Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence最新文献_第10页

Relationship between incorporation of choline into phosphatidylcholine and morphine binding sites. 胆碱并入磷脂酰胆碱与吗啡结合位点的关系。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-02-01

R Natsuki

{"title":"Relationship between incorporation of choline into phosphatidylcholine and morphine binding sites.","authors":"R Natsuki","doi":"","DOIUrl":"","url":null,"abstract":"Calcium (25 mM)-stimulated incorporation of choline into phosphatidylcholine (PC) and 3H-morphine (3H-M) binding was studied using cerebral crude synaptosomal fractions from acute morphine-treated (naive), morphine-dependent and morphine-withdrawn mice. Mice became physically dependent on morphine after ingesting morphine-mixed food. Morphine dependence inhibited the incorporation of 14C-choline into PC. The injection of naloxone (1 mg/kg) to morphine-dependent mice also inhibited the incorporation of 14C-choline into PC. The injection of morphine (10 mg/kg) to morphine-withdrawn mice stimulated the incorporation of 14C-choline into PC, but had no effect, either on acute morphine-treated mice or on morphine-dependent mice. Naloxone (1 mg/kg), morphine (10 mg/kg), morphine dependence and opiate withdrawal (20 hrs after the last exposure to morphine in food) all caused about a 25% decrease in 3H-M (10(-7) M) binding to mouse brain synaptosomes. The injection of 10 mg/kg of morphine 45 min before death caused an additional 20% decrease in 3H-morphine binding in the dependent and withdrawn mice, but not in the naive mice. Stereospecific binding (SSB) of 3H-M was evaluated with respect to: 1) the effect of naloxone treatment in vivo on 3H-M binding in vitro, 2) the effect of morphine treatment in vivo on 3H-M binding in vitro; and 3) the differences between 3H-M bound (in vitro) and both naloxone and morphine treatment (in vivo). SSB activity was high in morphine-withdrawn mice. These differences may be caused by changes in the opiate receptors related to tolerance and withdrawal, and may entail between PC and membrane receptors.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 1","pages":"57-70"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12492181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Studies on ethanol absorption from the intestine--blood ethanol and acetaldehyde concentrations in the various vessels]. [从肠道吸收乙醇的研究——血液中不同血管中的乙醇和乙醛浓度]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-02-01

T Shinohara, I Ijiri, C Fuke, T Kiriu, K Ameno

{"title":"[Studies on ethanol absorption from the intestine--blood ethanol and acetaldehyde concentrations in the various vessels].","authors":"T Shinohara, I Ijiri, C Fuke, T Kiriu, K Ameno","doi":"","DOIUrl":"","url":null,"abstract":"We describe the concentration gradient of ethanol at different blood sampling sites of dogs dosed via the jejunal segment or intravenously, and the subsequent recovery of intestinal fluid from the jejunal segment. After laparotomy a 30 cm length of jejunal segment with intact vascular supply was isolated. Blood samples were collected from the portal vein, hepatic vein, aorta and inferior vena cava. A 17% ethanol solution was used for a small dose group (0.4 g/kg) and a 33% solution for a large dose group (0.8 g/kg). In the small dose and large dose groups administered the solution via the jejunal segment, ethanol concentration in the blood of the portal vein increased rapidly and the highest ethanol concentration was detected in the portal vein, followed, in descending order by the hepatic vein, aorta and inferior vena cava. The highest acetaldehyde concentration in blood was detected in the hepatic vein, followed by that in the aorta while the lowest was in the portal vein and inferior vena cava in both groups. Each concentration gradient corresponded in order to systemic circulatory order from the intestine (ethanol absorption site) for ethanol concentration, or from the liver (acetaldehyde formation area) for acetaldehyde concentration. There was no difference in ethanol concentration among the four sampling sites in the case of intravenous ethanol injection, but a gradation of acetaldehyde concentration similar to that in the jejunal segment dosed cases was observed.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"27 1","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12763792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization to ambulation-increasing effects of cocaine after repeated administration in mice--roles of dose and interval of administration as well as experimental environments. 小鼠反复给药后对可卡因增加活动的致敏作用——剂量和给药间隔以及实验环境的作用

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1992-02-01

M Hirabayashi, S Tadokoro

引用次数: 0

Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers. 实验宿醉期间志愿者血液和尿液中乙醇、乙醛、醋酸酯和丙酮的浓度。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

S Tsukamoto, T Kanegae, M Saito, T Nagoya, M Shimamura, H Tainaka, M Kawaguchi

{"title":"Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers.","authors":"S Tsukamoto, T Kanegae, M Saito, T Nagoya, M Shimamura, H Tainaka, M Kawaguchi","doi":"","DOIUrl":"","url":null,"abstract":"Blood and urine samples were analyzed for ethanol, acetaldehyde, acetate and acetone during experimental hangover in 6 healthy male volunteers (A, B, C, D, E, F). They drank freely for some 4 hr. In flushers (A, F) at 9 hr after ingestion (ethanol: 92 g, 1.2 g/kg and 1.3 g/kg), acetaldehyde levels were low in the blood, but high in the urine (37 microM, 45 microM). Heavy drinkers, non-flushers of B (ethanol: 176 g, 2.5 g/kg), C (157 g, 2.4 g/kg) and E (182 g, 2.9 g/kg) had a slightly high [lactate]/[pyruvate] ratio and 3-hydroxybutyrate in the blood at 11 hr after alcohol ingestion. Blood ethanol levels were dose dependent and blood acetaldehyde in B and C had a slightly high 6.3 microM and 8.0 microM 9 hr later, respectively. B, C and E had a high urine acetone concentration (100 microM over) in hangover. In C, in particular, urine acetate and acetone levels were unusually high. The ratio in blood (urine) among alcohol metabolites at 9 hr after drinking was approximately ethanol 1000 (1000): acetaldehyde 0.2-1.0 (0.1-5.9): acetate 36-163 (22-1554): acetone 1-11 (3-47).","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"26 6","pages":"500-10"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12947520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A study of high school students with alcoholic parents]. [对父母酗酒的高中生的研究]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

K Suzuki

{"title":"[A study of high school students with alcoholic parents].","authors":"K Suzuki","doi":"","DOIUrl":"","url":null,"abstract":"This is the first study in Japan which estimates the frequency of children with alcoholic parents in the general population and investigates the addictive substances abused by these children. In order to determine which children have alcoholic parents, a 10-item set of questions concerning the alcohol problems of parents known as CAST-J (Children of Alcoholics Screening Test-Japan) was prepared using CAST (Children of Alcoholics Screening Test) as a reference. In a preliminary survey, CAST-J and CAST were performed on 20 cases diagnosed as children of parents with alcohol-related problems by psychiatrists and 112 students of medically-related school. From these results, it was decided that those who had answered affirmatively to at least three of the 10 questions in CAST-J were children of alcoholic parents (parents with alcohol-related problems). The present survey was performed on 1,754 high school students who underwent the CAST-J and AAIS (Adolescent Alcohol Involvement Scale). The information on the experience of smoking and thinner inhalation was also obtained. Among these high school students, 11.6% of the total (8.4% of males and 15.2% of females) had alcoholic parents. Among the high school students with alcoholic parents, 21.7% were found to be alcohol misusers or alcoholic-like drinkers in the AAIS, which was significantly more than the 10.6% of students without alcoholic parents. This significant difference was seen for both males and females. It was also found that significantly more high school students with alcoholic parents had experienced smoking and thinner inhalation than those without such parents. In conclusion, it appeared that more than 10% of Japanese high school students have alcoholic parents, and they also often misuse addictive substances such as alcohol, tobacco and thinner.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"26 6","pages":"511-21"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12947521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Influence of hepatitis C virus on the alcoholic liver diseases]. 丙型肝炎病毒对酒精性肝病的影响

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

N Yoshida, T Sadamoto, T Hatori, M Sugimoto, M Shibata, Y Ueno, T Abei

引用次数: 0

Modifications of ambulation-increasing effect of morphine and buprenorphine following repeated administration in mice. 吗啡和丁丙诺啡重复给药后小鼠活动能力增加作用的改变。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

T Asahi, H Kuribara, S Tadokoro

引用次数: 0

[Vertebral bone density and its correlation with various factors related to bone metabolism in alcoholics: a quantitative study by computed tomography]. [酗酒者椎体骨密度及其与骨代谢相关的各种因素的相关性:计算机断层成像定量研究]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

H Takahashi, K Maruyama, Y Shigeta, T Takagi, K Okuyama, Y Horie, S Miyaguchi, H Muraoka, S Takagi

{"title":"[Vertebral bone density and its correlation with various factors related to bone metabolism in alcoholics: a quantitative study by computed tomography].","authors":"H Takahashi, K Maruyama, Y Shigeta, T Takagi, K Okuyama, Y Horie, S Miyaguchi, H Muraoka, S Takagi","doi":"","DOIUrl":"","url":null,"abstract":"We measured vertebral bone density of 59 male alcoholics (ALC) using quantitative computed tomography (QCT). Bone density of ALC was decreased measured on admission compared with age-matched healthy male controls (ALC: 144 +/- 42, CONTROLS: 173 +/- 34 mg/cm3, p less than 0.05). The bone density was not correlated with serum ALP, Ca, and Pi. Serum parathyroid hormone and calcitonin were also not correlated with the bone density in ALC. Serum 25-(OH)-D showed significant positive correlation with the bone density (p less than 0.01) and 1,25-(OH)2-D showed trend of positive correlation with the bone density (p less than 0.01) in ALC. Severity of liver diseases did not have any relation to the bone density in ALC. Although the decreased bone density was not improved at the second QCT examined about 10 weeks after first QCT without medication, patients administered 1 microgram of 1 alpha-(OH)-D3 daily showed a significant increase in the bone density (on admission: 152 +/- 37, 10 weeks later: 162 +/- 35 mg/cm3, p less than 0.02). Combination therapy of 1 alpha-(OH)-D3 and calcitonin did not increase the bone density. These results indicate that bone density was decreased in ALC and a decrease in serum vitamin D metabolites may cause a decrease in the bone density, although liver dysfunction does not have a role in it. These data also suggest that 1 alpha-(OH)-D3 is effective in an increase in the bone density in ALC with osteoporosis after abstinence.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"26 6","pages":"489-99"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12947619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Studies on the mode of progression of alcoholic liver disease]. 酒精性肝病进展模式的研究

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

N Yoshida, T Hatori, Y Ueno, M Shibata, T Sadamoto, W Yamamuro, Y Sumino, H Nonaka, M Sugimoto, T Abei

{"title":"[Studies on the mode of progression of alcoholic liver disease].","authors":"N Yoshida, T Hatori, Y Ueno, M Shibata, T Sadamoto, W Yamamuro, Y Sumino, H Nonaka, M Sugimoto, T Abei","doi":"","DOIUrl":"","url":null,"abstract":"In order to elucidate the mode of progression of alcoholic liver disease, relationships among the drinking style, laboratory data, anti-HCV antibody and histological changes were investigated on 36 patients in whom the liver biopsy was repeatedly done. Following results were obtained (1) In the group of continuous drinking over 100g ethanol per day, histological progression was found in 11 of 13 patients (85%) regardless of positive anti-HCV. On the other hand, in the group of abstinence or temperance less than 60g daily alcohol intake, histological improvement was found in 6 of 11 patients (55%). (2) Histological improvement was predominantly seen by abstinence or temperance in the cases with lower levels of serum IgA and adenosine deaminase (ADA) on hospitalization and those with rapid decrease in serum gamma-GTP after hospitalization. In conclusion, the amount of ethanol was considered to be the most important factor to affect on a progression of alcoholic liver diseases. Assessment of laboratory data such as IgA and ADA on hospitalization and change in gamma-GTP after hospitalization were also thought to be useful in foreseeing the prognosis of alcoholic liver disease.","PeriodicalId":77015,"journal":{"name":"Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence","volume":"26 6","pages":"531-43"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12947523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Alcoholic dementia and divalent ions: derangement of calcium-homeostasis]. [酒精性痴呆和二价离子:钙稳态紊乱]。

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1991-12-01

M Tsuji, M Nakamura, S Tohara, T Nakajima

引用次数: 0