象牙海岸 HIV-1 和 HIV-2 流行病的负担。

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano
{"title":"象牙海岸 HIV-1 和 HIV-2 流行病的负担。","authors":"Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano","doi":"10.24875/AIDSRev.M24000076","DOIUrl":null,"url":null,"abstract":"<p><p>Simian immunodeficiency viruses (SIV) infecting chimpanzees (SIVcpz) and sooty mangabeys (SIVsm) are, respectively, the biological precursors of human immunodeficiency viruses (HIV) Types 1 and 2. Former French colonies in West Africa are the regions where retroviruses first jumped from primates to humans. Ivory Coast is nowadays a country of over 29 million people, being 2% (580,000) persons living with HIV (PLWH). However, one-quarter remains undiagnosed. Heterosexual transmission is by far the most frequent mechanism of HIV acquisition and women exhibit higher rates of infection than men. Despite preventive measures, HIV infection in children throughout breastfeeding remains significant. The proportion of PLWH carrying HIV-1 is rising whereas conversely HIV-2 carriers are steadily declining. A nationwide survey conducted on earlier 2024 showed that a total of 188,880 PLWH were on follow-up. HIV-1 infection was found in 163,947, HIV-2 in 5,114, and coinfection in 3,182. HIV type was not reported for 7,500. Antiretroviral therapy with tenofovir, lamivudine, and dolutegravir is by far the most frequently prescribed regimen in Ivory Coast (n = 168,543). Viral suppression is recognized in 94.3% of treated PLWH, despite one-third acknowledging unwanted treatment interruptions after failure of stock supplies. Given shared transmission routes with HIV, coinfection with other human retroviruses such as Human T-lymphotropic virus type-1 (HTLV-1) and/or hepatitis viruses B, C, and delta are frequent in Ivory Coast. Coinfections remain largely undiagnosed and poorly managed. In summary, the HIV pandemic caused by both HIV-1 and HIV-2 is a major public health challenge in Ivory Coast, where strategies for expanding diagnosis, sustain antiretroviral treatment, and manage coinfections warrant further efforts.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"001"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The burden of HIV-1 and HIV-2 epidemics in Ivory Coast.\",\"authors\":\"Bérenger Konan, Carmen de Mendoza, Christ-Hermannn Kouadio, Eric Martial-Yao, Fernando de Jesús, Octavio Corral, Vicente Soriano\",\"doi\":\"10.24875/AIDSRev.M24000076\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Simian immunodeficiency viruses (SIV) infecting chimpanzees (SIVcpz) and sooty mangabeys (SIVsm) are, respectively, the biological precursors of human immunodeficiency viruses (HIV) Types 1 and 2. Former French colonies in West Africa are the regions where retroviruses first jumped from primates to humans. Ivory Coast is nowadays a country of over 29 million people, being 2% (580,000) persons living with HIV (PLWH). However, one-quarter remains undiagnosed. Heterosexual transmission is by far the most frequent mechanism of HIV acquisition and women exhibit higher rates of infection than men. Despite preventive measures, HIV infection in children throughout breastfeeding remains significant. The proportion of PLWH carrying HIV-1 is rising whereas conversely HIV-2 carriers are steadily declining. A nationwide survey conducted on earlier 2024 showed that a total of 188,880 PLWH were on follow-up. HIV-1 infection was found in 163,947, HIV-2 in 5,114, and coinfection in 3,182. HIV type was not reported for 7,500. Antiretroviral therapy with tenofovir, lamivudine, and dolutegravir is by far the most frequently prescribed regimen in Ivory Coast (n = 168,543). Viral suppression is recognized in 94.3% of treated PLWH, despite one-third acknowledging unwanted treatment interruptions after failure of stock supplies. Given shared transmission routes with HIV, coinfection with other human retroviruses such as Human T-lymphotropic virus type-1 (HTLV-1) and/or hepatitis viruses B, C, and delta are frequent in Ivory Coast. Coinfections remain largely undiagnosed and poorly managed. In summary, the HIV pandemic caused by both HIV-1 and HIV-2 is a major public health challenge in Ivory Coast, where strategies for expanding diagnosis, sustain antiretroviral treatment, and manage coinfections warrant further efforts.</p>\",\"PeriodicalId\":7685,\"journal\":{\"name\":\"AIDS reviews\",\"volume\":\" \",\"pages\":\"001\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.24875/AIDSRev.M24000076\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/AIDSRev.M24000076","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

感染黑猩猩(SIVcpz)和褐猿(SIVsm)的猿类免疫缺陷病毒(SIV)分别是人类免疫缺陷病毒(HIV)1 型和 2 型的生物学前身。西非的前法国殖民地是逆转录病毒首次从灵长类动物跃迁到人类的地区。如今,象牙海岸有 2900 多万人口,2%(58 万人)是艾滋病毒感染者(PLWH)。然而,仍有四分之一的人未经诊断。异性传播是迄今为止最常见的艾滋病毒感染机制,女性的感染率高于男性。尽管采取了预防措施,但儿童在整个哺乳期感染艾滋病毒的情况仍然十分严重。艾滋病毒-1 携带者的比例正在上升,而艾滋病毒-2 携带者的比例则在稳步下降。2024 年初进行的一项全国性调查显示,共有 188 880 名艾滋病毒感染者接受了随访。其中 163 947 人感染了 HIV-1,5 114 人感染了 HIV-2,3 182 人合并感染。有 7 500 人未报告艾滋病毒类型。在象牙海岸,使用替诺福韦、拉米夫定和多罗替拉韦进行抗逆转录病毒治疗是迄今为止最常用的处方疗法(n = 168 543)。94.3%接受过治疗的艾滋病毒感染者的病毒得到了抑制,尽管有三分之一的感染者承认,在库存供应出现问题后,曾出现过不必要的治疗中断。由于与艾滋病毒的传播途径相同,象牙海岸经常出现合并感染其他人类逆转录病毒的情况,如人类 T 淋巴细胞病毒 1 型(HTLV-1)和/或乙型、丙型和三角型肝炎病毒。合并感染在很大程度上仍未得到诊断,而且管理不善。总之,HIV-1 和 HIV-2 导致的艾滋病毒大流行是象牙海岸公共卫生面临的一项重大挑战,需要进一步努力扩大诊断、维持抗逆转录病毒治疗和管理合并感染的战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The burden of HIV-1 and HIV-2 epidemics in Ivory Coast.

Simian immunodeficiency viruses (SIV) infecting chimpanzees (SIVcpz) and sooty mangabeys (SIVsm) are, respectively, the biological precursors of human immunodeficiency viruses (HIV) Types 1 and 2. Former French colonies in West Africa are the regions where retroviruses first jumped from primates to humans. Ivory Coast is nowadays a country of over 29 million people, being 2% (580,000) persons living with HIV (PLWH). However, one-quarter remains undiagnosed. Heterosexual transmission is by far the most frequent mechanism of HIV acquisition and women exhibit higher rates of infection than men. Despite preventive measures, HIV infection in children throughout breastfeeding remains significant. The proportion of PLWH carrying HIV-1 is rising whereas conversely HIV-2 carriers are steadily declining. A nationwide survey conducted on earlier 2024 showed that a total of 188,880 PLWH were on follow-up. HIV-1 infection was found in 163,947, HIV-2 in 5,114, and coinfection in 3,182. HIV type was not reported for 7,500. Antiretroviral therapy with tenofovir, lamivudine, and dolutegravir is by far the most frequently prescribed regimen in Ivory Coast (n = 168,543). Viral suppression is recognized in 94.3% of treated PLWH, despite one-third acknowledging unwanted treatment interruptions after failure of stock supplies. Given shared transmission routes with HIV, coinfection with other human retroviruses such as Human T-lymphotropic virus type-1 (HTLV-1) and/or hepatitis viruses B, C, and delta are frequent in Ivory Coast. Coinfections remain largely undiagnosed and poorly managed. In summary, the HIV pandemic caused by both HIV-1 and HIV-2 is a major public health challenge in Ivory Coast, where strategies for expanding diagnosis, sustain antiretroviral treatment, and manage coinfections warrant further efforts.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信