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American journal of respiratory and critical care medicine最新文献

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Severe Hypoxemia and Pulmonary Capillary Dilatations in PAH Patients Treated with Sotatercept. 索替西普治疗肺动脉高压患者的严重低氧血症和肺毛细血管扩张。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Karen M Olsson, Laurent Savale, Christophe Guignabert, Da-Hee Park, Jan C Kamp, Athénaïs Boucly, David Montani, Olivier Sitbon, Marc Humbert, Marius M Hoeper
{"title":"Severe Hypoxemia and Pulmonary Capillary Dilatations in PAH Patients Treated with Sotatercept.","authors":"Karen M Olsson, Laurent Savale, Christophe Guignabert, Da-Hee Park, Jan C Kamp, Athénaïs Boucly, David Montani, Olivier Sitbon, Marc Humbert, Marius M Hoeper","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Another Act in the Story of Oral Imatinib for PAH. 口服伊马替尼治疗多环芳烃故事的另一幕。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Mardi Gomberg-Maitland, Rogerio Souza
{"title":"Another Act in the Story of Oral Imatinib for PAH.","authors":"Mardi Gomberg-Maitland, Rogerio Souza","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considerations for Data Accuracy in Assessing PAH Care Delivery. 评估PAH护理交付数据准确性的考虑。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Chung-Chu Tung, Renin Chang
{"title":"Considerations for Data Accuracy in Assessing PAH Care Delivery.","authors":"Chung-Chu Tung, Renin Chang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the Reporting of Trials Evaluating Organ-Support Therapies Using Multistate Modeling. 使用多状态模型改进评估器官支持疗法的试验报告。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
David Hajage, Stéphane Gaudry, Alain Combes, Virginie Lemiale, Matthieu Schmidt, Jérôme Lambert
{"title":"Improving the Reporting of Trials Evaluating Organ-Support Therapies Using Multistate Modeling.","authors":"David Hajage, Stéphane Gaudry, Alain Combes, Virginie Lemiale, Matthieu Schmidt, Jérôme Lambert","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Rationale: </strong>Managing critically ill patients in the ICU often involves organ-support therapies (OST), such as mechanical ventilation, extracorporeal membrane oxygenation, renal replacement therapy, and various pharmacologic strategies. Clinical trials in this context pursue diverse goals-including improving survival, reducing OST use, facilitating weaning, or comparing timing of OST initiation-which leads to substantial heterogeneity in OST-related endpoints. One commonly used outcome, the number of OST-free days (OFD), has been criticized for its composite nature, which can obscure important clinical differences between patients with similar OFD values. Variability in how weaning success is defined, how intercurrent OST-free periods are handled, and how death is incorporated further complicates comparisons across trials.</p><p><strong>Objectives: </strong>To illustrate how multistate modeling can offer an intuitive framework for analyzing randomized clinical trials involving OSTs, and how this approach allows to better describe and compare patient conditions during the entire follow-up.</p><p><strong>Methods: </strong>We describe the core principles of multistate modeling, including its assumptions (like the Markov assumption), advantages, and limitations. We then present two recent randomized controlled trials evaluating OSTs and identify the main statistical challenges encountered in their analysis.</p><p><strong>Measurements and main results: </strong>Using a multistate modeling approach, we re-analyzed both trials to characterize and compare patient trajectories over time. The multistate framework enabled clearer insight into how interventions impact the timing of transitions between clinical states, providing a richer and more clinically relevant understanding of treatment effects.</p><p><strong>Conclusions: </strong>Multistate modeling can substantially inform the interpretation and primary analysis of a clinical trial evaluating an organ-support therapy.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Tung and Chang and to Suntharalingam et al. 回复董和张以及Suntharalingam等人。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Samuel G Rayner, Rachel J Le, Peter J Leary, John Hartney, Nathan Hatton, John Ryan
{"title":"Reply to Tung and Chang and to Suntharalingam <i>et al.</i>","authors":"Samuel G Rayner, Rachel J Le, Peter J Leary, John Hartney, Nathan Hatton, John Ryan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplifying Sotatercept in Pulmonary Arterial Hypertension: Genetic Context Meets Treatment-Response. 简化索特塞普治疗肺动脉高压：遗传背景符合治疗反应。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Bradley A Maron
{"title":"Simplifying Sotatercept in Pulmonary Arterial Hypertension: Genetic Context Meets Treatment-Response.","authors":"Bradley A Maron","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Camlipixant: A New Hope for Refractory Chronic Cough? Camlipixant：治疗难治性慢性咳嗽的新希望？
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Imran Satia, Stuart B Mazzone
{"title":"Camlipixant: A New Hope for Refractory Chronic Cough?","authors":"Imran Satia, Stuart B Mazzone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Other Side of the Coin of Pulmonary Fungal Diseases: Towards New Paradigms. 肺部真菌疾病的另一面：走向新范式。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Manuel Castillejos López, David Martínez Briseño
{"title":"The Other Side of the Coin of Pulmonary Fungal Diseases: Towards New Paradigms.","authors":"Manuel Castillejos López, David Martínez Briseño","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to de Benedictis: Publication Bias: For How Much Longer? 回复de Benedictis：发表偏倚：会持续多久？
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Andrew Bush
{"title":"Reply to de Benedictis: Publication Bias: For How Much Longer?","authors":"Andrew Bush","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-TB Sequelae and the Burden of "Long TB": Continuing TB Care after Treatment Completion. 结核后后遗症和“长期结核”的负担：完成治疗后继续结核治疗。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2025-04-30
Sara C Auld, Gregory P Bisson
{"title":"Post-TB Sequelae and the Burden of \"Long TB\": Continuing TB Care after Treatment Completion.","authors":"Sara C Auld, Gregory P Bisson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"None"},"PeriodicalIF":19.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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