[Lymphocyte adenylate cyclase activity in alcoholics].

M Watanabe, Y Katamura, A Nabeshima, H Ozawa, T Ashizawa, T Saito
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Abstract

Lymphocyte adenylate cyclase (AC) activity in alcoholics was examined. Gpp(NH)p-stimulated AC activity was not altered in lymphocyte membranes from alcoholics in acute withdrawal state. In the case of long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year, lymphocyte Gpp(NH)p-stimulated AC activity was slightly reduced but not significantly. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of Gpp(NH)p, was significantly reduced in lymphocyte membrane from long-term abstinent alcoholics. These results indicate that lymphocyte AC activity is a biological marker for alcoholics.

酗酒者淋巴细胞腺苷酸环化酶活性
研究了嗜酒者淋巴细胞腺苷酸环化酶(AC)的活性。急性戒断状态下,Gpp(NH)p刺激的淋巴细胞膜AC活性未发生改变。在长期戒酒的情况下,保持戒酒至少一年,淋巴细胞Gpp(NH)p刺激的AC活性略有降低,但不显著。然而,在Gpp(NH)p存在的情况下,250 mM乙醇对长期戒酒者淋巴细胞膜AC活性的诱导程度明显降低。这些结果表明淋巴细胞AC活性是嗜酒者的生物学标志物。
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