AIDS reviews最新文献

Dolutegravir shows efficacy in HTLV-1 infection. Dolutegravir对HTLV-1感染有效。

IF 2.5 4区医学

AIDS reviews Pub Date : 2026-04-27 DOI: 10.24875/AIDSRev.M26000095

Vicente Soriano

引用次数: 0

Antiretroviral therapy "à la carte". 按单点菜的抗逆转录病毒疗法。

IF 2.5 4区医学

AIDS reviews Pub Date : 2026-04-06 DOI: 10.24875/AIDSRev.M26000094

Vicente Soriano

引用次数: 0

Global research landscape of two-drug regimens for HIV treatment: a visual bibliometric analysis. 两种药物治疗HIV方案的全球研究概况：视觉文献计量分析。

IF 2.5 4区医学

AIDS reviews Pub Date : 2026-03-17 DOI: 10.24875/AIDSRev.25000029

Can Huang, Yanfang Sun, Meng Chen, Lin Zhang, Wei Liu

{"title":"Global research landscape of two-drug regimens for HIV treatment: a visual bibliometric analysis.","authors":"Can Huang, Yanfang Sun, Meng Chen, Lin Zhang, Wei Liu","doi":"10.24875/AIDSRev.25000029","DOIUrl":"10.24875/AIDSRev.25000029","url":null,"abstract":"With the advancement of antiretroviral therapy, two-drug regimens have emerged as a viable and promising strategy for human immunodeficiency virus (HIV) care and management, offering potential advantages in safety, treatment adherence, and cost-effectiveness. Although scholarly interest in this field is growing, a comprehensive bibliometric analysis remains lacking; accordingly, this study aimed to map the research landscape, identify emerging trends, and explore collaborative networks in the field of two-drug HIV treatment regimens. To this end, studies on two-drug HIV treatment regimens were retrieved from the Web of Science Core Collection. After screening and deduplication, key bibliometric data were extracted. Subsequent analyses were performed using the Bibliometrix R-package and VOSviewer to visualize annual publication output, geographical distribution, institutional collaborations, journal influence, author networks, and keyword evolution trends. Ultimately, 3,262 publications were included, with an annual growth rate of 9.23%. The United States was the most productive country (974 publications, 29.9%), while Harvard University topped institutional rankings (430 publications). AIDS was the leading journal (199 publications), and core authors (e.g., Carr A) contributed substantially. Keyword analysis revealed that two-drug regimens are transitioning from \"alternative options\" to \"mainstream choices\" in HIV treatment, with their development reflecting a focus on balancing efficacy and safety, as well as aligning technological innovation with clinical demands. This bibliometric study delineates the evolving landscape of two-drug HIV treatment research, with North America and Europe making prominent contributions. It highlights key research foci and collaboration patterns, providing valuable insights for researchers, clinicians, and policymakers to prioritize future research and optimize HIV treatment strategies.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"28 1","pages":"30-39"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Google DeepMind unlock the mystery of life's origin? DeepMind能解开生命起源之谜吗？

IF 2.5 4区医学

AIDS reviews Pub Date : 2026-02-19 DOI: 10.24875/AIDSRev.M26000093

Vicente Soriano

引用次数: 0

Extending longevity beyond the biological clock and the Dorian Gray syndrome. 延长寿命超越生物钟和多里安·格雷综合症。

IF 2.5 4区医学

AIDS reviews Pub Date : 2026-02-09 DOI: 10.24875/AIDSRev.M26000092

Vicente Soriano

引用次数: 0

Research on differences in sexual orientation and identity. 性取向和性认同差异的研究。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-22 DOI: 10.24875/AIDSRev.M25000091

Vicente Soriano, Ondina Vélez, José I Sánchez-Méndez, Nieves González-Rico, Luisa González

{"title":"Research on differences in sexual orientation and identity.","authors":"Vicente Soriano, Ondina Vélez, José I Sánchez-Méndez, Nieves González-Rico, Luisa González","doi":"10.24875/AIDSRev.M25000091","DOIUrl":"10.24875/AIDSRev.M25000091","url":null,"abstract":"The human being is sexed, as there are men and women. The presence of two complementary sexes provides a biological mechanism for evolution and adaptation to changing environments through reproduction with the admixture of distinct genetic traits. Ultimately, this reproductive meaning of sex provides its most important biological foundation. In humans, sexuality also plays a significant role in interpersonal relationships and affection, uniquely contributing to personhood, well-being, and flourishing. In this way, both meanings of human sexuality, reproductive and affective, can be challenged in certain scenarios, such as when there are intersex states of biological basis, nowadays referred to as disorders or differences of sex development (DSD), same-sex orientation, or gender dysphoria. Following the approach taken for DSD, same-sex attraction and transgender identity could be categorized medically as differences in sexual orientation and self-identity, respectively. This could provide a respectful framework for conducting research about sexuality. Herein, we examine the spectrum of differences in the sexual sphere and update on major determinants. Whereas biological factors lead to DSD, psychological and sociocultural variables largely contribute to same-sex orientation and transgender identity. Inclusive efforts for persons with atypical sexuality must be encouraged to avoid discrimination. However, these conditions should not be overlooked medically. Denying their relevance might discourage research that would ultimately benefit these individuals.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"163-170"},"PeriodicalIF":2.5,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental procedures in people living with HIV: a narrative review. 艾滋病毒感染者的牙科手术：叙述回顾。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.25000025

Rochman Mujayanto

{"title":"Dental procedures in people living with HIV: a narrative review.","authors":"Rochman Mujayanto","doi":"10.24875/AIDSRev.25000025","DOIUrl":"10.24875/AIDSRev.25000025","url":null,"abstract":"HIV affects over 39 million people globally and remains a challenge in oral health care despite advances in antiretroviral therapy (ART). The oral cavity often reflects immune status and serves as a site for opportunistic infections, making dental care essential in HIV management. This review explores four main aspects of dental care for people living with HIV (PLHIV): HIV pathophysiology, transmission risk during dental procedures, infection control strategies, and pre-treatment clinical assessment. Using the population-concept-context framework, literature was reviewed from PubMed, Scopus, and Web of Science spanning 2000-2025. Oral conditions such as candidiasis, Kaposi's sarcoma, and periodontal disease remain prevalent in PLHIV and are closely linked to HIV progression. The risk of HIV transmission in dental settings is very low (< 0.3% for percutaneous exposure) when standard precautions are followed, though stigma among providers persists. Effective infection control includes personal protective equipment, sterilization, and aerosol reduction. Pre-procedural evaluation (CD4 count, viral load, and hematological status) is vital for safe care. In cases of neutropenia, antibiotic prophylaxis may be needed, and elective procedures should be deferred. Dental treatment for PLHIV is safe when guided by evidence-based protocols. Integrating infection control, risk assessment, and personalized planning strengthens the role of dentistry in comprehensive HIV care.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"13-20"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicine at bedside or with smartphone? 床边用药还是智能手机用药？

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.M25000090

Vicente Soriano

引用次数: 0

Beating HIV from day 1: strengthening same-day antiretroviral therapy in South Africa: challenges, realities, and the path forward. 从第一天开始战胜艾滋病毒：在南非加强当日抗逆转录病毒治疗：挑战、现实和前进道路。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.25000020

Siyakudumisa Nontamo, Gabriel Tchuente-Kamsu, Nomboniso Agrinette-Madolo, Eugene-Jamot Ndebia

{"title":"Beating HIV from day 1: strengthening same-day antiretroviral therapy in South Africa: challenges, realities, and the path forward.","authors":"Siyakudumisa Nontamo, Gabriel Tchuente-Kamsu, Nomboniso Agrinette-Madolo, Eugene-Jamot Ndebia","doi":"10.24875/AIDSRev.25000020","DOIUrl":"10.24875/AIDSRev.25000020","url":null,"abstract":"Same-day initiation of antiretroviral therapy (ART), known as same-day ART, has been endorsed by the World Health Organization since 2017 as a strategy to improve treatment coverage, reduce HIV transmission, and increase the survival of people living with HIV. This approach aims to minimize loss to follow-up (LTFU) and strengthen engagement in care, particularly in high-prevalence settings such as South Africa. This review aims to synthesize available data on the benefits, challenges, and impacts of same-day ART, with a particular focus on resource-limited settings. A literature review was conducted on published studies that addressed the effectiveness, adherence, retention in care, and clinical outcomes associated with same-day ART. The studies indicate that same-day ART is associated with a significant improvement in treatment initiation and reduced delays in therapy. However, its success depends on several factors, including patient acceptability, healthcare system capacity, and the quality of psychosocial support. Increased risks of long-term LTFU have also been reported among certain vulnerable populations. Same-day ART represents a major advancement in the fight against HIV, but its implementation requires a contextualized approach, adequate training of healthcare providers, and strengthened psychosocial support to ensure long-term retention in care.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"153-162"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and perspectives in the HIV vaccine research over the past thirty-five years: A scientometrics analysis through CiteSpace. 过去35年来艾滋病毒疫苗研究的趋势和前景：通过CiteSpace进行科学计量学分析。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-17 DOI: 10.24875/AIDSRev.25000018

Xuannan Chen, Yizhou Zhuo, Yu Lai

{"title":"Trends and perspectives in the HIV vaccine research over the past thirty-five years: A scientometrics analysis through CiteSpace.","authors":"Xuannan Chen, Yizhou Zhuo, Yu Lai","doi":"10.24875/AIDSRev.25000018","DOIUrl":"10.24875/AIDSRev.25000018","url":null,"abstract":"Despite advances in antiretroviral therapy, developing an effective human immunodeficiency virus (HIV) vaccine remains pivotal for epidemic control. Through a scientometric analysis of 19,863 publications from the Web of Science Core Collection (1989-2023) using CiteSpace, this study delineates evolving trends and emerging frontiers in HIV vaccine research. The United States dominated contributions, with institutions like the National Institutes of Health and Harvard leading productivity. Clustering revealed two interconnected research trajectories, which are broad neutralizing antibody development, broad neutralizing antibody precursors, and immune mechanism exploration. Despite efficacy trials not resulting in licensed HIV vaccine advancements in antigen design and adjuvant strategies, they show promise. Key findings indicated structural biology, germinal center (GC) dynamics, antibody-dependent cellular cytotoxicity, and glycosylation shielding as pivotal research domains. Critical barriers include generating a specific immune response to new epitopes and glycosylation-mediated immune evasion. Future efforts should prioritize GC optimization to enhance B-cell affinity maturation, structure-guided epitope targeting through cryo-electron microscopy, and advances in antigen delivery. In addition, engineering vaccines to expand CXCR5+ T follicular helper cell populations may improve durable humoral immunity. This analysis underscores the necessity of multidisciplinary approaches to overcome HIV vaccine hurdles.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"138-152"},"PeriodicalIF":2.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0