American journal of respiratory and critical care medicine最新文献

{"title":"World Pneumonia Day 2024: Fighting Pneumonia and Antimicrobial Resistance.","authors":"Catia Cilloniz, Charles S Dela Cruz, Guinevere Dy-Agra, Rodolfo S Pagcatipunan","doi":"10.1164/rccm.202408-1540ED","DOIUrl":"https://doi.org/10.1164/rccm.202408-1540ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy. An Official American Thoracic Society Clinical Practice Guideline.","authors":"Don Hayes, Ann L Jennerich, Ryan D Coleman, Eric Abston, Gregory T Adamson, John T Berger, Sarah P Cohen, David S Cooper, Pirooz Eghtesady, Francis Fynn-Thompson, R Mark Grady, Stephanie M Hon, Charles W Hoopes, Teresa Jewell, Hayley Lewthwaite, Michelle F Liu, David C McGiffin, Mary P Mullen, Athar M Qureshi, David L S Morales","doi":"10.1164/rccm.202410-1901ST","DOIUrl":"https://doi.org/10.1164/rccm.202410-1901ST","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension in children often progresses despite optimal therapy. This document provides an evidence-based clinical practice guideline for the management of children with progressive pulmonary hypertension despite optimal therapy.</p><p><strong>Methods: </strong>A multidisciplinary panel identified pertinent questions regarding the management of children with pulmonary hypertension that has progressed despite optimal therapy, conducted systematic reviews of the relevant literature, and applied the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to develop clinical recommendations.</p><p><strong>Results: </strong>After reviewing the research evidence, the panel considered the balance of desirable (benefits) and undesirable (harms and burdens) effects of the interventions in each proposed question. Valuation of our main outcomes was also considered, along with resources required, equity, acceptability, and feasibility. Recommendations were developed for or against interventional strategies specific to children with pulmonary hypertension that has progressed despite optimal therapy.</p><p><strong>Conclusions: </strong>Although there is a growing population of children with pulmonary hypertension, there is a striking lack of empirical evidence regarding management of those whose disease has progressed despite optimal pharmacotherapy. The panel formulated and provided the rationale for clinical recommendations for or against interventional strategies based on this limited empirical evidence, coupled with expert opinion, to aid clinicians in the management of these complex pediatric patients. In addition, we identified important areas for future research.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Pneumonia Day: Why Do We Still Need It?","authors":"Andrew Bush, Grant Waterer","doi":"10.1164/rccm.202410-1883VP","DOIUrl":"https://doi.org/10.1164/rccm.202410-1883VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucus Plugs: A Treatable Trait for Preventing COPD Exacerbations.","authors":"Meghan Koo, Miranda Kirby","doi":"10.1164/rccm.202410-2081ED","DOIUrl":"https://doi.org/10.1164/rccm.202410-2081ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Pruning, Peripheral Air Space Alterations and Carbon Monoxide Transfer in Smokers.","authors":"Sylvia Verbanck, Pieter Boonen, Jef Vandemeulebroucke, Wilfried Cools, Raúl San José Estépar, Eef Vanderhelst","doi":"10.1164/rccm.202405-1043RL","DOIUrl":"https://doi.org/10.1164/rccm.202405-1043RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Population-Level Impact of Empiric Anti-Anaerobic Antibiotics among US Adults Hospitalized with Sepsis.","authors":"Andrew J Admon, Michael W Sjoding, Hallie C Prescott, Rishi Chanderraj, Robert P Dickson","doi":"10.1164/rccm.202405-0955RL","DOIUrl":"https://doi.org/10.1164/rccm.202405-0955RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow-controlled Expiration Reduces Lung Injury During Assisted Ventilation in Pigs with ARDS.","authors":"Sashko G Spassov, Lea Streicher, Eva Bohe, Patryk Dzierzawski, Silke Borgmann, Johannes Dinkelaker, Bernd Flamm, Johannes Spaeth, Johannes Schmidt, Stefan Schumann, Christin Wenzel","doi":"10.1164/rccm.202404-0869RL","DOIUrl":"https://doi.org/10.1164/rccm.202404-0869RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Biomarkers of Survival in Idiopathic Pulmonary Fibrosis.","authors":"Justin M Oldham, Yong Huang, Swaraj Bose, Shwu-Fan Ma, John S Kim, Alexandra Schwab, Christopher Ting, Kaniz Mou, Cathryn T Lee, Ayodeji Adegunsoye, Sahand Ghodrati, Janelle Vu Pugashetti, Nazanin Nazemi, Mary E Strek, Angela L Linderholm, Ching-Hsien Chen, Susan Murray, Rachel L Zemans, Kevin R Flaherty, Fernando J Martinez, Imre Noth","doi":"10.1164/rccm.202301-0117OC","DOIUrl":"10.1164/rccm.202301-0117OC","url":null,"abstract":"<p><p><b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high mortality. Reliable and accurate prognostic biomarkers are urgently needed. <b>Objectives:</b> To identify and validate circulating protein biomarkers of IPF survival. <b>Methods:</b> High-throughput proteomic data were generated using prospectively collected plasma samples from patients with IPF from the Pulmonary Fibrosis Foundation Patient Registry (discovery cohort) and the Universities of California, Davis; Chicago; and Virginia (validation cohort). Proteins associated with three-year transplant-free survival (TFS) were identified using multivariable Cox proportional hazards regression. Those associated with TFS after adjustment for false discovery in the discovery cohort were advanced for testing in the validation cohort, with proteins maintaining TFS association with consistent effect direction considered validated. After combining cohorts, functional analyses were performed, and machine learning was used to derive a proteomic signature of TFS. <b>Measurements and Main Results:</b> Of 2,921 proteins tested in the discovery cohort (<i>n</i> = 871), 231 were associated with differential TFS. Of these, 140 maintained TFS association with consistent effect direction in the validation cohort (<i>n</i> = 355). After cohorts were combined, the validated proteins with the strongest TFS association were latent-transforming growth factor β-binding protein 2 (hazard ratio [HR], 2.43; 95% confidence interval [CI] = 2.09-2.82), collagen α-1(XXIV) chain (HR, 2.21; 95% CI = 1.86-2.39), and keratin 19 (HR, 1.60; 95% CI = 1.47-1.74). In decision curve analysis, a proteomic signature of TFS outperformed a similarly derived clinical prediction model. <b>Conclusions:</b> In the largest proteomic investigation of IPF outcomes performed to date, we identified and validated 140 protein biomarkers of TFS. These results shed important light on potential drivers of IPF progression.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1111-1120"},"PeriodicalIF":19.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11092951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?","authors":"Jason H T Bates, David W Kaczka, Michaela Kollisch-Singule, Gary F Nieman, Donald P Gaver","doi":"10.1164/rccm.202307-1292VP","DOIUrl":"10.1164/rccm.202307-1292VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"787-788"},"PeriodicalIF":19.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is the Point of Bayesian Analysis?","authors":"Ewan C Goligher, Michael O Harhay","doi":"10.1164/rccm.202310-1757VP","DOIUrl":"10.1164/rccm.202310-1757VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"485-487"},"PeriodicalIF":19.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71433930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}