American journal of respiratory and critical care medicine最新文献

{"title":"From Repurposing to Refinement: Optimizing Levofloxacin for Treatment of Multidrug-Resistant Tuberculosis.","authors":"Jae-Joon Yim","doi":"10.1164/rccm.202503-0550ED","DOIUrl":"10.1164/rccm.202503-0550ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1126-1127"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of New Intrapulmonary Shunts in Pulmonary Arterial Hypertension Patients Treated with Sotatercept.","authors":"Stephen Mitchell, Olga Gomez-Rojas, Akshay Mathavan, Akash Mathavan, Saminder Kalra, Andrew Bryant, Ali Ataya","doi":"10.1164/rccm.202501-0056RL","DOIUrl":"10.1164/rccm.202501-0056RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1300-1302"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Tung <i>et al.</i>: Methodological Considerations in the Study of Preserved-Ratio Impaired Spirometry and Dementia Risk.","authors":"Jinyuan Wang, Yamei Tang","doi":"10.1164/rccm.202411-2319LE","DOIUrl":"10.1164/rccm.202411-2319LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1307"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do You Believe in Magic? Computed Tomography, Artificial Intelligence, and Chronic Obstructive Pulmonary Disease.","authors":"Peter M A Calverley","doi":"10.1164/rccm.202502-0521ed","DOIUrl":"https://doi.org/10.1164/rccm.202502-0521ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"11 1","pages":"1112-1113"},"PeriodicalIF":24.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.","authors":"Jessica M Madrigal, Jared A Fisher, Caroline N Pruitt, Linda M Liao, Barry I Graubard, Mary H Ward, Debra T Silverman, Rena R Jones","doi":"10.1164/rccm.202409-1738OC","DOIUrl":"10.1164/rccm.202409-1738OC","url":null,"abstract":"<p><p><b>Rationale:</b> Industrial facilities emit known lung carcinogens into air, but the association of these agents with lung cancer risk at environmental levels is unknown. <b>Objectives:</b> We sought to investigate industrial emissions and lung cancer risk. <b>Methods:</b> We used a U.S. regulatory database to estimate airborne exposure to known and probable human carcinogens (<i>n </i>= 31) emitted from industrial sources (1987-1995) for 442,986 participants in the NIH-AARP Diet and Health Study. We estimated inverse distance- and wind-weighted average exposures within 1, 2, 5, and 10 km of the enrollment residence. Using Cox proportional hazards models adjusted for smoking and other confounders, we evaluated lung cancer risk overall and by major histologic subtype (adenocarcinoma, squamous cell carcinoma, small cell carcinoma) for levels (tertiles and medians) of exposure to each agent. <b>Measurements and Main Results:</b> Among agents with prior evidence of lung carcinogenicity, overall risk was elevated for cobalt (5-km hazard ratio (HR) for tertile₃ (T₃) = 1.19; 95% confidence interval [CI] = 1.10-1.29; p-trend ⩽ 0.0001; 10-km HR_T3 = 1.15; 95% CI = 1.09-1.21; p-trend ⩽ 0.0001) and beryllium (5-km HR_T3 = 1.20; 95% CI = 0.94-1.55; p-trend = 0.15; 10-km HR_T3 = 1.15; 95% CI = 1.01-1.31; p-trend = 0.02). We also observed associations with benzene and nickel. For agents without prior evidence, styrene was associated with risk at 1 km (HR_T3 = 1.22; 95% CI = 1.00-1.48; p-trend = 0.03). Diethyl sulfate, chromium, and lead were also associated with risk. Associations for cobalt, benzene, nickel, and diethyl sulfate were most apparent for squamous cell carcinoma. <b>Conclusions:</b> Our novel findings show that relatively high air emissions of numerous carcinogenic industrial agents near the home were associated with lung cancer risk unexplained by smoking. These and the stronger associations for squamous cell carcinoma highlight the potential role of industrial exposures in lung cancer development.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1241-1252"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Currow <i>et al.</i> and to Akgün.","authors":"Amy Heinzerling, Robert Harrison, Jennifer Flattery, Jane C Fazio, Sheiphali Gandhi, Kristin J Cummings","doi":"10.1164/rccm.202502-0405LE","DOIUrl":"10.1164/rccm.202502-0405LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1312-1313"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for Data Accuracy in Assessing Pulmonary Arterial Hypertension Care Delivery.","authors":"Chung-Chu Tung, Renin Chang","doi":"10.1164/rccm.202502-0427LE","DOIUrl":"10.1164/rccm.202502-0427LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1313-1314"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Hypoxemia and Pulmonary Capillary Dilatations in Pulmonary Arterial Hypertension Patients Treated with Sotatercept.","authors":"Karen M Olsson, Laurent Savale, Christophe Guignabert, Da-Hee Park, Jan C Kamp, Athénaïs Boucly, David Montani, Olivier Sitbon, Marc Humbert, Marius M Hoeper","doi":"10.1164/rccm.202502-0344RL","DOIUrl":"10.1164/rccm.202502-0344RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1303-1305"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Tung and Chang and to Suntharalingam <i>et al.</i>","authors":"Samuel G Rayner, Rachel J Le, Peter J Leary, John Hartney, Nathan Hatton, John J Ryan","doi":"10.1164/rccm.202503-0533LE","DOIUrl":"10.1164/rccm.202503-0533LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1315-1316"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Lung Function Led to Loss of Life during the COVID-19 Pandemic.","authors":"Rachel L Eddy, Don D Sin","doi":"10.1164/rccm.202503-0695ED","DOIUrl":"10.1164/rccm.202503-0695ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1114-1115"},"PeriodicalIF":19.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}