American journal of respiratory and critical care medicine最新文献

{"title":"Aging Gracefully: Does Elexacaftor/Tezacaftor/Ivacaftor Safety and Efficacy Stand the Test of Time?","authors":"Gemma Wilson, Dominic Hughes","doi":"10.1164/rccm.202503-0746ED","DOIUrl":"10.1164/rccm.202503-0746ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1893-1895"},"PeriodicalIF":19.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission of Bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.","authors":"Reeve Sobol,Shaheed V Omar,Tyler Brown,Lavania Joseph,Keeren Lutchminarian,Linrui Tang,Yu Lan,Fay Willis,Angie Campbell,Joshua L Warren,Ted Cohen,James C M Brust,Kogieleum Naidoo,N Sarita Shah,Neel R Gandhi,Barun Mathema","doi":"10.1164/rccm.202506-1489oc","DOIUrl":"https://doi.org/10.1164/rccm.202506-1489oc","url":null,"abstract":"RATIONALEBedaquiline is a critical component of new drug-resistant tuberculosis (DR-TB) treatment regimens. Emergence of bedaquiline-resistant Mycobacterium tuberculosis (Mtb) threatens to undermine already limited treatment options. Understanding the evolution and transmission of bedaquiline-resistant strains is a high priority for TB control.OBJECTIVESWe evaluated the prevalence, strain genetic diversity, and transmission of bedaquiline resistance among people with DR-TB.METHODSWe conducted a prospective study of all patients diagnosed with TB resistant to a fluoroquinolone or a second-line injectable drug in KwaZulu-Natal province, South Africa, between 2018 and 2022. We utilized whole genome sequencing (WGS), SNP-based clustering, and Bayesian reconstruction of transmission trees to examine the genomic characteristics and transmission networks of bedaquiline-resistant Mtb strains.MEASUREMENTS AND MAIN RESULTSWe enrolled 843 of 1070 eligible individuals and obtained WGS for 632 participants. Of the sequenced isolates, 14% (n=89) were genotypically bedaquiline-resistant, 67% (n=60) of which were in clusters of recently transmitted infections. Resistance was present across all Mtb lineages and across strains with different resistance profiles to other TB drugs. We observed no differences in lineage distribution, bedaquiline resistance-associated mutations, or drug resistance profiles between clustered and non-clustered isolates. Transmission inference and geographic reconstruction of transmission networks indicate considerable unsampled cases within transmission networks.CONCLUSIONSBedaquiline resistance was common in this cohort of individuals with highly DR-TB. Most bedaquiline-resistant infections were attributable to recent transmission, involving Mtb strains with diverse genetic backgrounds and a variety of causative mutations. The diversity and transmissibility of bedaquiline-resistant Mtb signal a growing public health threat.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"7 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short Stature Is an Independent Risk Factor for Ventilatory Inefficiency and Higher Mortality in ARDS.","authors":"Ana C Monteiro,Brian Bartek,Sandhya Tripathi,Carolyn S Calfee,Michael A Matthay,Pratik Sinha","doi":"10.1164/rccm.202502-0505rl","DOIUrl":"https://doi.org/10.1164/rccm.202502-0505rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"103 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving from Critical Illness Syndromes Towards Biologic Molecular Endotypes: Making Progress.","authors":"John G Laffey,Evangelos J Giamarellos-Bourboulis","doi":"10.1164/rccm.202504-0784ed","DOIUrl":"https://doi.org/10.1164/rccm.202504-0784ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"31 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Liu et al., Zhou et al., and Dong et al.","authors":"Mohsen Sadatsafavi,Trung N Tran,Ghislaine Scelo,Ming-Ju Tsai,John Busby,Benjamin Emmanuel,Liam G Heaney,Christine Jenkins,Flavia Hoyte,Giorgio Walter Canonica,Rohit Katial,Enrico Heffler,Eileen Wang,Francesca Puggioni,Michael E Wechsler,Ledit R F Ardusso,Jorge Máspero,Martin Sivori,Cathy Emmas,Andrew N Menzies-Gow,Neda Stjepanovic,Sinthia Z Bosnic-Anticevich,Belinda Cochrane,Eve Denton,Peter G Gibson,Mark Hew,Peter G Middleton,Matthew J Peters,Guy G Brusselle,Renaud Louis,Florence Schleich,George C Christoff,Todor A Popov,Celine Bergeron,Mohit Bhutani,Kenneth R Chapman,Andréanne Côté,Simon Couillard,Delbert R Dorscheid,Libardo Jiménez-Maldonado,Ivan Solarte,Carlos A Torres-Duque,Susanne Hansen,Celeste M Porsbjerg,Charlotte Suppli Ulrik,Alan Altraja,Arnaud Bourdin,Konstantinos P Exarchos,Athena Gogali,Konstantinos Kostikas,Michael P Makris,Andriana I Papaioannou,Patrick D Mitchell,Takashi Iwanaga,Tatsuya Nagano,Yuji Tohda,Mona S Al-Ahmad,Désirée Larenas-Linnemann,Bernt Bøgvald Aarli,Piotr Kuna,Cláudia Chaves Loureiro,Riyad Al-Lehebi,Adeeb A Bulkhi,Wenjia Chen,Yah Ru Juang,Mariko Siyue Koh,Anqi Liu,Chin Kook Rhee,Borja G Cosio,Luis Perez-de-Llano,Diahn-Warng Perng,Chau-Chyun Sheu,Hao-Chien Wang,Bassam Mahboub,Laila Salameh,David J Jackson,Pujan H Patel,Paul E Pfeffer,Njira Lugogo,Roy Alton Pleasants,Aaron Beastall,Lakmini Bulathsinhala,Victoria Carter,Nevaashni Eleangovan,Kirsty Fletton,John Townend,Ruth B Murray,David B Price","doi":"10.1164/rccm.202508-1914le","DOIUrl":"https://doi.org/10.1164/rccm.202508-1914le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"23 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologics for Severe Asthma: Considering Heterogeneity and Follow-Up Duration in Assessing OCS-related Risk Reduction.","authors":"Can Liu,Hongjin Shi,Jinsong Zhang,Bing Hai","doi":"10.1164/rccm.202507-1712le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1712le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"41 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Susceptibility to Non-Tuberculous Mycobacterial Pulmonary Disease, Is the Chicken or the Egg?","authors":"Victor E Ortega,Elsje Pienaar,Patricio Escalante","doi":"10.1164/rccm.202508-1970ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-1970ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"15 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echoes of the Past: Radiation Recall Pneumonitis Following Extrapulmonary Radiation Therapy.","authors":"Luis Gorospe,Abel González-Huete,Margarita Martín-Martín,Miguel Ángel García-Pardo de Santayana,Rosa Mariela Mirambeaux-Villalona","doi":"10.1164/rccm.202502-0440im","DOIUrl":"https://doi.org/10.1164/rccm.202502-0440im","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"14 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncoding DNA Variants in Primary Ciliary Dyskinesia: Another Piece of the Diagnostic Puzzle.","authors":"Michal Shteinberg,Adam J Shapiro","doi":"10.1164/rccm.202508-1938ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-1938ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"7 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARDS Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.","authors":"Aartik Sarma,Stephanie A Christenson,Beth Shoshana Zha,Angela Oliveira Pisco,Lucile P A Neyton,Eran Mick,Pratik S Sinha,Jennifer G Wilson,Farzad Moazed,Aleksandra Leligdowicz,Manoj V Maddali,Emily R Siegel,Zoe M Lyon,Sidney Carillo Haller,Hanjing Zhuo,Alejandra Jauregui,Rajani Ghale,Saharai Caldera,Paula Hayakawa Serpa,Thomas Deiss,Christina Love,Ashley Byrne,Katrina L Kalantar,Joseph L DeRisi,David J Erle,Matthew F Krummel,Kirsten N Kangelaris,Carolyn M Hendrickson,Prescott G Woodruff,Michael A Matthay,Lieuwe D J Bos,Charles R Langelier,Carolyn S Calfee, ","doi":"10.1164/rccm.202407-1454oc","DOIUrl":"https://doi.org/10.1164/rccm.202407-1454oc","url":null,"abstract":"RATIONALETwo molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as \"hyperinflammatory\" or \"hypoinflammatory\" depends on plasma biomarker profiling. Limited data are available about the differences in the pulmonary biology of the molecular phenotypes.OBJECTIVESTo identify differences in the pulmonary biology of ARDS molecular phenotypes.MEASUREMENTSWe compared tracheal aspirate gene expression between hyperinflammatory and hypoinflammatory phenotypes in bulk RNASeq from COVID and non-COVID ARDS, and single cell RNASeq from non-COVID ARDS. In a subset of subjects, we also compared plasma proteomic data.MAIN RESULTSIn bulk RNASeq analyses, 1157 genes were differentially expressed (FDR < 0.1) between phenotypes in non-COVID ARDS, and 85 genes were differentially expressed between phenotypes in COVID ARDS. 18 genes were reproducibly differentially expressed between phenotypes in both cohorts, including greater expression of IL32, HSPA8, and PPP3CC in hyperinflammatory ARDS. Gene set enrichment analysis identified greater expression of granulopoiesis, T cell and interferon signaling, and integrated stress response pathways in hyperinflammatory ARDS. Network analysis of scRNASeq in a third group of patients identified greater T cell signaling to other immune cells in hyperinflammatory ARDS.CONCLUSIONSHyperinflammatory and hypoinflammatory ARDS molecular phenotypes have distinct air space biology. Hyperinflammatory ARDS is characterized by an increased interferon-stimulated gene expression and T cell activation in the lungs. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"18 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}