{"title":"[Alcohol drinking behavior based on the neurochemical background. I. Alcohol preference and brain monoamines].","authors":"K Mizohata","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The relationship between voluntary alcohol consumption and monoamine levels was studied in the inbred strains of C57BL/6N, C57BL/6J, A/J, BALB/cA, CBA/N, C3H/He and DBA/2Cr mice; the congenic mouse strain B10. Br/Sg, and the senescence accelerated mouse (SAM P1, SAM P2). C57BL strains exhibited a high alcohol preference whereas the other strains exhibited a low alcohol preference. A clear positive relationship was found between alcohol intake (g/kg/day) and brain norepinephrine (NE) level (r = 0.683, p < 0.05), and a clear negative relationship between alcohol intake and brain serotonin (5HT) level (r = -0.628, p < 0.05). These results suggest that a voluntary alcohol intake in mice is genetically influenced with the brain monoamines, and depend upon the levels of brain NE and 5HT.</p>","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 5","pages":"553-62"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The relationship between voluntary alcohol consumption and monoamine levels was studied in the inbred strains of C57BL/6N, C57BL/6J, A/J, BALB/cA, CBA/N, C3H/He and DBA/2Cr mice; the congenic mouse strain B10. Br/Sg, and the senescence accelerated mouse (SAM P1, SAM P2). C57BL strains exhibited a high alcohol preference whereas the other strains exhibited a low alcohol preference. A clear positive relationship was found between alcohol intake (g/kg/day) and brain norepinephrine (NE) level (r = 0.683, p < 0.05), and a clear negative relationship between alcohol intake and brain serotonin (5HT) level (r = -0.628, p < 0.05). These results suggest that a voluntary alcohol intake in mice is genetically influenced with the brain monoamines, and depend upon the levels of brain NE and 5HT.
研究了自交系C57BL/6N、C57BL/6J、A/J、BALB/cA、CBA/N、C3H/He和DBA/2Cr小鼠自愿饮酒与单胺水平的关系;同源小鼠菌株B10。Br/Sg，衰老加速小鼠(SAM P1, SAM P2)。C57BL菌株表现出较高的酒精偏好，而其他菌株表现出较低的酒精偏好。酒精摄入量(g/kg/d)与脑去甲肾上腺素(NE)水平呈显著正相关(r = 0.683, p < 0.05)，与脑血清素(5HT)水平呈显著负相关(r = -0.628, p < 0.05)。这些结果表明，小鼠的自愿饮酒受大脑单胺的遗传影响，并取决于大脑NE和5HT的水平。
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