AIDS reviews最新文献_第3页

Corrigendum for HIV-1 resistance and virological failure to treatment with the integrase inhibitors bictegravir, cabotegravir, and dolutegravir: a systematic literature review. 整合酶抑制剂比替格拉韦、卡替格拉韦和多替格拉韦治疗HIV-1耐药性和病毒学失败的勘误表：系统文献综述。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.M25000080

José L Blanco-Arévalo, Miguel García-Deltoro, Miguel Torralba, Manuel Vélez-Díaz-Pallarés, Antonio Castro, Darío Rubio-Rodríguez, Carlos Rubio-Terrés

引用次数: 0

HIV/HBV coinfection: understanding the complex interactions and their impact on spontaneous HBV clearance, chronic liver damage, cirrhosis, and hepatocellular carcinoma. HIV/HBV 合并感染：了解复杂的相互作用及其对自发性 HBV 清除、慢性肝损伤、肝硬化和肝细胞癌的影响。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.23000019

Jingwen Xiao, Yongzheng Zhang, Jia Wu, Xinping -Chen, Wei Zou

引用次数: 0

Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature. 艾滋病暴露前预防中的后天梅毒：科学文献系统回顾。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000006

Nathália L Pedrosa, Patrícia M Pinheiro, Wildo N de Araújo

{"title":"Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature.","authors":"Nathália L Pedrosa, Patrícia M Pinheiro, Wildo N de Araújo","doi":"10.24875/AIDSRev.24000006","DOIUrl":"https://doi.org/10.24875/AIDSRev.24000006","url":null,"abstract":"The aim of this study was systematically review the acquired syphilis before and during follow-up of pre-exposure prophylaxis (PrEP) for HIV. We analyzed articles that studied PrEP users with the outcome of acquired syphilis. The eligibility criteria were studies retrieved from the United States National Library of Medicine (Pubmed), Latin American and Caribbean Health Sciences Literature (Lilacs), Embase and Scopus databases, published between 2012 and 2023, in English, Spanish or Portuguese. We performed the descriptive synthesis and quality analysis of selected studies using the Newcastle Ottawa scale or Cochrane scale. We also used random-effects models to generate pooled rate estimates for syphilis before PrEP and during follow-up. A total of 4412 studies were found and 35 were selected, all in English, and almost all with high or satisfactory quality. The review found a PrEP syphilis rate of 6.0%. A summary of three studies estimated a 2.34-fold increased risk of syphilis acquisition during PrEP, with an incidence rate of 8.89 cases/100 person-years. These findings warrant caution due to study heterogeneity. Compared to HIV-positive individuals, PrEP users exhibit potentially higher syphilis rates, particularly among those aged 33-38 years, and factors such as age ≥ 35 years, MSM status, prior sexually-transmitted infections, and longer PrEP duration (every 6 months) are associated. Future research should further investigate these PrEP-related factors contributing to heightened syphilis risk.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 3","pages":"121-129"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV infection and esophageal cancer in Sub-Saharan Africa: a comprehensive meta-analysis. 撒哈拉以南非洲地区的艾滋病毒感染与食道癌：一项综合荟萃分析。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.23000018

Gabriel Kamsu-Tchuente, Eugene J Ndebia

{"title":"HIV infection and esophageal cancer in Sub-Saharan Africa: a comprehensive meta-analysis.","authors":"Gabriel Kamsu-Tchuente, Eugene J Ndebia","doi":"10.24875/AIDSRev.23000018","DOIUrl":"10.24875/AIDSRev.23000018","url":null,"abstract":"Africa hosts the highest burden of esophageal cancer (49%) and HIV (60%) worldwide. It is imperative to investigate the synergistic impact of these two diseases on African populations. This study conducted an exhaustive computerized search of databases, including Medline/PubMed, Embase, Web of Science, Scopus, Cochrane library, and African Journals Online, to identify eligible studies up to October 2023. HIV infection was the exposure, esophageal cancer risk was the outcome, and healthy subjects with no cancer history served as comparators. Study quality was assessed using the Newcastle-Ottawa scale, and potential publication bias was evaluated through funnel plots and the Egger test. Meta-analyses were conducted using Stata 17.0 software and involved a thorough examination of 98,397 studies. Out of these, eight studies originating from Eastern and Southern Africa, recognized as esophageal cancer hotspots on the continent, met the eligibility criteria. The analysis revealed a non-significant association between HIV infection and esophageal cancer risk (odds ratio = 1.34 [95% confidence interval, 0.85-2.12]; with 0.26 as p-value of overall effects). The Egger test yielded a p-value of 0.2413, suggesting the absence of publication bias. In summary, this systematic review and meta-analysis indicate that there is no established causal link between HIV infection and esophageal cancer risk. However, further research is essential to delve into the potential mechanisms underlying this relationship.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 1","pages":"15-22"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV-1 infection and the hematopoietic microenvironment. HIV-1感染与造血微环境。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000015

Hanyun Wang, Jiliang Zou, Ying Luo, Xinping Chen, Wei Zou

{"title":"HIV-1 infection and the hematopoietic microenvironment.","authors":"Hanyun Wang, Jiliang Zou, Ying Luo, Xinping Chen, Wei Zou","doi":"10.24875/AIDSRev.24000015","DOIUrl":"https://doi.org/10.24875/AIDSRev.24000015","url":null,"abstract":"HIV-1 infection causes abnormal hematopoiesis, which is the result of the interactions among HIV-1, hematopoietic stem cells (HSCs), and hematopoietic microenvironment. However, the underlying mechanisms of abnormal hematopoiesis in HIV infection are still not completely understood. Recent studies on hematopoietic microenvironment provide new insights on HIV-1 pathogenesis. Based on these studies, we summarized the detrimental influences of HIV, mainly HIV viral proteins Gag, Tat, Gp120, and Nef, on hematopoietic microenvironment. These viral proteins interfere with the development of HSCs and hematopoiesis by affecting mesenchymal stem cells, osteoblasts, endothelial cells, and related signaling factors within the microenvironment. At the same time, we introduced the research progress of targeted therapy for HIV viral proteins and tried to solve the hard-to-correct hematopoietic abnormalities after ART by combining targeted therapy with HIV viral proteins from the direction of hematopoietic microenvironment. Our manuscript will not only enhance our understanding of the pathogenesis of HIV infection from the root of blood cell development but also have important implications for the functional cure of HIV infection.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 4","pages":"143-150"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Castleman's disease: one disease, multiple etiologies. 卡斯尔曼氏病：一种疾病，多种病因。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.M25000079

Jorge Esteban-Sampedro, Mario Martín-Portugués, Pedro Durán-Del Campo, Román Fernández-Güitián, Jaime E Ruiz-Becerra, Víctor Moreno-Torres

{"title":"Castleman's disease: one disease, multiple etiologies.","authors":"Jorge Esteban-Sampedro, Mario Martín-Portugués, Pedro Durán-Del Campo, Román Fernández-Güitián, Jaime E Ruiz-Becerra, Víctor Moreno-Torres","doi":"10.24875/AIDSRev.M25000079","DOIUrl":"https://doi.org/10.24875/AIDSRev.M25000079","url":null,"abstract":"Castleman disease (CD) comprises a heterogeneous group of rare lymphoproliferative disorders characterized by similar morphological features in nodal biopsies. Since Benjamin Castleman's initial description in 1956, our understanding of CD has progressed substantially. The intricate mechanisms underlying the four recognized subtypes of multicentric CD (MCD) have been studied thoroughly during recent decades. Major disease contributors include the identification of certain viral infections, namely human herpes virus-8 (HHV-8) and HIV; and the discovery of molecular and genetic mechanisms driving disease development and progression and the consequent development of biological targeted therapies, notably siltuximab and rituximab. The CD has been associated with autoimmune, autoinflammatory, and hematological disorders. Along with epidemiological data, the current classification of CD encompasses unicentric CD and MCD. MCD is further subdivided into HHV-8-associated MCD, polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin (POEMS)-associated MCD, and idiopathic MCD (iMCD), which includes thrombocytopenia, anasarca, fever, reticulin TAFRO-iMCD, and iMCD-not-otherwise-specified (iMCD-NOS). While these subtypes share common histological and similar clinical manifestations, they represent distinct conditions. In this review, we discuss the differences in epidemiology, pathophysiology, histology, clinical presentation, and treatment for all distinct CD subtypes. We focus on the role of viral infections in CD development and epidemiology. We finally end by acknowledging areas where further research is needed to uncover the complex nature of CD.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 4","pages":"158-172"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral interventions for tobacco use in HIV-infected smokers: systematic review and pairwise, network meta-analysis of randomized trials. 艾滋病感染者烟草使用的行为干预：随机试验的系统综述和配对网络荟萃分析。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000008

Xinyu Huang, Junjie Ren, Liying Zhou, Xu Hui, Liping Guo, Li Xu, Kehu Yang

{"title":"Behavioral interventions for tobacco use in HIV-infected smokers: systematic review and pairwise, network meta-analysis of randomized trials.","authors":"Xinyu Huang, Junjie Ren, Liying Zhou, Xu Hui, Liping Guo, Li Xu, Kehu Yang","doi":"10.24875/AIDSRev.24000008","DOIUrl":"10.24875/AIDSRev.24000008","url":null,"abstract":"Smoking among persons living with HIV infection (PLWH) is estimated to be 2-3 times greater than that in the general population. Data suggest that cigarette smoking is more common among PLWH because of several factors, including lower socioeconomic status, previous, or concurrent illicit drug and alcohol use, younger age, lower education level, and concomitant depressive symptoms. Cigarette smoking among PLWH has been associated with a higher risk of certain cancers and infections as well as lowered response to antiretroviral therapy. Randomized controlled trials on behavioral interventions for tobacco use among smokers with HIV were searched in the PubMed, Cochrane Library, EMBASE, and Web of Science databases. The retrieval period was from the inception of databases to November 2023. Network meta-analysis (NMA) was performed using the Stata 18.0 software with 19 studies (3190 subjects), of which 15 reported 7-day point prevalence abstinence and seven of which reported continuous abstinence. The NMA results showed that compared with general advice plus self-help brochure, text messaging (relative risk [RR] = 4.60, 95% confidence interval [CI], 1.12-18.81) and cell phone counseling (RR = 3.29, 95% CI, 1.71-6.32) were the most effective for 7-day point prevalence abstinence among smokers with HIV infection. Moreover, the meta-analysis showed that compared with smoking counseling and self-help brochures, continuous abstinence was statistically significantly enhanced after behavioral interventions (RR = 2.52, 95% CI, 1.51-4.20). The study revealed very low-to-high-quality evidence that text messaging, telephone counseling, and smoking cessation websites were effective for smokers with HIV infection.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 3","pages":"111-120"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors and mortality outcomes of COVID-19 in people living with HIV: a systematic review and meta-analysis. 艾滋病毒感染者中 COVID-19 的风险因素和死亡结果：系统回顾和荟萃分析。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.23000017

Mahmoud Kandeel

{"title":"Risk factors and mortality outcomes of COVID-19 in people living with HIV: a systematic review and meta-analysis.","authors":"Mahmoud Kandeel","doi":"10.24875/AIDSRev.23000017","DOIUrl":"10.24875/AIDSRev.23000017","url":null,"abstract":"This study was performed to reveal the risk factors associated with mortality in people living with HIV (PLHIV) who were diagnosed with COVID-19. Studies reporting deaths among PLHIV and infected with SARS-CoV-2 were investigated. After protocol setup and registration, the extracted sources were categorized and assessed for quality. This study examined ten articles with a total of 46,136 patients. Patients aged ≥ 60 years (hazard ratio [HR] = 2.22; 95% CI: 1.617, 3.050; p < 0.001), male (HR = 1.668; 95% CI: 1.179, 2.361; p = 0.004), and people with diabetes (risk ratio [RR] = 3.34; 95% CI: 1.45, 7.68; p = 0.005) were at higher risk of death. Adherence to antiretroviral therapy (ART) reduced mortality risk (RR = 0.90; 95% CI: 0.83, 0.98; p = 0.02). Patients in the survival groups showed a statistically significant lower mean of C-reactive protein (mean difference = 114.08; 95% -74.05, 154.10; p < 0.001). Deceased patients showed higher mean levels of interleukin-6 (IL-6). Chronic respiratory disorders, hypertension, oxygen requirement, admission to an intensive care unit, D-dimer levels, and HIV viral load < 50 copies RNA/mL before admission did not show statistically significant differences between the deceased and survival groups. ART therapy reduced mortality risk (RR = 0.90; 95% 0.83, 0.98; p = 0.02). Identifying PLHIV at higher mortality risk could improve the outcomes of COVID-19 by stratifying these patients to the most effective treatment in a timely fashion.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 1","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted infections keep rising up. 性传播感染持续上升。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSREV.M24000077

Vicente Soriano, Ana Treviño

引用次数: 0

The risk for pandemic avian influenza. 禽流感大流行的风险。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.M25000078

Vicente Soriano

引用次数: 0