American journal of respiratory and critical care medicine最新文献

{"title":"Domestic Mixed-Dust Pneumoconiosis.","authors":"Thomas Villeneuve, Simon Foulquier, Alexandre N'Guyen, Anna Vigier, Grégoire Prévot","doi":"10.1164/rccm.202312-2356IM","DOIUrl":"10.1164/rccm.202312-2356IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1267-1268"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.","authors":"","doi":"10.1164/rccm.v210erratum8","DOIUrl":"10.1164/rccm.v210erratum8","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"1280"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Chronic Altitude Exposure on Chronic Obstructive Pulmonary Disease Outcomes in the SPIROMICS Cohort: An Observational Cohort Study.","authors":"Rajat Suri, Daniela Markovic, Han Woo, Mehrdad Arjomandi, R Graham Barr, Russell P Bowler, Gerard Criner, Jeffrey L Curtis, Mark T Dransfield, M Bradley Drummond, Spyridon Fortis, MeiLan K Han, Eric A Hoffman, Robert J Kaner, Joel D Kaufman, Jerry A Krishnan, Fernando J Martinez, Jill Ohar, Victor E Ortega, Robert Paine, Xavier Soler, Prescott G Woodruff, Nadia N Hansel, Christopher B Cooper, Donald P Tashkin, Russell G Buhr, Igor Z Barjaktarevic","doi":"10.1164/rccm.202310-1965OC","DOIUrl":"10.1164/rccm.202310-1965OC","url":null,"abstract":"<p><p><b>Rationale:</b> Individuals with chronic obstructive pulmonary disease (COPD) have airflow obstruction and maldistribution of ventilation. For those living at high altitude, any gas exchange abnormality is compounded by reduced partial pressures of inspired oxygen. <b>Objectives:</b> Does residence at higher altitude exposure affect COPD outcomes, including lung function, imaging characteristics, symptoms, health status, functional exercise capacity, exacerbations, and mortality? <b>Methods:</b> From the SPIROMICS (Subpopulation and Intermediate Outcome Measures in COPD Study) cohort, we identified individuals with COPD living below 1,000 ft (305 m) elevation (<i>n</i> = 1,367) versus above 4,000 ft (1,219 m) elevation (<i>n</i> = 288). Multivariable regression models were used to evaluate associations of exposure to high altitude with COPD-related outcomes. <b>Measurements and Main Results:</b> Living at higher altitude was associated with reduced functional exercise capacity as defined by 6-minute-walk distance (-32.3 m [95% confidence interval, -49.8 to -14.8 m]). There were no differences in patient-reported outcomes as defined by symptoms (COPD Assessment Test and modified Medical Research Council dyspnea scale), or health status (St. George's Respiratory Questionnaire). Higher altitude was not associated with a different rate of FEV₁ decline. Higher altitude was associated with lower odds of severe exacerbations (incidence rate ratio, 0.65 [95% confidence interval, 0.46 to 0.90]). There were no differences in small airway disease, air trapping, or emphysema. In longitudinal analyses, higher altitude was associated with increased mortality (hazard ratio, 1.25 [95% confidence interval, 1.0 to 1.55]); however, this association was no longer significant when accounting for air pollution. <b>Conclusions:</b> Long-term altitude exposure is associated with reduced functional exercise capacity in individuals with COPD, but this did not translate into differences in symptoms or health status. In addition, long-term high-altitude exposure did not affect progression of disease as defined by longitudinal changes in spirometry. Clinical trial registered with www.clinicaltrials.gov (NCT01969344).</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1210-1218"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis.","authors":"Simon Feys, Martina Cardinali-Benigni, Hanne Moon Lauwers, Cato Jacobs, Annelies Stevaert, Samuel M Gonçalves, Cristina Cunha, Yves Debaveye, Greet Hermans, Jannes Heylen, Stephanie Humblet-Baron, Katrien Lagrou, Lenn Maessen, Philippe Meersseman, Marijke Peetermans, Alvaro Redondo-Rios, Laura Seldeslachts, Marick R Starick, Karin Thevissen, Greetje Vande Velde, Christophe Vandenbriele, Lore Vanderbeke, Alexander Wilmer, Lieve Naesens, Frank L van de Veerdonk, Johan Van Weyenbergh, Toni Gabaldón, Joost Wauters, Agostinho Carvalho","doi":"10.1164/rccm.202401-0145OC","DOIUrl":"10.1164/rccm.202401-0145OC","url":null,"abstract":"<p><p><b>Rationale:</b> The influence of the lung bacterial microbiome, including potential pathogens, in patients with influenza-associated pulmonary aspergillosis (IAPA) or coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) has yet to be explored. <b>Objectives:</b> To explore the composition of the lung bacterial microbiome and its association with viral and fungal infection, immunity, and outcome in severe influenza versus COVID-19 with or without aspergillosis. <b>Methods:</b> We performed a retrospective study in mechanically ventilated patients with influenza and COVID-19 with or without invasive aspergillosis in whom BAL for bacterial culture (with or without PCR) was obtained within 2 weeks after ICU admission. In addition, 16S rRNA gene sequencing data and viral and bacterial load of BAL samples from a subset of these patients, and of patients requiring noninvasive ventilation, were analyzed. We integrated 16S rRNA gene sequencing data with existing immune parameter datasets. <b>Measurements and Main Results:</b> Potential bacterial pathogens were detected in 20% (28/142) of patients with influenza and 37% (104/281) of patients with COVID-19, whereas aspergillosis was detected in 38% (54/142) of patients with influenza and 31% (86/281) of patients with COVID-19. A significant association between bacterial pathogens in BAL fluid and 90-day mortality was found only in patients with influenza, particularly patients with IAPA. Patients with COVID-19, but not patients with influenza, showed increased proinflammatory pulmonary cytokine responses to bacterial pathogens. <b>Conclusions:</b> Aspergillosis is more frequently detected in the lungs of patients with severe influenza than bacterial pathogens. Detection of bacterial pathogens associates with worse outcome in patients with influenza, particularly in those with IAPA, but not in patients with COVID-19. The immunological dynamics of tripartite viral-fungal-bacterial interactions deserve further investigation.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1230-1242"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Just Look East (the Other Way) When There's Smoke Billowing to the West.","authors":"Laura C Myers, Nina Pak, Eric Balaban, Neeta Thakur, Kevin Cromar","doi":"10.1164/rccm.202405-0993VP","DOIUrl":"10.1164/rccm.202405-0993VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1183-1185"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"November 15 Highlight.","authors":"","doi":"10.1164/rccm.210i10xxxii","DOIUrl":"https://doi.org/10.1164/rccm.210i10xxxii","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"xxxii-xxxiv"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Expiration Date for Etomidate?","authors":"Michael C Sklar, Duminda N Wijeysundera","doi":"10.1164/rccm.202409-1743ED","DOIUrl":"10.1164/rccm.202409-1743ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1178-1180"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension.","authors":"","doi":"10.1164/rccm.v210erratum7","DOIUrl":"10.1164/rccm.v210erratum7","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"210 10","pages":"1279-1280"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unfortunate Inheritance: Child Asthma in the Aftermath of Redlining.","authors":"Sonali Bose, Kecia Carroll","doi":"10.1164/rccm.202406-1225ED","DOIUrl":"10.1164/rccm.202406-1225ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1171-1173"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Systemic Complement Signatures in the Progression of Chronic Obstructive Pulmonary Disease.","authors":"Katarina M DiLillo, Lisa Ruvuna, Katherine A Pratte, Karina A Serban, Wassim W Labaki, MeiLan K Han, Christine M Freeman, Russell P Bowler, Jeffrey L Curtis, Kelly B Arnold","doi":"10.1164/rccm.202311-2059LE","DOIUrl":"10.1164/rccm.202311-2059LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1269-1272"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}