AIDS reviews最新文献_第9页

New SARS-CoV-2 Variants Challenge Vaccines Protection. 新的SARS-CoV-2变种挑战疫苗保护。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-02-22 DOI: 10.24875/AIDSRev.M21000040

Vicente Soriano, José V Fernández-Montero

引用次数: 8

The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. 了解COVID-19治疗和试验阶段的重要性。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-02-08 DOI: 10.24875/AIDSRev.200001261

Daniel O Griffin, Denise Brennan-Rieder, Binh Ngo, Pierre Kory, Marco Confalonieri, Leland Shapiro, Jose Iglesias, Michael Dube, Neha Nanda, Gino K In, Daniel Arkfeld, Preet Chaudhary, Vito M Campese, Diana L Hanna, David Sawcer, Glenn Ehresmann, David Peng, Miroslaw Smorgorzewski, April Amstrong, Eivind H Vinjevoll, Rajkumar Dasgupta, Fred R Sattler, Cristina Mussini, Oriol Mitjà, Vicente Soriano, Nicolas Peschanski, Gilles Hayem, Maria Carmela Piccirillo, António Lobo-Ferreira, Iraldo B Rivero, Ivan F H Hung, Marc Rendell, Stephen Ditmore, Joseph Varon, Paul Marik

{"title":"The Importance of Understanding the Stages of COVID-19 in Treatment and Trials.","authors":"Daniel O Griffin, Denise Brennan-Rieder, Binh Ngo, Pierre Kory, Marco Confalonieri, Leland Shapiro, Jose Iglesias, Michael Dube, Neha Nanda, Gino K In, Daniel Arkfeld, Preet Chaudhary, Vito M Campese, Diana L Hanna, David Sawcer, Glenn Ehresmann, David Peng, Miroslaw Smorgorzewski, April Amstrong, Eivind H Vinjevoll, Rajkumar Dasgupta, Fred R Sattler, Cristina Mussini, Oriol Mitjà, Vicente Soriano, Nicolas Peschanski, Gilles Hayem, Maria Carmela Piccirillo, António Lobo-Ferreira, Iraldo B Rivero, Ivan F H Hung, Marc Rendell, Stephen Ditmore, Joseph Varon, Paul Marik","doi":"10.24875/AIDSRev.200001261","DOIUrl":"https://doi.org/10.24875/AIDSRev.200001261","url":null,"abstract":"COVID-19, caused by SARS-CoV-2, continues to be a major health problem since its first description in Wuhan, China, in December 2019. Multiple drugs have been tried to date in the treatment of COVID-19. Critical to treatment of COVID-19 and advancing therapeutics is an appreciation of the multiple stages of this disease and the importance of timing for investigation and use of various agents. We considered articles related to COVID-19 indexed on PubMed published January 1, 2020-November 15, 2020, and considered papers on the medRxiv preprint server. We identified relevant stages of COVID-19 including three periods: pre-exposure, incubation, and detectable viral replication; and five phases: the viral symptom phase, the early inflammatory phase, the secondary infection phase, the multisystem inflammatory phase, and the tail phase. This common terminology should serve as a framework to guide when COVID-19 therapeutics being studied or currently in use is likely to provide benefit rather than harm.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 1","pages":"40-47"},"PeriodicalIF":2.2,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25345237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62

Study of quality of life and depression in people living with HIV/AIDS in India. 印度艾滋病毒/艾滋病感染者的生活质量和抑郁研究。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-01-01 DOI: 10.24875/AIDSRev.20000114

Deepak Jain, Y M Pavan Kumar, V K Katyal, Promil Jain, Jay P Kumar, Shreya Singh

{"title":"Study of quality of life and depression in people living with HIV/AIDS in India.","authors":"Deepak Jain, Y M Pavan Kumar, V K Katyal, Promil Jain, Jay P Kumar, Shreya Singh","doi":"10.24875/AIDSRev.20000114","DOIUrl":"https://doi.org/10.24875/AIDSRev.20000114","url":null,"abstract":"The aim of this study was to assess the quality of life (QOL) and the severity of depression in people living with HIV/AIDS (PLWHA) and investigate its correlates. This was a cross-sectional study on 700 PLWHA in India. World Health Organization QOL HIV (WHOQOL HIV-BREF) and Patient Health Questionnaire-9 (PHQ-9) were used to assess QOL and depression in PLWHA, respectively. The study population was divided into five groups on the basis of Cluster of Differentiation 4 (CD4) count as follows: Group A [< 50 cells/μL], Group B [50-199 cells/μL], Group C [200-349 cells/μL], Group D [350-499 cells/μL], and Group E [>500 cells/μL]. The lowest mean scores were noted under Group A [< 50 cells/μL] in physical and psychological domains and the highest mean scores were noted under Group E [> 500 cells/μL] in physical and environment domains. PHQ9 scores negatively correlated with QOL domains and the correlation was statistically significant (p < 0.001) with the highest negative correlation was found in relation to the psychological domain (r = -0.739). The PHQ9 score in those who do not have opportunistic illnesses (7.23 ± 6.14) was lower in comparison to those who had opportunistic illnesses (9.81 ± 6.40) and the difference was statistically significant (p < 0.001). We observed that there was almost a chronological increase in the individual QOL domain score and a decrease in the PHQ9 score with an increase in CD4 count. Our result supports the implementation of routine screening for depression in antiretroviral therapy centers and multidisciplinary interventions to improve outcomes among depressed PLWHA.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 4","pages":"186-195"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central nervous system disorders in HIV-infected individuals using distinct antiretroviral drugs. 使用不同抗逆转录病毒药物的hiv感染者中枢神经系统疾病。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-01-01 DOI: 10.24875/AIDSRev.M21000044

Álvaro Mena

引用次数: 1

Unveiling Long COVID-19 Disease. 揭示长期COVID-19疾病。

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-12-23 DOI: 10.24875/AIDSRev.M20000039

Vicente Soriano, Pilar Ganado-Pinilla, Miguel Sánchez-Santos, Pablo Barreiro

引用次数: 8

Course of Disease and Clinical Outcome of Infective Endocarditis in HIV-infected Individuals: A Systematic Review and Meta-analysis. hiv感染者感染性心内膜炎的病程和临床结果:一项系统综述和荟萃分析。

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-12-23 DOI: 10.24875/AIDSRev.19000117

Joris Bos, Christiaan F J Antonides, Roos E Barth, Kerstin Klipstein-Grobusch, Ruchika Meel, Alinda G Vos

{"title":"Course of Disease and Clinical Outcome of Infective Endocarditis in HIV-infected Individuals: A Systematic Review and Meta-analysis.","authors":"Joris Bos, Christiaan F J Antonides, Roos E Barth, Kerstin Klipstein-Grobusch, Ruchika Meel, Alinda G Vos","doi":"10.24875/AIDSRev.19000117","DOIUrl":"https://doi.org/10.24875/AIDSRev.19000117","url":null,"abstract":"Infective endocarditis (IE) causes substantial morbidity and mortality if untreated. The clinical course of IE might be different in HIV-positive patients as a result of immune dysfunction. This systematic review investigates the clinical course of IE in HIV-positive compared to HIV-negative patients. A systematic search was performed in PubMed, EMBASE, and Cochrane Library and registered in PROSPERO (CRD42016048649). All articles from 1996 and onward addressing the clinical outcome of HIV-positive adults suffering from IE were reviewed and included based on predefined inclusion and exclusion criteria. A meta-analysis was performed for the outcome mortality. Twenty-three articles were included of which eight included HIVpositive patients only, and 15 compared HIV-positive to HIV-negative patients. Two studies included patients on antiretroviral therapy (ART). HIV and intravenous drug use (IVDU) were closely related. Mortality was higher in HIV-positive patients with a CD4 count below 200 cells/μl than in HIV-positive patients with a higher CD4 count, while mortality was similar for HIV-positive compared to HIV-negative patients (risk ratio = 0.86 [95% confidence interval: 0.53-1.40]). No difference was found in length of hospital stay or rehospitalization. Clinical outcomes were strongly related to the right- or left-sided endocarditis. The clinical course of IE is not different for patients with and without HIV. Clinical outcomes were mainly associated with other factors, such as IVDU and side of cardiac involvement, rather than HIV status.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"22 4","pages":"183-194"},"PeriodicalIF":2.2,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38784567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial Strategies for Long-term Control of HIV Infection. 长期控制HIV感染的组合策略。

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-12-23 DOI: 10.24875/AIDSRev.19000128

Daekee Kwon, Mi-Jung Han, Kwang-Won Seo, Kyung-Sun Kang

引用次数: 0

Coinfection of Tuberculosis and HIV in Nigeria: A Systematic Review and Meta-analysis. 尼日利亚结核病和艾滋病合并感染：系统综述和荟萃分析。

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-12-01 DOI: 10.24875/AIDSRev.20000068

Eleazar E Reward, Anthony C Ike, Sophia O Muo, Busola F Soga-Oke, Emmanuel M Mbaawuaga

{"title":"Coinfection of Tuberculosis and HIV in Nigeria: A Systematic Review and Meta-analysis.","authors":"Eleazar E Reward, Anthony C Ike, Sophia O Muo, Busola F Soga-Oke, Emmanuel M Mbaawuaga","doi":"10.24875/AIDSRev.20000068","DOIUrl":"10.24875/AIDSRev.20000068","url":null,"abstract":"Tuberculosis (TB) and HIV/AIDS are major public health issues globally. The burden of these diseases is particularly significant in Nigeria due to the high TB and HIV/AIDS prevalence. This meta-analysis for the 1st time addressed the TB/HIV coinfection prevalence in Nigeria at the regional level. A total of 58 relevant publications comprising 80 studies (n = 44,508) were obtained from PUBMED, ScienceDirect, African Journals Online, and Cochrane Library databases using carefully constructed keywords combinations. The PRISMA guideline was followed for this meta-analysis. Two independent reviewers conducted the publication screening, data extraction and methodological quality appraisal with a third reviewer serving as arbitrator. The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 2","pages":"82-90"},"PeriodicalIF":2.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38659870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Successful Antiretroviral Therapy on Immune Activation and Reconstitution in HIV Infected Adults: A Systematic Review and Meta-Analysis. 成功的抗逆转录病毒治疗对HIV感染成人免疫激活和重建的影响:系统回顾和荟萃分析

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-10-26 DOI: 10.24875/AIDSRev.20000039

Tawanda M Nyambuya, Phiwayinkosi V Dludla, Vuyolwethu Mxinwa, Bongani B Nkambule

{"title":"The Effect of Successful Antiretroviral Therapy on Immune Activation and Reconstitution in HIV Infected Adults: A Systematic Review and Meta-Analysis.","authors":"Tawanda M Nyambuya, Phiwayinkosi V Dludla, Vuyolwethu Mxinwa, Bongani B Nkambule","doi":"10.24875/AIDSRev.20000039","DOIUrl":"https://doi.org/10.24875/AIDSRev.20000039","url":null,"abstract":"We performed a systematic review and meta-analysis to investigate the impact of antiretroviral therapy (ART) on immune activation and reconstitution in people living with human immunodeficiency virus (PLWH). The PubMed electronic database and gray literature were searched from inception until March 2020. Studies were included if they reported the levels of immune activation and reconstitution at baseline and post-treatment. The random-effect model was used to calculate effect sizes. We included a total of ten studies comprising of 1 553 PLWH with an average age of 38.02 ± 10.10 years and a male/female ratio of 3.76. Pooled estimates showed a modest increase in the level of immune activation post-treatment (SMD: 0.64 [95% CI: -1.34, 2.63]; I2 = 98%, pH < 0.00001). In addition, treatment with ART significantly reconstituted the immune system (SMD: 0.70 [95% CI: 0.27, 1.44]; I2 = 68%, pH = 0.009). Notably, the level of immune reconstitution was independent of viral load or the treatment duration but dependent on the class of ARV drugs. Consequently, protease inhibitors were associated with the highest degree of immune restoration, followed by chemokine antagonists and lastly integrase inhibitors. In conclusion, immune activation persists in PLWH despite viral suppression and the degree of immune reconstitution is dependent on the drug class. Therefore, inclusion of protease inhibitors in ART may be of great benefit in immune restoration in patients with very low CD4 count.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 1","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40544484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Vitamin D, Selenium, or Zinc Supplementation in HIV: A Systematic Review. 补充维生素D、硒或锌对HIV的影响：系统综述。

IF 2.2 4区医学

AIDS reviews Pub Date : 2020-10-26 DOI: 10.24875/AIDSRev.20000126

Ibukun Kayode, U. Anaba

{"title":"Effect of Vitamin D, Selenium, or Zinc Supplementation in HIV: A Systematic Review.","authors":"Ibukun Kayode, U. Anaba","doi":"10.24875/AIDSRev.20000126","DOIUrl":"https://doi.org/10.24875/AIDSRev.20000126","url":null,"abstract":"We conducted a systematic review to examine evidence from randomized controlled trials studying the effect of Vitamin D, selenium, or zinc supplementation in human immunodeficiency virus (HIV). An electronic literature search was carried out using Ovid Medline, Embase, CINHAL, Cochrane Center Register of Controlled Trials, Database of Systematic Reviews, Psych Info and PubMed. Eligible articles were assessed for methodological quality on the basis of the adequacy of the randomization process, concealment of allocation, blinding of intervention and outcome, and completeness of follow-up. A total of 24 single supplement trials (Vitamin D, selenium, and zinc) involving 5948 participants were included for this review. Evidence from seven Vitamin D trials showed no damaging or beneficial effect of Vitamin D supplementation on HIV disease progression in HIV-infected adults or children/adolescents. Six of the selenium studies found that providing daily selenium supplementation to HIV-infected adults' increased CD4 cell counts and reduce the risk of diarrhea morbidity and hospital admission rate for HIV-related conditions and opportunistic infection in HIV-infected adults. Evidence from eleven zinc trials showed some evidence of a potential beneficial effect of zinc supplementation on diarrhea morbidity and immune function. However, further research in larger and more diverse populations of HIV patients is required to fully investigate the effect of these nutrients on clinically relevant outcomes in HIV disease, the optimal dose, and the cost-benefit or cost-effectiveness of Vitamin D, selenium, or zinc supplementation.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 3 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47510003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2