The Importance of Understanding the Stages of COVID-19 in Treatment and Trials.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-02-08 DOI:10.24875/AIDSRev.200001261

Daniel O Griffin, Denise Brennan-Rieder, Binh Ngo, Pierre Kory, Marco Confalonieri, Leland Shapiro, Jose Iglesias, Michael Dube, Neha Nanda, Gino K In, Daniel Arkfeld, Preet Chaudhary, Vito M Campese, Diana L Hanna, David Sawcer, Glenn Ehresmann, David Peng, Miroslaw Smorgorzewski, April Amstrong, Eivind H Vinjevoll, Rajkumar Dasgupta, Fred R Sattler, Cristina Mussini, Oriol Mitjà, Vicente Soriano, Nicolas Peschanski, Gilles Hayem, Maria Carmela Piccirillo, António Lobo-Ferreira, Iraldo B Rivero, Ivan F H Hung, Marc Rendell, Stephen Ditmore, Joseph Varon, Paul Marik

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引用次数: 62

Abstract

COVID-19, caused by SARS-CoV-2, continues to be a major health problem since its first description in Wuhan, China, in December 2019. Multiple drugs have been tried to date in the treatment of COVID-19. Critical to treatment of COVID-19 and advancing therapeutics is an appreciation of the multiple stages of this disease and the importance of timing for investigation and use of various agents. We considered articles related to COVID-19 indexed on PubMed published January 1, 2020-November 15, 2020, and considered papers on the medRxiv preprint server. We identified relevant stages of COVID-19 including three periods: pre-exposure, incubation, and detectable viral replication; and five phases: the viral symptom phase, the early inflammatory phase, the secondary infection phase, the multisystem inflammatory phase, and the tail phase. This common terminology should serve as a framework to guide when COVID-19 therapeutics being studied or currently in use is likely to provide benefit rather than harm.

查看原文本刊更多论文

了解COVID-19治疗和试验阶段的重要性。

由SARS-CoV-2引起的COVID-19自2019年12月在中国武汉首次发现以来，一直是一个重大的健康问题。迄今为止，已经尝试了多种药物来治疗COVID-19。对COVID-19治疗和推进治疗方法至关重要的是认识到这种疾病的多个阶段以及调查和使用各种药物的时机的重要性。我们考虑了2020年1月1日至2020年11月15日在PubMed上发表的与COVID-19相关的文章，以及在medRxiv预印本服务器上发表的论文。我们确定了COVID-19的相关阶段，包括三个时期:暴露前、潜伏期和可检测的病毒复制;五个阶段:病毒症状期、早期炎症期、继发感染期、多系统炎症期、尾期。这一通用术语应作为一个框架，指导正在研究或目前使用的COVID-19治疗方法何时可能带来益处而不是危害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.