American Journal of Tropical Medicine and Hygiene最新文献_第10页

Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study. 与自然妊娠相比，体外受精-胚胎移植后肺结核的临床特征和结局：一项回顾性研究。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0644

Jiayu Wen, Jian-Qing He

{"title":"Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study.","authors":"Jiayu Wen, Jian-Qing He","doi":"10.4269/ajtmh.24-0644","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0644","url":null,"abstract":"We compared the clinical characteristics and outcomes of active tuberculosis (TB) during pregnancy after in vitro fertilization-embryo transfer (IVF-ET) with those in natural pregnancies. The aim was to assess the impact of the mode of pregnancy on TB and to gain a deeper understanding of the clinical characteristics of TB during pregnancy in women who conceived through IVF-ET. This study retrospectively reviewed medical records to analyze maternal and perinatal outcomes in women with active TB during pregnancy, comparing those who conceived through IVF-ET with those who conceived naturally. Using a 1:2 propensity score matching method, this study included 37 pregnant women with active TB who conceived through IVF-ET and 74 matched pregnant women with active TB who conceived naturally. In the IVF-ET group, all patients developed TB during early to mid-pregnancy, with an average onset at 11 weeks. In contrast, the natural pregnancy group had a later onset, averaging 17 weeks (P = 0.002). The IVF-ET group had higher fever and miliary TB frequency than the natural pregnancy group (94.6% versus 62.2% and 74.3% versus 27.4%, respectively, P <0.05). Although there were no significant differences in maternal intensive care unit admission rates or TB-related mortality between the two groups (24.3% versus 18.9% and 2.7% versus 6.8%, respectively, P >0.05), the IVF-ET group showed higher fetal mortality (94.6% versus 56.8%, respectively, P <0.001). IVF-ET was found to contribute to the exacerbation and spread of TB, underscoring the need for enhanced screening in the future.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumococcal Carriage in the Sahel Region of Burkina Faso before a 13-Valent Pneumococcal Conjugate Vaccination Campaign. 在开展13价肺炎球菌结合疫苗接种运动之前，布基纳法索萨赫勒地区的肺炎球菌携带情况。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0746

Robert Lamoussa Zoma, Lana Childs, Issa Ouedraogo, Guetwendé Sawadogo, T Félix Tarbangdo, Aristide Zoma, Soufiane Sanou, Brice Bicaba, Simon Sanou, Fahmina Akhter, Mahamoudou Ouattara, Jennifer R Verani, Lesley McGee, Miwako Kobayashi, H Flavien Aké

{"title":"Pneumococcal Carriage in the Sahel Region of Burkina Faso before a 13-Valent Pneumococcal Conjugate Vaccination Campaign.","authors":"Robert Lamoussa Zoma, Lana Childs, Issa Ouedraogo, Guetwendé Sawadogo, T Félix Tarbangdo, Aristide Zoma, Soufiane Sanou, Brice Bicaba, Simon Sanou, Fahmina Akhter, Mahamoudou Ouattara, Jennifer R Verani, Lesley McGee, Miwako Kobayashi, H Flavien Aké","doi":"10.4269/ajtmh.24-0746","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0746","url":null,"abstract":"Burkina Faso introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2013 and achieved >90% three-dose coverage. Recently, the Sahel Region has experienced a security crisis, resulting in decreasing PCV13 coverage. We examined pneumococcal carriage before a mass PCV13 campaign in the Sahel Region in 2022. In January and February 2022, we conducted a cross-sectional, age-stratified pneumococcal carriage study among healthy individuals in Dori, the capital of the Sahel Region. We collected nasopharyngeal (all participants) and oropharyngeal swabs (participants 5 years old and older). Pneumococci isolated by culture were serotyped by polymerase chain reaction and/or Quellung. We evaluated overall and vaccine serotype pneumococcal carriage prevalence by age group. Among 1,079 participants, overall pneumococcal carriage prevalence was 57.2%; carriage was highest in children 1 year old (71.8%) and 1-11 months old (69.7%) and lowest in participants 15 years old or older (30.0%). Vaccine serotype carriage prevalence was 12.8%, ranging from 5.6% in participants 15 years old or older to 17.8% in children 5-14 years old. PCV13 vaccination history was unknown for 59.6% of age-eligible children. Among children with card-confirmed or verbally reported PCV13 history, most (99.0%) had no history of PCV13 receipt. Eight years after PCV13 introduction and in a conflict-affected area with declining PCV13 coverage, more than 1 in 10 children and 1 in 20 participants 15 years old or older are colonized with a vaccine serotype. These results will be used to evaluate the mass PCV13 campaign impact and help inform policy surrounding pneumococcal conjugate vaccine use during humanitarian crises.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a Weighted Absolute Percentage Error-Based Method for Calculating the Aggregate Accuracy of Reported Malaria Surveillance Data. 基于加权绝对百分比误差的方法在计算疟疾监测报告数据总精度中的应用。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0804

Smita Das, Arantxa Roca-Feltrer, Michael Hainsworth

引用次数: 0

Investigating Oropouche as a Possible Etiology for Febrile Illness in a Clinical Cohort from Colombia, 2014-2015. 调查2014-2015年哥伦比亚临床队列中Oropouche作为发热性疾病的可能病因

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0758

Christine S Walsh, Jenny C Cardenas, Lady Y Gutierréz-Silva, Maria U González, Christopher N Mores, Berlin Londono-Renteria, Rebecca C Christofferson

引用次数: 0

Poached Egg Lesions in the Colon Because of Amebiasis. 阿米巴病引起的结肠病变。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0852

Lalit Chandra Kummetha, Venkatesh Vaithiyam, Surbhi Goyal

引用次数: 0

Transcriptomic Analysis of Mayaro Virus-Infected Human Macrophages: Effects on Inflammatory and Antiviral Response. Mayaro病毒感染的人巨噬细胞转录组学分析：对炎症和抗病毒反应的影响。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0682

Lady Johana Hernández-Sarmiento, Y S Tamayo-Molina, Silvio Urcuqui-Inchima

{"title":"Transcriptomic Analysis of Mayaro Virus-Infected Human Macrophages: Effects on Inflammatory and Antiviral Response.","authors":"Lady Johana Hernández-Sarmiento, Y S Tamayo-Molina, Silvio Urcuqui-Inchima","doi":"10.4269/ajtmh.24-0682","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0682","url":null,"abstract":"Mayaro virus (MAYV) belongs to the Togaviridae family and is the etiologic agent of Mayaro fever, a disease in which inflammatory responses play a critical role in viral pathogenesis. Macrophages are targets of viral infection and key components of innate immunity and antiviral response. This study analyzed an RNA-sequencing (RNA-seq) dataset to gain insights into inflammatory and antiviral responses in monocyte-derived macrophages (MDMs) infected with the MAYV strain (Venezuelan 2010) at a multiplicity of infection (MOI) of 10. The RNA-seq results were validated by real-time quantitative polymerase chain reaction in MDMs infected with the MAYV strain from Brazil (MOI of 2). In addition, the replication capacity of MAYV and the resulting cell death in infected MDMs were assessed using plaque assays and flow cytometry. At 72 hours post-infection, transcriptomic analysis revealed that MAYV promotes a robust proinflammatory response by upregulating the expression of Toll-like receptors, RIG-I-like receptors, and the nuclear factor-κB complex. This strong inflammatory response was accompanied by a robust antiviral response dependent on type I/III interferon and interleukin-27. Both antiviral responses are mediated through the Janus kinase/signal transducer and activator of transcription signaling pathway, leading to the expression of interferon-stimulated genes. Moreover, MAYV-infected MDMs expressed markers of programmed cell death. These findings highlight the inflammatory response and antiviral activity of MDMs at a late stage in MAYV infection, suggesting a critical role of macrophages in MAYV pathogenesis.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CCM and RTAT Malaria Interventions. CCM和RTAT疟疾干预措施。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 Print Date: 2025-06-04 DOI: 10.4269/ajtmh.25-0056

Richard W Steketee

引用次数: 0

Program Evaluation of Community Case Management with Reactive Test and Treat for Malaria in a High-Transmission Setting. 在高传播环境中对疟疾进行反应性检测和治疗的社区病例管理项目评估。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 Print Date: 2025-06-04 DOI: 10.4269/ajtmh.24-0405

Austin Weynand, Manuela Hauser, Caitlin Bond, James Sichivula Lupiya, Dickson Phiri, Bruce Phiri, Molly Mantus, Benjamin Kussin-Shoptaw, Mike Chaponda, Mbanga Muleba, Jean-Bertin B Kabuya, Gershom Chongwe, William J Moss, Matthew M Ippolito

{"title":"Program Evaluation of Community Case Management with Reactive Test and Treat for Malaria in a High-Transmission Setting.","authors":"Austin Weynand, Manuela Hauser, Caitlin Bond, James Sichivula Lupiya, Dickson Phiri, Bruce Phiri, Molly Mantus, Benjamin Kussin-Shoptaw, Mike Chaponda, Mbanga Muleba, Jean-Bertin B Kabuya, Gershom Chongwe, William J Moss, Matthew M Ippolito","doi":"10.4269/ajtmh.24-0405","DOIUrl":"10.4269/ajtmh.24-0405","url":null,"abstract":"Community case management (CCM) combined with reactive test-and-treat (RTAT) for malaria was implemented by the National Malaria Elimination Program in a holoendemic region of Zambia. We assessed the impact of CCM + RTAT activities on malaria care seeking, health facility cases, and hospital mortality. We analyzed data from community surveys, a health facility-based passive surveillance network, and a hospital-based severe malaria surveillance system to compare metrics across the program eras (July 2016-July 2018, August 2018-October 2019, and November 2019-July 2021). Geospatial mapping was used to visualize trends in referrals and mortality. Clinical profiles of 696 hospitalized children with malaria were compared and in-hospital mortality were analyzed across periods using multiple logistic regression. There were more frequent health contacts for malaria reported by community members and a corresponding decrease in health facility malaria cases during CCM + RTAT. Pediatric patients admitted to the hospital with malaria during CCM + RTAT had less severe disease and shorter lengths of stay and in-hospital mortality was lower (odds ratio: 0.24, 95% CI: 0.07-0.84, P = 0.025). Geospatial mapping of the home villages of children hospitalized with malaria showed a wider catchment during CCM + RTAT than before or after. In this high malaria transmission setting, CCM + RTAT increased access to care, shifted malaria case burden from health facilities to community health workers, and improved in-hospital outcomes for malaria, likely from earlier referral. However, RTAT + CCM in this high-transmission area proved unsustainable because of excessive consumption of malaria commodities.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":"1207-1214"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partnership to Develop an Inter-Disciplinary Schistosomiasis Research Training Program in Uganda. 在乌干达建立跨学科血吸虫病研究培训方案的伙伴关系。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0645

Damalie Nakanjako, Moses Egesa, Helen Byakwaga, Casim Umba Tolo, Anatol Maranda Byaruhanga, Prudence Beinamaryo, Grace Banturaki, Lydia Nakiyingi, Ponsiano Ocama, Moses R Kamya, Alison M Elliott

{"title":"Partnership to Develop an Inter-Disciplinary Schistosomiasis Research Training Program in Uganda.","authors":"Damalie Nakanjako, Moses Egesa, Helen Byakwaga, Casim Umba Tolo, Anatol Maranda Byaruhanga, Prudence Beinamaryo, Grace Banturaki, Lydia Nakiyingi, Ponsiano Ocama, Moses R Kamya, Alison M Elliott","doi":"10.4269/ajtmh.24-0645","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0645","url":null,"abstract":"The WHO 2021-2030 roadmap for neglected tropical diseases (NTDs) and the 2022 Kigali Declaration urge academic research institutions to unite in combating NTDs, including schistosomiasis, and emphasize the importance of strategic partnerships to free more than 1 billion people who require interventions against NTDs. We conducted stakeholder meetings to understand the landscape of schistosomiasis research training in Uganda and the existing collaborations with research institutions in sub-Saharan Africa, Europe, the United Kingdom, and the United States. In focus group discussions (involving 33 individuals from four institutions), key challenges were summarized into four emerging themes: 1) limited physical infrastructure for schistosomiasis research and training, 2) a low critical mass of scientists with competencies in schistosomiasis research, 3) a limited scope of current schistosomiasis research, and 4) limited advocacy and community engagement for schistosomiasis control. National and international partnerships, as well as partnerships between academics and implementers, should be harnessed to establish a vibrant network for schistosomiasis research training in resource-limited settings where the disease remains endemic.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scabies: A Catastrophe that Befalls Bangladesh amidst Floods. 疥疮：洪水中降临孟加拉国的灾难。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-04-22 DOI: 10.4269/ajtmh.24-0684

Sakan Binte Imran

引用次数: 0