American journal of physiologic imaging最新文献_第7页

Factors affecting the Gates' measurement of glomerular filtration rate. 影响盖茨测定肾小球滤过率的因素。

American journal of physiologic imaging Pub Date : 1990-01-01

M Awdeh, K Kouris, I M Hassan, H M Abdel-Dayem

引用次数: 0

Investigation by scintigraphic methods of platelet kinetics under normal and septic shock conditions in the experimental baboon model. 用闪烁法研究正常和感染性休克条件下实验狒狒模型血小板动力学。

American journal of physiologic imaging Pub Date : 1990-01-01

I C Dormehl, J G Kilian, M Maree, L Jacobs

引用次数: 0

Evaluation of technetium-99m disofenin by column and instant thin-layer chromatography: demonstration of radiocolloid as a cause for splenic uptake. 用色谱柱和即时薄层色谱法评价锝-99m异苯醚:证明放射性胶体是脾摄取的一个原因。

American journal of physiologic imaging Pub Date : 1990-01-01

J I Hirsch, M J Fratkin, J Balseiro

{"title":"Evaluation of technetium-99m disofenin by column and instant thin-layer chromatography: demonstration of radiocolloid as a cause for splenic uptake.","authors":"J I Hirsch, M J Fratkin, J Balseiro","doi":"","DOIUrl":"","url":null,"abstract":"We found persistent splenic uptake in 5% of patients undergoing hepatobiliary imaging with Tc-99m Disofenin when administered within a few minutes after labeling, suggesting the presence of radiocolloid. Hydrolyzed reduced Tc-99m colloid (HR-Tc) present in labeled Disofenin kits is controversial and may be dependent on method of assay and radiochemical kinetics. Kits were therefore evaluated by gel column (GCC) and instant thin-layer (ITLC) chromatographic methods. Tc-99m Disofenin was prepared according to the manufacturer's instructions and was maintained at room temperature (23 degrees C) or was incubated at 37 degrees C for 0.5 hr and then held at 23 degrees C. Aliquots were obtained at intervals over 5 hr and applied to Sephadex G-15 resin columns and ITLC-SG strips, with distilled water as mobile phase. GCC showed 14.9% +/- 3.4% and 11.0% +/- 2.9% initial values of HR-Tc at 23 degrees C and 37 degrees C treatments, respectively. HR-Tc decreased over time with each treatment. ITLC showed 1.2% +/- 0.4% and 1.3% +/- 0.2% HR-Tc, with no change over time. ITLC appears to be an insensitive method for the detection of HR-Tc. Incubation of Tc-99m with Disofenin kits for 30 min at 37 degrees C or for 1 hr at 23 degrees C offers an empiric method to ensure HR-Tc levels acceptable for nuclear imaging.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"5 1","pages":"22-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13522866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetic modeling of radiolabeled antibody distribution in man. 放射性标记抗体在人体内分布的药代动力学模型。

American journal of physiologic imaging Pub Date : 1990-01-01

A Rescigno, H Bushe, A B Brill, M Rusckowski, T W Griffin, D J Hnatowich

{"title":"Pharmacokinetic modeling of radiolabeled antibody distribution in man.","authors":"A Rescigno, H Bushe, A B Brill, M Rusckowski, T W Griffin, D J Hnatowich","doi":"","DOIUrl":"","url":null,"abstract":"This paper describes a method for the interpretation of the pharmacokinetics in cancer patients of an anti-CEA monoclonal antibody labeled with 111In. To determine the fate of the radiolabeled antibody administered i.v. to ten colon patients, the radioactivity contained in liver, spleen, kidneys, bone marrow, and tumor was measured and serum samples were counted. In addition each serum and urine sample was also analyzed by HPLC. The labeled antibody and two other radioactive species were observed in serum: an immunocomplex and a catabolic product. The computer program SAAM was used to fit the data. Thus, the rate constants for a number of pharmacokinetic models were calculated using the time-dependent serum radioactivity curves for each of the three species and the time-dependent radioactivity contained in normal organs. We also computed the model parameters for different connections between different organs, and using noncompartmental methods, the transit time, permanence time, and yield of those organs. Our results suggest that the immunocomplexes are formed in the circulation between circulating antibody and antigen, and that the rate of uptake by the liver depends on the concentration of the antibody in blood and not of the immunocomplex. Following deposition in the liver, free antibody does not appear to reenter the circulation, but once there it is catabolized. All breakdown products are then cleared into urine via serum.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"5 4","pages":"141-50"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13245825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MR image time-intensity relations in spleen and kidney: a comparative study of GdDTPA, albumin-(GdDTPA), and Gd2O3 colloid. 脾脏和肾脏的MR图像时间-强度关系:GdDTPA，白蛋白-(GdDTPA)和Gd2O3胶体的比较研究。

American journal of physiologic imaging Pub Date : 1990-01-01

P F Daly, J B Zimmerman, J A Cannillo, G L Wolf

引用次数: 0

Continuous arterial positron monitor for quantitation in PET imaging. 连续动脉正电子监测仪在PET成像中的定量。

American journal of physiologic imaging Pub Date : 1990-01-01

A D Nelson, R F Muzic, F Miraldi, G J Muswick, G P Leisure, W Voelker

{"title":"Continuous arterial positron monitor for quantitation in PET imaging.","authors":"A D Nelson, R F Muzic, F Miraldi, G J Muswick, G P Leisure, W Voelker","doi":"","DOIUrl":"","url":null,"abstract":"Quantitative measures of physiologic function with PET require continuous monitoring of arterial positron isotope concentration. A device has been developed that automates this process. This device has advantages over manual sampling techniques with syringes since fewer personnel are required, measurements are less error prone, and more continuous measures of arterial positron concentration are available. A constant flow infusion/withdrawal pump withdraws blood from the radial artery through a catheter connected to 0.5 mm inner diameter teflon tubing. This tubing is wrapped around a 50 mm thick by 50 mm diameter NaI(T1) crystal that is interfaced to a photomultiplier tube (PMT) and encased in a cylindrical lead shield. This crystal detects 511 Kev photons that result from positron annihilation. The device sensitivity is greater than 240 (cts/sec)/(microCi/ml) corresponding to a peak activity of approximately 10,000 cts/sec for a 50 mCi bolus injection in an adult. The system dynamic response has been measured and the true arterial input function is recovered by deconvolution. The system has been used clinically for more than 400 human PET studies and has been a reliable continuous monitor of arterial positron concentration.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"5 2","pages":"84-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13404099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct stereotactic intracerebral injection of monoclonal antibodies and their fragments: a potential approach to brain tumor immunotherapy. 直接立体定向脑内注射单克隆抗体及其片段:一种潜在的脑肿瘤免疫治疗方法。

American journal of physiologic imaging Pub Date : 1990-01-01

M Liebert, R L Wahl, G Lawless, P E McKeever, J A Taren, W H Beierwaltes, R Brasswell

引用次数: 0

Magnetic resonance imaging and scintigraphic correlation in thyroid disorders. 甲状腺疾病的磁共振成像与显像相关性。

American journal of physiologic imaging Pub Date : 1990-01-01

B Eisenberg, M G Velchick, C Spritzer, H Kressel, A Alavi

引用次数: 0

The predictive value of Tc-99m DTPA renography in obstructive uropathy using animal model. 动物模型Tc-99m DTPA肾造影对梗阻性尿病的预测价值。

American journal of physiologic imaging Pub Date : 1990-01-01

R H Bahar, A H Elgazzar, F M Abu-Zidan, M Sabha, I M Francis, K Kouris, M Awdeh, H M Abdel-Dayem, T Nilsson, K E Britton

{"title":"The predictive value of Tc-99m DTPA renography in obstructive uropathy using animal model.","authors":"R H Bahar, A H Elgazzar, F M Abu-Zidan, M Sabha, I M Francis, K Kouris, M Awdeh, H M Abdel-Dayem, T Nilsson, K E Britton","doi":"","DOIUrl":"","url":null,"abstract":"There is no simple analytical test. Radionuclide diuretic renography (RDR), being a dynamic imaging study reflecting the function of the kidney and the urodynamics of the urinary tracts, has the potential to predict the outcome of surgery in obstructive uropathy. In 12 sheep, we occluded one ureter for a maximum of seven weeks and followed up for a maxim of five weeks after release of occlusion. Repeated Tc-99m DTPA diuretic renography studies were performed and the results were correlated with the duration of complete ureteric occlusion. The renal uptake percentage and the extraction slope of the time activity curve (TAC) showed progressive and steady decrease over the period of the occlusion. By the fifth week there was very low uptake (less than 18%) and the TAC was almost flat, suggestive of severe nephropathy. The parenchymal transit time index (PTTI) showed immediate rise after occlusion but with no progressive increase in its value. By the fifth week it dropped down to normal. After release, the recovery of function showed good correlation with the renal uptake percentage and extraction slope of TAC before release of occlusion. Therefore both these parameters, rather than PTTI, can be used to predict the outcome of surgery before the release of complete obstruction of the ureter.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"5 3","pages":"107-11"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13435501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced ST-segment elevation in leads over infarcted area and residual myocardial ischemia in patients with previous myocardial infarction. 既往心肌梗死患者运动诱导梗死区导联st段抬高及残余心肌缺血。

American journal of physiologic imaging Pub Date : 1990-01-01

T Shimonagata, T Nishimura, T Uehara, K Hayashida, M Saito, T Sumiyoshi

{"title":"Exercise-induced ST-segment elevation in leads over infarcted area and residual myocardial ischemia in patients with previous myocardial infarction.","authors":"T Shimonagata, T Nishimura, T Uehara, K Hayashida, M Saito, T Sumiyoshi","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to evaluate the clinical significance of exercise-induced ST elevation in patients who had previous myocardial infarction. Electrocardiographic leads were placed over the infarcted area in 65 patients who had previous myocardial infarction (PMI; isolated left anterior descending coronary artery disease). All patients also had stress thallium scan. Exercise-induced ST changes in leads placed over patients' infarcted areas were compared with the extent of both their myocardial ischemia [thallium ischemic score (TIS)] and the area of their infarcted tissue [defect score (DS)]. The latter was derived from a circumferential profile analysis. In patients who had PMI less than three months after the onset of myocardial infarction (n = 36), the left ventricular ejection fraction (LVEF) and the extent of abnormal left ventricular wall motion did not significantly differ from those in patients with exercise-induced ST elevation (greater than 2 mm, n = 26; less than 2 mm, n = 10). In patients who had PMI more than three months after the onset of myocardial infarction (n = 29), patients with high exercise-induced ST elevation (greater than 2 mm, n = 15) showed left ventricular dyskinesis more frequently than those with low ST elevations (less than 2 mm, n = 14). In addition, the former showed higher DS and lower TIS than the latter. In patients who had PMI less than three months after onset (n = 26), 73% of those with ST elevations with prominent upright T waves (n = 15) also had transient thallium defects in their infarcted areas. They also had higher LVEF and TIS than those with low ST elevations (less than 2 mm, n = 11). These results indicated that exercise-induced ST elevations in leads placed over the infarcted areas are to be interpreted differently depending on the degree of recovery of injured myocardial tissue.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"5 3","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13436793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0