Biodistribution and dosimetry of 3F8 neuroblastoma monoclonal antibody.

A D Nelson, F Miraldi, N K Cheung
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Abstract

A method has been developed for quantitating radiolabeled antibody concentrations from images obtained with standard gamma cameras. The method is based on orthogonal projections and accounts both for the effective attenuation of gamma rays and the finite depth dependent resolution of a gamma camera. The method was verified in experimental phantoms and subsequently used in patient studies to quantitate radiolabeled antibody concentrations in neuroblastoma tumors. The in vivo measurements of tumor radioactivity levels were confirmed at biopsy in one patient.

3F8神经母细胞瘤单克隆抗体的生物分布及剂量测定。
一种方法已经开发定量放射性标记抗体浓度从图像获得标准伽玛相机。该方法基于正交投影,考虑了伽马射线的有效衰减和伽马相机的有限深度相关分辨率。该方法在实验幻影中得到验证,随后在患者研究中用于量化神经母细胞瘤肿瘤中放射标记的抗体浓度。肿瘤放射性水平的体内测量在一个病人的活组织检查中得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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