American Journal of Tropical Medicine and Hygiene最新文献

A Rare Case of Isolated Pulmonary Leishmaniasis. 一例罕见的孤立性肺利什曼病。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0757

Nicolas Degand, Louis Dan Medioni, Bethan Eveleigh, Johanna Laurent, Tomy Anfrie, Nouhaila Fadil, Sidali Benyoussef, Olivier Raguin, Josephine Dorin, Veronique Blanc, Christophe Ravel, Christelle Pomares

{"title":"A Rare Case of Isolated Pulmonary Leishmaniasis.","authors":"Nicolas Degand, Louis Dan Medioni, Bethan Eveleigh, Johanna Laurent, Tomy Anfrie, Nouhaila Fadil, Sidali Benyoussef, Olivier Raguin, Josephine Dorin, Veronique Blanc, Christophe Ravel, Christelle Pomares","doi":"10.4269/ajtmh.24-0757","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0757","url":null,"abstract":"Leishmaniasis caused by Leishmania infantum is endemic in the south of France. Here, we report a case of isolated pulmonary leishmaniasis in a patient with chronic obstructive pulmonary disease. In November 2023, the patient underwent a transbronchial biopsy, which resulted in a histopathological diagnosis of leishmaniasis. This finding was confirmed by polymerase chain reaction (PCR) testing targeting Leishmania species on the biopsy tissue and positive serology, although the results of PCR testing on peripheral blood were negative. These results supported a diagnosis of isolated pulmonary leishmaniasis. Additionally, no clinical or biological indicators of visceral leishmaniasis were identified. Atypical forms of leishmaniasis are rare and often lead to delayed diagnosis. In cases with unusual clinical presentations and a history of exposure in an endemic area, evaluation for leishmaniasis should include a comprehensive assessment of all potentially affected organs, regardless of the patient's immune status.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Resistance in Sub-Saharan Africa: A Comprehensive Landscape Review. 撒哈拉以南非洲抗菌素耐药性：全面概况综述。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.25-0035

Valentina Totaro, Giacomo Guido, Sergio Cotugno, Elda De Vita, Muhammad Asaduzzaman, Giulia Patti, Francesco Vladimiro Segala, Giovanni Putoto, Luisa Frallonardo, Ferenc Balázs Farkas, Botond Lakatos, Nicola Veronese, Pietro Locantore, Francesco Di Gennaro, Annalisa Saracino

{"title":"Antimicrobial Resistance in Sub-Saharan Africa: A Comprehensive Landscape Review.","authors":"Valentina Totaro, Giacomo Guido, Sergio Cotugno, Elda De Vita, Muhammad Asaduzzaman, Giulia Patti, Francesco Vladimiro Segala, Giovanni Putoto, Luisa Frallonardo, Ferenc Balázs Farkas, Botond Lakatos, Nicola Veronese, Pietro Locantore, Francesco Di Gennaro, Annalisa Saracino","doi":"10.4269/ajtmh.25-0035","DOIUrl":"https://doi.org/10.4269/ajtmh.25-0035","url":null,"abstract":"Antimicrobial resistance (AMR) is a critical health challenge in sub-Saharan Africa (SSA), driven by socioeconomic disparities, weak healthcare systems, and inadequate pharmaceutical regulation. This review examines AMR prevalence, drivers, and consequences in SSA, emphasizing the need for urgent interventions. A literature review was conducted using PubMed, Web of Science, Scopus, and Google Scholar, including studies published from January 2000 to June 2024. The focus was on AMR epidemiology, public health impacts, and interventions specific to SSA. High resistance rates were identified in Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. Key drivers include limited healthcare access; antibiotic misuse; poor surveillance; inadequate water, sanitation, and hygiene infrastructure; and poverty. AMR leads to increased mortality, prolonged hospital stays, and higher healthcare costs, with SSA projected to face 4.1 million AMR-related deaths annually by 2050 without action. Addressing AMR in SSA requires strengthening healthcare systems, expanding surveillance, enforcing pharmaceutical regulations, and enhancing education. International collaboration and funding are essential to mitigate AMR's impacts and support progress toward universal health coverage and the Sustainable Development Goals.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malaria Influenced Outcomes of Yorktown Sieges: 1781 and 1862. 疟疾影响约克城围攻的结果：1781年和1862年。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.25-0186

G Dennis Shanks

{"title":"Malaria Influenced Outcomes of Yorktown Sieges: 1781 and 1862.","authors":"G Dennis Shanks","doi":"10.4269/ajtmh.25-0186","DOIUrl":"https://doi.org/10.4269/ajtmh.25-0186","url":null,"abstract":"During two critically important battles on the Yorktown peninsula in Virginia in 1781, during the American Revolutionary War and in 1862 during the US Civil War, malaria played a vital role in determining how many soldiers were fit to fight. Lord Cornwallis' British Army was besieged by a Franco-American Army under Washington and forced to surrender when the Royal Navy could not relieve them. At the time of the October capitulation, most British soldiers were sick from fevers probably due to malaria whereas less than 8% of American soldiers were ill. This differential disease effect was likely due to lower exposure and partial immunity in the Americans. A very different military campaign in the same area was also disrupted by malaria more than 80 years later during the US Civil War. General McClellan failed in his attempt to capture the rebel capital at Richmond when forced to camp in the swamps of the Chickahominy River by Confederate defensive works leading to a malaria epidemic in summer 1862. Disease did not solely determine the military outcome, but malaria strongly influenced how many soldiers could be maintained in a field army. Malaria remains capable of causing mass casualties in deployed military forces.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatal Outcome in a Pregnant Woman with HELLP Syndrome and Dengue. HELLP综合征和登革热孕妇的致命结局。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0785

Pierina A Garavito-Pérez, Joe C Olivares-López, Virgilio E Failoc-Rojas, Miguel A Vences

{"title":"Fatal Outcome in a Pregnant Woman with HELLP Syndrome and Dengue.","authors":"Pierina A Garavito-Pérez, Joe C Olivares-López, Virgilio E Failoc-Rojas, Miguel A Vences","doi":"10.4269/ajtmh.24-0785","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0785","url":null,"abstract":"Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is a rare complication consisting of pregnancy-induced hypertension, hemolysis, elevated liver enzymes, and thrombocytopenia. Dengue, caused by an arbovirus, manifests with fever, thrombocytopenia, and hemorrhagic symptoms. We report a 26-year-old primigravida at 29 weeks of gestation from northern Peru with preeclampsia. During hospitalization, she developed fever, thrombocytopenia, and was diagnosed with severe dengue by a positive nonstructural protein 1 antigen test. Her condition worsened because of preeclampsia with signs of severity. She was admitted to the intensive care unit, and she did undergo a cesarean section. On the seventh day, she developed HELLP syndrome and multiple organ failure, culminating in her death on the ninth day. In endemic areas, it is important to consider clinical scenarios where the simultaneous manifestation of hypertensive disease and dengue may occur in the pregnant population, as timely diagnosis and appropriate management of both diseases are key to improve clinical outcomes.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmission Dynamics of Mpox in Peru During the 2022 Outbreak. 2022年秘鲁麻疹暴发期间的传播动态。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0361

M Gabriela Soto-Cabezas, Adrián Vásquez-Mejía, Martha Calderón, Mary Reyes-Vega, Yrene I Blancas-Blas, Anderson N Soriano-Moreno, María A Vargas, Kely R Meza, Jorge R Uchuya, Diego Castro-Garro, Sergio Luque-Mamani, Oswaldo G E Espinoza-Hurtado, Cesar V Munayco

{"title":"Transmission Dynamics of Mpox in Peru During the 2022 Outbreak.","authors":"M Gabriela Soto-Cabezas, Adrián Vásquez-Mejía, Martha Calderón, Mary Reyes-Vega, Yrene I Blancas-Blas, Anderson N Soriano-Moreno, María A Vargas, Kely R Meza, Jorge R Uchuya, Diego Castro-Garro, Sergio Luque-Mamani, Oswaldo G E Espinoza-Hurtado, Cesar V Munayco","doi":"10.4269/ajtmh.24-0361","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0361","url":null,"abstract":"In July 2022, mpox was declared an international public health emergency because of a surge in cases across Europe and America. This study assessed transmission dynamics and factors associated with hospitalization during the 2022 mpox outbreak in Peru. We performed a cross-sectional study using the Surveillance System of the National Center of Epidemiology, Prevention, and Disease Control (CDC-Peru) data. We estimated the basic reproduction number (R0), effective reproduction number (Rt), and the duration of the outbreak phases. We conducted mathematical modeling of the outbreak and estimated the serial interval. Additionally, we used Poisson regression with robust variance to identify hospitalization factors, using prevalence ratio. Between July and December 2022, 3,677 confirmed cases (96.3% male, mean age 32.6 years) were reported to the CDC-Peru. Of these, 75.0% were men who have sex with men (MSM), 55.6% had HIV infection, and 5.2% were hospitalized. The R0 was 2.37, with an exponential growth phase lasting 7 weeks, and Rt dropped to non-epidemic levels after 14 weeks. The incubation period and recovery period were estimated to be 6 days and 22 days, respectively. The serial interval was 9.3 days. HIV infection increased hospitalization risk. The 2022 mpox outbreak in Peru was characterized by primarily affecting a young MSM population, with a significant proportion being people living with HIV. Hospitalization was associated with HIV coinfection. This outbreak showed exponential growth during the first 7 weeks, followed by a marked deceleration of transmission.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undesired Effects of Psorylea corylifolia (Bakuchi) in a Vitiligo Patient. 白癜风患者服用补骨银叶（Bakuchi）的不良影响。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0822

Oviya Selvam, Yogindher Singh R, Manobalan Karunanandhan, Ayanchetty Haripraba

引用次数: 0

Burden of Malaria in Adults in Sahelian Niger: A Retrospective Study (2019-2021). 尼日尔萨赫勒地区成人疟疾负担：一项回顾性研究（2019-2021）。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0613

Elhadji Yacoudima Y M Aminou, Médard Djedanem, Lazoumar Ramatoulaye, Wazodan Al Moustapha, Idriss Hamidou Leyo, Jean Testa, Ronan Jambou

{"title":"Burden of Malaria in Adults in Sahelian Niger: A Retrospective Study (2019-2021).","authors":"Elhadji Yacoudima Y M Aminou, Médard Djedanem, Lazoumar Ramatoulaye, Wazodan Al Moustapha, Idriss Hamidou Leyo, Jean Testa, Ronan Jambou","doi":"10.4269/ajtmh.24-0613","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0613","url":null,"abstract":"In the Sahel, malaria transmission is highly dependent on rainfall, and control efforts are conducted during the rainy season. However, because of climate changes, the objectives of this study were to better define the period of transmission in the different ecoclimatic regions and the burden of the disease in young adults, which is poorly investigated. The data from districts in the different ecological zones of Niger were compared. During this study, 26% of all consultations were malaria related, of which 59% were malaria confirmed. This represented 12,000 to 19,000 cases and 12.9 to 25.6 deaths per 100,000 inhabitants. An increase of incidence was seen over the study period but a decline in case fatality rate was also observed. Depending on region, children under 14 years of age (half of the population) accounted for 43-80% of cases, which in contrast, underlines a significant malaria burden in young adults, especially in arid regions where transmission is lower. The majority of cases occurred from August to October but appeared later in arid zones. The number of cases positively correlated with the cumulative rainfall over the previous five weeks. However, 17-26% of cases were identified during the dry season. This study highlights a high transmission rate that extends throughout the dry season, with ∼50% of cases registered representing patients >14 years of age, and 25% of cases >25 years. Young adults should thus be considered an at-risk group and should be included in strategies for control.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probable Primary Cutaneous Cryptococcosis in an Immunocompetent Man after Contact with Wild Bird Droppings. 一免疫正常男子接触野鸟粪便后可能得原发性皮肤隐球菌病。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0646

Felipe Tavares Rodrigues, Priscilla Filippo Alvim de Minas Santos, Regina Casz Schechtman

引用次数: 0

Progressively Enlarging Lip Swelling in an Indian Child Due to Entomophthorales Infection. 印度儿童因虫蛉感染而逐渐增大的嘴唇肿胀。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.24-0775

Souradeep Chowdhury, Gagandeep Singh, Immaculata Xess

引用次数: 0

Maintaining Vital Medical Education Programs Despite the Devastating Effects of the Sudanese War. 维持重要的医学教育计划，尽管苏丹战争的破坏性影响。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.4269/ajtmh.25-0004

Mamoun Homeida, Suzan Homeida, Arwa Abubaker, Hassan Mukhtar, Charles D Mackenzie

引用次数: 0