P R Silverman, S B Feinstein, R M Lang, C E McCoy, E D Frederickson, P W Walley, D Janzen, A Neumann, K M Borow
{"title":"Contrast echocardiography: effects of microbubbles on coronary blood flow and left ventricular hemodynamics.","authors":"P R Silverman, S B Feinstein, R M Lang, C E McCoy, E D Frederickson, P W Walley, D Janzen, A Neumann, K M Borow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Contrast echocardiography is currently being used to define and quantitate myocardial perfusion at the time of cardiac catheterization. Limited and conflicting data exist regarding the physiologic effects of microbubble-containing contrast agents. In the present study, coronary blood flow measured using an electromagnetic flow meter, blood pressure, and heart rate responses were studied in six dogs. An ECG-gated power injector was used to deliver 7 to 9 ml of sonicated and nonsonicated solutions (saline, Renografin-76, dextrose 50% and 70%, and sorbitol 70%) through an intra-aortic catheter placed above the aortic cusps. Paired injections of sonicated and nonsonicated agents were compared to determine whether the presence of microbubbles affected the physiologic response to these agents. Simultaneous recordings of two-dimensional cross-sectional images of the left ventricle were obtained. Data are expressed as percentage of change from preinjection control values. Within 10 seconds of an injection, decreases in coronary blood flow occurred in a range from -1 to -10% compared with preinjection control values. Coronary blood flow increased between 10 and 25 seconds postinjection within a range from +11 to +29%. Systemic blood pressures rose during injections and then declined below control values within 10 seconds. The magnitude of the decline in systolic blood pressure ranged from -5. to -18%. Diastolic blood pressure declined in a range from -13 to -33%. Within 20-30 seconds postinjection, systemic blood pressure rose above control values. The magnitude of the systolic and diastolic blood pressure rise ranged from +4 to +11%.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 4","pages":"158-64"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13766423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M G Niemeyer, E K Pauwels, E E van der Wall, M J Cramer, J F Verzijlbergen, A H Zwinderman, C A Ascoop
{"title":"Detection of multivessel disease in patients with sustained myocardial infarction by thallium 201 myocardial scintigraphy: no additional value of quantitative analysis.","authors":"M G Niemeyer, E K Pauwels, E E van der Wall, M J Cramer, J F Verzijlbergen, A H Zwinderman, C A Ascoop","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was performed to determine the value of visual and quantitative thallium 201 scintigraphy for the detection of multivessel disease in 67 patients with a sustained transmural myocardial infarction. Also the viability of the myocardial regions corresponding to pathologic Q-waves was evaluated. Of the 67 patients, 51 patients had multivessel coronary artery disease (76%). The sensitivity of the exercise test was 53%, of thallium scintigraphy 69%, when interpreted visually, and 67%, when analysed quantitatively. The specificity of these methods was 69%, 56%, and 50%, respectively. Sixty-two infarct-related flow regions were detected by visual analysis of the thallium scans, total redistribution was observed in 11/62 (18%) of patients, partial redistribution in 26/62 (42%), and no redistribution in 25/62 (40%) of patients. The infarct-related areas with total redistribution on the thallium scintigrams were more likely to be associated with normal or hypokinetic wall motion (7/11: 64%) than the areas with a persistent defect (7/25:28%) (P = 0.05), which were more related with akinetic or dyskinetic wall motion. Based on our results, it is concluded that 1) both visual and quantitative analysis of thallium exercise scintigraphy have limited value to predict the presence or absence of multivessel coronary artery disease in patients with sustained myocardial infarction, and 2) exercise-induced thallium redistribution may occur within the infarct zone, suggesting the presence of viable but jeopardized myocardium in presumed fibrotic myocardial areas.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 3","pages":"105-14"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13928876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Eisenberg, E R Arrington, M F Hartshorne, A H Tzamaloukas, T M Elliott, L J Gibel
{"title":"Intraperitoneal radiocolloid imaging in dialysate leaks.","authors":"B Eisenberg, E R Arrington, M F Hartshorne, A H Tzamaloukas, T M Elliott, L J Gibel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the increasing use of continuous ambulatory peritoneal dialysis (CAPD), a number of complications related to the leakage of dialysate from the abdominal cavity have been described (Dubin and Froelich: Clinical Nuclear Medicine 10(3): 173, 174, 1985; Johnson et al.: Archives of Surgery 122(8): 952-954, 1987; Ducassou et al.: Journal of Nuclear Medicine 25(1): 68, 69, 1984; Walker and Fish: Journal of Nuclear Medicine 29(9): 1596-1602, 1988; Eisenberg et al.: Clinical Nuclear Medicine 13(2): 99-101, 1988). The use of intraperitoneal radiolabeled colloid has been previously described to image entities such as hernias, patent processus vaginalis, abdominal wall, and diaphragmatic leakage by other specialities, but has not been described in the general imaging literature. This paper illustrates a simple, noninvasive method of determining the site of dialysate leak and its importance to assist further patient management.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 4","pages":"155-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13678424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Shapiro, J M Gonin, M Tuscan, R Wiggins, D A Campbell, J Juni
{"title":"Demonstration by iodine-131-hippurate renography of a marked sensitivity of some transplanted kidneys to volume contraction.","authors":"B Shapiro, J M Gonin, M Tuscan, R Wiggins, D A Campbell, J Juni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Incidental observations made in a canine renal transplant model in which both native and transplanted kidneys were present revealed that abnormal I-131-iodohippurate renograms were derived from some of the transplanted kidneys in the presence of mild dehydration. In these cases, the renogram normalized with fluid administration. In contrast, the renograms derived from the native kidneys were unaffected by the mild dehydration of the animals. These findings demonstrate a greater sensitivity to dehydration of some transplanted kidneys when compared to normal kidneys.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13789519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T K Chaudhuri, S Fink, R H Burger, I C Netto, J D Palmer
{"title":"Physiological considerations in radionuclide urodynamic studies.","authors":"T K Chaudhuri, S Fink, R H Burger, I C Netto, J D Palmer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radionuclear imaging of micturition (RNIM) (Nuclear Uroflowmetry, Voiding Nuclear Cystogram) measures bladder volumes, bladder emptying times, and urinary flow rates. These data help to differentiate normal subjects from those with obstructive uropathy or neuromuscular failure and to quantify the deficit. We discuss the physiological considerations of importance to physicians ordering and interpreting this convenient and noninvasive diagnostic procedure.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 2","pages":"70-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13808546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M S Sharaf el-Deane, K W Logan, B M Parker, R A Holmes
{"title":"Aneurysmectomy prognosticators by equilibrium multi-gated cardiac blood pool scintigraphy.","authors":"M S Sharaf el-Deane, K W Logan, B M Parker, R A Holmes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Non-invasive assessment of left ventricular aneurysm (LVA) resection prognosticators was obtained in 13 multigated cardiac blood pool scintigrams by applying Fourier analysis to identify regions of interest. Results were compared to contrast ventriculograms performed at recent cardiac catheterization. Excellent correlation of the contractile section ejection fraction (CSEF) was found between the two techniques, r = .92 (P less than or equal to .0001). The CSEF correlated inversely with the left ventricular end diastolic pressure (LVEDP), r = .83 (P less than or equal to .0004), implying that LVEDP is not an independent prognosticator. The relative LVA size expressed as a fraction of the left ventricle in end diastole (LVASF) correlated less strongly with LVASF derived from contrast ventriculography, r = .67 (P = .012). This was probably due to additive inherent errors in contrast ventriculography geometric assumptions. Paradoxical stroke steal fraction (PSSF) defined as the reverse stroke lost in the LVA divided by the left ventricular forward stroke, was calculated from subtraction images. We propose a resectability score utilizing the product of the scintigraphically derived CSEF X LVASF X PSSF X 1,000 to obtain non-invasive pre-operative prognostication of LVA resection and post-operative evaluation.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 4","pages":"124-30"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13703307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experience with the renal scintigraphic captopril test in an elderly population.","authors":"T K Chaudhuri, S Fink","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The records of 18 consecutive patients referred to a Veterans Administration Hospital nuclear medicine service for renal scintigraphic tests to rule out renovascular hypertension were reviewed. The men were elderly (mean age, 62 years), and risk factors for untoward reactions, including long-standing hypertension, severe peripheral vascular disease, diabetes, chronic renal failure, and recent diuretic use were present. Despite these risks, there was no test morbidity, and the authors conclude that the renal scintigraphic test with captopril enhancement is well tolerated and deserves continued application and evaluation.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13789521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biodistribution and dosimetry of 3F8 neuroblastoma monoclonal antibody.","authors":"A D Nelson, F Miraldi, N K Cheung","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method has been developed for quantitating radiolabeled antibody concentrations from images obtained with standard gamma cameras. The method is based on orthogonal projections and accounts both for the effective attenuation of gamma rays and the finite depth dependent resolution of a gamma camera. The method was verified in experimental phantoms and subsequently used in patient studies to quantitate radiolabeled antibody concentrations in neuroblastoma tumors. The in vivo measurements of tumor radioactivity levels were confirmed at biopsy in one patient.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 4","pages":"143-50"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13766422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of expert systems to mammographic image analysis.","authors":"H M Cook, M D Fox","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A prototype expert system was designed for differentiation of 16 circumscribed breast abnormalities utilizing findings identified by a human observer from X-ray mammograms, clinical data, and patient history. An off-the-shelf expert system shell served as the foundation for the rule base. The system runs on standard microcomputer hardware. Preliminary results suggest the expert system may be valuable in improving the ability of relatively unskilled observers to screen X-ray mammograms. Overall, radiology residents with limited experience in mammographic image analysis obtained a diagnostic accuracy level of 40% on their own, whereas they attained 73% accuracy level when using the expert system. A group of biomedical engineering students with no prior experience in mammographic image analysis obtained on the average an 80% diagnostic accuracy level utilizing the expert system in comparison with the 70% average accuracy level obtained by practicing radiologists without use of the system.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14060150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reversible acute unilateral diminished pulmonary ventilation and perfusion caused by a mucous plug.","authors":"M G Velchik, M Tobin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of acute unilateral decreased pulmonary ventilation and perfusion caused by a mucous plug documented by bronchoscopy is presented, and the literature is reviewed.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"4 2","pages":"66-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13897923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}