AIDS reviews最新文献

The burden of HIV-1 and HIV-2 epidemics in Ivory Coast. 象牙海岸 HIV-1 和 HIV-2 流行病的负担。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-11-07 DOI: 10.24875/AIDSRev.M24000076

Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano

{"title":"The burden of HIV-1 and HIV-2 epidemics in Ivory Coast.","authors":"Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano","doi":"10.24875/AIDSRev.M24000076","DOIUrl":"https://doi.org/10.24875/AIDSRev.M24000076","url":null,"abstract":"Simian immunodeficiency viruses (SIV) infecting chimpanzees (SIVcpz) and sooty mangabeys (SIVsm) are, respectively, the biological precursors of human immunodeficiency viruses (HIV) Types 1 and 2. Former French colonies in West Africa are the regions where retroviruses first jumped from primates to humans. Ivory Coast is nowadays a country of over 29 million people, being 2% (580,000) persons living with HIV (PLWH). However, one-quarter remains undiagnosed. Heterosexual transmission is by far the most frequent mechanism of HIV acquisition and women exhibit higher rates of infection than men. Despite preventive measures, HIV infection in children throughout breastfeeding remains significant. The proportion of PLWH carrying HIV-1 is rising whereas conversely HIV-2 carriers are steadily declining. A nationwide survey conducted on earlier 2024 showed that a total of 188,880 PLWH were on follow-up. HIV-1 infection was found in 163,947, HIV-2 in 5,114, and coinfection in 3,182. HIV type was not reported for 7,500. Antiretroviral therapy with tenofovir, lamivudine, and dolutegravir is by far the most frequently prescribed regimen in Ivory Coast (n = 168,543). Viral suppression is recognized in 94.3% of treated PLWH, despite one-third acknowledging unwanted treatment interruptions after failure of stock supplies. Given shared transmission routes with HIV, coinfection with other human retroviruses such as Human T-lymphotropic virus type-1 (HTLV-1) and/or hepatitis viruses B, C, and delta are frequent in Ivory Coast. Coinfections remain largely undiagnosed and poorly managed. In summary, the HIV pandemic caused by both HIV-1 and HIV-2 is a major public health challenge in Ivory Coast, where strategies for expanding diagnosis, sustain antiretroviral treatment, and manage coinfections warrant further efforts.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox 2024 outbreak. 猴痘 2024 年爆发

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-09-26 DOI: 10.24875/AIDSRev.M24000075

Vicente Soriano, Pablo Barreiro

引用次数: 0

Playing catching up: Proceedings of the 1^st Spanish conference on genomic medicine. 迎头赶上：第一届西班牙基因组医学会议记录。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-09-26 DOI: 10.24875/AIDSRev.M24000074

Manuel Corpas, Vicente Soriano, Teresa Perucho, Juan S Rincón-Redondo, Manuel Pérez-Alonso, Juan A G Ranea, Carmen de Mendoza, Federico Morán

{"title":"Playing catching up: Proceedings of the 1st Spanish conference on genomic medicine.","authors":"Manuel Corpas, Vicente Soriano, Teresa Perucho, Juan S Rincón-Redondo, Manuel Pérez-Alonso, Juan A G Ranea, Carmen de Mendoza, Federico Morán","doi":"10.24875/AIDSRev.M24000074","DOIUrl":"10.24875/AIDSRev.M24000074","url":null,"abstract":"On May 23-24, 2024, the 1st Spanish Conference on Genomic Medicine convened in Madrid, Spain. An international and multidisciplinary group of experts gathered to discuss the current state and prospects of genomic medicine in the Spanish-speaking world. There were 278 attendees from Latin America, US, UK, Germany, and Spain, and the topics covered included rare diseases, genome medicine in national health systems (NHSs), artificial intelligence, and commercial development ventures. One particular area of attention was our still sketchy understanding of genome variants. This is evidenced by the fact that many diagnoses in rare diseases continue to yield odysseys that take years, with up to 50% of cases that may go undiagnosed. Since a lot of the genome remains to poorly understood, as new technologies such as long read sequencing become more ubiquitous and cheaper, it is expected that current gaps in genome references will improve. However, disparities within the NHSs suggest that advancements do not necessarily rely on resources but the appropriate regulation and pathways for education of professionals being properly implemented. This is where Genomics England can be a clinical genomic implementation example for routine health care. Ethical challenges, including privacy, informed consent, equity, representation, and genetic discrimination, also require the need for robust legal frameworks and culturally sensitive practices. The future of genomics in Spanish-speaking countries depends on addressing all of these issues. By navigating these challenges responsibly, Spanish-speaking countries can harness the power of genomics to improve health outcomes and advance scientific knowledge, ensuring that the benefits of personalized medicine are realized in an inclusive and equitable manner.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthen the doctor-patient relationship and avoid administrative stifling. 加强医患关系，避免行政窒息。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-07-16 DOI: 10.24875/AIDSRev.M24000073

Vicente Soriano, Pablo Barreiro

引用次数: 0

On the origin of life on earth. 地球生命的起源

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-27 DOI: 10.24875/AIDSRev.M24000071

Vicente Soriano, Rubén Herce

引用次数: 0

International HTLV Conference, London, June 3-5, 2024. 国际 HTLV 大会，伦敦，2024 年 6 月 3-5 日。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-27 DOI: 10.24875/AIDSRev.M24000072

Carmen de Mendoza, Vicente Soriano

引用次数: 0

HTLV-1/2 infection in Italy: a narrative review of epidemiological studies. 意大利的 HTLV-1/2 感染：流行病学研究综述。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-17 DOI: 10.24875/AIDSRev.24000007

Beatrice Macchi, Sandro Grelli, Francesca Marino-Merlo, Antonio Mastino

{"title":"HTLV-1/2 infection in Italy: a narrative review of epidemiological studies.","authors":"Beatrice Macchi, Sandro Grelli, Francesca Marino-Merlo, Antonio Mastino","doi":"10.24875/AIDSRev.24000007","DOIUrl":"10.24875/AIDSRev.24000007","url":null,"abstract":"The human T-cell leukemia virus type 1 (HTLV-1) was first described in 1980. It is spread in highly endemic regions in the world, such as the Southwestern part of Japan, sub-Saharan Africa and South America, Caribbean, Middle East, and Australo-Melanesia regions. HTLV-1 causes adult T cell leukemia and is associated with many inflammatory conditions, most notably HTLV-1-associated myelopathy/tropic spastic paraparesis. HTLV-2, first isolated in 1982, was recognized as a common infection in intravenous drug users, but a clear association with disease remains elusive. The first estimate of HTLV-1-positive individuals worldwide, in 1993, was around 10-20 millions. Due to the lack of global population-based prevalence studies, this is considered an underestimate at the moment. Furthermore, HTLV-1 prevalence in Europe is impacted by changing migration flows. Particularly, no data on HTLV-1 prevalence in the general population in Italy are available. Here, we report a systematic literature review of studies conducted in Italy on HTLV-1/2 from 1980 to 2023. Based on the criteria we adopted a total of 426 publications were found (64 reviews, 99 epidemiological, and 263 translational studies). The contents of some representative publications are summarized and discussed. Moreover, an approximate estimation of about 26,000 HTLV-1 positive foreigners living in Italy was obtained from updated data of foreigners from each single country officially registered as resident in Italy and from data on HTLV-1 prevalence among the general population in the corresponding countries.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The origin of the four major focus of HTLV-1 in Latin America. 拉丁美洲 HTLV-1 四大病灶的起源。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-03-05 DOI: 10.24875/AIDSRev.M24000070

Vicente Soriano, José Manuel Ramos

引用次数: 0

Obelisks - Newly discovered virus-like particles. 方尖碑--新发现的类病毒粒子。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-03-05 DOI: 10.24875/AIDSREV.M24000069

Vicente Soriano, Víctor Moreno-Torres, Octavio Corral

引用次数: 0

Early and contemporary drivers of the HIV-1 group M pandemic. M 组艾滋病毒大流行的早期和当代驱动因素。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-03-05 DOI: 10.24875/AIDSRev.23000021

Jude P Brennan-Calland

{"title":"Early and contemporary drivers of the HIV-1 group M pandemic.","authors":"Jude P Brennan-Calland","doi":"10.24875/AIDSRev.23000021","DOIUrl":"https://doi.org/10.24875/AIDSRev.23000021","url":null,"abstract":"HIV emerged silently taking time to spread and become visible only through geographically isolated clusters of life-threatening immunodeficiency, known as AIDS since the early 80s. The clusters of infection expanded, overlapping to evolve into a pandemic that is ongoing and almost as silent. Phylogenetic analysis places the emergence of HIV-1 group M, the subtype responsible for the pandemic, in the human population more than 100 years ago. Once established, the rate and direction of spread of HIV-1 from local, to national, to contemporary pandemic proportions have varied over time and place. The literature presents many theories on the emergence and drivers of the spread of the virus over the past century. Here, historical evidence and phylogenetic models are reviewed to seek clarity on the emergence, geographic spread and key world events that mark the progression of the HIV-1 pandemic. This narrative review places particular focus on: war (both its direct and indirect affects), trade and economic expansion, changes in sexual behaviors, and public health policy. Investigating the impact of major world events and policy on the emergence and spread of HIV-1 may aid better understanding of what influences the viruses transmission dynamic. By identifying multilateral targets that influence transmission, up-scaled efforts to effectively control, if not remove, HIV-1 from the human population become a possibility. Suggestions for revisions in HIV-1 global public health policy are discussed. Refocused efforts to tackle HIV-1 transmission and replace the need to manage the pathology of this terrible disease are both ethically and economically just.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0