Unraveling the complex interplay: HIV and male infertility.

IF 2.5 4区医学 Q4 IMMUNOLOGY

AIDS reviews Pub Date : 2025-07-21 DOI:10.24875/AIDSRev.25000004

Xiaoqing He, Jun Yin, Kun He, Honghong Yang, Yushan Wu, Min Liu

{"title":"Unraveling the complex interplay: HIV and male infertility.","authors":"Xiaoqing He, Jun Yin, Kun He, Honghong Yang, Yushan Wu, Min Liu","doi":"10.24875/AIDSRev.25000004","DOIUrl":null,"url":null,"abstract":"<p><p>This review elucidates the complex interplay between HIV infection and male infertility, underscoring the multifaceted mechanisms through which HIV undermines male reproductive health. These mechanisms encompass diminished semen quality, orchitis, hypogonadism, and leukocytospermia. Concurrently, while antiretroviral therapy (ART) is salvific, it may pose additional fertility challenges. The introduction of highly suppressive ART has revolutionized the reproductive landscape for HIVserodiscordant couples, enabling them to plan for children with minimal risk of HIV transmission, thereby justifying the Undetectable = Untransmissible (U = U) paradigm. Despite these impediments, sperm washing in conjunction with sophisticated assisted reproductive technologies (ARTs), such as in vitro fertilization and intracytoplasmic sperm injection, offers efficacious fertility solutions for HIV-positive males, substantially mitigating the risk of HIV transmission. Psychological and ethical considerations further shape fertility treatment decisions and outcomes within this demographic. Future research should focus on elucidating the long-term effects of ART on male fertility and devising targeted interventions to enhance reproductive health in HIV-positive men.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/AIDSRev.25000004","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

This review elucidates the complex interplay between HIV infection and male infertility, underscoring the multifaceted mechanisms through which HIV undermines male reproductive health. These mechanisms encompass diminished semen quality, orchitis, hypogonadism, and leukocytospermia. Concurrently, while antiretroviral therapy (ART) is salvific, it may pose additional fertility challenges. The introduction of highly suppressive ART has revolutionized the reproductive landscape for HIVserodiscordant couples, enabling them to plan for children with minimal risk of HIV transmission, thereby justifying the Undetectable = Untransmissible (U = U) paradigm. Despite these impediments, sperm washing in conjunction with sophisticated assisted reproductive technologies (ARTs), such as in vitro fertilization and intracytoplasmic sperm injection, offers efficacious fertility solutions for HIV-positive males, substantially mitigating the risk of HIV transmission. Psychological and ethical considerations further shape fertility treatment decisions and outcomes within this demographic. Future research should focus on elucidating the long-term effects of ART on male fertility and devising targeted interventions to enhance reproductive health in HIV-positive men.

查看原文本刊更多论文

解开复杂的相互作用：艾滋病毒和男性不育。

这篇综述阐明了艾滋病毒感染与男性不育之间复杂的相互作用，强调了艾滋病毒破坏男性生殖健康的多方面机制。这些机制包括精液质量下降、睾丸炎、性腺功能减退和白血球精子症。同时，虽然抗逆转录病毒疗法（ART）具有拯救作用，但它可能带来额外的生育挑战。高度抑制性抗逆转录病毒治疗的采用彻底改变了艾滋病毒血清不一致夫妇的生殖环境，使他们能够以最小的艾滋病毒传播风险为子女进行规划，从而证明了“无法检测到=无法传播”（U = U）范式是合理的。尽管存在这些障碍，精子清洗结合复杂的辅助生殖技术（ARTs），如体外受精和胞浆内精子注射，为艾滋病毒阳性男性提供了有效的生育解决方案，大大降低了艾滋病毒传播的风险。心理和伦理方面的考虑进一步影响了这一人群的生育治疗决定和结果。未来的研究应侧重于阐明抗逆转录病毒治疗对男性生育能力的长期影响，并设计有针对性的干预措施，以加强艾滋病毒阳性男子的生殖健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

AIDS reviews 医学-传染病学

CiteScore

3.40

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.