American Journal of Tropical Medicine and Hygiene最新文献_第2页

Harnessing Molecular Techniques to Inform Species-Specific Hookworm Prevalence and Infection Intensity and Detect Strongyloides in Dak Lak Province, Vietnam. 利用分子技术了解越南达克湖省特定种类钩虫流行率和感染强度并检测类圆线虫。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0670

Wenyu Liu, Adam W Bartlett, Katrina Blazek, Sze Fui Hii, Clare E F Dyer, Vito Colella, Rebecca J Traub, Dinh Ng-Nguyen, Susana Vaz Nery

{"title":"Harnessing Molecular Techniques to Inform Species-Specific Hookworm Prevalence and Infection Intensity and Detect Strongyloides in Dak Lak Province, Vietnam.","authors":"Wenyu Liu, Adam W Bartlett, Katrina Blazek, Sze Fui Hii, Clare E F Dyer, Vito Colella, Rebecca J Traub, Dinh Ng-Nguyen, Susana Vaz Nery","doi":"10.4269/ajtmh.24-0670","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0670","url":null,"abstract":"Quantitative polymerase chain reaction (qPCR) is an increasingly recognized diagnostic tool for soil-transmitted helminths (STHs), overcoming limitations of microscopy. We compared qPCR with Kato-Katz (KK) and sodium nitrate flotation (SNF; specific gravities 1.2 and 1.3) in determining STH prevalence and infection intensity using samples from a community survey of 351 people in Dak Lak province, Vietnam. Established correlation formulas were used to convert qPCR cycle threshold values to eggs per gram to compare infection intensity. Sensitivity, specificity, and agreement between methods were also investigated. Hookworm was the predominant STH detected, with prevalences of 70.3% (95% CI: 63.6-76.9) by qPCR, 59.1% (95% CI: 46.3-72.4) by 1.2SNF, 56.5% (95% CI: 43.2-69.4) by 1.3SNF, and 47.8% (95% CI: 34.6-57.6) by KK. Detection of Ascaris lumbricoides and Trichuris trichiura was low across methods. Prevalences of zoonotic hookworm Ancylostoma ceylanicum and Strongyloides species by qPCR were 3.0% (95% CI: 1.3-6.4) and 17.3% (95% CI: 8.1-22.3), respectively. qPCR detected higher prevalence of moderate- (8.3% versus <2%) and heavy-intensity (9.4% versus 0%) infections than microscopy. The sensitivities of microscopy methods were 81.0% (1.2SNF), 75.8% (1.3SNF), and 67.4% (KK). Diagnostic agreement for hookworm was moderate between qPCR and KK and between qPCR and 1.3SNF, and it was good between qPCR and 1.2SNF. The superior performance of qPCR in detecting hookworm coupled with the capacity to differentiate hookworm species and detect Strongyloides spp. supports the role of qPCR to inform control strategies, particularly for zoonotic reservoirs and use of macrocyclic lactones.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proactive Tethering to Prevent Guinea Worm Infections among Dogs in Chad: An Analysis of the Impacts of Timing and Dog Selection. 主动拴绳预防乍得狗的麦地那龙线虫感染：时间和狗选择的影响分析。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0673

Hannah Smalley, Pinar Keskinocak, Julie Swann, Maryann G Delea, Obiora A Eneanya, Adam Weiss

{"title":"Proactive Tethering to Prevent Guinea Worm Infections among Dogs in Chad: An Analysis of the Impacts of Timing and Dog Selection.","authors":"Hannah Smalley, Pinar Keskinocak, Julie Swann, Maryann G Delea, Obiora A Eneanya, Adam Weiss","doi":"10.4269/ajtmh.24-0673","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0673","url":null,"abstract":"Guinea worm, or dracunculiasis, has been targeted for eradication. Since the detection of the disease in animals, particularly domestic dogs in Chad, eradication efforts have become more challenging as animal infections perpetuate the cycle of infection and continue to put humans at risk. A wide range of community-based interventions is used to reduce infections, and the proactive tethering of dogs was introduced in 2020 to aid in the eradication efforts. This approach aims to contain dogs to prevent them from infecting water sources and to minimize exposure to water sources harboring infective Guinea worm larvae. However, tethering guidelines are not uniformly adhered to across communities. We adapted an agent-based simulation model to analyze various proactive tethering scenarios that consider dog selection methods, time of year, and time of day. Tethering 100% of dogs year-round but releasing them for part of the day (e.g., at night) results in 19-24% more infections compared with the full-day tethering of 60% of dogs year-round. Tethering 80% of dogs during the 3 months of peak infectivity, from April to June, results in 5-9% fewer infections than tethering 100% of dogs for 6 months during the dry season, from November to April. Because of the protracted prepatent period of Guinea worm disease (∼10-14 months), the results of interventions are not known until 1 year after they are implemented. Understanding the long-term impacts of tethering decisions when they are made is extremely important for achieving the ultimate goal of Guinea worm eradication.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a Lassa Fever Specimen Biobank in Nigeria. 在尼日利亚建立拉沙热标本生物库。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0527

Hanesh F Chi, Johnson Etafo, Fritz Fonkeng, Gbenga-Ayeni Bosede Olufunke, Ronke Ireneh, Chukwuyem Abejegah, Sampson Owhin, Stella Somiari, Aurélia Vessière, Daniel G Bausch, Imane El Idrissi, Warren Fransman, Cassandra Kelly-Cirino, Emmanuel Agogo, Devy M Emperador, Nelson A Adedosu

{"title":"Establishment of a Lassa Fever Specimen Biobank in Nigeria.","authors":"Hanesh F Chi, Johnson Etafo, Fritz Fonkeng, Gbenga-Ayeni Bosede Olufunke, Ronke Ireneh, Chukwuyem Abejegah, Sampson Owhin, Stella Somiari, Aurélia Vessière, Daniel G Bausch, Imane El Idrissi, Warren Fransman, Cassandra Kelly-Cirino, Emmanuel Agogo, Devy M Emperador, Nelson A Adedosu","doi":"10.4269/ajtmh.24-0527","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0527","url":null,"abstract":"Despite being a dangerous disease found across West Africa, with occasional cases imported elsewhere, few medical countermeasures for Lassa fever are available, with no vaccine or validated treatment, and limited regulatory-approved diagnostics. Scientific research on the Lassa virus (LASV) is needed to accelerate the development of such tools but is dependent on access to high-quality biological samples. To meet this need, we have established a well-curated biobank to prospectively collect, process, and store high-quality, well-characterized clinical specimens from patients with Lassa fever at the Federal Medical Center Owo (FMCO) in Nigeria. Patients presenting to FMCO with symptoms of Lassa fever were tested for LASV by polymerase chain reaction and screened for eligibility. Samples of whole blood, plasma, and serum were collected at baseline, and at 4- and 8-weeks post-baseline from LASV-positive (LASV+) participants. Of 197 participants enrolled, 99 were LASV+ and 98 LASV-negative. In total, 3,599 sample aliquots were stored, comprised of 264 whole blood, 1,572 serum, and 1,763 plasma samples. The Lassa fever biobank now provides support for scientific research, including the evaluation of diagnostics and biomarkers, as well as the development and validation of other medical countermeasures for the detection, prevention, and control of Lassa fever. Processes for accessing samples are described.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Dengue and Chikungunya Viruses in Mosquitoes from Nepal. 尼泊尔蚊子中登革热和基孔肯雅病毒的检测。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0685

Maurine Mumo Mutua, Sandesh Rimal, Sabin Shrestha, Anjana Kharbuja, Anjali Dulal, Suprabha Subedi, Renu Bhandari Dumre, Ashma Khadka, Ishan Gautam, Himal Luitel, Merveille Kapandji, Shingo Inoue, Yuki Takamatsu, Basu Dev Pandey, Satoshi Kaneko, Takeshi Urano, Kouichi Morita, Shyam Prakash Dumre, Mya Myat Ngwe Tun

{"title":"Detection of Dengue and Chikungunya Viruses in Mosquitoes from Nepal.","authors":"Maurine Mumo Mutua, Sandesh Rimal, Sabin Shrestha, Anjana Kharbuja, Anjali Dulal, Suprabha Subedi, Renu Bhandari Dumre, Ashma Khadka, Ishan Gautam, Himal Luitel, Merveille Kapandji, Shingo Inoue, Yuki Takamatsu, Basu Dev Pandey, Satoshi Kaneko, Takeshi Urano, Kouichi Morita, Shyam Prakash Dumre, Mya Myat Ngwe Tun","doi":"10.4269/ajtmh.24-0685","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0685","url":null,"abstract":"The dengue virus (DENV) and chikungunya virus (CHIKV) infection present with similar symptoms and are transmitted by Aedes mosquitoes. Until now, there have been no reported cases of DENV and CHIKV being detected in mosquitoes in Nepal. This study identified circulating arboviruses from mosquitoes collected in the capital city Kathmandu, and Dhading, Bhaktapur, and Lalitpur districts of Central Nepal in 2023. Of 105 Aedes pooled samples, 16 (15.2%) were positive for DENV, and six (5.7%) were positive for CHIKV by quantitative real-time polymerase chain reaction. DENV-2 was the most common serotype (11.4%), aligning with recent outbreaks in Nepal in 2023, followed by DENV-3 and DENV-4 (1.9% each). To the best of our knowledge, our study is the first report to detect DENV and CHIKV in Aedes mosquitoes circulating in Nepal. This study highlights the need for mosquito surveillance to prevent future outbreaks of mosquito-borne diseases in Nepal.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Overlapping Spectrum of Primary Tubercular Myositis and Immune-Mediated Myositis: Diagnostic Challenges in Three Cases. 原发性结核性肌炎和免疫介导性肌炎的重叠谱：三个病例的诊断挑战。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0546

Augustine Jose, Aishwarya Gopal, Lovely Kumari, K L Jagan Babu, Sreerekha Jinkala, Mamatha Gorijavolu, M S Gayathri, Chengappa Kavadichanda, Molly Mary Thabah

{"title":"The Overlapping Spectrum of Primary Tubercular Myositis and Immune-Mediated Myositis: Diagnostic Challenges in Three Cases.","authors":"Augustine Jose, Aishwarya Gopal, Lovely Kumari, K L Jagan Babu, Sreerekha Jinkala, Mamatha Gorijavolu, M S Gayathri, Chengappa Kavadichanda, Molly Mary Thabah","doi":"10.4269/ajtmh.24-0546","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0546","url":null,"abstract":"Primary tubercular myositis is a rare extra-pulmonary manifestation of tuberculosis (TB). We present three cases of biopsy-proven granulomatous myositis, all of which had an initial clinical picture suggestive of dermatomyositis and serological positivity for a myositis-specific antibody. Case 1 was initially diagnosed as dermatomyositis, but the patient, a 46-year-old woman, deteriorated rapidly after immunosuppression and succumbed to disseminated TB. In Case 2, the patient, a 43-year-old woman, developed subacute proximal weakness after the initiation of anti-tuberculous therapy (ATT) for lymph node TB but recovered with continued therapy and the addition of immunomodulation. Case 3 was initially diagnosed as dermatomyositis, and the patient, a 34-year-old man, showed an inflammatory mass in the right thigh, in addition to generalized proximal weakness, and improved significantly after anti-tubercular treatment. In Case 1, TB likely mimicked dermatomyositis, but the patient deteriorated before the response to ATT could be assessed. Patient 2 developed tubercular granulomatous myositis, along with a possible flare of underlying immune-mediated myositis after the diagnosis of TB lymphadenitis and required both ATT and immunosuppression. Patient 3 showed marked improvement after ATT alone, suggesting TB as the primary pathology. In this series, we highlight the diagnostic challenges in recognizing tubercular myositis in patients who present with generalized proximal weakness resembling autoimmune myositis, emphasizing the need for muscle biopsy in refractory cases and a high index of suspicion for TB in endemic regions. Early recognition and appropriate treatment can lead to favorable outcomes in these patients.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hand Hygiene Knowledge, Attitudes, Practices, and Hand Dirtiness of Primary School Students Before and After a Behavioral Change Intervention During the COVID-19 Pandemic, Belize 2022-2023. 伯利兹，2022-2023年COVID-19大流行期间行为改变干预前后小学生的手卫生知识、态度、做法和手脏

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0617

Anh N Ly, Christina Craig, Kelsey McDavid, Dian Maheia, Yolanda Gongora, Francis Morey, Russell Manzanero, Alexandra Medley, Allison Stewart, Allison Lino, Ramiro Quezada, Rosalva Blanco, Vickie Romero, Gerhaldine Morazan, Ella Hawes, Oluwadara Okeremi, Kanako Ishida, Matthew Lozier, Kristy O Murray

{"title":"Hand Hygiene Knowledge, Attitudes, Practices, and Hand Dirtiness of Primary School Students Before and After a Behavioral Change Intervention During the COVID-19 Pandemic, Belize 2022-2023.","authors":"Anh N Ly, Christina Craig, Kelsey McDavid, Dian Maheia, Yolanda Gongora, Francis Morey, Russell Manzanero, Alexandra Medley, Allison Stewart, Allison Lino, Ramiro Quezada, Rosalva Blanco, Vickie Romero, Gerhaldine Morazan, Ella Hawes, Oluwadara Okeremi, Kanako Ishida, Matthew Lozier, Kristy O Murray","doi":"10.4269/ajtmh.24-0617","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0617","url":null,"abstract":"Hand hygiene (HH) can prevent the spread of infectious diseases and school absenteeism. However, limited data exist on HH practices at schools. Our study assesses the impact of a pilot HH intervention in 12 schools in Belize during the coronavirus disease 2019 (COVID-19) pandemic. After a national assessment of existing water, sanitation, and hygiene resources (December 2021-January 2022), 12 pilot schools were selected to evaluate an HH intervention, which included environmental nudges and HH education. Baseline assessments occurred in March 2022, the HH intervention was implemented during October 2022-May 2023, and follow-up assessments were conducted in June 2023. Student knowledge, attitudes, practices (KAP), and hand dirtiness were assessed at baseline and follow-up. There were no changes in overall KAP median scores between the baseline and the follow-up surveys (knowledge: 3 of 4; attitudes: 11 of 12; practices: 8 of 8). There was an increase in the proportion of students who reported cleaning hands during critical moments, such as before eating and after using the restroom. Observations showed that 83% of students at baseline and 71% of students at follow-up washed their hands with soap after using the restroom. The median hand dirtiness score was seven at baseline and five at follow-up (lower score corresponds to dirtier hands). We did not observe improvements in HH after the intervention. It is possible that the decrease in perceived risk of infection as COVID-19 protocols from baseline to follow-up were reduced in schools contributed to the decrease in HH practices.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Clinical and Epidemiologic Factors Associated with Mortality in Tuberculous Meningitis in Ceará State, Brazil. 与巴西塞埃尔<e:1>州结核性脑膜炎死亡率相关的临床和流行病学因素

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0480

Luís Arthur Brasil Gadelha Farias, Aldenise de Olinda Castro, Marcos Maciel Sousa, Marina Pinheiro Catunda Jucá, Pedro Pinheiro de Negreiros Bessa, Deborah Nayara Santos de Farias, Giuliana de Fátima Lima Morais, Nathalia Camilla Maciel Jenkins, Roberto da Justa Pires Neto, Tania Maria Silva Coelho, Melissa Soares Medeiros, Evelyne Santana Girão, Maura Salaroli de Oliveira, Silvia Figueiredo Costa, Lauro Vieira Perdigão Neto

{"title":"The Clinical and Epidemiologic Factors Associated with Mortality in Tuberculous Meningitis in Ceará State, Brazil.","authors":"Luís Arthur Brasil Gadelha Farias, Aldenise de Olinda Castro, Marcos Maciel Sousa, Marina Pinheiro Catunda Jucá, Pedro Pinheiro de Negreiros Bessa, Deborah Nayara Santos de Farias, Giuliana de Fátima Lima Morais, Nathalia Camilla Maciel Jenkins, Roberto da Justa Pires Neto, Tania Maria Silva Coelho, Melissa Soares Medeiros, Evelyne Santana Girão, Maura Salaroli de Oliveira, Silvia Figueiredo Costa, Lauro Vieira Perdigão Neto","doi":"10.4269/ajtmh.24-0480","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0480","url":null,"abstract":"The aim of this study was to characterize and evaluate the risk factors for mortality in hospitalized patients with tuberculous meningitis (TBM). This was a retrospective study of hospitalized patients with TBM between 2016 and 2023 in Ceará State, Brazil. Generalized linear regression was performed to identify factors predictive of in-hospital mortality. The British Medical Research Council Severity (BMRCS) grading system for TBM was evaluated upon patient admission. Of the 94 patients with TBM enrolled in the study, the median age was 39.6 years, 86.7% were men, 81.2% were positive for HIV upon admission, 33.0% had prior tuberculosis, and 4.3% had multidrug-resistant infections. In-hospital mortality was 31.9% for all patients with a final diagnosis of TBM. When multivariable analysis was applied, significant associations with increased in-hospital mortality were seen among patients with BMRCS grade III (odds ratio [OR] 1.42; 95% CI 0.49-4.08), low hemoglobin levels (OR 6.44; 95% CI 0.59-70.27), low hematocrit levels (OR 0.53; 95% CI 0.04-5.97), higher aspartate aminotransferase (AST) levels (OR 1.98; 95% CI 0.67-5.77), and fewer cerebrospinal fluid (CSF) lymphocytes (OR 1.38; 95% CI 0.50-3.80) and decreased in-hospital mortality in those with orally administered rifampin, isoniazid, pyrazinamide, and ethambutol (RHZE) (OR 0.28; 95% CI 0.10-0.79). Mortality was higher among patients with BMRCS grade III, low hemoglobin levels, low hematocrit levels, higher AST, and fewer CSF lymphocytes, and lower in those orally administered RHZE.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Malaria and Pain: A Mini-Review. 疟疾和疼痛之间的关系：一个小回顾。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.25-0205

Yuri Chaves Martins, Peyton J Murin, Beatriz Nogueira Siqueira-E-Silva, Cláudio Tadeu Daniel-Ribeiro

引用次数: 0

Intravenous Levosimendan for Acute Heart Failure with Renal Impairment Following Severe Scorpion Envenomation: Case Report and Literature Review. 左西孟旦静脉注射治疗严重蝎子中毒后急性心力衰竭伴肾功能损害：病例报告及文献回顾。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.25-0020

Karama Bouchaala, Mabrouk Bahloul, Amina Hadded, Oussama Haddar, Chokri Ben Hamida

{"title":"Intravenous Levosimendan for Acute Heart Failure with Renal Impairment Following Severe Scorpion Envenomation: Case Report and Literature Review.","authors":"Karama Bouchaala, Mabrouk Bahloul, Amina Hadded, Oussama Haddar, Chokri Ben Hamida","doi":"10.4269/ajtmh.25-0020","DOIUrl":"https://doi.org/10.4269/ajtmh.25-0020","url":null,"abstract":"Acute heart failure, presenting as either cardiogenic shock or pulmonary edema, is the main cause of mortality because of scorpion envenomation (SE) in many tropical and subtropical parts of the world. Standard heart failure treatment, including inotropes and diuretics to treat cardiogenic shock and pulmonary edema, was used in most studies. However, the role of the inotrope levosimendan in the treatment of cardiogenic shock complicated by pulmonary edema and renal impairment after SE has rarely been reported, to the best of our knowledge. Here, we report this case of severe SE complicated by cardiogenic shock and pulmonary edema successfully managed with levosimendan in a 4-year-old patient. As a consequence, the use of this inotropic drug seems to be beneficial in severe cases of SE complicated by severe cardiogenic shock and not stabilized by the usually used inotropic and vasopressor agents (dobutamine and noradrenaline). Further studies are needed to confirm the usefulness of levosimendan in cardiogenic shock related to severe SE.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic Use in Pediatric Dengue Cases in Taiwan: A National Administrative Database Analysis. 台湾儿童登革热病例抗生素使用：国家行政数据库分析。

IF 1.9 4区医学

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-27 DOI: 10.4269/ajtmh.24-0414

Yi-Jung Shen, Chia-En Lien, Yiing-Jenq Chou, Nicole Huang, Theodore Tsai

{"title":"Antibiotic Use in Pediatric Dengue Cases in Taiwan: A National Administrative Database Analysis.","authors":"Yi-Jung Shen, Chia-En Lien, Yiing-Jenq Chou, Nicole Huang, Theodore Tsai","doi":"10.4269/ajtmh.24-0414","DOIUrl":"https://doi.org/10.4269/ajtmh.24-0414","url":null,"abstract":"Nonspecific dengue clinical manifestations lead to avoidable antibiotic use. We describe antibiotic use in confirmed pediatric dengue cases and associated healthcare utilization and medical costs, including from antibiotic-associated adverse drug events (ADEs). From Taiwanese national administrative databases, children with confirmed dengue between 2009 and 2015 who were younger than 18 years old, without bacterial infection, and who were prescribed antibiotics a week before or after laboratory diagnosis were propensity score matched and compared with nonrecipients, using regression models for ADEs and medical care expenditures. A total of 1,959 out of 6,938 children (28.2%) with confirmed dengue without bacterial infection received antibiotics. Recipients were more likely to incur emergency department visits (odds ratio [OR]: 3.16; 95% CI: 2.62-3.81), hospitalizations (OR: 4.20; 95% CI: 3.48-5.07), and higher predicted medical care expenditures (new Taiwan dollar [NTD] $16,914 versus NTD $14,104) in a 30-day follow-up period. They also had significantly higher odds of overall defined (OR: 1.72; 95% CI: 1.42-2.09), dermatologic-related (OR: 1.83; 95% CI: 1.36-2.46), and gastrointestinal-related (OR: 1.67; 95% CI: 1.31-2.12) ADEs. A substantial proportion of pediatric patients with dengue received potentially avoidable courses of antibiotics. Recipients were more likely to experience ADEs, incurring more medical care utilization and expenditures than untreated cases.","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0