion by immunoassay. Only three isolates showed evidence of hrp2 deletion by both assays. In an area of low to moderate transmission in Tanzania, false-positive mRDTs are relatively common (12% of positive tests), and false-negative mRDTs are even more common (22% of negative tests), but hrp2/3 deletion causing false-negative mRDTs remains rare (<1% of negative tests).","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated Coronavirus Disease 2019 Patients: An Analysis of Four Observational Studies in Four Countries on Two Continents.

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-01-21 DOI: 10.4269/ajtmh.24-0257

Siebe G Blok, Luigi Pisani, Elisa Estenssoro, Juliana Carvalho Ferreira, Michela Botta, Ana Motos, Ignacio Martin-Loeches, Antoni Torres, Marcus J Schultz, Frederique Paulus, David M P van Meenen

{"title":"Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated Coronavirus Disease 2019 Patients: An Analysis of Four Observational Studies in Four Countries on Two Continents.","authors":"Siebe G Blok, Luigi Pisani, Elisa Estenssoro, Juliana Carvalho Ferreira, Michela Botta, Ana Motos, Ignacio Martin-Loeches, Antoni Torres, Marcus J Schultz, Frederique Paulus, David M P van Meenen","doi":"10.4269/ajtmh.24-0257","DOIUrl":"10.4269/ajtmh.24-0257","url":null,"abstract":"Epidemiology, ventilator management, and outcomes in patients with acute respiratory distress syndrome (ARDS) because of coronavirus disease 2019 (COVID-19) have been described extensively but have never been compared between countries. We performed an individual patient data analysis of four observational studies to compare epidemiology, ventilator management, and outcomes. We used propensity score weighting to control for confounding factors. The analysis included 6,702 patients: 1,500 from Argentina, 844 from Brazil, 975 from the Netherlands, and 3,383 from Spain. There were substantial differences in baseline characteristics between countries. There were small differences in ventilation management. Intensive care unit mortality was higher in Argentina and Brazil compared with the Netherlands and Spain (59.6% and 56.6% versus 32.1% and 34.7%; P <0.001). The median number of days free from ventilation and alive at day 28 was equally low (0 [0-7], 0 [0-18], 1 [0-16], and 0 [0-16] days, respectively; P = 0.03), and the median number of days free from ventilation and alive at day 60 was higher in the Netherlands and Spain (0 [0-37], 0 [0-50], 33 [0-48], and 26 [0-48] days, respectively; P <0.001). Propensity score matching confirmed the outcome differences. Thus, the outcome of COVID-19 ARDS patients in Argentina and Brazil was substantially worse compared with that of patients in the Netherlands and Spain. It is unlikely that this results from differences in case mix or ventilation management.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0