{"title":"Microbes Meets Host: The Next Frontier in Sepsis Classification.","authors":"Clea R Barnett,Lieuwe D J Bos,Leopoldo N Segal","doi":"10.1164/rccm.202507-1590ed","DOIUrl":"https://doi.org/10.1164/rccm.202507-1590ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"89 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam M Deane,Diane Heels-Ansdell,Francois Lauzier,Neill K J Adhikari,Deborah Cook
{"title":"Reply to Wang et al.: Closing the Gaps: Enhancing Risk Factor Evaluation for Patient-Important Upper Gastrointestinal Bleeding.","authors":"Adam M Deane,Diane Heels-Ansdell,Francois Lauzier,Neill K J Adhikari,Deborah Cook","doi":"10.1164/rccm.202506-1513le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1513le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"80 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emma J Leacy,Daniel D Fraughen,Ronan C Heeney,Michelle Casey,Mark Sherlock,Michael W O'Reilly,Mark P Murphy,Annie M Curtis,Tomás P Carroll,Noel G McElvaney
{"title":"Seasonal Changes in Circulating Alpha-1 Antitrypsin Are Altered by Sex and Genetic Deficiency.","authors":"Emma J Leacy,Daniel D Fraughen,Ronan C Heeney,Michelle Casey,Mark Sherlock,Michael W O'Reilly,Mark P Murphy,Annie M Curtis,Tomás P Carroll,Noel G McElvaney","doi":"10.1164/rccm.202506-1341rl","DOIUrl":"https://doi.org/10.1164/rccm.202506-1341rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"123 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Echocardiographic Metrics of Right Ventricular Function Reliably Predict Mortality in Pulmonary Embolism? Doubts Persist.","authors":"Yuejuan Cao,Chunjun Li","doi":"10.1164/rccm.202506-1338le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1338le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"38 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to Cao and Li: Can Echocardiographic Metrics of Right Ventricular Function Reliably Predict Mortality in Pulmonary Embolism? Doubts Persist.","authors":"Manuel Ruiz-Bailén","doi":"10.1164/rccm.202506-1476le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1476le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"20 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deepshikha C Ashana,Kimberly S Johnson,Ernestine C Briggs,Samantha Morrison,Maragatha Kuchibhatla,Nidhi Charan,Christopher E Cox
{"title":"Intensive Care Unit Practices That Address Traumatic Stress Among Clinicians: A U.S. Survey.","authors":"Deepshikha C Ashana,Kimberly S Johnson,Ernestine C Briggs,Samantha Morrison,Maragatha Kuchibhatla,Nidhi Charan,Christopher E Cox","doi":"10.1164/rccm.202504-0978rl","DOIUrl":"https://doi.org/10.1164/rccm.202504-0978rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"15 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accurate and Early Diagnosis of NSCLC Using Aberrant Fragmentomic Features of Circulating Cell-Free Mitochondrial DNA.","authors":"Fan Peng,Siyuan Wang,Huanmin Jiao,Miao Dang,Huanqin Zhang,Kaixiang Zhou,Wenjie Guo,Shanshan Guo,Zhaolei Cui,Zhiyun Gong,Renquan Lu,Ke Dong,Xiumin Ma,Yang Liu,Jinliang Xing","doi":"10.1164/rccm.202411-2247oc","DOIUrl":"https://doi.org/10.1164/rccm.202411-2247oc","url":null,"abstract":"BACKGROUNDEarly differential diagnosis of benign and malignant lung diseases is a critical challenge in the clinical oncology of non-small cell lung cancer (NSCLC). We aim to develop a novel strategy utilizing circulating cell free mtDNA (ccf-mtDNA) fragmentomics for accurate and early diagnosis of NSCLC.METHODSWe analyzed capture-based ccf-mtDNA sequencing data of 2,306 plasma samples from 1,357 NSCLC patients, 432 benign lung diseases (BLD) patients, and 517 healthy controls (HCs) obtained from three hospitals. Subsequently, using ccf-mtDNA fragmentomic features, we developed models for Differential diagnosis of Benign and Malignant lung diseases (DBM) and Early Diagnosis of NSCLC (EDL).RESULTSOur analysis revealed significantly aberrant fragmentomic features of ccf-mtDNA in NSCLC patients compared with those in BLD patients and HCs. Remarkably, the DBM model demonstrated remarkable capability to distinguish NSCLC from BLD, outperforming serum biomarkers with an AUC exceeding 0.9551 in three validation cohorts. Still, the DBM model exhibited superior diagnostic performance even for small nodules (< 1 cm), achieving an AUC of 0.9151. Moreover, the DBM model demonstrated precise clinical management ability of pulmonary lesions, thereby avoiding unnecessary invasive procedures in BLD patients and preventing delayed treatment in NSCLC patients. Furthermore, the EDL model demonstrated outstanding performance in detecting stage 0 - Ⅰ NSCLC, with an AUC exceeding 0.9759.CONCLUSIONSOur multicenter study provides a novel non-invasive approach using ccf-mtDNA fragmentomics for the differential diagnosis of benign and malignant lung diseases and early diagnosis of NSCLC, with potential applications in clinical decision-making in the management of NSCLC.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"55 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential Risk of Eccentric Diaphragm Contraction in the STIMULUS Trial.","authors":"Taiga Itagaki,Yusuke Akimoto,Jun Oto","doi":"10.1164/rccm.202506-1452le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1452le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"1 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dino B A Tan,Maike Stentenbach,Erin Bolitho,Chantalia Tedja,Erick Aresgado,Ching-Hsien Chen,Angela Linderholm,Justin Oldham,Yuben Moodley,
{"title":"Let-7f-5p Has Anti-Fibrotic Properties and Is Reduced in Circulatory sEV in Progressive IPF.","authors":"Dino B A Tan,Maike Stentenbach,Erin Bolitho,Chantalia Tedja,Erick Aresgado,Ching-Hsien Chen,Angela Linderholm,Justin Oldham,Yuben Moodley, ","doi":"10.1164/rccm.202504-0882rl","DOIUrl":"https://doi.org/10.1164/rccm.202504-0882rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"4 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}