AIDS reviews最新文献_第2页

Will AI soon replace doctors? 人工智能会很快取代医生吗？

IF 2 4区医学

AIDS reviews Pub Date : 2026-01-01 DOI: 10.24875/AIDSRev.M26000097

Vicente Soriano

引用次数: 0

Off-label use of antiretroviral drugs: ethical and legal implications for clinical decision-making. 说明书外使用抗逆转录病毒药物：临床决策的伦理和法律影响。

IF 2 4区医学

AIDS reviews Pub Date : 2026-01-01 DOI: 10.24875/AIDSRev.26000007

Drozdz-Vergara Andrea, Domingo-Chiva Esther, Blázquez-Abellán Gemma, Rodríguez-García Alba

{"title":"Off-label use of antiretroviral drugs: ethical and legal implications for clinical decision-making.","authors":"Drozdz-Vergara Andrea, Domingo-Chiva Esther, Blázquez-Abellán Gemma, Rodríguez-García Alba","doi":"10.24875/AIDSRev.26000007","DOIUrl":"https://doi.org/10.24875/AIDSRev.26000007","url":null,"abstract":"The use of authorized medicinal products under conditions other than those approved, commonly referred to as off-label use, is an increasingly frequent practice in health care. It is particularly relevant in the therapeutic management of human immunodeficiency virus infection, where treatment innovation often outpaces regulatory updates. In the absence of specific protocols to guide the appropriateness of off-label prescribing, this narrative review analyses, from an ethical and legal perspective, the conditions under which off-label use may be considered an appropriate therapeutic option. To this end, we examine the clinical foundations of off-label use, including the quality and certainty of the available scientific evidence and its impact on the benefit-risk and cost-benefit balance, the exceptional nature of its use, and the application of decision-making algorithms to guide prescribing. We also identify the main ethical dilemmas associated with off-label use from principlist, virtue-based, and utilitarian bioethical perspectives, as well as the principal conflicts of interest among the different stakeholders involved in the off-label use of antiretroviral drugs. Finally, we propose strategies aimed at promoting a more prudent, equitable, and transparent use of off-label medicines, strengthening responsible, patient-centered decision-making.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"28 2","pages":"45-55"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-acting HIV treatment and prevention: a bibliometric analysis and science mapping. 长效艾滋病毒治疗和预防：文献计量学分析和科学制图。

IF 2 4区医学

AIDS reviews Pub Date : 2026-01-01 DOI: 10.24875/AIDSRev.26000016

Özlem Gül, Nazife D Demirbaş

{"title":"Long-acting HIV treatment and prevention: a bibliometric analysis and science mapping.","authors":"Özlem Gül, Nazife D Demirbaş","doi":"10.24875/AIDSRev.26000016","DOIUrl":"10.24875/AIDSRev.26000016","url":null,"abstract":"Long-acting antiretroviral therapy and long-acting pre-exposure prophylaxis (PrEP) have rapidly become prominent areas of HIV research. To our knowledge, as of June 30, 2026, no previous bibliometric study had jointly mapped the long-acting HIV treatment and prevention literatures within a single Scopus-based science-mapping framework. We conducted a comprehensive bibliometric analysis of English-language research articles and reviews indexed in Scopus, with no restriction on publication year. A total of 1573 publications met the inclusion criteria. Publication output, citation patterns, collaboration networks, conceptual structure, and thematic evolution were examined using co-authorship, keyword co-occurrence, bibliographic coupling, co-citation, and thematic-map analyses. The literature showed an annual growth rate of 32.1%, and 36.1% of publications involved international co-authorship. The United States was the leading corresponding author country, followed by several European countries. Scientific output increased rapidly, with early growth centered on cabotegravir/rilpivirine trials and more recent expansion involving lenacapavir-related research. Keyword and thematic analyses identified long-acting PrEP and cabotegravir/rilpivirine as central, well-established topics, whereas lenacapavir has emerged as a recent and increasingly central research theme. A substantial share of the most-cited literature was linked to industry-funded or industry-affiliated clinical development programs. These findings provide an integrated map of long-acting HIV treatment and prevention research and may inform future research priorities, international collaborations, and implementation research.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"28 3","pages":"85-94"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between tuberculosis, HIV infection, and diabetes mellitus: should we integrate screening and care? A systematic review. 结核病、艾滋病毒感染和糖尿病之间的关系：我们是否应该整合筛查和护理？系统回顾。

IF 2 4区医学

AIDS reviews Pub Date : 2026-01-01 DOI: 10.24875/AIDSRev.26000010

Aulia Insani Latif, Mutmainnah Sari, Petra Mandysová, Kana Suzuki, Nur Hijrah Tiala, Olivia Fristisia H Pabetting, Akbar Harisa, Muhammad Abu

{"title":"Association between tuberculosis, HIV infection, and diabetes mellitus: should we integrate screening and care? A systematic review.","authors":"Aulia Insani Latif, Mutmainnah Sari, Petra Mandysová, Kana Suzuki, Nur Hijrah Tiala, Olivia Fristisia H Pabetting, Akbar Harisa, Muhammad Abu","doi":"10.24875/AIDSRev.26000010","DOIUrl":"https://doi.org/10.24875/AIDSRev.26000010","url":null,"abstract":"Tuberculosis (TB) and HIV/AIDS are among the leading infectious diseases worldwide, while diabetes mellitus (DM) is a major chronic endocrine and metabolic disorder. Together, these conditions contribute substantially to the global burden of disease and mortality and are increasingly recognized as interconnected comorbidities. The combination of these three diseases can worsen patients' health conditions, increase mortality risk, and complicate treatment, which is why this study aims to summarize the relationship between HIV, TB, and DM. To achieve this, a systematic literature search was conducted across four databases PubMed, Wiley, ScienceDirect, and Scopus focusing on English articles from the last 5 years, where researchers independently established eligibility criteria, conducted a comprehensive search, meticulously extracted data, and determined the risk of bias. The findings indicate a significant relationship between these conditions, as the six articles analyzed showed that the prevalence of DM in TB patients ranged from 7.6% to 22.6%, while the prevalence of HIV in TB patients reached up to 38.57%. Specifically, DM increases the risk of developing active TB and is associated with unfavorable treatment outcomes, whereas HIV progressively impairs cell-mediated immunity through CD4+ T-cell depletion, substantially increasing the risk of progression from latent TB infection to active disease. Ultimately, there is a complex relationship between HIV, TB, and DM that adversely affects patients' overall health, leading to the conclusion that integrated screening and management for these three diseases are essential to reduce mortality risk and improve treatment outcomes.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"28 3","pages":"118-125"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on differences in sexual orientation and identity. 性取向和性认同差异的研究。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-22 DOI: 10.24875/AIDSRev.M25000091

Vicente Soriano, Ondina Vélez, José I Sánchez-Méndez, Nieves González-Rico, Luisa González

{"title":"Research on differences in sexual orientation and identity.","authors":"Vicente Soriano, Ondina Vélez, José I Sánchez-Méndez, Nieves González-Rico, Luisa González","doi":"10.24875/AIDSRev.M25000091","DOIUrl":"10.24875/AIDSRev.M25000091","url":null,"abstract":"The human being is sexed, as there are men and women. The presence of two complementary sexes provides a biological mechanism for evolution and adaptation to changing environments through reproduction with the admixture of distinct genetic traits. Ultimately, this reproductive meaning of sex provides its most important biological foundation. In humans, sexuality also plays a significant role in interpersonal relationships and affection, uniquely contributing to personhood, well-being, and flourishing. In this way, both meanings of human sexuality, reproductive and affective, can be challenged in certain scenarios, such as when there are intersex states of biological basis, nowadays referred to as disorders or differences of sex development (DSD), same-sex orientation, or gender dysphoria. Following the approach taken for DSD, same-sex attraction and transgender identity could be categorized medically as differences in sexual orientation and self-identity, respectively. This could provide a respectful framework for conducting research about sexuality. Herein, we examine the spectrum of differences in the sexual sphere and update on major determinants. Whereas biological factors lead to DSD, psychological and sociocultural variables largely contribute to same-sex orientation and transgender identity. Inclusive efforts for persons with atypical sexuality must be encouraged to avoid discrimination. However, these conditions should not be overlooked medically. Denying their relevance might discourage research that would ultimately benefit these individuals.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"163-170"},"PeriodicalIF":2.5,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental procedures in people living with HIV: a narrative review. 艾滋病毒感染者的牙科手术：叙述回顾。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.25000025

Rochman Mujayanto

{"title":"Dental procedures in people living with HIV: a narrative review.","authors":"Rochman Mujayanto","doi":"10.24875/AIDSRev.25000025","DOIUrl":"10.24875/AIDSRev.25000025","url":null,"abstract":"HIV affects over 39 million people globally and remains a challenge in oral health care despite advances in antiretroviral therapy (ART). The oral cavity often reflects immune status and serves as a site for opportunistic infections, making dental care essential in HIV management. This review explores four main aspects of dental care for people living with HIV (PLHIV): HIV pathophysiology, transmission risk during dental procedures, infection control strategies, and pre-treatment clinical assessment. Using the population-concept-context framework, literature was reviewed from PubMed, Scopus, and Web of Science spanning 2000-2025. Oral conditions such as candidiasis, Kaposi's sarcoma, and periodontal disease remain prevalent in PLHIV and are closely linked to HIV progression. The risk of HIV transmission in dental settings is very low (< 0.3% for percutaneous exposure) when standard precautions are followed, though stigma among providers persists. Effective infection control includes personal protective equipment, sterilization, and aerosol reduction. Pre-procedural evaluation (CD4 count, viral load, and hematological status) is vital for safe care. In cases of neutropenia, antibiotic prophylaxis may be needed, and elective procedures should be deferred. Dental treatment for PLHIV is safe when guided by evidence-based protocols. Integrating infection control, risk assessment, and personalized planning strengthens the role of dentistry in comprehensive HIV care.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"13-20"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicine at bedside or with smartphone? 床边用药还是智能手机用药？

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.M25000090

Vicente Soriano

引用次数: 0

Beating HIV from day 1: strengthening same-day antiretroviral therapy in South Africa: challenges, realities, and the path forward. 从第一天开始战胜艾滋病毒：在南非加强当日抗逆转录病毒治疗：挑战、现实和前进道路。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-18 DOI: 10.24875/AIDSRev.25000020

Siyakudumisa Nontamo, Gabriel Tchuente-Kamsu, Nomboniso Agrinette-Madolo, Eugene-Jamot Ndebia

{"title":"Beating HIV from day 1: strengthening same-day antiretroviral therapy in South Africa: challenges, realities, and the path forward.","authors":"Siyakudumisa Nontamo, Gabriel Tchuente-Kamsu, Nomboniso Agrinette-Madolo, Eugene-Jamot Ndebia","doi":"10.24875/AIDSRev.25000020","DOIUrl":"10.24875/AIDSRev.25000020","url":null,"abstract":"Same-day initiation of antiretroviral therapy (ART), known as same-day ART, has been endorsed by the World Health Organization since 2017 as a strategy to improve treatment coverage, reduce HIV transmission, and increase the survival of people living with HIV. This approach aims to minimize loss to follow-up (LTFU) and strengthen engagement in care, particularly in high-prevalence settings such as South Africa. This review aims to synthesize available data on the benefits, challenges, and impacts of same-day ART, with a particular focus on resource-limited settings. A literature review was conducted on published studies that addressed the effectiveness, adherence, retention in care, and clinical outcomes associated with same-day ART. The studies indicate that same-day ART is associated with a significant improvement in treatment initiation and reduced delays in therapy. However, its success depends on several factors, including patient acceptability, healthcare system capacity, and the quality of psychosocial support. Increased risks of long-term LTFU have also been reported among certain vulnerable populations. Same-day ART represents a major advancement in the fight against HIV, but its implementation requires a contextualized approach, adequate training of healthcare providers, and strengthened psychosocial support to ensure long-term retention in care.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"153-162"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and perspectives in the HIV vaccine research over the past thirty-five years: A scientometrics analysis through CiteSpace. 过去35年来艾滋病毒疫苗研究的趋势和前景：通过CiteSpace进行科学计量学分析。

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-17 DOI: 10.24875/AIDSRev.25000018

Xuannan Chen, Yizhou Zhuo, Yu Lai

{"title":"Trends and perspectives in the HIV vaccine research over the past thirty-five years: A scientometrics analysis through CiteSpace.","authors":"Xuannan Chen, Yizhou Zhuo, Yu Lai","doi":"10.24875/AIDSRev.25000018","DOIUrl":"10.24875/AIDSRev.25000018","url":null,"abstract":"Despite advances in antiretroviral therapy, developing an effective human immunodeficiency virus (HIV) vaccine remains pivotal for epidemic control. Through a scientometric analysis of 19,863 publications from the Web of Science Core Collection (1989-2023) using CiteSpace, this study delineates evolving trends and emerging frontiers in HIV vaccine research. The United States dominated contributions, with institutions like the National Institutes of Health and Harvard leading productivity. Clustering revealed two interconnected research trajectories, which are broad neutralizing antibody development, broad neutralizing antibody precursors, and immune mechanism exploration. Despite efficacy trials not resulting in licensed HIV vaccine advancements in antigen design and adjuvant strategies, they show promise. Key findings indicated structural biology, germinal center (GC) dynamics, antibody-dependent cellular cytotoxicity, and glycosylation shielding as pivotal research domains. Critical barriers include generating a specific immune response to new epitopes and glycosylation-mediated immune evasion. Future efforts should prioritize GC optimization to enhance B-cell affinity maturation, structure-guided epitope targeting through cryo-electron microscopy, and advances in antigen delivery. In addition, engineering vaccines to expand CXCR5+ T follicular helper cell populations may improve durable humoral immunity. This analysis underscores the necessity of multidisciplinary approaches to overcome HIV vaccine hurdles.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"138-152"},"PeriodicalIF":2.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline characteristics of people living with HIV with different CD4(+) T cell depletion. 不同CD4(+) T细胞耗竭的HIV感染者的基线特征

IF 2.5 4区医学

AIDS reviews Pub Date : 2025-12-11 DOI: 10.24875/AIDSRev.25000027

Peipei Luo, Juan Jin, Dingsheng Kong, Guoxiang Yang

引用次数: 0