印度艾滋病毒/艾滋病感染者的生活质量和抑郁研究。

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Deepak Jain, Y M Pavan Kumar, V K Katyal, Promil Jain, Jay P Kumar, Shreya Singh
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引用次数: 0

摘要

本研究的目的是评估艾滋病毒/艾滋病(PLWHA)患者的生活质量(QOL)和抑郁严重程度,并调查其相关性。这是一项针对印度700名艾滋病感染者的横断面研究。采用世界卫生组织艾滋病毒质量调查(WHOQOL HIV- bref)和患者健康问卷-9 (PHQ-9)分别评估PLWHA患者的生活质量和抑郁程度。按CD4细胞计数分为A组[< 50个细胞/μL]、B组[50 ~ 199个细胞/μL]、C组[200 ~ 349个细胞/μL]、D组[350 ~ 499个细胞/μL]、E组[>500个细胞/μL]。A组生理和心理领域平均得分最低[< 50 cells/μL], E组生理和环境领域平均得分最高[> 500 cells/μL]。PHQ9得分与生活质量域呈负相关,相关性有统计学意义(p < 0.001),与心理域负相关最高(r = -0.739)。无机会性疾病组PHQ9得分(7.23±6.14)低于机会性疾病组(9.81±6.40),差异有统计学意义(p < 0.001)。我们观察到,随着CD4计数的增加,个体QOL结构域评分几乎按时间顺序增加,PHQ9评分下降。我们的研究结果支持在抗逆转录病毒治疗中心实施常规抑郁症筛查和多学科干预,以改善抑郁症感染者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of quality of life and depression in people living with HIV/AIDS in India.

The aim of this study was to assess the quality of life (QOL) and the severity of depression in people living with HIV/AIDS (PLWHA) and investigate its correlates. This was a cross-sectional study on 700 PLWHA in India. World Health Organization QOL HIV (WHOQOL HIV-BREF) and Patient Health Questionnaire-9 (PHQ-9) were used to assess QOL and depression in PLWHA, respectively. The study population was divided into five groups on the basis of Cluster of Differentiation 4 (CD4) count as follows: Group A [< 50 cells/μL], Group B [50-199 cells/μL], Group C [200-349 cells/μL], Group D [350-499 cells/μL], and Group E [>500 cells/μL]. The lowest mean scores were noted under Group A [< 50 cells/μL] in physical and psychological domains and the highest mean scores were noted under Group E [> 500 cells/μL] in physical and environment domains. PHQ9 scores negatively correlated with QOL domains and the correlation was statistically significant (p < 0.001) with the highest negative correlation was found in relation to the psychological domain (r = -0.739). The PHQ9 score in those who do not have opportunistic illnesses (7.23 ± 6.14) was lower in comparison to those who had opportunistic illnesses (9.81 ± 6.40) and the difference was statistically significant (p < 0.001). We observed that there was almost a chronological increase in the individual QOL domain score and a decrease in the PHQ9 score with an increase in CD4 count. Our result supports the implementation of routine screening for depression in antiretroviral therapy centers and multidisciplinary interventions to improve outcomes among depressed PLWHA.

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来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
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