AIDS reviews最新文献

Human immunodeficiency virus/acquired immunodeficiency syndrome in Pakistan - Progress, barriers, and future directions.

IF 1.9 4区医学

AIDS reviews Pub Date : 2025-03-11 DOI: 10.24875/AIDSRev.24000017

Hasnain Javed, Muhammad Shafiq, Muhammad Sheraz-Zafar, Aroob Akram, Mehmood Qadir, Muhammad Zeeshan-Hyder, Warda Fatima, Abida Bano

{"title":"Human immunodeficiency virus/acquired immunodeficiency syndrome in Pakistan - Progress, barriers, and future directions.","authors":"Hasnain Javed, Muhammad Shafiq, Muhammad Sheraz-Zafar, Aroob Akram, Mehmood Qadir, Muhammad Zeeshan-Hyder, Warda Fatima, Abida Bano","doi":"10.24875/AIDSRev.24000017","DOIUrl":"https://doi.org/10.24875/AIDSRev.24000017","url":null,"abstract":"Human immunodeficiency virus (HIV) was first reported in Pakistan in 1987. Initially believed to have a low HIV prevalence mainly confined to high-risk groups such as injection drug users (IDUs) and commercial sex workers. However, HIV prevalence has steadily increased, with Punjab and Sindh provinces reporting the highest rates. Heterosexual transmission is the most frequent transmission route. High-risk populations include IDUs, men having sex with men, commercial sex workers, as well as truck drivers and miners. Furthermore, HIV has spread from urban centers to rural areas. The World Health Organization has reported over 200,000 HIV cases in Pakistan, making it the second-largest HIV-positive nation in Asia after India. The proportion of undiagnosed individuals is high and antiretroviral coverage is suboptimal. Fear of societal discrimination often leads individuals with HIV to hide their status, further spreading the virus. Mother-to-child transmission is another significant concern. Challenges in patient adherence to antiretroviral therapy (ART) exist, with many patients missing follow-up appointments. ART access due to shortages is frequent stemming from the reliance on imports. To mitigate the growing burden of HIV in Pakistan, it is essential to prioritize prevention through awareness campaigns and robust screening and antiretroviral programs targeting high-risk populations.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simplification of antiretroviral therapy: comparative review of two-drug and three-drug regimens in HIV treatment.

IF 1.9 4区医学

AIDS reviews Pub Date : 2025-02-17 DOI: 10.24875/AIDSRev.M25000081

Carmen Hidalgo-Tenorio, Javier Martínez-Sanz

{"title":"Simplification of antiretroviral therapy: comparative review of two-drug and three-drug regimens in HIV treatment.","authors":"Carmen Hidalgo-Tenorio, Javier Martínez-Sanz","doi":"10.24875/AIDSRev.M25000081","DOIUrl":"https://doi.org/10.24875/AIDSRev.M25000081","url":null,"abstract":"Combined antiretroviral therapies have revolutionized HIV management. Triple-drug regimens (3DR) have been the cornerstone of HIV treatment, which provide durable virologic suppression, reduce HIV-related morbidity and mortality, and improve immune reconstitution. However, 3DR are associated to long-term toxicities. In certain settings, two-drug regimens (2DR) present non-inferior virological efficacy compared to 3DR and may improve tolerability and adherence. In this review, we examine the efficacy, safety, and patient-centered outcomes of 3DR and 2DR, and the potential benefits of transitioning from triple to dual therapy regimens in people with HIV. We conducted a literature search on PubMed, EMBASE, and the Cochrane Library databases for studies published between January 2010 and June 2024. Overall data support the non-inferior efficacy of 2DR to 3DR in the management of HIV, with no evidence of an increased risk of subclinical failure with dual therapy. Switching from 3DR to 2DR may reduce the risk of drug interactions and toxicity. Within the 2DR, the long-acting therapies represent the most innovative dual therapy since they simplify the treatment by reducing from triple to dual therapy along shifting from daily pills to bi-monthly injections. Long-acting 2DR are effective, provide high levels of satisfaction, and improve adherence and quality of life.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted infections keep rising up. 性传播感染不断上升。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-11-15 DOI: 10.24875/AIDSREV.M24000077

Vicente Soriano, Ana Treviño

引用次数: 0

The burden of HIV-1 and HIV-2 epidemics in Ivory Coast. 象牙海岸 HIV-1 和 HIV-2 流行病的负担。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-11-07 DOI: 10.24875/AIDSRev.M24000076

Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano

{"title":"The burden of HIV-1 and HIV-2 epidemics in Ivory Coast.","authors":"Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano","doi":"10.24875/AIDSRev.M24000076","DOIUrl":"10.24875/AIDSRev.M24000076","url":null,"abstract":"Simian immunodeficiency viruses (SIV) infecting chimpanzees (SIVcpz) and sooty mangabeys (SIVsm) are, respectively, the biological precursors of human immunodeficiency viruses (HIV) Types 1 and 2. Former French colonies in West Africa are the regions where retroviruses first jumped from primates to humans. Ivory Coast is nowadays a country of over 29 million people, being 2% (580,000) persons living with HIV (PLWH). However, one-quarter remains undiagnosed. Heterosexual transmission is by far the most frequent mechanism of HIV acquisition and women exhibit higher rates of infection than men. Despite preventive measures, HIV infection in children throughout breastfeeding remains significant. The proportion of PLWH carrying HIV-1 is rising whereas conversely HIV-2 carriers are steadily declining. A nationwide survey conducted on earlier 2024 showed that a total of 188,880 PLWH were on follow-up. HIV-1 infection was found in 163,947, HIV-2 in 5,114, and coinfection in 3,182. HIV type was not reported for 7,500. Antiretroviral therapy with tenofovir, lamivudine, and dolutegravir is by far the most frequently prescribed regimen in Ivory Coast (n = 168,543). Viral suppression is recognized in 94.3% of treated PLWH, despite one-third acknowledging unwanted treatment interruptions after failure of stock supplies. Given shared transmission routes with HIV, coinfection with other human retroviruses such as Human T-lymphotropic virus type-1 (HTLV-1) and/or hepatitis viruses B, C, and delta are frequent in Ivory Coast. Coinfections remain largely undiagnosed and poorly managed. In summary, the HIV pandemic caused by both HIV-1 and HIV-2 is a major public health challenge in Ivory Coast, where strategies for expanding diagnosis, sustain antiretroviral treatment, and manage coinfections warrant further efforts.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"151-157"},"PeriodicalIF":1.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox 2024 outbreak. 猴痘 2024 年爆发

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-09-26 DOI: 10.24875/AIDSRev.M24000075

Vicente Soriano, Pablo Barreiro

引用次数: 0

Playing catching up: Proceedings of the 1^st Spanish conference on genomic medicine. 迎头赶上：第一届西班牙基因组医学会议记录。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-09-26 DOI: 10.24875/AIDSRev.M24000074

Manuel Corpas, Vicente Soriano, Teresa Perucho, Juan S Rincón-Redondo, Manuel Pérez-Alonso, Juan A G Ranea, Carmen de Mendoza, Federico Morán

{"title":"Playing catching up: Proceedings of the 1st Spanish conference on genomic medicine.","authors":"Manuel Corpas, Vicente Soriano, Teresa Perucho, Juan S Rincón-Redondo, Manuel Pérez-Alonso, Juan A G Ranea, Carmen de Mendoza, Federico Morán","doi":"10.24875/AIDSRev.M24000074","DOIUrl":"10.24875/AIDSRev.M24000074","url":null,"abstract":"On May 23-24, 2024, the 1st Spanish Conference on Genomic Medicine convened in Madrid, Spain. An international and multidisciplinary group of experts gathered to discuss the current state and prospects of genomic medicine in the Spanish-speaking world. There were 278 attendees from Latin America, US, UK, Germany, and Spain, and the topics covered included rare diseases, genome medicine in national health systems (NHSs), artificial intelligence, and commercial development ventures. One particular area of attention was our still sketchy understanding of genome variants. This is evidenced by the fact that many diagnoses in rare diseases continue to yield odysseys that take years, with up to 50% of cases that may go undiagnosed. Since a lot of the genome remains to poorly understood, as new technologies such as long read sequencing become more ubiquitous and cheaper, it is expected that current gaps in genome references will improve. However, disparities within the NHSs suggest that advancements do not necessarily rely on resources but the appropriate regulation and pathways for education of professionals being properly implemented. This is where Genomics England can be a clinical genomic implementation example for routine health care. Ethical challenges, including privacy, informed consent, equity, representation, and genetic discrimination, also require the need for robust legal frameworks and culturally sensitive practices. The future of genomics in Spanish-speaking countries depends on addressing all of these issues. By navigating these challenges responsibly, Spanish-speaking countries can harness the power of genomics to improve health outcomes and advance scientific knowledge, ensuring that the benefits of personalized medicine are realized in an inclusive and equitable manner.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"130-140"},"PeriodicalIF":1.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthen the doctor-patient relationship and avoid administrative stifling. 加强医患关系，避免行政窒息。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-07-16 DOI: 10.24875/AIDSRev.M24000073

Vicente Soriano, Pablo Barreiro

引用次数: 0

On the origin of life on earth. 地球生命的起源

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-27 DOI: 10.24875/AIDSRev.M24000071

Vicente Soriano, Rubén Herce

引用次数: 0

International HTLV Conference, London, June 3-5, 2024. 国际 HTLV 大会，伦敦，2024 年 6 月 3-5 日。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-27 DOI: 10.24875/AIDSRev.M24000072

Carmen de Mendoza, Vicente Soriano

引用次数: 0

HTLV-1/2 infection in Italy: a narrative review of epidemiological studies. 意大利的 HTLV-1/2 感染：流行病学研究综述。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-06-17 DOI: 10.24875/AIDSRev.24000007

Beatrice Macchi, Sandro Grelli, Francesca Marino-Merlo, Antonio Mastino

{"title":"HTLV-1/2 infection in Italy: a narrative review of epidemiological studies.","authors":"Beatrice Macchi, Sandro Grelli, Francesca Marino-Merlo, Antonio Mastino","doi":"10.24875/AIDSRev.24000007","DOIUrl":"10.24875/AIDSRev.24000007","url":null,"abstract":"The human T-cell leukemia virus type 1 (HTLV-1) was first described in 1980. It is spread in highly endemic regions in the world, such as the Southwestern part of Japan, sub-Saharan Africa and South America, Caribbean, Middle East, and Australo-Melanesia regions. HTLV-1 causes adult T cell leukemia and is associated with many inflammatory conditions, most notably HTLV-1-associated myelopathy/tropic spastic paraparesis. HTLV-2, first isolated in 1982, was recognized as a common infection in intravenous drug users, but a clear association with disease remains elusive. The first estimate of HTLV-1-positive individuals worldwide, in 1993, was around 10-20 millions. Due to the lack of global population-based prevalence studies, this is considered an underestimate at the moment. Furthermore, HTLV-1 prevalence in Europe is impacted by changing migration flows. Particularly, no data on HTLV-1 prevalence in the general population in Italy are available. Here, we report a systematic literature review of studies conducted in Italy on HTLV-1/2 from 1980 to 2023. Based on the criteria we adopted a total of 426 publications were found (64 reviews, 99 epidemiological, and 263 translational studies). The contents of some representative publications are summarized and discussed. Moreover, an approximate estimation of about 26,000 HTLV-1 positive foreigners living in Italy was obtained from updated data of foreigners from each single country officially registered as resident in Italy and from data on HTLV-1 prevalence among the general population in the corresponding countries.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"53-63"},"PeriodicalIF":1.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0