Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review.

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Pedro R S Almeida, Carlos A C Rafael, Victor Pimentel, Ana B Abecasis, Cruz S Sebastião, Joana de Morais
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引用次数: 0

Abstract

More than two decades after introducing antiretroviral therapy (ART), several challenges still prevail in keeping well people living with HIV, even with "Test and Treat" and/or "Rapid Start of ART" initiatives, as well as the scale-up of ART worldwide to promote access and adherence to treatment. This review examined articles on ART adherence in Africa between 2016 and 2023, published in English and indexed in PubMed. A total of 16 articles out of 2415 were eligible and included for analyses. Overall, good ART adherence rates in sub-Saharan African (SSA) regions ranged from 43% to 84%. Rates in the center of the SSA region ranged from 58% to 80%, in the north from 50% to 83%, in the south from 77% to 84%, in the west from 43% to 60%, and in the east from 69% to 73%. Most African countries use self-reporting to assess treatment adherence, which is frequently unreliable. The main factors with negative influence on ART adherence were comorbidities, lack of motivation, socioeconomic difficulties, or side effects. Conclusion: Adherence to ART is a good indicator for controlling the spread of HIV in a given region. It is important to overcome the barriers that make it difficult to comply with ART and reinforce the factors that facilitate access to medication.

撒哈拉以南非洲地区 HIV-1 患者坚持抗逆转录病毒疗法的情况:系统综述。
在引入抗逆转录病毒疗法(ART)二十多年后,即使采取了 "检测和治疗 "和/或 "快速启动抗逆转录病毒疗法 "的措施,以及在全球范围内扩大抗逆转录病毒疗法的规模,以促进治疗的可及性和依从性,但要让艾滋病毒感染者保持良好的状态仍面临着一些挑战。本综述研究了 2016 年至 2023 年间有关非洲抗逆转录病毒疗法依从性的文章,这些文章均以英文发表,并被 PubMed 索引。在 2415 篇文章中,共有 16 篇符合条件并纳入分析。总体而言,撒哈拉以南非洲(SSA)地区抗逆转录病毒疗法的良好依从率从43%到84%不等。撒哈拉以南非洲地区中部的比率在 58% 至 80% 之间,北部在 50% 至 83% 之间,南部在 77% 至 84% 之间,西部在 43% 至 60% 之间,东部在 69% 至 73% 之间。大多数非洲国家采用自我报告的方式来评估治疗依从性,但这种方式往往并不可靠。对坚持抗逆转录病毒疗法产生负面影响的主要因素是合并症、缺乏动力、社会经济困难或副作用。结论坚持抗逆转录病毒疗法是控制特定地区艾滋病传播的一个良好指标。重要的是要克服导致难以坚持抗逆转录病毒疗法的障碍,并加强有利于获得药物治疗的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
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