American journal of respiratory and critical care medicine最新文献

{"title":"Biologic Therapy in Severe Asthma: Methodological Gaps and Opportunities for Greater Precision.","authors":"Jingxuan Zhou,Yu Ji,Bin Wei","doi":"10.1164/rccm.202507-1733le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1733le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"100 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Evidence for Biologics in Preventing Oral Corticosteroid-related Adverse Outcomes in Severe Asthma.","authors":"Weikai Dong,Zhaoqi Du,Wei Li","doi":"10.1164/rccm.202507-1741le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1741le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"18 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes Associated with the Super-Exacerbator Phenotype after a Hospitalization for COPD.","authors":"Carolyn G Garcia,Aruna Priya,Eduardo R Núñez,Yael Tarshish,Viswanathan Shankar,Penelope S Pekow,David H Au,Peter K Lindenauer","doi":"10.1164/rccm.202507-1700rl","DOIUrl":"https://doi.org/10.1164/rccm.202507-1700rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"318 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE, Matrix Metalloproteinases, and Tuberculosis: Immunologic Consequences of Helminth Co-Infection.","authors":"Maria-Cristina I Loader,Sory E Vásquez Alves,Neusa L Vásquez Alves,Jorge Coronel,Carmen Taquiri,Fabiola Díaz-Soria,William H Elson,Daniela E Kirwan,Robert H Gilman,Jon S Friedland","doi":"10.1164/rccm.202507-1710rl","DOIUrl":"https://doi.org/10.1164/rccm.202507-1710rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"28 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelomatous Pleural Effusion: A Rare Initial Manifestation of Multiple Myeloma.","authors":"Guo Li,Yang Liu,Min Pang,Peng Wang,San-Jun Guo,Guo-Lu Jiang","doi":"10.1164/rccm.202505-1050im","DOIUrl":"https://doi.org/10.1164/rccm.202505-1050im","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"80 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Nontuberculous Mycobacteria Mortality in the United States, 1999-2020.","authors":"Ko-Yun Chang,Yu-Che Lee,Chih-Yun Chang,Charles L Daley","doi":"10.1164/rccm.202504-0939rl","DOIUrl":"https://doi.org/10.1164/rccm.202504-0939rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"61 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis.","authors":"Leonardo Martinez,Jeffrey I Campbell,Lauren Linde,Fadila Boulahbal,Joan A Cayla,Tsira Chakhaia,Pei-Chun Chan,Cheng Chen,Chi-Tai Fang,Greg Fox,Louis Grandjean,Djohar Hannoun,Anneke Hesseling,C Robert Horsburgh,Li-Min Huang,Qiao Liu,Rufaida Mazahir,Chih-Hsin Lee,Li-Na Lee,Rutger Bennet,Sahar Nejat,Amita Gupta,Mrinalini Das,Megan Murray,Chuan-Chin Huang,Helena Del Corral,Dione Benjumea-Bedoya,Ye Shen,Mercedes Becerra,Vicky Chang,Sonya Krishnan,Petra Heinmueller,Timothy Brewer,Petros Isaakidis,Anja M Hauri,Lena Shah,Lisa Trieu,James A Seddon","doi":"10.1164/rccm.202411-2340oc","DOIUrl":"https://doi.org/10.1164/rccm.202411-2340oc","url":null,"abstract":"RATIONALERecent empirical research suggests isoniazid may lead to a risk reduction of incident tuberculosis among close tuberculosis contacts of multi-drug resistant (MDR) tuberculosis.OBJECTIVESTo evaluate the association between isoniazid tuberculosis preventive treatment (TPT), compared to no treatment, upon incident tuberculosis in household contacts of MDR tuberculosis cases using a large global consortium of tuberculosis contact tracing studies.METHODSWe conducted a systematic review and individual-participant meta-analysis among observational studies of household contact tracing studies. Participants were included if they were exposed to someone with MDR-tuberculosis and were given either 6 months of isoniazid TPT or no TPT. Our primary outcome was incident tuberculosis in contacts exposed to tuberculosis. We derived adjusted hazard ratios (aHRs) using mixed-effects, multivariable survival regression models with study-level random effects. The effectiveness of isoniazid TPT against incident tuberculosis was estimated through propensity score matching. We stratified our results by contact age, background tuberculosis burden, and Mycobacterium tuberculosis infection status.MEASUREMENTS AND MAIN RESULTSWe included participant-level data from 6,668 contacts exposed to multidrug-resistant tuberculosis from 17 countries. The effectiveness of isoniazid TPT against incident tuberculosis in contacts of multidrug-resistant tuberculosis was 57% (aHR, 0.43; 95% CI, 0.26-0.71) and did not appreciably change with adjustment for additional potential confounders. The reduction in incident tuberculosis was marginally greater among child (<20 years old) contacts (0.51; 95% CI, 0.28-0.92) compared to adult contacts (0.69; 95% CI, 0.22-2.20). The reduction in incidence was 73% (0.27; 95% CI, 0.11-0.70) in the first year of follow-up; effectiveness dropped to 60% (0.40; 95% CI, 0.15-1.06) from 12-23 months of follow-up and was non-significant after two years (28% effectiveness; 0.72; 95% CI, 0.33-1.54).CONCLUSIONSAmong over 6,500 contacts of MDR-tuberculosis, isoniazid TPT was highly effective in preventing incident tuberculosis. The reduction was greatest in high-burden countries and waned after 2 years of follow-up.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"156 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Epithelial Heterogeneity and Mucus Plugging in Asthmatic Bronchioles.","authors":"Stephen A Schworer,Hiroaki Murano,Hong Dang,Matthew R Markovetz,Minako Saito,Takafumi Kato,Takanori Asakura,Gang Chen,Rodney C Gilmore,Lisa C Morton,Catharina van Heusden,Michael Chua,Ella Strickler,Zoey Y Wisniewski,Gillian Crisp,Elodie Mitchell,Kayleigh A Doherty,Shania Mastan,Humberto E Trejo Bittar,Brittany A Cody,John B Trudeau,Gabriela De la Cruz,Lauren M Ralph,Frederic B Askin,Reynold A Panettieri,Cynthia J Koziol-White,Kevin M Byrd,Alessandra Livraghi-Butrico,Wanda K O'Neal,Scott H Randell,Sally E Wenzel,Kenichi Okuda,Richard C Boucher","doi":"10.1164/rccm.202409-1849oc","DOIUrl":"https://doi.org/10.1164/rccm.202409-1849oc","url":null,"abstract":"RATIONALEBronchiolar dysfunction is associated with asthma exacerbations and poor symptom control. However, the molecular pathophysiology of asthmatic bronchiolar disease is poorly defined.OBJECTIVESTest the hypothesis that asthmatic bronchioles exhibit disturbances in epithelial biology that produce MUC5AC-dominated mucus plugs.METHODSPeripheral lung tissues from severe asthmatics, fatal asthmatics (FA), and controls were evaluated with histology, RNA in situ hybridization, and immunohistochemistry. Isolated bronchiolar and bronchial basal cell responses to IL13 were compared in culture. Spatial transcriptomics and multiplex immunophenotyping were performed on excised tissue sections.MEASUREMENTS AND MAIN RESULTSIn excised tissues, severe and FA bronchiolar epithelia, depleted of distal airway secretory cells (DASCs) and enriched in MUC5AC goblet cells, circumscribed MUC5AC-dominated mucus plugs. In cultured bronchiolar basal cells, IL13 suppressed FOXA2 and DASC gene signatures and upregulated MUC5AC expression. Additional studies in severe and FA excised tissues demonstrated that bronchiolar epithelia were populated by MUC5AC-expressing goblet cell niches heterogeneously distributed within single segments and, indeed, individual bronchioles. Spatial transcriptomics and immuno-proteomics of these MUC5AC-expressing bronchiolar niches identified increased goblet, suprabasal (SERPINB3), and basal cell, juxtaposed to a loss of DASC, gene signatures. MUC5AC-high niche bronchiolar basal cells expressed reduced FOXA2 and elevated type-2 inflammatory (T2) gene signatures. Immune cell distributions surrounding asthmatic bronchioles differed from controls but did not correlate with MUC5AC-high niches.CONCLUSIONSAsthmatic bronchioles exhibit a T2-driven proximalization associated with mucus plugging. MUC5AC-high niches were identified heterogeneously in bronchiolar epithelia independent of immune cell localizations, suggesting asthmatic bronchioles contain cellular niches which perpetuate T2-initiated epithelial remodeling.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"30 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cornucopia of Plasma Proteomics in Moderate-Severity Community-acquired Pneumonia.","authors":"Richard G Wunderink","doi":"10.1164/rccm.202507-1734ed","DOIUrl":"https://doi.org/10.1164/rccm.202507-1734ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"90 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxemia with Sotatercept.","authors":"Mardi Gomberg-Maitland, Rogerio Souza, Lewis J Rubin","doi":"10.1164/rccm.202506-1492LE","DOIUrl":"10.1164/rccm.202506-1492LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}