American journal of respiratory and critical care medicine最新文献

{"title":"Right Ventricular Injury Phenotypes: Is Coupling the Missing Link in the RECHO-ICU Trial?","authors":"José Carlos Gasca-Aldama, Karen Harumi López Rodríguez, Osvaldo Alexis Marché Fernández, Juan Ángel Morales Ferrer, José Ernesto Juárez León","doi":"10.1093/ajrccm/aamag531","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag531","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Lin et al.: Incorporating Mortality into the Longitudinal Analysis of Lung Function in Fibrotic Lung Disease.","authors":"Roger J Lewis","doi":"10.1093/ajrccm/aamag556","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag556","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Gasca-Aldama et al.: Right Ventricular Injury Phenotypes: Is Coupling the Missing Link in the RECHO-ICU Trial?","authors":"Adrien Joseph, Bruno Evrard, Cyril Charron, Gwenaël Prat, Alexis Dürr, Michel Slama, Philippe Vignon, Antoine Vieillard-Baron","doi":"10.1093/ajrccm/aamag532","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag532","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating Mortality into the Longitudinal Analysis of Lung Function in Fibrotic Lung Disease.","authors":"Dan-Yu Lin, Peter Smith, Chunqin Deng","doi":"10.1093/ajrccm/aamag555","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag555","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Coding Variants in FOXF1 are Associated with Pulmonary Arterial Hypertension","authors":"Jose Gomez-Arroyo,Arjan C Houweling,Alex V Postma,Tushar Ganjawala,Dennis Dooijes,Harm Jan Bogaard,Jurjan Aman,Rob Zwart,Joseph A Kitzmiller,Gabriëla G Edel,Aleksey Porollo,Lilian J Meijboom,Nidhy P Varghese,Philip Hale,Jason Hong,Na Zhu,Carrie L Welch,Yufeng Shen,Francis X McCormack,Micheala A Aldred,Matthew T Weirauch,Robbert J Rottier,Pawel Stankiewicz,Stefan Graf,Christopher Rhodes,Wendy K Chung,Jeffrey A Whitsett,William J Zacharias,Lisa J Martin,Vladimir V Kalinichenko,William C Nichols","doi":"10.1093/ajrccm/aamag550","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag550","url":null,"abstract":"Abstract Rationale Most patients with nonheritable forms of pulmonary arterial hypertension (PAH) lack identifiable pathogenic variants. Increasing evidence suggests that, in addition to high-impact predicted loss-of-function variants, rare missense coding variants may also contribute to disease pathogenesis. Objectives We identified ultra-rare missense variants in FOXF1 in two index cases with PAH. FOXF1 encodes a highly conserved transcription factor essential for lung vascular development. We sought to define the frequency of FOXF1 variants, characterize FOXF1 expression, and assess the functional relevance of FOXF1 alterations in PAH. Methods Three independent international PAH cohorts were analyzed for predicted deleterious FOXF1 variants. FOXF1 expression was evaluated using bulk and single-cell RNA sequencing and immunofluorescence. Bioinformatic and chromatin-profiling approaches were used to identify potential downstream transcriptional targets, followed by promoter-reporter assays in vitro. Measurements and Main Results Nine novel and one rare missense variants, one start-site variant, and one in-frame deletion in FOXF1 were identified across the three cohorts. FOXF1 expression was reduced in PAH lungs and localized predominantly to the endothelial cell compartment. Histopathological analysis revealed heterogeneous FOXF1 expression, with the lowest levels in phenotypically abnormal endothelial cells within complex vascular lesions. Single-cell analyses confirmed reduced endothelial FOXF1 expression in PAH, whereas broad FOXF1 downregulation across endothelial populations was not observed in other chronic lung diseases. Integration of CUT&Tag and ATAC-seq identified a canonical FOXF1-binding motif within the BMPR2 promoter. Promoter-reporter assays further supported FOXF1-dependent transcriptional regulation of BMPR2 and demonstrated reduced transcriptional activity of PAH-associated FOXF1 variants. Conclusions Large-scale genomic and transcriptomic analyses support an association between FOXF1 dysregulation and PAH and identify BMPR2 as a potential downstream transcriptional target.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"37 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial multidomain six-minute walk assessment for dynamic risk prediction in idiopathic pulmonary fibrosis.","authors":"Abhimanyu Chandel, Stephanie Morgan, Junad M Chowdhury, Zein Kattih, Vikramjit Khangoora, Christopher A Thomas, Christopher S King, Steven D Nathan","doi":"10.1093/ajrccm/aamag552","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag552","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oscillometry Detects Early Lung Injury and Predicts Future Abnormal Spirometry in World Trade Center Survivors.","authors":"Eunsil Seok, Katherine Siu, Yuyan Wang, Ziyue Wang, Myeonggyun Lee, Beno W Oppenheimer, Roberta M Goldring, Yongzhao Shao, Joan Reibman, Mengling Liu","doi":"10.1093/ajrccm/aamag551","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag551","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biallelic variants in CFAP20DC cause primary ciliary dyskinesia due to abnormal ciliary clearance.","authors":"Diana Carolin Bracht, Hanan E Shamseldin, Gerard W Dougherty, Laure-Emmanuelle Zaragosi, Eyyüp Uctepe, Melih Hangül, Fowzan S Alkuraya, Hong Luo, Julia Wallmeier, Heymut Omran","doi":"10.1093/ajrccm/aamag524","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag524","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Niches in ARDS: Heterogeneity within the injured lungs.","authors":"Dan Wang, Na Li, Depeng Jiang, Daoxin Wang, Mingdong Hu, Weijie Dong","doi":"10.1093/ajrccm/aamag545","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag545","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 Global Initiative for Asthma (GINA) Strategy Report: Executive Summary and Key Changes.","authors":"Helen K Reddel, Keith Allan, Leonard B Bacharier, Matteo Bonini, Arnaud Bourdin, Christopher Brightling, Roland Buhl, Jeremiah Chakaya, Alvaro A Cruz, Francine M Ducharme, Liesbeth Duijts, Louise Fleming, Hiromasa Inoue, Alan Kaplan, Fanny Wai San Ko, Jerry A Krishnan, Mark L Levy, Refiloe Masekela, Paulo Marcio Pitrez, Sundeep Salvi, Arzu Yorgancioğlu, Min Zhang, Guy Brusselle","doi":"10.1093/ajrccm/aamag542","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag542","url":null,"abstract":"<p><p>The Global Initiative for Asthma (GINA) Strategy Report provides a comprehensive, annually updated evidence-based approach to asthma diagnosis, assessment, treatment, and prevention across the lifespan. Its central approach is personalized, iterative care based on the Assess-Adjust-Review cycle for both symptom control and reduction of future risk (including severe exacerbations, persistent airflow limitation, and treatment-related harm). GINA emphasizes objective confirmation of diagnosis wherever possible, and regular assessment of lung function, inhaler technique, adherence, multimorbidity, risk factors (including Type-2 biomarkers), and patient goals and preferences. GINA strongly recommends that all adults, adolescents, children and most preschoolers with asthma should receive inhaled corticosteroid (ICS)-containing treatment. GINA recommends against short-acting beta2-agonist (SABA)-only treatment. For adults/adolescents, GINA Track 1 using low-dose ICS-formoterol, an anti-inflammatory reliever (AIR), either as-needed-only (AIR-only) or as maintenance-and-reliever therapy (MART), is preferred because of its substantial reduction in severe exacerbations compared with SABA-based regimens, and its simplicity. Age-specific treatment pathways in children also emphasize ICS-containing therapy and exacerbation prevention. For difficult-to-treat and severe asthma, GINA provides structured guidance, emphasizing diagnostic verification, optimization of modifiable factors, inflammatory phenotyping, biologic therapy selection, and (as for all patients) systemic corticosteroid stewardship. Acute exacerbation care incorporates long-term preventive treatment, including post-discharge reassessment of management and action plan. Key 2026 updates include expanded AIR options for adults and children, revised guidance on severe asthma and selection of biologic treatment, and substantial updates to acute asthma management. GINA integrates evidence-based management with shared decision-making, self-management education, implementation, and global advocacy to reduce preventable asthma morbidity and mortality.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}