Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence最新文献_第7页

Acute effects of tobacco smoking on the autonomic nervous system in comparison with alcohol drinking. 与饮酒相比，吸烟对自主神经系统的急性影响。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-12-01

M Furuta, M Miyao

{"title":"Acute effects of tobacco smoking on the autonomic nervous system in comparison with alcohol drinking.","authors":"M Furuta, M Miyao","doi":"","DOIUrl":"","url":null,"abstract":"A total of 21 male university students were used to investigate the acute physical effects on the autonomic nervous system of two adult daily habits; smoking and drinking. A tobacco loading trial and an alcohol loading trial were conducted, keeping the conditions as uniform as possible. The nine subjects were instructed to smoke two cigarettes in 10 minutes, and their blood pressure, heart rate, and pupil diameter were measured. In addition, blood samples were taken 30 minutes after initiation of the trial, and the level of nicotine in the samples was measured (Trial 1). The twelve subjects were instructed to drink one large bottle of beer in 10 minutes, and the same parameters were measured. (Trial 2: trial for comparison). The pupil diameter decreased significantly 30 minutes after the subjects started smoking. Also, the heart rate increased suddenly as soon as the subjects started smoking, and the increase in the heart rate was pronounced for the 10 minutes that they were smoking. The maximal and minimal blood pressures generally did not fluctuate greatly. On the other hand, the pupil diameter tended to decrease slightly as soon as the subjects began drinking, and no significant difference in this value was noted. Also, even though the heart rate tended to increase slightly, no significant difference was noted in this value. In contrast, the maximal blood pressure increased significantly when the subjects started drinking, and tended to decrease gradually after they finished drinking.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 6","pages":"647-56"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12662529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Alcohol drinking behavior based on the neurochemical background. I. Alcohol preference and brain monoamines]. [基于神经化学背景的饮酒行为。酒精偏好与脑单胺]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

K Mizohata

引用次数: 0

Ethanol enhances, but diazepam and pentobarbital reduce the ambulation-increasing effect of caffeine in mice. 乙醇增强了小鼠的活动能力，但安定和戊巴比妥降低了咖啡因增加活动能力的作用。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

H Kuribara, T Asahi, S Tadokoro

{"title":"Ethanol enhances, but diazepam and pentobarbital reduce the ambulation-increasing effect of caffeine in mice.","authors":"H Kuribara, T Asahi, S Tadokoro","doi":"","DOIUrl":"","url":null,"abstract":"The interactions of caffeine (10 mg/kg p. o.) with various doses of ethanol, diazepam or pentobarbital were investigated by observing the ambulatory activity of mice. The ambulatory activities after the coadministration of caffeine with ethanol (1.6, 2.4 and 3.2 g/kg p. o.) were significantly higher than those after the single administration of the corresponding doses of individual drugs. Ethanol alone significantly increased the activity with ataxia at 2.4 and 3.2 g/kg, suggesting that 1.6 g/kg of ethanol was an optimum dose for studying the interaction of caffeine with ethanol. Although diazepam (0.25, 0.5 and 2 mg/kg s. c.) and pentobarbital (1, 3 and 10 mg/kg s. c.) alone did not change the activity, they significantly reduced the effect of caffeine. Naloxone (1 and 5 mg/kg s. c.) did not modify the effect of caffeine alone, but, at 5 mg/kg, it was effective in significantly reducing the ambulation-increasing effect of caffeine with ethanol (1.6 g/kg) to nearly the level of caffeine alone. Ca-cyanamide (5 mg/kg p. o., pretreatment 30 min before), reserpine (1 mg/kg s. c., pretreatment 4 hr before) and alpha-methyl-p-tyrosine (200 mg/kg i. p., pretreatment 1 hr before) reduced the ambulation increment induced by caffeine alone or combination of caffeine with ethanol. Ethanol, diazepam and pentobarbital are classified as CNS depressants, and caffeine as a CNS stimulant. However, the present experiment demonstrated that the interaction of caffeine with ethanol was very different from that of caffeine with diazepam or pentobarbital. In the enhancing interaction of caffeine and ethanol, both dopaminergic and endogenous opioid systems may be involved.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 5","pages":"528-39"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12619523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ethanol on mouse brain microsomal phospholipid turnover. 乙醇对小鼠脑微粒体磷脂转化的影响。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

R Natsuki

{"title":"Effect of ethanol on mouse brain microsomal phospholipid turnover.","authors":"R Natsuki","doi":"","DOIUrl":"","url":null,"abstract":"In an investigation of the effects of chronic and acute ethanol administration on phospholipid synthesis, mice subjected to chronic or acute ethanol administration were intraventricularly injected with 1,332 kBq of 2-3H-glycerol (3H-glycerol) and 4,070 kBq of 32P-phosphoric acid 15 min after the ethanol injection. One hour later, mice were sacrificed, and brain microsomes were prepared for analysis of incorporation of radioactivity into phospholipids. Chronic ethanol treatment significantly decreased incorporation of 3H-glycerol and 32P-phosphoric acid into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol plus phosphatidylserine. However, acute ethanol treatment had no marked effect on incorporation of 3H-glycerol or 32P-phosphoric acid into any of these phospholipids. On the other hand, chronic ethanol administration had no significant effect on incorporation of the radioisotopes into triphosphoinositide (TPI) or diphosphoinositide (DPI) in microsomal fractions, or the 3H- and 32P-TPI/DPI ratios. However, acute ethanol administration decreased the incorporation of 3H-glycerol into DPI and TPI, but did not change the TPI/DPI ratio; it also significantly increased the 32P-TPI/DPI ratio and decreased 32P-phosphoric acid incorporation into DPI but did not significantly affect 32P-phosphoric acid incorporation into TPI. Chronic ethanol administration is thought to have altered the turnover of phospholipids in the microsomal membrane, thereby affecting both the levels and turnover of neurotransmitters. In addition, the change of labeled TPI/DPI ratio observed after acute ethanol treatment may reflect nicotinic receptor activity in the mouse brain.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 5","pages":"509-18"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12619521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of alcohol abuse from the viewpoint of multiple substance abuse. 从多种药物滥用的角度看酒精滥用的模式。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

M Yamasaki, H Suwaki, S Horii

引用次数: 0

[Lymphocyte adenylate cyclase activity in alcoholics]. 酗酒者淋巴细胞腺苷酸环化酶活性

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

M Watanabe, Y Katamura, A Nabeshima, H Ozawa, T Ashizawa, T Saito

引用次数: 0

[Alcohol drinking behavior based on the neurochemical background. II. Alcohol preference and aging]. [基于神经化学背景的饮酒行为。2酒精偏好与老化]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

K Mizohata

{"title":"[Alcohol drinking behavior based on the neurochemical background. II. Alcohol preference and aging].","authors":"K Mizohata","doi":"","DOIUrl":"","url":null,"abstract":"The present studies have investigated the relationship between alcohol behavior and aging in several strains of mice. First experiments have carried out whether a free choice of 10% (v/v) ethanol and tap water for 4 weeks changes the alcohol preference and the brain neurotransmitters in three inbred strains of mice, C57BL/6J, C3H/He and DBA/2Cr. Mice of these strains showed mean ethanol intakes of 4.41, 1.76 and 0.77 g/kg/day, respectively. Levels of the brain monoamines did not change in the alcohol preferring C57BL/6J mice, but in those with less preference of alcohol, C3H/He and DBA/2Cr, there were significant increases in dopamine and 5HT levels during the four weeks experiment. Second studies have reexamined if the factor of aging affects on the alcohol preference or drinking behavior in mice. Intake of 10% ethanol (ml/day) and alcohol preference (%) increased significantly with age. A further study was conducted in which groups of 16 week old mice were checked for alcohol preference along with a completely naive control group. The alcohol preference and alcohol intake were maximum in mice given free access to ethanol at 4 weeks of age. These results suggest that a) the mouse strain with a low preference of alcohol undergo neurochemical changes after exposure to 10% ethanol and water even be free choice, and b) alcohol drinking behaviors are not only affected on the general aspects but also the factor of aging and the conditions in which mice have expressed the accesses to alcohol.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 5","pages":"563-72"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12620104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of acetaldehyde on ethanol absorption in the canine jejunum. 乙醛对犬空肠乙醇吸收的影响。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-10-01

T Shinohara, I Ijiri, C Fuke, T Kiriu, K Ameno

{"title":"Effect of acetaldehyde on ethanol absorption in the canine jejunum.","authors":"T Shinohara, I Ijiri, C Fuke, T Kiriu, K Ameno","doi":"","DOIUrl":"","url":null,"abstract":"The effects of acetaldehyde on ethanol absorption from the intestinal tract were studied using canine jejunal segment. A thirty-centimeter jejunal segment with intact vascular supply was isolated, and jejunal absorption studies were performed by administering a 17% ethanol solution (0.4 g/kg) into the lumen of the jejunal segment. In the control group, blood ethanol concentrations in the portal vein increased rapidly, with a peak level of 9.8 +/- 1.9 mM 30 min after administration. In the cyanamide-pretreated group, dogs were injected intravenously with cyanamide (100 mg/kg), an inhibitor of acetaldehyde dehydrogenase, 150 min before ethanol dosing. The blood ethanol concentration in the portal vein of this group, accompanied by a high acetaldehyde concentration, increased gradually, reaching a peak of 10.7 +/- 1.84 mM 120 min after ethanol administration. Each concentration gradient corresponded to the systemic circulatory order from the portal vein for ethanol concentration, and from the hepatic vein for acetaldehyde concentration. The absorbed amount of ethanol in the control and cyanamide-pretreated groups was 94.9 +/- 4.1% and 69.3 +/- 4.8%, respectively. Pharmacokinetic analysis indicated that a presence of high acetaldehyde concentration in the blood resulted in less ethanol reaching the systemic circulation (control: 7.34 +/- 2.95 h-1, cyanamide-pretreated: 1.08 +/- 0.75 h-1). The results also suggest that the absorption of ethanol from the intestine decreases when there is a high acetaldehyde concentration in the blood.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 5","pages":"519-27"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12619522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effects of dietary proteins on analgesic activity of tolerance and physical dependence on morphine in rats]. 膳食蛋白对吗啡耐受性和身体依赖大鼠镇痛活性的影响。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-06-01

Y Fukagawa, M Funada, H Mizoguchi, M Narita, T Suzuki, M Misawa

{"title":"[Effects of dietary proteins on analgesic activity of tolerance and physical dependence on morphine in rats].","authors":"Y Fukagawa, M Funada, H Mizoguchi, M Narita, T Suzuki, M Misawa","doi":"","DOIUrl":"","url":null,"abstract":"Effects of dietary proteins such as casein and egg albumin on analgesic activity of, tolerance to and physical dependence on morphine in rats were examined. There was no difference in analgesic activity after acute administration of morphine 10 mg/kg, s.c. between rats treated with casein food or egg albumin food and normal food for 5 or 21 days. The development of tolerance to morphine analgesia in rats treated with albumin food but not with casein food was suppressed during daily morphine 10 mg/kg, s.c. on 5 consecutive days. Rats were treated with casein or albumin food mixed with morphine (0.5 mg/g of food) for 5 days. Morphine intake in rats treated with albumin food was significantly decreased as compared to that with morphine admixed casein or normal food. Body weight loss by naloxone in morphine-dependent rats was significantly less in both casein food and albumin food groups than in the normal food group. These results suggest that chronic dietary treatment with albumin may produce a partial inhibition of development of tolerance to morphine analgesia and that with casein may attenuate morphine withdrawal manifestation in rats.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 3","pages":"266-75"},"PeriodicalIF":0.0,"publicationDate":"1992-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Relationship between alcohol use and depressive/anxiety symptoms among a general population: a review of literature]. [普通人群中酒精使用与抑郁/焦虑症状的关系:文献综述]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-06-01

Y Mino, T Tsuda, H Aoyama, H Ohara

引用次数: 0